{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T12:02:47Z","timestamp":1789473767343,"version":"build-2803163510"},"reference-count":51,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2011,7,1]],"date-time":"2011-07-01T00:00:00Z","timestamp":1309478400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2011,7,1]],"date-time":"2011-07-01T00:00:00Z","timestamp":1309478400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain, Behavior, and Immunity"],"published-print":{"date-parts":[[2011,7]]},"DOI":"10.1016\/j.bbi.2010.10.002","type":"journal-article","created":{"date-parts":[[2010,10,9]],"date-time":"2010-10-09T04:47:29Z","timestamp":1286599649000},"page":"922-931","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":61,"title":["The lymphoid chemokine, CXCL13, is dispensable for the initial recruitment of B cells to the acutely inflamed central nervous system"],"prefix":"10.1016","volume":"25","author":[{"given":"Emily K.","family":"Rainey-Barger","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie M.","family":"Rumble","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen J.","family":"Lalor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nilufer","family":"Esen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin M.","family":"Segal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David N.","family":"Irani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbi.2010.10.002_b0005","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1038\/ni1100","article-title":"Germinal center dark and light zone organization is mediated by CXCR4 and CXCR5","volume":"5","author":"Allen","year":"2004","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.bbi.2010.10.002_b0010","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.jneuroim.2008.04.025","article-title":"Lymphoid chemokines in chronic neuroinflammation","volume":"198","author":"Aloisi","year":"2008","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.bbi.2010.10.002_b0015","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1038\/35018581","article-title":"A chemokine-driven positive feedback loop organizes lymphoid follicles","volume":"406","author":"Ansel","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.bbi.2010.10.002_b0020","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/S1074-7613(01)00257-6","article-title":"CXCL13 is required for B1 cell homing, natural antibody production, and body cavity immunity","volume":"16","author":"Ansel","year":"2002","journal-title":"Immunity"},{"key":"10.1016\/j.bbi.2010.10.002_b0025","doi-asserted-by":"crossref","first-page":"7676","DOI":"10.4049\/jimmunol.176.12.7676","article-title":"CXC chemokine ligand 13 plays a role in experimental autoimmune encephalomyelitis","volume":"176","author":"Bagaeva","year":"2006","journal-title":"J. Immunol."},{"key":"10.1016\/j.bbi.2010.10.002_b0030","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1034\/j.1600-065X.2003.00067.x","article-title":"Chemokines in the systemic organization of immunity","volume":"195","author":"Campbell","year":"2003","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.bbi.2010.10.002_b0035","doi-asserted-by":"crossref","first-page":"4834","DOI":"10.1182\/blood-2008-10-186999","article-title":"Progressive multifocal leukoencephalopathy after rituximab in HIV-negative patients: a report of 57 cases from the Research on Adverse Drug Events and Reports project","volume":"113","author":"Carson","year":"2009","journal-title":"Blood"},{"key":"10.1016\/j.bbi.2010.10.002_b0040","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.4049\/jimmunol.168.3.1001","article-title":"Ectopic expression of the murine chemokines CCL21a and CCL21b induces the formation of lymph node-like structures in pancreas, but not skin, of transgenic mice","volume":"168","author":"Chen","year":"2002","journal-title":"J. Immunol."},{"key":"10.1016\/j.bbi.2010.10.002_b0045","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.jneuroim.2006.06.015","article-title":"Suppression of established experimental autoimmune encephalomyelitis and formation of meningeal lymphoid follicles by lymphotoxin \u03b2 receptor-Ig fusion protein","volume":"179","author":"Columba-Cabezas","year":"2006","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.bbi.2010.10.002_b0050","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1006\/jaut.2000.0371","article-title":"Relapsing and remitting experimental autoimmune encephalomyelitis in B cell deficient mice","volume":"14","author":"Dittel","year":"2000","journal-title":"J. Autoimmun."},{"key":"10.1016\/j.bbi.2010.10.002_b0055","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.jneuroim.2005.09.003","article-title":"Recognition of Staphylococcus aureus-derived peptidoglycan (PGN) but not intact bacteria is mediated by CD14 in microglia","volume":"170","author":"Esen","year":"2005","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.bbi.2010.10.002_b0060","doi-asserted-by":"crossref","first-page":"3955","DOI":"10.4049\/jimmunol.164.8.3955","article-title":"Cutting edge: ectopic expression of the chemokine TCA4\/SLC is sufficient to trigger lymphoid neogenesis","volume":"164","author":"Fan","year":"2000","journal-title":"J. Immunol."},{"key":"10.1016\/j.bbi.2010.10.002_b0065","doi-asserted-by":"crossref","first-page":"5968","DOI":"10.1158\/1078-0432.CCR-09-0108","article-title":"CXCL13 and CXCL12 in central nervous system lymphoma patients","volume":"15","author":"Fischer","year":"2009","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.bbi.2010.10.002_b0070","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1016\/S0092-8674(00)81798-5","article-title":"A putative chemokine receptor, BLR1, directs B cell migration to defined lymphoid organs and specific anatomic compartments of the spleen","volume":"87","author":"Forster","year":"1996","journal-title":"Cell"},{"key":"10.1016\/j.bbi.2010.10.002_b0075","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1146\/annurev.immunol.17.1.399","article-title":"Development and maturation of secondary lymphoid tissues","volume":"17","author":"Fu","year":"1999","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.bbi.2010.10.002_b0080","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1053\/j.seminhematol.2010.01.002","article-title":"Rituximab-associated infections","volume":"47","author":"Gea-Banacloche","year":"2010","journal-title":"Semin. Hematol."},{"key":"10.1016\/j.bbi.2010.10.002_b0085","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1111\/j.1600-065X.1997.tb01013.x","article-title":"The role of antibody in recovery from alphavirus encephalitis","volume":"159","author":"Griffin","year":"1997","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.bbi.2010.10.002_b0090","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1056\/NEJMoa0706383","article-title":"B-cell depletion with rituximab in relapsing-remitting multiple sclerosis","volume":"358","author":"Hauser","year":"2008","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.bbi.2010.10.002_b0095","doi-asserted-by":"crossref","first-page":"1460","DOI":"10.4049\/jimmunol.0903710","article-title":"CXCL13 blockade disrupts B lymphocyte organization in tertiary lymphoid structures without altering B cell receptor bias or preventing diabetes in nonobese diabetic mice","volume":"185","author":"Henry","year":"2010","journal-title":"J. Immunol."},{"key":"10.1016\/j.bbi.2010.10.002_b0105","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1189\/jlb.69.3.331","article-title":"Lymphoid neogenesis: de novo formation of lymphoid tissue in chronic inflammation through expression of homing chemokines","volume":"69","author":"Hjelmstrom","year":"2001","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.bbi.2010.10.002_b0100","doi-asserted-by":"crossref","first-page":"4480","DOI":"10.4049\/jimmunol.161.9.4480","article-title":"B cell-deficient mice develop experimental allergic encephalomyelitis with demyelination after myelin oligodendrocyte glycoprotein sensitization","volume":"161","author":"Hjelmstrom","year":"1998","journal-title":"J. Immunol."},{"key":"10.1016\/j.bbi.2010.10.002_b0110","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1093\/brain\/awh680","article-title":"Chemokines in multiple sclerosis: CXCL12 and CXCL13 up-regulation is differentially linked to CNS immune cell recruitment","volume":"129","author":"Krumbholz","year":"2006","journal-title":"Brain"},{"key":"10.1016\/j.bbi.2010.10.002_b0115","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.jneuroim.2010.05.017","article-title":"Lymphoid chemokines in the CNS","volume":"224","author":"Lalor","year":"2010","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.bbi.2010.10.002_b0120","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1084\/jem.187.4.655","article-title":"B-cell attracting chemokine 1, a human CXC chemokine expressed in lymphoid tissues, selectively attracts B lymphocytes via BLR1\/CXCR5","volume":"187","author":"Legler","year":"1998","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.bbi.2010.10.002_b0125","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1126\/science.1658936","article-title":"Antibody-mediated clearance of alphavirus infection from neurons","volume":"254","author":"Levine","year":"1991","journal-title":"Science"},{"key":"10.1016\/j.bbi.2010.10.002_b0130","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1007\/s00415-008-0785-y","article-title":"CSF B-lymphocyte chemoattractant (CXCL13) in the early diagnosis of acute Lyme neuroborreliosis","volume":"255","author":"Ljostad","year":"2008","journal-title":"J. Neurol."},{"key":"10.1016\/j.bbi.2010.10.002_b0135","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/S1074-7613(00)80199-5","article-title":"BLC expression in pancreatic islets causes B cell recruitment and lymphotoxin-dependent lymphoid neogenesis","volume":"12","author":"Luther","year":"2000","journal-title":"Immunity"},{"key":"10.1016\/j.bbi.2010.10.002_b0140","doi-asserted-by":"crossref","first-page":"424","DOI":"10.4049\/jimmunol.169.1.424","article-title":"Differing activities of homeostatic chemokines CCL19, CCL21, and CXCL12 in lymphocyte and dendritic cell recruitment and lymphoid neogenesis","volume":"169","author":"Luther","year":"2002","journal-title":"J. Immunol."},{"key":"10.1016\/j.bbi.2010.10.002_b0145","doi-asserted-by":"crossref","first-page":"3432","DOI":"10.1002\/(SICI)1521-4141(199911)29:11<3432::AID-IMMU3432>3.0.CO;2-2","article-title":"B cells are critical to induction of experimental allergic encephalomyelitis by protein but not by a short encephalitogenic peptide","volume":"29","author":"Lyons","year":"1999","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.bbi.2010.10.002_b0150","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1038\/25630","article-title":"Turning off follicular dendritic cells","volume":"395","author":"Mackay","year":"1998","journal-title":"Nature"},{"key":"10.1016\/j.bbi.2010.10.002_b0155","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.jneuroim.2003.10.056","article-title":"Intracerebral expression of CXCL13 and BAFF is accompanied by formation of lymphoid follicle-like structures in the meninges of mice with relapsing experimental autoimmune encephalomyelitis","volume":"148","author":"Magliozzi","year":"2004","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.bbi.2010.10.002_b0160","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1093\/brain\/awm038","article-title":"Meningeal B-cell follicles in secondary progressive multiple sclerosis associate with early onset of disease and severe cortical pathology","volume":"130","author":"Magliozzi","year":"2007","journal-title":"Brain"},{"key":"10.1016\/j.bbi.2010.10.002_b0165","doi-asserted-by":"crossref","first-page":"4791","DOI":"10.4049\/jimmunol.173.8.4791","article-title":"A novel model for lymphocytic infiltration of the thyroid gland generated by transgenic expression of the CC chemokine CCL21","volume":"173","author":"Martin","year":"2004","journal-title":"J. Immunol."},{"key":"10.1016\/j.bbi.2010.10.002_b0170","first-page":"3420","article-title":"Regulatory B cells inhibit EAE initiation in mice while other B cells promote disease progression","volume":"118","author":"Matsushita","year":"2008","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bbi.2010.10.002_b0175","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1172\/JCI7830","article-title":"BCA-1 is highly expressed in Helicobacter pylori-induced mucosa-associated lymphoid tissue and gastric lymphoma","volume":"104","author":"Mazzucchelli","year":"1999","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bbi.2010.10.002_b0180","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1084\/jem.159.1.77","article-title":"Immunocytochemical identification and quantification of the mononuclear cells in the cerebrospinal fluid, meninges, and brain during acute viral meningoencephalitis","volume":"159","author":"Moench","year":"1984","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.bbi.2010.10.002_b0185","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/S1471-4906(02)02218-4","article-title":"CXCR5+ T cells: follicular homing takes center stage in T-helper-cell responses","volume":"23","author":"Moser","year":"2002","journal-title":"Trends Immunol."},{"key":"10.1016\/j.bbi.2010.10.002_b0190","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1034\/j.1600-065X.2003.00073.x","article-title":"The impact of CCR7 and CXCR5 on lymphoid organ development and systemic immunity","volume":"195","author":"Muller","year":"2003","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.bbi.2010.10.002_b0195","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1084\/jem.189.2.403","article-title":"Lymphotoxin-\u03b1\/\u03b2 and tumor necrosis factor are required for stromal cell expression of homing chemokines in B and T cell areas of the spleen","volume":"189","author":"Ngo","year":"1999","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.bbi.2010.10.002_b0200","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1056\/NEJMoa044397","article-title":"A randomized, placebo-controlled trial of natalizumab for relapsing multiple sclerosis","volume":"354","author":"Polman","year":"2006","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.bbi.2010.10.002_b0205","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1038\/nri1130","article-title":"Three or more routes for leukocyte migration into the central nervous system","volume":"3","author":"Ransohoff","year":"2003","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.bbi.2010.10.002_b0210","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1186\/1742-2094-6-42","article-title":"The chemokine CXCL13 is a key regulator of B cell recruitment to the cerebrospinal fluid in acute Lyme neuroborreliosis","volume":"6","author":"Rupprecht","year":"2009","journal-title":"J. Neuroinflamm."},{"key":"10.1016\/j.bbi.2010.10.002_b0215","doi-asserted-by":"crossref","first-page":"2003","DOI":"10.1212\/WNL.0b013e3181c5b457","article-title":"Increased cerebrospinal fluid concentrations of the chemokine CXCL13 in active MS","volume":"73","author":"Sellebjerg","year":"2009","journal-title":"Neurology"},{"key":"10.1016\/j.bbi.2010.10.002_b0220","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1111\/j.1750-3639.2004.tb00049.x","article-title":"Detection of ectopic B-cell follicles with germinal centers in the meninges of patients with secondary progressive multiple sclerosis","volume":"14","author":"Serafini","year":"2004","journal-title":"Brain Pathol."},{"key":"10.1016\/j.bbi.2010.10.002_b0225","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1128\/jvi.58.1.107-115.1986","article-title":"Monoclonal antibody cure and prophylaxis of lethal Sindbis virus encephalitis in mice","volume":"58","author":"Stanley","year":"1986","journal-title":"J. Virol."},{"key":"10.1016\/j.bbi.2010.10.002_b0230","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1002\/eji.200535123","article-title":"CNS viral infection diverts homing of antibody-secreting cells from lymphoid organs to the CNS","volume":"36","author":"Tschen","year":"2006","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.bbi.2010.10.002_b0245","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/0165-5728(93)90056-5","article-title":"Virus specificity and isotype expression of intraparenchymal antibody-secreting cells during Sindbis virus encephalitis in mice","volume":"48","author":"Tyor","year":"1993","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.bbi.2010.10.002_b0235","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/0165-5728(89)90118-5","article-title":"Characterization of the local and systemic B cell response of normal and athymic nude mice with Sindbis virus encephalitis","volume":"24","author":"Tyor","year":"1989","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.bbi.2010.10.002_b0240","doi-asserted-by":"crossref","first-page":"4016","DOI":"10.4049\/jimmunol.149.12.4016","article-title":"Long term intraparenchymal Ig secretion after acute viral encephalitis in mice","volume":"149","author":"Tyor","year":"1992","journal-title":"J. Immunol."},{"key":"10.1016\/j.bbi.2010.10.002_b0250","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1002\/jlb.62.5.634","article-title":"Novel lymphocyte-specific CC chemokines and their receptors","volume":"62","author":"Yoshie","year":"1997","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.bbi.2010.10.002_b0255","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1615\/CritRevImmunol.v19.i1.10","article-title":"Recent advances in chemokines and chemokine receptors","volume":"19","author":"Zlotnik","year":"1999","journal-title":"Crit. Rev. Immunol."}],"container-title":["Brain, Behavior, and Immunity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0889159110005088?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0889159110005088?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T07:27:09Z","timestamp":1760167629000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0889159110005088"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,7]]},"references-count":51,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2011,7]]}},"alternative-id":["S0889159110005088"],"URL":"https:\/\/doi.org\/10.1016\/j.bbi.2010.10.002","relation":{},"ISSN":["0889-1591"],"issn-type":[{"value":"0889-1591","type":"print"}],"subject":[],"published":{"date-parts":[[2011,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The lymphoid chemokine, CXCL13, is dispensable for the initial recruitment of B cells to the acutely inflamed central nervous system","name":"articletitle","label":"Article Title"},{"value":"Brain, Behavior, and Immunity","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbi.2010.10.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2010 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}