{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T16:55:48Z","timestamp":1780073748848,"version":"3.54.0"},"reference-count":64,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2012,10,1]],"date-time":"2012-10-01T00:00:00Z","timestamp":1349049600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2012,10,1]],"date-time":"2012-10-01T00:00:00Z","timestamp":1349049600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2013,9,1]],"date-time":"2013-09-01T00:00:00Z","timestamp":1377993600000},"content-version":"vor","delay-in-days":335,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain, Behavior, and Immunity"],"published-print":{"date-parts":[[2012,10]]},"DOI":"10.1016\/j.bbi.2012.07.009","type":"journal-article","created":{"date-parts":[[2012,7,25]],"date-time":"2012-07-25T19:34:29Z","timestamp":1343244869000},"page":"1136-1149","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":37,"title":["Trypanosoma cruzi-induced depressive-like behavior is independent of meningoencephalitis but responsive to parasiticide and TNF-targeted therapeutic interventions"],"prefix":"10.1016","volume":"26","author":[{"given":"Glaucia","family":"Vilar-Pereira","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea Alice da","family":"Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabela Resende","family":"Pereira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael Rodrigues","family":"Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Otac\u00edlio Cruz","family":"Moreira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luciana Rodrigues","family":"de Almeida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda Santos","family":"de Souza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica Santos","family":"Rocha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseli","family":"Lannes-Vieira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbi.2012.07.009_b0005","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.phrs.2003.07.016","article-title":"Studies on the anti-inflammatory effects of Fluoxetine in the rat","volume":"49","author":"Abdel-Salam","year":"2004","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.bbi.2012.07.009_b0010","unstructured":"Bahi, A., Dreyer, J.L., in press. Hippocampus-specific deletion of tissue plasminogen activator \u201ctPA\u201d in adult mice impairs depression- and anxiety-like behaviors. Eur. Neuropsychopharmacol."},{"key":"10.1016\/j.bbi.2012.07.009_b0015","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1590\/S0036-46652002000100006","article-title":"Long term evaluation of etiological treatment of Chagas disease with benznidazole","volume":"44","author":"Can\u00e7ado","year":"2002","journal-title":"Rev. Inst. Med. Trop. S\u00e3o Paulo."},{"key":"10.1016\/j.bbi.2012.07.009_b0020","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1128\/IAI.01434-08","article-title":"Preferential brain homing following intranasal administration of Trypanosoma cruzi","volume":"77","author":"Caradonna","year":"2009","journal-title":"Infect. Immun."},{"key":"10.1016\/j.bbi.2012.07.009_b0025","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1590\/S0074-02762012000200010","article-title":"Acute experimental Trypanosoma cruzi infection: establishing a murine model that utilises non-invasive measurements of disease parameters","volume":"107","author":"da Silva","year":"2012","journal-title":"Mem. Inst. Oswaldo Cruz"},{"key":"10.1016\/j.bbi.2012.07.009_b0030","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1038\/nrn2297","article-title":"From inflammation to sickness and depression: when the immune system subjugates the brain","volume":"9","author":"Dantzer","year":"2008","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.bbi.2012.07.009_b0035","first-page":"192","article-title":"Pentoxifylline suppression of tumor necrosis factor gene transcription","volume":"110","author":"Doherty","year":"1991","journal-title":"Surgery"},{"key":"10.1016\/j.bbi.2012.07.009_b0040","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1016\/S1286-4579(01)01461-7","article-title":"Prevalence of CD8(+)alpha beta T cells in Trypanosoma cruzi-elicited myocarditis is associated with acquisition of CD62L(Low)LFA-1(High)VLA-4(High) activation phenotype and expression of IFN-gamma-inducible adhesion and chemoattractant molecules","volume":"3","author":"dos Santos","year":"2001","journal-title":"Microbes Infect."},{"key":"10.1016\/j.bbi.2012.07.009_b0045","doi-asserted-by":"crossref","first-page":"R390","DOI":"10.1152\/ajpregu.00335.2003","article-title":"Fluoxetine-induced changes in body weight and 5-HT1A receptor-mediated hormone secretion in rats on a tryptophan-deficient diet","volume":"286","author":"D\u2019Souza","year":"2004","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"10.1016\/j.bbi.2012.07.009_b0050","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1590\/S0074-02762009000900027","article-title":"Cellular and genetic mechanisms involved in the generation of protective and pathogenic immune responses in human Chagas disease","volume":"1","author":"Dutra","year":"2009","journal-title":"Mem. Inst. Oswaldo Cruz"},{"key":"10.1016\/j.bbi.2012.07.009_b0055","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1590\/S0074-02762003000300021","article-title":"Increased plasma levels of tumor necrosis factor-alpha in asymptomatic \u201cindeterminate\u201d and Chagas disease cardiomyopathy patients","volume":"98","author":"Ferreira","year":"2003","journal-title":"Mem. Inst. Oswaldo Cruz"},{"key":"10.1016\/j.bbi.2012.07.009_b0060","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.ijcard.2004.05.025","article-title":"Risk stratification in a Brazilian hospital-based cohort of 1220 outpatients with heart failure: role of Chagas\u2019 heart disease","volume":"102","author":"Freitas","year":"2005","journal-title":"Int. J. Cardiol."},{"key":"10.1016\/j.bbi.2012.07.009_b0065","first-page":"1","article-title":"HIV-1 Tat activates indoleamine 2,3 dioxygenase in murine organotypic hippocampal slice cultures in a p38 mitogen-activated protein kinase-dependent manner","volume":"2","author":"Fu","year":"2011","journal-title":"J. Neuroinflamm."},{"key":"10.1016\/j.bbi.2012.07.009_b0070","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1016\/j.bbi.2010.11.008","article-title":"Effects of stressors and immune activating agents on peripheral and central cytokines in mouse strains that differ in stressor responsivity","volume":"25","author":"Gibb","year":"2011","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.bbi.2012.07.009_b0075","doi-asserted-by":"crossref","first-page":"7960","DOI":"10.1128\/IAI.73.12.7960-7966.2005","article-title":"Type 1 chemokine receptor expression in Chagas\u2019 disease correlates with morbidity in cardiac patients","volume":"73","author":"Gomes","year":"2005","journal-title":"Infect. Immun."},{"key":"10.1016\/j.bbi.2012.07.009_b0080","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1037\/h0071444","article-title":"Emotional behavior in the rat: I. Defecation and urination as measures of individual differences in emotionality","volume":"18","author":"Hall","year":"1941","journal-title":"J. Comp. Psychol."},{"key":"10.1016\/j.bbi.2012.07.009_b0085","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/S0163-4453(97)91380-3","article-title":"Toxoplasmosis, behaviour and personality","volume":"35","author":"Holliman","year":"1997","journal-title":"J. Infect."},{"key":"10.1016\/j.bbi.2012.07.009_b0090","doi-asserted-by":"crossref","first-page":"2232","DOI":"10.1001\/jama.297.20.2232","article-title":"Burden, features, and outcome of neurological involvement in acute falciparum malaria in Kenyan children","volume":"297","author":"Idro","year":"2007","journal-title":"JAMA"},{"key":"10.1016\/j.bbi.2012.07.009_b0095","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1590\/S0074-02761981000400003","article-title":"Formas encefalopaticas de enfermedad de Chagas cronica observadas en Argentina","volume":"4","author":"Jorg","year":"1981","journal-title":"Mem. Inst. Oswaldo Cruz"},{"key":"10.1016\/j.bbi.2012.07.009_b0100","first-page":"12","article-title":"The endless race between Trypanosoma cruzi and host immunity: lessons for and beyond Chagas disease","volume":"15","author":"Junqueira","year":"2010","journal-title":"Expert Rev. Mol. Med."},{"key":"10.1016\/j.bbi.2012.07.009_b0105","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/j.neuropharm.2011.08.018","article-title":"Depressive-like behavior induced by tumor necrosis factor-\u03b1 in mice","volume":"62","author":"Kaster","year":"2012","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.bbi.2012.07.009_b0110","doi-asserted-by":"crossref","first-page":"2689","DOI":"10.1096\/fj.09-150920","article-title":"Indoleamine 2,3-dioxigenase (IDO) is critical for host resistance against Trypanosoma cruzi","volume":"24","author":"Knubel","year":"2010","journal-title":"FASEB J."},{"key":"10.1016\/j.bbi.2012.07.009_b0115","doi-asserted-by":"crossref","first-page":",G9","DOI":"10.1152\/ajpgi.00267.2010","article-title":"Fluoxetine inhibits NF-\u03baB signaling in intestinal epithelial cells and ameliorates experimental colitis and colitis-associated colon cancer in mice","volume":"301","author":"Koh","year":"2011","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.bbi.2012.07.009_b0120","doi-asserted-by":"crossref","first-page":"e645","DOI":"10.1371\/journal.pntd.0000645","article-title":"The centennial of the discovery of Chagas disease: facing the current challenges","volume":"4","author":"Lannes-Vieira","year":"2010","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.bbi.2012.07.009_b0125","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1007\/978-1-4419-6612-4_23","article-title":"TNF-\u03b1 and TNFR in Chagas disease: from protective immunity to pathogenesis of chronic cardiomyopathy","volume":"691","author":"Lannes-Vieira","year":"2011","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.bbi.2012.07.009_b0130","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.1016\/j.bbi.2008.05.002","article-title":"Reducing post-traumatic anxiety by immunization","volume":"22","author":"Lewitus","year":"2008","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.bbi.2012.07.009_b0135","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"10.1016\/j.bbi.2012.07.009_b0140","doi-asserted-by":"crossref","first-page":"e20955","DOI":"10.1371\/journal.pone.0020955","article-title":"Social isolation-induced aggression potentiates anxiety and depressive-like behavior in male mice subjected to unpredictable chronic mild stress","volume":"6","author":"Ma","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.bbi.2012.07.009_b0145","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1007\/s11011-008-9118-1","article-title":"The inflammatory & neurodegenerative (I&ND) hypothesis of depression: leads for future research and new drug developments in depression","volume":"24","author":"Maes","year":"2009","journal-title":"Metab. Brain Dis."},{"key":"10.1016\/j.bbi.2012.07.009_b0150","doi-asserted-by":"crossref","first-page":"2485","DOI":"10.1016\/j.molimm.2010.06.002","article-title":"Benznidazole blocks NF-kappaB activation but not AP-1 through inhibition of IKK","volume":"47","author":"Manarin","year":"2010","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.bbi.2012.07.009_b0155","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1590\/S0004-282X1994000200008","article-title":"Cognitive impairment in human chronic Chagas\u2019 disease","volume":"52","author":"Mangone","year":"1994","journal-title":"Arq. Neuropsiq."},{"key":"10.1016\/j.bbi.2012.07.009_b0160","first-page":"461","article-title":"Depress\u00e3o e doen\u00e7a de Chagas: um estudo preliminar do estado emocional em pacientes chag\u00e1sicos","volume":"47","author":"Marchi","year":"1998","journal-title":"J. Bras. Psiquiatr."},{"key":"10.1016\/j.bbi.2012.07.009_b0165","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.micinf.2008.11.012","article-title":"Treatment of chronically Trypanosoma cruzi-infected mice with a CCR1\/CCR5 antagonist (Met-RANTES) results in amelioration of cardiac tissue damage","volume":"11","author":"Medeiros","year":"2009","journal-title":"Microbes Infect."},{"key":"10.1016\/j.bbi.2012.07.009_b0170","doi-asserted-by":"crossref","first-page":"475","DOI":"10.2307\/3279787","article-title":"Tissue tropism of different Trypanosoma cruzi strains","volume":"64","author":"Melo","year":"1978","journal-title":"J. Parasitol."},{"key":"10.1016\/j.bbi.2012.07.009_b0175","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.bbi.2009.09.009","article-title":"Depression and immunity: a role for T cells?","volume":"24","author":"Miller","year":"2010","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.bbi.2012.07.009_b0180","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1016\/j.bbi.2008.04.001","article-title":"Inoculation of Bacillus Calmette-Guerin to mice induces an acute episode of sickness behavior followed by chronic depressive-like behavior","volume":"22","author":"Moreau","year":"2008","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.bbi.2012.07.009_b0185","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1590\/S0037-86822008000100013","article-title":"Chagas disease as a mechanistic model for testing a novel hypothesis","volume":"41","author":"Mosovich","year":"2008","journal-title":"Rev. Soc. Bras. Med. Trop."},{"key":"10.1016\/j.bbi.2012.07.009_b0190","first-page":"57","article-title":"Estresse e resili\u00eancia em doen\u00e7a de Chagas","volume":"24","author":"Mota","year":"2006","journal-title":"Aletheia"},{"key":"10.1016\/j.bbi.2012.07.009_b0195","doi-asserted-by":"crossref","unstructured":"Novaes, R.D., Gon\u00e7alves, R.V., Penitente, A.R., Talvani, A., Neves, C.A., Natali, A.J., Maldonado, I.R., 2012. Trypanosoma cruzi infection alters glucose metabolism at rest and during exercise without modifying the morphology of pancreatic islets in rats. Pathol. Res. Pract. (Jun 30. Epub ahead of print).","DOI":"10.1016\/j.prp.2012.05.016"},{"key":"10.1016\/j.bbi.2012.07.009_b0200","doi-asserted-by":"crossref","first-page":"e20719","DOI":"10.1371\/journal.pone.0020719","article-title":"Prolonged depression-like behavior caused by immune challenge: influence of mouse strain and social environment","volume":"6","author":"Painsipp","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.bbi.2012.07.009_b0205","first-page":"214","article-title":"The importance of clinical, psychological and social effects experienced by patients with American trypanosomiasis (Chagas\u2019 disease)","volume":"88","author":"Petana","year":"1980","journal-title":"Bol. Oficina Sanit. Panam."},{"key":"10.1016\/j.bbi.2012.07.009_b0210","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1016\/j.trstmh.2009.04.012","article-title":"Central nervous system involvement in Chagas disease: a hundred-year-old history","volume":"103","author":"Pittella","year":"2009","journal-title":"Trans. R. Soc. Trop. Med. Hyg."},{"key":"10.1016\/j.bbi.2012.07.009_b0215","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1515\/REVNEURO.2000.11.1.53","article-title":"Animal models of depression: utility for transgenic research","volume":"11","author":"Porsolt","year":"2000","journal-title":"Rev. Neurosci."},{"key":"10.1016\/j.bbi.2012.07.009_b0220","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1590\/S0004-282X2000000200010","article-title":"Evidencias de compromiso cerebral en el estadio cr\u00f3nico de la enfermedad de chagas obtenidas por medio del potencial p 300 y de electroencefalograf\u00eda cuantificada","volume":"58","author":"Prost","year":"2000","journal-title":"Arq. Neuropsiquiatr."},{"key":"10.1016\/j.bbi.2012.07.009_b0225","doi-asserted-by":"crossref","first-page":"1388","DOI":"10.1016\/S0140-6736(10)60061-X","article-title":"Chagas disease","volume":"375","author":"Rassi","year":"2010","journal-title":"Lancet"},{"key":"10.1016\/j.bbi.2012.07.009_b0230","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1002\/art.10097","article-title":"Tumor necrosis factor alpha-mediated joint destruction is inhibited by targeting osteoclasts with osteoprotegerin","volume":"46","author":"Redlich","year":"2002","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.bbi.2012.07.009_b0235","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/S0165-5728(03)00254-6","article-title":"Essential role of VLA-4\/VCAM-1 pathway in the establishment of CD8+ T-cell-mediated Trypanosoma cruzi-elicited meningoencephalitis","volume":"142","author":"Roff\u00ea","year":"2003","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.bbi.2012.07.009_b0240","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/S0304-3940(01)01885-7","article-title":"SHIRPA, a protocol for behavioral assessment: validation for longitudinal study of neurological dysfunction in mice","volume":"306","author":"Rogers","year":"2001","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.bbi.2012.07.009_b0245","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/j.bbi.2010.12.005","article-title":"Lymphocytes in neuroprotection, cognition and emotion: is intolerance really the answer?","volume":"25","author":"Rook","year":"2011","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.bbi.2012.07.009_b0250","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1093\/eurjhf\/hfn040","article-title":"Immunological mechanisms of pentoxifylline in chronic heart failure","volume":"11","author":"Shaw","year":"2009","journal-title":"Eur. J. Heart Fail."},{"key":"10.1016\/j.bbi.2012.07.009_b0255","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1006\/clim.1999.4716","article-title":"Chagas\u2019 disease encephalitis: intense CD8+ lymphocytic infiltrate is restricted to the acute phase, but is not related to the presence of Trypanosoma cruzi antigens","volume":"92","author":"Silva","year":"1999","journal-title":"Clin. Immunol."},{"key":"10.1016\/j.bbi.2012.07.009_b0260","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4303\/jnp\/N100901","article-title":"Trypanosoma cruzi-induced central nervous system alterations: from the entry of inflammatory cells to potential cognitive and psychiatric abnormalities","volume":"1","author":"Silva","year":"2010","journal-title":"J. Neuroparasit."},{"key":"10.1016\/j.bbi.2012.07.009_b0265","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1007\/s00436-009-1526-6","article-title":"Toxoplasma gondii: host-parasite interaction and behavior manipulation","volume":"105","author":"Silva","year":"2009","journal-title":"Parasitol. Res."},{"key":"10.1016\/j.bbi.2012.07.009_b0270","doi-asserted-by":"crossref","unstructured":"Silverio, J.C., Pereira, I.R., Cipitelli. M.daC., Vinagre, N.F., Rodrigues, M.M., Gazzinelli, R.T., Lannes-Vieira, J., 2012. CD8(+) T-cells expressing interferon gamma or perforin play antagonistic roles in heart injury in experimental Trypanosoma cruzi-elicited cardiomyopathy. PLoS Pathog. 8, e1002645.","DOI":"10.1371\/journal.ppat.1002645"},{"key":"10.1016\/j.bbi.2012.07.009_b0275","first-page":"645","article-title":"American trypanosomiasis (Chagas disease) and the nervous system","volume":"81","author":"Spina-Franca","year":"1998","journal-title":"Bull. Soc. Pathol. Exot. Filiales."},{"key":"10.1016\/j.bbi.2012.07.009_b0280","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1007\/BF00428203","article-title":"The tail suspension test: a new method for screening antidepressants in mice","volume":"85","author":"Steru","year":"1985","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.bbi.2012.07.009_b0285","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1086\/381892","article-title":"Elevated concentrations of CCL2 and tumor necrosis factor-alpha in chagasic cardiomyopathy","volume":"38","author":"Talvani","year":"2004","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.bbi.2012.07.009_b0290","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/0035-9203(88)90272-6","article-title":"Trypanosoma cruzi infection in diabetic mice","volume":"82","author":"Tanowitz","year":"1988","journal-title":"Trans. R. Soc. Trop. Med. Hyg."},{"key":"10.1016\/j.bbi.2012.07.009_b0295","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/j.pharmthera.2007.10.001","article-title":"Tumor necrosis factor antagonist mechanisms of action: a comprehensive","volume":"117","author":"Tracey","year":"2008","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.bbi.2012.07.009_b0300","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/S0278-5846(02)00338-X","article-title":"Role of selective serotonin reuptake inhibitors in psychiatric disorders: a comprehensive review","volume":"27","author":"Vaswani","year":"2003","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.bbi.2012.07.009_b0305","doi-asserted-by":"crossref","first-page":"1368","DOI":"10.1128\/IAI.01450-08","article-title":"Trypanosoma cruzi promotes neuronal and glial cell survival through the neurotrophic receptor TrkC","volume":"77","author":"Weinkauf","year":"2009","journal-title":"Infect. Immun."},{"key":"10.1016\/j.bbi.2012.07.009_b0310","doi-asserted-by":"crossref","first-page":"1474","DOI":"10.1016\/S0140-6736(89)92929-2","article-title":"Oxpentifylline in endotoxaemia","volume":"2","author":"Zabel","year":"1989","journal-title":"Lancet"},{"key":"10.1016\/j.bbi.2012.07.009_b0315","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1016\/j.mehy.2009.04.013","article-title":"Psychosis may be associated with toxoplasmosis","volume":"73","author":"Zhu","year":"2009","journal-title":"Med. Hypotheses"},{"key":"10.1016\/j.bbi.2012.07.009_b0320","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.meegid.2011.12.009","article-title":"The revised Trypanosoma cruzi subspecific nomenclature: rationale, epidemiological relevance and research applications","volume":"12","author":"Zingales","year":"2012","journal-title":"Infect. Genet. Evol."}],"container-title":["Brain, Behavior, and Immunity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0889159112001924?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0889159112001924?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T07:31:25Z","timestamp":1760167885000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0889159112001924"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,10]]},"references-count":64,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2012,10]]}},"alternative-id":["S0889159112001924"],"URL":"https:\/\/doi.org\/10.1016\/j.bbi.2012.07.009","relation":{},"ISSN":["0889-1591"],"issn-type":[{"value":"0889-1591","type":"print"}],"subject":[],"published":{"date-parts":[[2012,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Trypanosoma cruzi-induced depressive-like behavior is independent of meningoencephalitis but responsive to parasiticide and TNF-targeted therapeutic interventions","name":"articletitle","label":"Article Title"},{"value":"Brain, Behavior, and Immunity","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbi.2012.07.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2012 Elsevier Inc.","name":"copyright","label":"Copyright"}]}}