{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:04:12Z","timestamp":1791331452317,"version":"4.3.1"},"reference-count":52,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain, Behavior, and Immunity"],"published-print":{"date-parts":[[2011,1]]},"DOI":"10.1016\/j.bbi.2010.09.001","type":"journal-article","created":{"date-parts":[[2010,9,8]],"date-time":"2010-09-08T04:55:29Z","timestamp":1283921729000},"page":"110-119","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":110,"title":["S-Propargyl-cysteine, a novel hydrogen sulfide-modulated agent, attenuates lipopolysaccharide-induced spatial learning and memory impairment: Involvement of TNF signaling and NF-\u03baB pathway in rats"],"prefix":"10.1016","volume":"25","author":[{"given":"Qi-Hai","family":"Gong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-Long","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin-Hua","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Xin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Zhun","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbi.2010.09.001_b0005","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1523\/JNEUROSCI.16-03-01066.1996","article-title":"The possible role of hydrogen sulfide as an endogenous neuromodulator","volume":"16","author":"Abe","year":"1996","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bbi.2010.09.001_b0010","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/S0197-4580(00)00124-X","article-title":"Inflammation and Alzheimer\u2019s disease","volume":"21","author":"Akiyama","year":"2000","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.bbi.2010.09.001_b0015","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/S0140-6736(06)69113-7","article-title":"Alzheimer\u2019s disease","volume":"68","author":"Blennow","year":"2006","journal-title":"Lancet"},{"key":"10.1016\/j.bbi.2010.09.001_b0020","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1038\/nrn2038","article-title":"Microglia-mediated neurotoxicity: uncovering the molecular mechanisms","volume":"8","author":"Block","year":"2007","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.bbi.2010.09.001_b0025","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.tips.2003.12.004","article-title":"Beta-secretase inhibition for the treatment of Alzheimer\u2019s disease-promise and challenge","volume":"25","author":"Citron","year":"2004","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.bbi.2010.09.001_b0030","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/j.jep.2006.05.030","article-title":"Effect of aged garlic extract on APP processing and tau phosphorylation in Alzheimer\u2019s transgenic model Tg2576","volume":"108","author":"Chauhan","year":"2006","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.bbi.2010.09.001_b0035","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/S0171-2985(86)80064-X","article-title":"Production of tumor necrosis factor in unprimed mice. Mechanism of endotoxin-mediated tumor necrosis","volume":"171","author":"Flick","year":"1986","journal-title":"Immunobiology"},{"key":"10.1016\/j.bbi.2010.09.001_b0040","doi-asserted-by":"crossref","first-page":"S81","DOI":"10.1016\/S0092-8674(02)00703-1","article-title":"Missing pieces in the NF-kappaB puzzle","volume":"109","author":"Ghosh","year":"2002","journal-title":"Cell"},{"key":"10.1016\/j.bbi.2010.09.001_b0045","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1046\/j.1460-9568.2003.02506.x","article-title":"Beta-amyloid peptide potentiates inflammatory responses induced by lipopolysaccharide, interferon-gamma and advanced glycation endproductsT in a murine microglia cell line","volume":"17","author":"Gasic-Milenkovic","year":"2003","journal-title":"Eur. J. NeuroSci."},{"key":"10.1016\/j.bbi.2010.09.001_b0050","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1053\/jhep.2003.50004","article-title":"Cyclooxygenase-derived products modulate the increased intrahepatic resistance of cirrhotic rat livers","volume":"37","author":"Graupera","year":"2003","journal-title":"Hepatology"},{"key":"10.1016\/j.bbi.2010.09.001_b0055","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.lfs.2004.10.067","article-title":"Protective effects of Ginkgo biloba leaf extract on aluminum-induced brain dysfunction in rats","volume":"77","author":"Gong","year":"2005","journal-title":"Life Sci."},{"key":"10.1016\/j.bbi.2010.09.001_b0060","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.neulet.2007.09.042","article-title":"Anti-amyloidogenic activity of S-allyl-l-cysteine and its activity to destabilize Alzheimer\u2019s beta-amyloid fibrils in vitro","volume":"429","author":"Gupta","year":"2007","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.bbi.2010.09.001_b0065","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/j.it.2008.05.002","article-title":"Why neurodegenerative diseases are progressive: uncontrolled inflammation drives disease progression","volume":"29","author":"Gao","year":"2008","journal-title":"Trends Immunol."},{"key":"10.1016\/j.bbi.2010.09.001_b0070","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.pbb.2010.04.006","article-title":"Hydrogen sulfide attenuates lipopolysaccharide-induced cognitive impairment: a pro-inflammatory pathway in rats","volume":"96","author":"Gong","year":"2010","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.bbi.2010.09.001_b0075","doi-asserted-by":"crossref","unstructured":"Gong, Q.H., Pan, L.L., Liu, X.H., Wang, Q., Huang, H., Zhu, Y.Z., 2010. S-Propargyl-cysteine (ZYZ-802), a sulphur-containing amino acid, attenuates beta-amyloid-induced cognitive deficits and pro-inflammatory response: involvement of ERK1\/2 and NF-kappaB pathway in rats. Amino acids 2010 Jul 17. (Epub ahead of print). PMID: 20640462.","DOI":"10.1007\/s00726-010-0685-1"},{"key":"10.1016\/j.bbi.2010.09.001_b0080","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/S0006-8993(98)00227-3","article-title":"Brain inflammatory response induced by intracerebroventricular infusion of lipopolysaccharide: an immunohistochemical study","volume":"794","author":"Hauss-Wegrzyniak","year":"1998","journal-title":"Brain Res."},{"key":"10.1016\/j.bbi.2010.09.001_b0085","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1083\/jcb.200705042","article-title":"Deletion of tumor necrosis factor death receptor inhibits amyloid beta generation and prevents learning and memory deficits in Alzheimer\u2019s mice","volume":"178","author":"He","year":"2007","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.bbi.2010.09.001_b0090","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1111\/j.1471-4159.2006.04283.x","article-title":"Hydrogen sulfide attenuates lipopolysaccharide-induced inflammation by inhibition of p38 mitogen-activated protein kinase in microglia","volume":"100","author":"Hu","year":"2007","journal-title":"J. Neurochem."},{"key":"10.1016\/j.bbi.2010.09.001_b0095","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1111\/j.1474-9726.2009.00543.x","article-title":"Neuroprotective effects of hydrogen sulfide on Parkinson\u2019s disease rat models","volume":"9","author":"Hu","year":"2010","journal-title":"Aging Cell"},{"key":"10.1016\/j.bbi.2010.09.001_b0100","doi-asserted-by":"crossref","first-page":"6309","DOI":"10.1523\/JNEUROSCI.20-16-06309.2000","article-title":"Regional difference in susceptibility to lipopolysaccharide-induced neurotoxicity in the rat brain: role of microglia","volume":"20","author":"Kim","year":"2000","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bbi.2010.09.001_b0105","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1096\/fj.04-1815fje","article-title":"Hydrogen sulfide protects neurons from oxidative stress","volume":"18","author":"Kimura","year":"2004","journal-title":"FASEB J."},{"key":"10.1016\/j.bbi.2010.09.001_b0110","doi-asserted-by":"crossref","first-page":"8240","DOI":"10.1523\/JNEUROSCI.1808-05.2005","article-title":"Microglial phagocytosis induced by fibrillar beta-amyloid and IgGs are differentially regulated by proinflammatory cytokines","volume":"25","author":"Koenigsknecht-Talboo","year":"2005","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bbi.2010.09.001_b0115","doi-asserted-by":"crossref","first-page":"8843","DOI":"10.1523\/JNEUROSCI.2868-05.2005","article-title":"Lipopolysaccharide-induced inflammation exacerbates tau pathology by a cyclin-dependent kinase 5-mediated pathway in a transgenic model of Alzheimer\u2019s disease","volume":"25","author":"Kitazawa","year":"2005","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bbi.2010.09.001_b0120","doi-asserted-by":"crossref","first-page":"5709","DOI":"10.1523\/JNEUROSCI.20-15-05709.2000","article-title":"Ibuprofen suppresses plaque pathology and inflammation in a mouse model for Alzheimer\u2019s disease","volume":"20","author":"Lim","year":"2000","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bbi.2010.09.001_b0125","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1038\/nri910","article-title":"NF-kappaB regulation in the immune system","volume":"2","author":"Li","year":"2002","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.bbi.2010.09.001_b0130","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.coph.2005.10.007","article-title":"Hydrogen sulphide \u2013 a novel mediator of inflammation?","volume":"6","author":"Li","year":"2006","journal-title":"Curr. Opin. Pharmacol."},{"key":"10.1016\/j.bbi.2010.09.001_b0135","first-page":"2246","article-title":"Plasma levels of endogenous hydrogen sulfide and homocysteine in patients with Alzheimer\u2019s disease and vascular dementia and the significance thereof","volume":"88","author":"Liu","year":"2008","journal-title":"Chin. Med. J."},{"key":"10.1016\/j.bbi.2010.09.001_b0140","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.1016\/j.neurobiolaging.2009.06.001","article-title":"Astrocytes produce the antiinflammatory and neuroprotective agent hydrogen sulfide","volume":"30","author":"Lee","year":"2009","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.bbi.2010.09.001_b0145","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1097\/FJC.0b013e3181bae160","article-title":"4-Guanidino-n-butyl syringate (leonurine) protects H9c2 rat ventricular cells from hypoxia-induced apoptosis","volume":"54","author":"Liu","year":"2009","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"10.1016\/j.bbi.2010.09.001_b0150","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/0165-0270(84)90007-4","article-title":"Developments of a water-maze procedure for studying spatial learning in the rat","volume":"11","author":"Morris","year":"1984","journal-title":"J. Neurosci. Methods"},{"key":"10.1016\/j.bbi.2010.09.001_b0155","doi-asserted-by":"crossref","first-page":"271","DOI":"10.3233\/JAD-2006-9S330","article-title":"Inflammation, anti-inflammatory agents and Alzheimer disease: the last 12years","volume":"9","author":"McGeer","year":"2006","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.bbi.2010.09.001_b0160","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1016\/j.neurobiolaging.2006.03.013","article-title":"NSAIDs and Alzheimer disease: epidemiological, animal model and clinical studies","volume":"28","author":"McGeer","year":"2007","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.bbi.2010.09.001_b0165","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.brainres.2008.01.095","article-title":"Ibuprofen reduces Abeta, hyperphosphorylated tau and memory deficits in Alzheimer mice","volume":"1207","author":"McKee","year":"2008","journal-title":"Brain Res."},{"key":"10.1016\/j.bbi.2010.09.001_b0170","first-page":"29","article-title":"Neuroinflammation and tumor necrosis factor signaling in the pathophysiology of Alzheimer\u2019s disease","volume":"1","author":"McAlpine","year":"2008","journal-title":"J. Inflam. Res."},{"key":"10.1016\/j.bbi.2010.09.001_b0175","doi-asserted-by":"crossref","first-page":"473","DOI":"10.3233\/JAD-2009-1158","article-title":"Neuropathology and the neuroinflammation idea","volume":"18","author":"Mrak","year":"2009","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.bbi.2010.09.001_b0180","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.expneurol.2009.12.018","article-title":"Control of neuroinflammation as a therapeutic strategy for amyotrophic lateral sclerosis and other neurodegenerative disorders","volume":"222","author":"Mosley","year":"2010","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.bbi.2010.09.001_b0185","first-page":"BR328","article-title":"Neuroprotective effect of garlic compounds in amyloid-beta peptide-induced apoptosis in vitro","volume":"8","author":"Peng","year":"2002","journal-title":"Med. Sci. Monit."},{"key":"10.1016\/j.bbi.2010.09.001_b0190","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1002\/glia.20467","article-title":"Systemic LPS causes chronic neuroinflammation and progressive neurodegeneration","volume":"55","author":"Qin","year":"2007","journal-title":"Glia"},{"key":"10.1016\/j.bbi.2010.09.001_b0195","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1523\/JNEUROSCI.4469-04.2005","article-title":"Neuroinflammation alters the hippocampal pattern of behaviorally induced Arc expression","volume":"25","author":"Rosi","year":"2005","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bbi.2010.09.001_b0200","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1084\/jem.187.2.143","article-title":"Regulation of immune responses by NF-kappa B\/Rel transcription factor","volume":"187","author":"Sha","year":"1998","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.bbi.2010.09.001_b0205","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/S0969-9961(03)00069-X","article-title":"Lipopolysaccharide-induced-neuroinflammation increases intracellular accumulation of amyloid precursor protein and amyloid beta peptide in APPswe transgenic mice","volume":"14","author":"Sheng","year":"2003","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.bbi.2010.09.001_b0210","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1007\/s00228-007-0400-7","article-title":"Clinical use and pharmacological properties of selective COX-2 inhibitors","volume":"64","author":"Shi","year":"2008","journal-title":"Eur. J. Clin. Pharmacol."},{"key":"10.1016\/j.bbi.2010.09.001_b0215","doi-asserted-by":"crossref","first-page":"359","DOI":"10.3233\/JAD-2008-13402","article-title":"Inflammatory aspects of Alzheimer disease and other neurodegenerative disorders","volume":"13","author":"Schwab","year":"2008","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.bbi.2010.09.001_b0220","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1089\/ars.2008.2253","article-title":"3-Mercaptopyruvate sulfurtransferase produces hydrogen sulfide and bound sulfane sulfur in the brain","volume":"11","author":"Shibuya","year":"2009","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.bbi.2010.09.001_b0225","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1002\/jnr.20752","article-title":"Lipopolysaccharide-induced microglial activation induces learning and memory deficits without neuronal cell death in rats","volume":"83","author":"Tanaka","year":"2006","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.bbi.2010.09.001_b0230","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.nbd.2006.12.006","article-title":"Pro-inflammatory conditions promote neuronal damage mediated by amyloid precursor protein and decrease its phagocytosis and degradation by microglial cells in culture","volume":"26","author":"Von Bernhardi","year":"2007","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.bbi.2010.09.001_b0235","doi-asserted-by":"crossref","first-page":"7563","DOI":"10.1073\/pnas.96.13.7563","article-title":"Nonsteroid drug selectivities for cyclo-oxygenase-1 rather than cyclo-oxygenase-2 are associated with human gastrointestinal toxicity: a full in vitro analysis","volume":"96","author":"Warner","year":"1999","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.bbi.2010.09.001_b0240","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/sj.cdd.4401189","article-title":"Tumor necrosis factor signaling","volume":"10","author":"Wajant","year":"2003","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.bbi.2010.09.001_b0245","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1089\/152308603768295249","article-title":"The gasotransmitter role of hydrogen sulfide","volume":"5","author":"Wang","year":"2003","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.bbi.2010.09.001_b0250","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1097\/FJC.0b013e3181ac8e12","article-title":"S-Propargyl-cysteine protects both adult rat hearts and neonatal cardiomyocytes from ischemia\/hypoxia injury: the contribution of the hydrogen sulfide-mediated pathway","volume":"54","author":"Wang","year":"2009","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"10.1016\/j.bbi.2010.09.001_b0255","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1089\/ars.2009.2947","article-title":"The therapeutic effects of S-allylcysteine and S-propargyl-cysteine on myocardial ischemia is mediated via modulation of endogenous H2S","volume":"12","author":"Wang","year":"2010","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.bbi.2010.09.001_b0260","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1016\/j.tins.2006.07.006","article-title":"The brain as a target of inflammation: common pathways link inflammatory and neurodegenerative diseases","volume":"29","author":"Zipp","year":"2006","journal-title":"Trends Neurosci."}],"container-title":["Brain, Behavior, and Immunity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0889159110004599?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0889159110004599?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T07:25:11Z","timestamp":1760167511000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0889159110004599"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,1]]},"references-count":52,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2011,1]]}},"alternative-id":["S0889159110004599"],"URL":"https:\/\/doi.org\/10.1016\/j.bbi.2010.09.001","relation":{},"ISSN":["0889-1591"],"issn-type":[{"value":"0889-1591","type":"print"}],"subject":[],"published":{"date-parts":[[2011,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"S-Propargyl-cysteine, a novel hydrogen sulfide-modulated agent, attenuates lipopolysaccharide-induced spatial learning and memory impairment: Involvement of TNF signaling and NF-\u03baB pathway in rats","name":"articletitle","label":"Article Title"},{"value":"Brain, Behavior, and Immunity","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbi.2010.09.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2010 Elsevier Inc. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}