{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T12:00:37Z","timestamp":1789992037102,"version":"4.0.1"},"reference-count":45,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2012,2,1]],"date-time":"2012-02-01T00:00:00Z","timestamp":1328054400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2012,2,1]],"date-time":"2012-02-01T00:00:00Z","timestamp":1328054400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain, Behavior, and Immunity"],"published-print":{"date-parts":[[2012,2]]},"DOI":"10.1016\/j.bbi.2011.09.016","type":"journal-article","created":{"date-parts":[[2011,10,17]],"date-time":"2011-10-17T13:47:28Z","timestamp":1318859248000},"page":"311-317","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":85,"title":["Mast cell degranulation distinctly activates trigemino-cervical and lumbosacral pain pathways and elicits widespread tactile pain hypersensitivity"],"prefix":"10.1016","volume":"26","author":[{"given":"Dan","family":"Levy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanessa","family":"Kainz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rami","family":"Burstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew M.","family":"Strassman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbi.2011.09.016_b0005","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1038\/sj.bjp.0701793","article-title":"Ovalbumin-induced neurogenic inflammation in the bladder of sensitized rats","volume":"124","author":"Ahluwalia","year":"1998","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.bbi.2011.09.016_b0010","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/0306-4522(91)90355-R","article-title":"C-FOS-like immunoreactivity in rat brainstem neurons following noxious chemical stimulation of the nasal mucosa","volume":"41","author":"Anton","year":"1991","journal-title":"Neuroscience"},{"key":"10.1016\/j.bbi.2011.09.016_b0015","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/S0304-3959(01)00257-3","article-title":"Chronic low-level administration of diquat increases the nociceptive response to gastric distension in rats: role of mast cells and tachykinin receptor activation","volume":"92","author":"Anton","year":"2001","journal-title":"Pain"},{"key":"10.1016\/j.bbi.2011.09.016_b0020","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1111\/j.1468-2982.2004.00852.x","article-title":"Headache in systemic mastocytosis: a case report with pathophysiological considerations","volume":"25","author":"Ashina","year":"2005","journal-title":"Cephalalgia"},{"key":"10.1016\/j.bbi.2011.09.016_b0025","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1053\/j.gastro.2006.11.039","article-title":"Mast cell-dependent excitation of visceral-nociceptive sensory neurons in irritable bowel syndrome","volume":"132","author":"Barbara","year":"2007","journal-title":"Gastroenterology"},{"key":"10.1016\/j.bbi.2011.09.016_b0030","doi-asserted-by":"crossref","first-page":"4878","DOI":"10.1523\/JNEUROSCI.12-12-04878.1992","article-title":"Increased c-fos expression in spinal neurons after irritation of the lower urinary tract in the rat","volume":"12","author":"Birder","year":"1992","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bbi.2011.09.016_b0230","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1007\/BF00227263","article-title":"Cyclophosphamide cystitis as a model of visceral pain in rats. A survey of hindbrain structures involved in visceroception and nociception using the expression of c-Fos and Krox-24 proteins","volume":"108","author":"Bon","year":"1996","journal-title":"Exp. Brain. Res. Experimentelle Hirnforschung"},{"key":"10.1016\/j.bbi.2011.09.016_b0040","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1097\/01.ju.0000079766.49550.94","article-title":"Characterization of cyclophosphamide cystitis, a model of visceral and referred pain, in the mouse: species and strain differences","volume":"170","author":"Bon","year":"2003","journal-title":"J. Urol."},{"key":"10.1016\/j.bbi.2011.09.016_b0045","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1002\/ana.21994","article-title":"Thalamic sensitization transforms localized pain into widespread allodynia","volume":"68","author":"Burstein","year":"2010","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.bbi.2011.09.016_b0050","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1152\/jn.1998.79.2.964","article-title":"Chemical stimulation of the intracranial dura induces enhanced responses to facial stimulation in brain stem trigeminal neurons","volume":"79","author":"Burstein","year":"1998","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.bbi.2011.09.016_b0055","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1002\/1531-8249(200005)47:5<614::AID-ANA9>3.0.CO;2-N","article-title":"An association between migraine and cutaneous allodynia","volume":"47","author":"Burstein","year":"2000","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.bbi.2011.09.016_b0060","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.jpain.2007.10.017","article-title":"Hind paw incision in the rat produces long-lasting colon hypersensitivity","volume":"9","author":"Cameron","year":"2008","journal-title":"J. Pain"},{"key":"10.1016\/j.bbi.2011.09.016_b0065","doi-asserted-by":"crossref","first-page":"2145","DOI":"10.1016\/S0140-6736(99)01306-9","article-title":"Visceral pain","volume":"353","author":"Cervero","year":"1999","journal-title":"Lancet"},{"key":"10.1016\/j.bbi.2011.09.016_b0070","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1023\/A:1018853728251","article-title":"Mast cell degranulation induces delayed rectal allodynia in rats: role of histamine and 5-HT","volume":"43","author":"Coelho","year":"1998","journal-title":"Dig. Dis. Sci."},{"key":"10.1016\/j.bbi.2011.09.016_b0075","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1152\/jn.1993.69.4.1071","article-title":"Chemosensitivity and sensitization of nociceptive afferents that innervate the hairy skin of monkey","volume":"69","author":"Davis","year":"1993","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.bbi.2011.09.016_b0080","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1007\/s00011-004-1263-3","article-title":"The effect of cutaneous mast cell degranulation on sensitivity to heat","volume":"53","author":"Drummond","year":"2004","journal-title":"Inflamm. Res."},{"key":"10.1016\/j.bbi.2011.09.016_b0085","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1002\/ana.21537","article-title":"Medullary pain facilitating neurons mediate allodynia in headache-related pain","volume":"65","author":"Edelmayer","year":"2009","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.bbi.2011.09.016_b0090","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/S0006-8993(00)03026-2","article-title":"Acute stress increases permeability of the blood-brain-barrier through activation of brain mast cells","volume":"888","author":"Esposito","year":"2001","journal-title":"Brain Res."},{"key":"10.1016\/j.bbi.2011.09.016_b0095","doi-asserted-by":"crossref","first-page":"2249","DOI":"10.1152\/jappl.1988.64.5.2249","article-title":"IgE-challenged human lung mast cells excite vagal sensory neurons in vitro","volume":"64","author":"Greene","year":"1988","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.bbi.2011.09.016_b0100","doi-asserted-by":"crossref","unstructured":"Hamilton, M.J., Hornick, J.L., Akin, C., Castells, M.C., Greenberger, N.J., 2011. Mast cell activation syndrome: A newly recognized disorder with systemic clinical manifestations. J. Allergy Clin. Immunol.","DOI":"10.1016\/j.jaci.2011.04.037"},{"key":"10.1016\/j.bbi.2011.09.016_b0105","doi-asserted-by":"crossref","first-page":"e2266","DOI":"10.1371\/journal.pone.0002266","article-title":"Case-control cohort study of patients\u2019 perceptions of disability in mastocytosis","volume":"3","author":"Hermine","year":"2008","journal-title":"PloS one"},{"key":"10.1016\/j.bbi.2011.09.016_b0110","doi-asserted-by":"crossref","first-page":"5S","DOI":"10.1111\/1523-1747.ep12468899","article-title":"Systemic mastocytosis: retrospective review of a decade\u2019s clinical experience at the Brigham and Women\u2019s Hospital","volume":"96","author":"Horan","year":"1991","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.bbi.2011.09.016_b0115","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1093\/bja\/83.3.442","article-title":"Inflammation of the rat urinary bladder is associated with a referred thermal hyperalgesia which is nerve growth factor dependent","volume":"83","author":"Jaggar","year":"1999","journal-title":"Br. J. Anaesth."},{"key":"10.1016\/j.bbi.2011.09.016_b0120","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1136\/gut.2010.213108","article-title":"The mast cell stabiliser ketotifen decreases visceral hypersensitivity and improves intestinal symptoms in patients with irritable bowel syndrome","volume":"59","author":"Klooker","year":"2010","journal-title":"Gut"},{"key":"10.1016\/j.bbi.2011.09.016_b0125","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1016\/0306-4522(93)90439-M","article-title":"Spinal and hindbrain structures involved in visceroception and visceronociception as revealed by the expression of Fos, Jun and Krox-24 proteins","volume":"55","author":"Lanteri-Minet","year":"1993","journal-title":"Neuroscience"},{"key":"10.1016\/j.bbi.2011.09.016_b0130","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1007\/s11916-009-0040-y","article-title":"Migraine pain, meningeal inflammation, and mast cells","volume":"13","author":"Levy","year":"2009","journal-title":"Curr. Pain Headache Reports"},{"key":"10.1016\/j.bbi.2011.09.016_b0135","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.pain.2007.03.012","article-title":"Mast cell degranulation activates a pain pathway underlying migraine headache","volume":"130","author":"Levy","year":"2007","journal-title":"Pain"},{"key":"10.1016\/j.bbi.2011.09.016_b0140","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1152\/jn.1988.60.2.438","article-title":"Leukotriene B4 decreases the mechanical and thermal thresholds of C- fiber nociceptors in the hairy skin of the rat","volume":"60","author":"Martin","year":"1988","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.bbi.2011.09.016_b0145","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1002\/(SICI)1096-9861(19980119)390:3<311::AID-CNE1>3.0.CO;2-4","article-title":"Proximal colon distention increases Fos expression in the lumbosacral spinal cord and activates sacral parasympathetic NADPHd-positive neurons in rats","volume":"390","author":"Martinez","year":"1998","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.bbi.2011.09.016_b0150","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1016\/S0306-4522(96)00633-1","article-title":"Fos immunohistochemical determination of brainstem neuronal activation in the muskrat after nasal stimulation","volume":"78","author":"McCulloch","year":"1997","journal-title":"Neuroscience"},{"key":"10.1016\/j.bbi.2011.09.016_b0155","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/j.lfs.2007.11.027","article-title":"Abolishment of TNBS-induced visceral hypersensitivity in mast cell deficient rats","volume":"82","author":"Ohashi","year":"2008","journal-title":"Life Sci."},{"key":"10.1016\/j.bbi.2011.09.016_b0160","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1111\/j.1526-4610.2007.00871.x","article-title":"Episodic dural stimulation in awake rats: a model for recurrent headache","volume":"47","author":"Oshinsky","year":"2007","journal-title":"Headache"},{"key":"10.1016\/j.bbi.2011.09.016_b0165","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1196\/annals.1443.023","article-title":"Mast cells: multifaceted immune cells with diverse roles in health and disease","volume":"1143","author":"Rao","year":"2008","journal-title":"Ann. N.Y. Acad. Sci."},{"key":"10.1016\/j.bbi.2011.09.016_b0170","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/S0306-4522(97)00147-4","article-title":"Tumour necrosis factor-alpha induces ectopic activity in nociceptive primary afferent fibres","volume":"81","author":"Sorkin","year":"1997","journal-title":"Neuroscience"},{"key":"10.1016\/j.bbi.2011.09.016_b0175","doi-asserted-by":"crossref","first-page":"3725","DOI":"10.1523\/JNEUROSCI.14-06-03725.1994","article-title":"Distribution of fos-like immunoreactivity in the medullary and upper cervical dorsal horn produced by stimulation of dural blood vessels in the rat","volume":"14","author":"Strassman","year":"1994","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bbi.2011.09.016_b0180","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1002\/cne.903310406","article-title":"Somatotopic and laminar organization of fos-like immunoreactivity in the medullary and upper cervical dorsal horn induced by noxious facial stimulation in the rat","volume":"331","author":"Strassman","year":"1993","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.bbi.2011.09.016_b0185","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/0306-4522(92)90508-Y","article-title":"Serotonin is a directly-acting hyperalgesic agent in the rat","volume":"48","author":"Taiwo","year":"1992","journal-title":"Neuroscience"},{"key":"10.1016\/j.bbi.2011.09.016_b0190","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/S0022-5347(01)67669-9","article-title":"Activation of bladder mast cells in interstitial cystitis: a light and electron microscopic study","volume":"153","author":"Theoharides","year":"1995","journal-title":"J. Urol."},{"key":"10.1016\/j.bbi.2011.09.016_b0195","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/S0304-3959(01)00285-8","article-title":"Hypersensitivity to visceral and cutaneous pain in the irritable bowel syndrome","volume":"93","author":"Verne","year":"2001","journal-title":"Pain"},{"key":"10.1016\/j.bbi.2011.09.016_b0200","doi-asserted-by":"crossref","first-page":"2708","DOI":"10.1523\/JNEUROSCI.14-05-02708.1994","article-title":"Behavioral evidence of trigeminal neuropathic pain following chronic constriction injury to the rat\u2019s infraorbital nerve","volume":"14","author":"Vos","year":"1994","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bbi.2011.09.016_b0235","doi-asserted-by":"crossref","first-page":"1573","DOI":"10.2174\/138161211796196918","article-title":"Visceral Pain: Spinal Afferents, Enteric Mast Cells, Enteric Nervous System and Stress","volume":"17","author":"Wood","year":"2011","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.bbi.2011.09.016_b0210","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1124\/jpet.107.123745","article-title":"Sensitization and activation of intracranial meningeal nociceptors by mast cell mediators","volume":"322","author":"Zhang","year":"2007","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.bbi.2011.09.016_b0215","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.pain.2010.10.002","article-title":"Tumor necrosis factor-alpha induces sensitization of meningeal nociceptors mediated via local COX and p38 MAP kinase actions","volume":"152","author":"Zhang","year":"2010","journal-title":"Pain"},{"key":"10.1016\/j.bbi.2011.09.016_b0220","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1111\/j.1468-2982.2007.01523.x","article-title":"Modulation of meningeal nociceptors mechanosensitivity by peripheral proteinase-activated receptor-2: the role of mast cells","volume":"28","author":"Zhang","year":"2008","journal-title":"Cephalalgia"},{"key":"10.1016\/j.bbi.2011.09.016_b0225","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.pain.2007.03.029","article-title":"Visceral and somatic hypersensitivity in a subset of rats following TNBS-induced colitis","volume":"134","author":"Zhou","year":"2008","journal-title":"Pain"}],"container-title":["Brain, Behavior, and Immunity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0889159111005599?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0889159111005599?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T07:30:44Z","timestamp":1760167844000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0889159111005599"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,2]]},"references-count":45,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2012,2]]}},"alternative-id":["S0889159111005599"],"URL":"https:\/\/doi.org\/10.1016\/j.bbi.2011.09.016","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.13371978.14742081","asserted-by":"object"}]},"ISSN":["0889-1591"],"issn-type":[{"value":"0889-1591","type":"print"}],"subject":[],"published":{"date-parts":[[2012,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mast cell degranulation distinctly activates trigemino-cervical and lumbosacral pain pathways and elicits widespread tactile pain hypersensitivity","name":"articletitle","label":"Article Title"},{"value":"Brain, Behavior, and Immunity","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbi.2011.09.016","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2011 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}