{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T03:15:41Z","timestamp":1793157341625,"version":"4.5.0"},"reference-count":48,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2013,11,1]],"date-time":"2013-11-01T00:00:00Z","timestamp":1383264000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,11,1]],"date-time":"2013-11-01T00:00:00Z","timestamp":1383264000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"NSF","award":["IOS-11-18792"],"award-info":[{"award-number":["IOS-11-18792"]}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain, Behavior, and Immunity"],"published-print":{"date-parts":[[2013,11]]},"DOI":"10.1016\/j.bbi.2013.08.011","type":"journal-article","created":{"date-parts":[[2013,9,5]],"date-time":"2013-09-05T23:47:54Z","timestamp":1378424874000},"page":"159-163","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":108,"special_numbering":"C","title":["Mice exposed to dim light at night exaggerate inflammatory responses to lipopolysaccharide"],"prefix":"10.1016","volume":"34","author":[{"given":"Laura K.","family":"Fonken","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zachary M.","family":"Weil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Randy J.","family":"Nelson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbi.2013.08.011_b0005","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.anbehav.2009.10.012","article-title":"Illness-induced anorexia may reduce trade-offs between digestion and immune function","volume":"79","author":"Adamo","year":"2010","journal-title":"Anim. Behav."},{"key":"10.1016\/j.bbi.2013.08.011_b0010","doi-asserted-by":"crossref","first-page":"7618","DOI":"10.4049\/jimmunol.174.12.7618","article-title":"Circadian oscillations of clock genes, cytolytic factors, and cytokines in rat NK cells","volume":"174","author":"Arjona","year":"2005","journal-title":"J. Immunol."},{"key":"10.1016\/j.bbi.2013.08.011_b0015","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1016\/j.it.2012.08.007","article-title":"Immunity\u2019s fourth dimension: approaching the circadian-immune connection","volume":"33","author":"Arjona","year":"2012","journal-title":"Trends Immunol."},{"key":"10.1016\/j.bbi.2013.08.011_b0020","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1098\/rsbl.2010.1108","article-title":"Chronic exposure to dim light at night suppresses immune responses in Siberian hamsters","volume":"7","author":"Bedrosian","year":"2011","journal-title":"Biol. Lett."},{"key":"10.1016\/j.bbi.2013.08.011_b0025","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.bbi.2013.05.009","article-title":"Artificial light at night alters delayed-type hypersensitivity reaction in response to acute stress in Siberian hamsters","volume":"34","author":"Bedrosian","year":"2013","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.bbi.2013.08.011_b0030","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1038\/mp.2012.96","article-title":"Chronic dim light at night provokes reversible depression-like phenotype: possible role for TNF","volume":"18","author":"Bedrosian","year":"2013","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.bbi.2013.08.011_b0035","doi-asserted-by":"crossref","first-page":"4143","DOI":"10.1182\/blood-2003-03-0779","article-title":"Circadian clock genes oscillate in human peripheral blood mononuclear cells","volume":"102","author":"Boivin","year":"2003","journal-title":"Blood"},{"key":"10.1016\/j.bbi.2013.08.011_b0040","doi-asserted-by":"crossref","first-page":"e29801","DOI":"10.1371\/journal.pone.0029801","article-title":"Circadian clocks in mouse and human CD4+ T cells","volume":"6","author":"Bollinger","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.bbi.2013.08.011_b0045","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.3109\/07420528.2013.803196","article-title":"Dim light at night does not disrupt timing or quality of sleep in mice","volume":"30","author":"Borniger","year":"2013","journal-title":"Chronobiol. Int."},{"key":"10.1016\/j.bbi.2013.08.011_b0050","doi-asserted-by":"crossref","first-page":"e63752","DOI":"10.1371\/journal.pone.0063752","article-title":"Sleep loss and the inflammatory response in mice under chronic environmental circadian disruption","volume":"8","author":"Brager","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.bbi.2013.08.011_b0055","doi-asserted-by":"crossref","first-page":"5796","DOI":"10.4049\/jimmunol.1001026","article-title":"Dysregulation of inflammatory responses by chronic circadian disruption","volume":"185","author":"Castanon-Cervantes","year":"2010","journal-title":"J. Immunol."},{"key":"10.1016\/j.bbi.2013.08.011_b0060","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1046\/j.1365-8711.2001.04882.x","article-title":"The first world atlas of the artificial night sky brightness","volume":"328","author":"Cinzano","year":"2001","journal-title":"MNRAS"},{"key":"10.1016\/j.bbi.2013.08.011_b0065","article-title":"The circadian clock and asthma","author":"Durrington","year":"2013","journal-title":"Thorax"},{"key":"10.1016\/j.bbi.2013.08.011_b0070","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.bbr.2009.07.001","article-title":"Influence of light at night on murine anxiety- and depressive-like responses","volume":"205","author":"Fonken","year":"2009","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.bbi.2013.08.011_b0075","doi-asserted-by":"crossref","first-page":"18664","DOI":"10.1073\/pnas.1008734107","article-title":"Light at night increases body mass by shifting the time of food intake","volume":"107","author":"Fonken","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.bbi.2013.08.011_b0080","doi-asserted-by":"crossref","first-page":"26","DOI":"10.3109\/07420528.2011.635831","article-title":"Dim light at night increases immune function in nile grass rats, a diurnal rodent","volume":"29","author":"Fonken","year":"2011","journal-title":"Chronobiol. Int."},{"key":"10.1016\/j.bbi.2013.08.011_b0085","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1177\/0748730413493862","article-title":"Dim light at night disrupts molecular circadian rhythms and affects weight gain","volume":"28","author":"Fonken","year":"2013","journal-title":"J. Biol. Rhythms"},{"key":"10.1016\/j.bbi.2013.08.011_b0090","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.bbi.2013.02.004","article-title":"Stress-induced glucocorticoids as a neuroendocrine alarm signal of danger","volume":"33","author":"Frank","year":"2013","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.bbi.2013.08.011_b0095","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1111\/j.1365-2664.2012.02212.x","article-title":"Reducing the ecological consequences of night-time light pollution: options and developments","volume":"49","author":"Gaston","year":"2012","journal-title":"J. Appl. Ecol."},{"key":"10.1016\/j.bbi.2013.08.011_b0100","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1186\/ar4146","article-title":"The role of the circadian clock in rheumatoid arthritis","volume":"15","author":"Gibbs","year":"2013","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.bbi.2013.08.011_b0105","doi-asserted-by":"crossref","first-page":"142","DOI":"10.3181\/00379727-103-25439","article-title":"Susceptibility rhythm to E. coli endotoxin and bioassay","volume":"103","author":"Halberg","year":"1960","journal-title":"Proc. Soc. Exp. Biol. Med."},{"key":"10.1016\/j.bbi.2013.08.011_b0110","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1248\/bpb.30.621","article-title":"Characterization of the molecular clock in mouse peritoneal macrophages","volume":"30","author":"Hayashi","year":"2007","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.bbi.2013.08.011_b0115","doi-asserted-by":"crossref","first-page":"21407","DOI":"10.1073\/pnas.0906361106","article-title":"A circadian clock in macrophages controls inflammatory immune responses","volume":"106","author":"Keller","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.bbi.2013.08.011_b0120","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1152\/physrev.00011.2010","article-title":"Physiology of microglia","volume":"91","author":"Kettenmann","year":"2011","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.bbi.2013.08.011_b0125","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/S0166-2236(00)02088-9","article-title":"Cytokine-induced sickness behaviour: mechanisms and implications","volume":"25","author":"Konsman","year":"2002","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.bbi.2013.08.011_b0130","first-page":"E1000","article-title":"Neural control of the anorexia-cachexia syndrome","volume":"295","author":"Laviano","year":"2008","journal-title":"Am. J. Physiol.-Endoc. M"},{"key":"10.1016\/j.bbi.2013.08.011_b0135","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.3892\/mmr.2013.1331","article-title":"Altered melatonin secretion and circadian gene expression with increased proinflammatory cytokine expression in early-stage sepsis patients","volume":"7","author":"Li","year":"2013","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.bbi.2013.08.011_b0140","doi-asserted-by":"crossref","first-page":"1430","DOI":"10.3109\/07420520903408358","article-title":"Diurnal variation in endotoxin-induced mortality in mice: correlation with proinflammatory factors","volume":"26","author":"Marpegan","year":"2009","journal-title":"Chronobiol. Int."},{"key":"10.1016\/j.bbi.2013.08.011_b0145","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.biopsych.2013.02.019","article-title":"How might circadian rhythms control mood? Let me count the ways","volume":"74","author":"McClung","year":"2013","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.bbi.2013.08.011_b0150","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1146\/annurev-neuro-060909-153128","article-title":"Central and peripheral circadian clocks in mammals","volume":"35","author":"Mohawk","year":"2012","journal-title":"Annu. Rev. Neurosci."},{"key":"10.1016\/j.bbi.2013.08.011_b0155","series-title":"Principles and Practice of Sleep Medicine","first-page":"471","article-title":"Shift work","author":"Monk","year":"2000"},{"key":"10.1016\/j.bbi.2013.08.011_b0160","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1254\/jphs.11069FP","article-title":"Selective upregulation of Per1 mRNA expression by ATP through activation of P2X7 purinergic receptors expressed in microglial cells","volume":"116","author":"Nakazato","year":"2011","journal-title":"J. Pharmacol. Sci."},{"key":"10.1016\/j.bbi.2013.08.011_b0165","doi-asserted-by":"crossref","first-page":"12662","DOI":"10.1073\/pnas.1209965109","article-title":"Circadian clock protein cryptochrome regulates the expression of proinflammatory cytokines","volume":"109","author":"Narasimamurthy","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.bbi.2013.08.011_b0170","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1111\/j.1365-2990.2012.01306.x","article-title":"Review: microglia of the aged brain: primed to be activated and resistant to regulation","volume":"39","author":"Norden","year":"2013","journal-title":"Neuropathol. Appl. Neurobiol."},{"key":"10.1016\/j.bbi.2013.08.011_b0175","doi-asserted-by":"crossref","first-page":"e47087","DOI":"10.1371\/journal.pone.0047087","article-title":"Long-lasting effects of sepsis on circadian rhythms in the mouse","volume":"7","author":"O\u2019Callaghan","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.bbi.2013.08.011_b0180","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1038\/nature09702","article-title":"Circadian clocks in human red blood cells","volume":"469","author":"O\u2019Neill","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.bbi.2013.08.011_b0185","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.jneuroim.2010.04.015","article-title":"Paying the circadian toll: the circadian response to LPS injection is dependent on the Toll-like receptor 4","volume":"225","author":"Paladino","year":"2010","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.bbi.2013.08.011_b0190","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/S0092-8674(02)00722-5","article-title":"Coordinated transcription of key pathways in the mouse by the circadian clock","volume":"109","author":"Panda","year":"2002","journal-title":"Cell"},{"key":"10.1016\/j.bbi.2013.08.011_b0195","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1136\/oem.2009.046797","article-title":"Incidence of metabolic syndrome among night-shift healthcare workers","volume":"67","author":"Pietroiusti","year":"2010","journal-title":"Occup. Environ. Med."},{"key":"10.1016\/j.bbi.2013.08.011_b0200","doi-asserted-by":"crossref","first-page":"2193","DOI":"10.2741\/1690","article-title":"Fever and hypothermia in systemic inflammation: recent discoveries and revisions","volume":"10","author":"Romanovsky","year":"2005","journal-title":"Front. Biosci."},{"key":"10.1016\/j.bbi.2013.08.011_b0205","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1038\/nri3386","article-title":"Circadian control of the immune system","volume":"13","author":"Scheiermann","year":"2013","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.bbi.2013.08.011_b0210","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/j.bbi.2011.10.001","article-title":"Circadian expression of clock genes in mouse macrophages, dendritic cells, and B cells","volume":"26","author":"Silver","year":"2012","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.bbi.2013.08.011_b0215","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.immuni.2011.12.017","article-title":"The circadian clock controls toll-like receptor 9-mediated innate and adaptive immunity","volume":"36","author":"Silver","year":"2012","journal-title":"Immunity"},{"key":"10.1016\/j.bbi.2013.08.011_b0220","doi-asserted-by":"crossref","first-page":"E2457","DOI":"10.1073\/pnas.1206274109","article-title":"Core circadian protein CLOCK is a positive regulator of NF-kappaB-mediated transcription","volume":"109","author":"Spengler","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.bbi.2013.08.011_b0225","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.mrrev.2009.01.003","article-title":"Electric light causes cancer? Surely you are joking, Mr. Stevens","volume":"682","author":"Stevens","year":"2009","journal-title":"Mutat. Res."},{"key":"10.1016\/j.bbi.2013.08.011_b0230","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1038\/nature744","article-title":"Extensive and divergent circadian gene expression in liver and heart","volume":"417","author":"Storch","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.bbi.2013.08.011_b0235","doi-asserted-by":"crossref","first-page":"e4800","DOI":"10.1136\/bmj.e4800","article-title":"Shift work and vascular events: systematic review and meta-analysis","volume":"345","author":"Vyas","year":"2012","journal-title":"BMJ"},{"key":"10.1016\/j.bbi.2013.08.011_b0240","doi-asserted-by":"crossref","first-page":"1190","DOI":"10.1016\/j.bbi.2010.05.011","article-title":"Protracted downregulation of CX3CR1 on microglia of aged mice after lipopolysaccharide challenge","volume":"24","author":"Wynne","year":"2010","journal-title":"Brain Behav. Immun."}],"container-title":["Brain, Behavior, and Immunity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0889159113004224?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0889159113004224?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T07:33:45Z","timestamp":1760168025000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0889159113004224"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,11]]},"references-count":48,"alternative-id":["S0889159113004224"],"URL":"https:\/\/doi.org\/10.1016\/j.bbi.2013.08.011","relation":{},"ISSN":["0889-1591"],"issn-type":[{"value":"0889-1591","type":"print"}],"subject":[],"published":{"date-parts":[[2013,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mice exposed to dim light at night exaggerate inflammatory responses to lipopolysaccharide","name":"articletitle","label":"Article Title"},{"value":"Brain, Behavior, and Immunity","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbi.2013.08.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}