{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T18:34:53Z","timestamp":1792521293599,"version":"4.5.0"},"reference-count":73,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2014,3,1]],"date-time":"2014-03-01T00:00:00Z","timestamp":1393632000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,3,1]],"date-time":"2014-03-01T00:00:00Z","timestamp":1393632000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"Nutricia Research"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain, Behavior, and Immunity"],"published-print":{"date-parts":[[2014,3]]},"DOI":"10.1016\/j.bbi.2013.12.005","type":"journal-article","created":{"date-parts":[[2013,12,11]],"date-time":"2013-12-11T13:03:04Z","timestamp":1386766984000},"page":"197-206","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":394,"special_numbering":"C","title":["Altered gut microbiota and activity in a murine model of autism spectrum disorders"],"prefix":"10.1016","volume":"37","author":[{"given":"Caroline G.M.","family":"de Theije","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harm","family":"Wopereis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1880-6163","authenticated-orcid":false,"given":"Mohamed","family":"Ramadan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiemen","family":"van Eijndthoven","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jolanda","family":"Lambert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Knol","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johan","family":"Garssen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aletta D.","family":"Kraneveld","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raish","family":"Oozeer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbi.2013.12.005_b0005","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/1471-230X-11-22","article-title":"Gastrointestinal flora and gastrointestinal status in children with autism \u2013 comparisons to neurotypical children and correlation with autism severity","volume":"11","author":"Adams","year":"2011","journal-title":"BMC Gastroenterol."},{"key":"10.1016\/j.bbi.2013.12.005_b0010","doi-asserted-by":"crossref","first-page":"4983","DOI":"10.1038\/sj.onc.1206521","article-title":"Repression of MUC2 gene expression by butyrate, a physiological regulator of intestinal cell maturation","volume":"22","author":"Augenlicht","year":"2003","journal-title":"Oncogene"},{"key":"10.1016\/j.bbi.2013.12.005_b0015","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1002\/(SICI)1098-2302(199909)35:2<146::AID-DEV7>3.0.CO;2-G","article-title":"Maternal separation disrupts the integrity of the intestinal microflora in infant rhesus monkeys","volume":"35","author":"Bailey","year":"1999","journal-title":"Dev. Psychobiol."},{"key":"10.1016\/j.bbi.2013.12.005_b0020","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1079\/BJN20051451","article-title":"Effects of infant formula containing a mixture of galacto- and fructo-oligosaccharides or viable Bifidobacterium animalis on the intestinal microflora during the first 4 months of life","volume":"94","author":"Bakker-Zierikzee","year":"2005","journal-title":"Br. J. Nutr."},{"key":"10.1016\/j.bbi.2013.12.005_b0025","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0046231","article-title":"Gut microbiota composition is correlated to grid floor induced stress and behavior in the BALB\/c mouse","volume":"7","author":"Bangsgaard Bendtsen","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.bbi.2013.12.005_b0030","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1111\/j.1365-2982.2012.01906.x","article-title":"Microbes and the gut\u2013brain axis","volume":"24","author":"Bercik","year":"2012","journal-title":"Neurogastroenterol. Motil"},{"key":"10.1016\/j.bbi.2013.12.005_b0035","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1053\/j.gastro.2011.04.052","article-title":"The intestinal microbiota affect central levels of brain-derived neurotropic factor and behavior in mice","volume":"141","author":"Bercik","year":"2011","journal-title":"Gastroenterology"},{"key":"10.1016\/j.bbi.2013.12.005_b0040","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/S0306-9877(98)90107-4","article-title":"Autism and Clostridium tetani","volume":"51","author":"Bolte","year":"1998","journal-title":"Med. Hypotheses"},{"key":"10.1016\/j.bbi.2013.12.005_b0045","article-title":"Evaluation, diagnosis, and treatment of gastrointestinal disorders in individuals with ASDs: a consensus report","volume":"125","author":"Buie","year":"2010","journal-title":"Pediatrics"},{"key":"10.1016\/j.bbi.2013.12.005_b0050","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1042\/BJ20082222","article-title":"The regulation of intestinal mucin MUC2 expression by short-chain fatty acids: implications for epithelial protection","volume":"420","author":"Burger-van Paassen","year":"2009","journal-title":"Biochem. J."},{"key":"10.1016\/j.bbi.2013.12.005_b0055","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1038\/nmeth.f.303","article-title":"QIIME allows analysis of high-throughput community sequencing data","volume":"7","author":"Caporaso","year":"2010","journal-title":"Nat. Methods"},{"key":"10.1016\/j.bbi.2013.12.005_b0060","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1099\/00207713-24-2-256","article-title":"Eubacterium cylindroides (Rocchi) Holdeman and Moore: emended description and designation of neotype strain","volume":"24","author":"Cato","year":"1974","journal-title":"Int. J. Syst. Bacteriol."},{"key":"10.1016\/j.bbi.2013.12.005_b0065","doi-asserted-by":"crossref","first-page":"1696","DOI":"10.1001\/jama.2013.2270","article-title":"Prenatal valproate exposure and risk of autism spectrum disorders and childhood autism","volume":"309","author":"Christensen","year":"2013","journal-title":"JAMA"},{"key":"10.1016\/j.bbi.2013.12.005_b8000","article-title":"The microbiome-gut-brain axis during early life regulates the hippocampal serotonergic system in a sex-dependent manner","author":"Clarke","year":"2012","journal-title":"Mol. psychiatr"},{"key":"10.1016\/j.bbi.2013.12.005_b9025","doi-asserted-by":"crossref","first-page":"D141","DOI":"10.1093\/nar\/gkn879","article-title":"The Ribosomal Database Project: improved alignments and new tools for rRNA analysis","volume":"37","author":"Cole","year":"2009","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.bbi.2013.12.005_b0070","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1038\/nrn3346","article-title":"Mind-altering microorganisms: the impact of the gut microbiota on brain and behaviour","volume":"13","author":"Cryan","year":"2012","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.bbi.2013.12.005_b0075","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.brainres.2008.09.088","article-title":"Valproic acid regulates catecholaminergic pathways by concentration-dependent threshold effects on TH mRNA synthesis and degradation","volume":"1247","author":"D\u2019Souza","year":"2009","journal-title":"Brain Res."},{"key":"10.1016\/j.bbi.2013.12.005_b0080","doi-asserted-by":"crossref","first-page":"e76993","DOI":"10.1371\/journal.pone.0076993","article-title":"Fecal microbiota and metabolome of children with autism and pervasive developmental disorder not otherwise specified","volume":"8","author":"De Angelis","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.bbi.2013.12.005_b0085","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1097\/MPG.0b013e3181dcc4a5","article-title":"Alterations of the intestinal barrier in patients with autism spectrum disorders and in their first-degree relatives","volume":"51","author":"de Magistris","year":"2010","journal-title":"J. Pediatr. Gastroenterol. Nutr."},{"issue":"Suppl. 1","key":"10.1016\/j.bbi.2013.12.005_b0090","doi-asserted-by":"crossref","first-page":"S70","DOI":"10.1016\/j.ejphar.2011.07.013","article-title":"Pathways underlying the gut-to-brain connection in autism spectrum disorders as future targets for disease management","volume":"668","author":"de Theije","year":"2011","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.bbi.2013.12.005_b0345","article-title":"Microbiota is essential for social development in the mouse","volume":"1","author":"Desbonnet","year":"2013","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.bbi.2013.12.005_b0100","doi-asserted-by":"crossref","first-page":"3047","DOI":"10.1073\/pnas.1010529108","article-title":"Normal gut microbiota modulates brain development and behavior","volume":"108","author":"Diaz Heijtz","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.bbi.2013.12.005_b0105","article-title":"Environmental risk factors for autism","volume":"4","author":"Dietert","year":"2011","journal-title":"Emerg. Health Threats J."},{"key":"10.1016\/j.bbi.2013.12.005_b0110","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1016\/j.neubiorev.2010.12.013","article-title":"Fetal exposure to teratogens: evidence of genes involved in autism","volume":"35","author":"Dufour-Rainfray","year":"2011","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.bbi.2013.12.005_b9030","doi-asserted-by":"crossref","first-page":"2460","DOI":"10.1093\/bioinformatics\/btq461","article-title":"Search and clustering orders of magnitude faster than BLAST","volume":"26","author":"Edgar","year":"2010","journal-title":"Bioinformatics"},{"key":"10.1016\/j.bbi.2013.12.005_b0115","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1016\/j.anaerobe.2010.06.008","article-title":"Pyrosequencing study of fecal microflora of autistic and control children","volume":"16","author":"Finegold","year":"2010","journal-title":"Anaerobe"},{"key":"10.1016\/j.bbi.2013.12.005_b0120","doi-asserted-by":"crossref","first-page":"S6","DOI":"10.1086\/341914","article-title":"Gastrointestinal Microflora Studies in Late-Onset Autism","volume":"35","author":"Finegold","year":"2002","journal-title":"Clin. Infect. Dis."},{"issue":"Suppl. 10","key":"10.1016\/j.bbi.2013.12.005_b0125","first-page":"3","article-title":"Epidemiology of autistic disorder and other pervasive developmental disorders","volume":"66","author":"Fombonne","year":"2005","journal-title":"J. Clin. Psychiatry"},{"key":"10.1016\/j.bbi.2013.12.005_b0130","doi-asserted-by":"crossref","first-page":"1174","DOI":"10.1017\/S0007114507862349","article-title":"Assessing changes in composition of intestinal microbiota in neonatal BALB\/c mice through cluster analysis of molecular markers","volume":"99","author":"Fujiwara","year":"2008","journal-title":"Br. J. Nutr."},{"key":"10.1016\/j.bbi.2013.12.005_b0135","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.autneu.2006.01.007","article-title":"Novel gut afferents: Intrinsic afferent neurons and intestinofugal neurons","volume":"125","author":"Furness","year":"2006","journal-title":"Auton. Neurosci."},{"key":"10.1016\/j.bbi.2013.12.005_b0140","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1016\/j.biopsych.2010.09.031","article-title":"Validating gamma oscillations and delayed auditory responses as translational biomarkers of autism","volume":"68","author":"Gandal","year":"2010","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.bbi.2013.12.005_b0145","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/j.bbi.2004.09.002","article-title":"Activation in vagal afferents and central autonomic pathways: early responses to intestinal infection with Campylobacter jejuni","volume":"19","author":"Goehler","year":"2005","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.bbi.2013.12.005_b0150","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1002\/aur.1253","article-title":"Molecular characterisation of gastrointestinal microbiota of children with autism (with and without gastrointestinal dysfunction) and their neurotypical siblings","volume":"5","author":"Gondalia","year":"2012","journal-title":"Autism Res."},{"key":"10.1016\/j.bbi.2013.12.005_b0155","first-page":"582","article-title":"A simplified Monte Carlo significance test procedure. Journal of the Royal Statistical Society","author":"Hope","year":"1968","journal-title":"Series B (Methodological)"},{"key":"10.1016\/j.bbi.2013.12.005_b0160","doi-asserted-by":"crossref","first-page":"e68322","DOI":"10.1371\/journal.pone.0068322","article-title":"Reduced Incidence of Prevotella and Other Fermenters in Intestinal Microflora of Autistic Children","volume":"8","author":"Kang","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.bbi.2013.12.005_b0165","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1017\/S1461145711001714","article-title":"Autism-like behaviours with transient histone hyperacetylation in mice treated prenatally with valproic acid","volume":"16","author":"Kataoka","year":"2013","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"10.1016\/j.bbi.2013.12.005_b0170","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1111\/jnc.12147","article-title":"Male-specific alteration in excitatory post-synaptic development and social interaction in pre-natal valproic acid exposure model of autism spectrum disorder","volume":"124","author":"Kim","year":"2013","journal-title":"J. Neurochem."},{"key":"10.1016\/j.bbi.2013.12.005_b0175","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/gm228","article-title":"Gut microbiome\u2013host interactions in health and disease","volume":"3","author":"Kinross","year":"2011","journal-title":"Genome Med."},{"key":"10.1016\/j.bbi.2013.12.005_b0180","first-page":"36","article-title":"Colon microflora in infants fed formula with galacto- and fructo-oligosaccharides: more like breast-fed infants","volume":"40","author":"Knol","year":"2005","journal-title":"J. Pediatr. Gastroenterol. Nutr."},{"key":"10.1016\/j.bbi.2013.12.005_b0185","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1038\/nrmicro2297","article-title":"Host interactions of probiotic bacterial surface molecules: comparison with commensals and pathogens","volume":"8","author":"Lebeer","year":"2010","journal-title":"Nat. Rev. Micro."},{"key":"10.1016\/j.bbi.2013.12.005_b0190","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1002\/jnr.21521","article-title":"Developmental expression of histone deacetylase 11 in the murine brain","volume":"86","author":"Liu","year":"2008","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.bbi.2013.12.005_b0195","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1007\/BF01538320","article-title":"Sex differences in autism","volume":"12","author":"Lord","year":"1982","journal-title":"J. Autism. Dev. Disord."},{"key":"10.1016\/j.bbi.2013.12.005_b0200","doi-asserted-by":"crossref","first-page":"1987","DOI":"10.1007\/s10620-012-2286-1","article-title":"Does the human gut microbiota contribute to the etiology of autism spectrum disorders?","volume":"57","author":"Louis","year":"2012","journal-title":"Dig. Dis. Sci."},{"key":"10.1016\/j.bbi.2013.12.005_b0205","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1186\/1471-2105-7-371","article-title":"UniFrac \u2013 an online tool for comparing microbial community diversity in a phylogenetic context","volume":"7","author":"Lozupone","year":"2006","journal-title":"BMC Bioinformatics"},{"key":"10.1016\/j.bbi.2013.12.005_b0210","doi-asserted-by":"crossref","first-page":"8228","DOI":"10.1128\/AEM.71.12.8228-8235.2005","article-title":"UniFrac: a new phylogenetic method for comparing microbial communities","volume":"71","author":"Lozupone","year":"2005","journal-title":"Appl. Environ. Microbiol."},{"key":"10.1016\/j.bbi.2013.12.005_b0215","article-title":"Short-chain fatty acid fermentation products of the gut microbiome: implications in autism spectrum disorders","volume":"23","author":"MacFabe","year":"2012","journal-title":"Microb. Ecol. Health Dis."},{"key":"10.1016\/j.bbi.2013.12.005_b0220","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.bbr.2006.07.025","article-title":"Neurobiological effects of intraventricular propionic acid in rats: possible role of short chain fatty acids on the pathogenesis and characteristics of autism spectrum disorders","volume":"176","author":"MacFabe","year":"2007","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.bbi.2013.12.005_b0225","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.bbr.2010.10.005","article-title":"Effects of the enteric bacterial metabolic product propionic acid on object-directed behavior, social behavior, cognition, and neuroinflammation in adolescent rats: relevance to autism spectrum disorder","volume":"217","author":"MacFabe","year":"2011","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.bbi.2013.12.005_b0230","doi-asserted-by":"crossref","first-page":"6788","DOI":"10.1128\/AEM.05346-11","article-title":"Transmission of intestinal Bifidobacterium longum subsp. longum strains from mother to infant, determined by multilocus sequencing typing and amplified fragment length polymorphism","volume":"77","author":"Makino","year":"2011","journal-title":"Appl. Environ. Microbiol."},{"key":"10.1016\/j.bbi.2013.12.005_b0235","doi-asserted-by":"crossref","first-page":"7220","DOI":"10.1128\/AEM.70.12.7220-7228.2004","article-title":"Use of 16S rRNA gene-targeted group-specific primers for real-time PCR analysis of predominant bacteria in human feces","volume":"70","author":"Matsuki","year":"2004","journal-title":"Appl. Environ. Microbiol."},{"key":"10.1016\/j.bbi.2013.12.005_b0240","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1136\/jmg.37.7.489","article-title":"A clinical study of 57 children with fetal anticonvulsant syndromes","volume":"37","author":"Moore","year":"2000","journal-title":"J. Med. Genet."},{"key":"10.1016\/j.bbi.2013.12.005_b0245","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1007\/s00213-010-2010-9","article-title":"Maternal separation as a model of brain-gut axis dysfunction","volume":"214","author":"O\u2019Mahony","year":"2011","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.bbi.2013.12.005_b0250","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.biopsych.2008.06.026","article-title":"Early life stress alters behavior, immunity, and microbiota in rats: implications for irritable bowel syndrome and psychiatric illnesses","volume":"65","author":"O\u2019Mahony","year":"2009","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.bbi.2013.12.005_b0255","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.reprotox.2009.02.014","article-title":"Valproic acid in pregnancy: how much are we endangering the embryo and fetus?","volume":"28","author":"Ornoy","year":"2009","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.bbi.2013.12.005_b0260","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1099\/jmm.0.46101-0","article-title":"Differences between the gut microflora of children with autistic spectrum disorders and that of healthy children","volume":"54","author":"Parracho","year":"2005","journal-title":"J. Med. Microbiol."},{"key":"10.1016\/j.bbi.2013.12.005_b9040","doi-asserted-by":"crossref","first-page":"7188","DOI":"10.1093\/nar\/gkm864","article-title":"SILVA: a comprehensive online resource for quality checked and aligned ribosomal RNA sequence data compatible with ARB","volume":"35","author":"Pruesse","year":"2007","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.bbi.2013.12.005_b0265","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1017\/S0012162205001076","article-title":"Characteristics of fetal anticonvulsant syndrome associated autistic disorder","volume":"47","author":"Rasalam","year":"2005","journal-title":"Dev. Med. Child Neurol."},{"key":"10.1016\/j.bbi.2013.12.005_b0270","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.ntt.2013.01.004","article-title":"In utero exposure to valproic acid and autism \u2013 a current review of clinical and animal studies","volume":"36","author":"Roullet","year":"2013","journal-title":"Neurotoxicol. Teratol."},{"key":"10.1016\/j.bbi.2013.12.005_b0275","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1016\/j.neuroscience.2010.06.069","article-title":"Behavioral and molecular changes in the mouse in response to prenatal exposure to the anti-epileptic drug valproic acid","volume":"170","author":"Roullet","year":"2010","journal-title":"Neuroscience"},{"key":"10.1016\/j.bbi.2013.12.005_b0280","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1126\/science.1206095","article-title":"The Toll-like receptor 2 pathway establishes colonization by a commensal of the human microbiota","volume":"332","author":"Round","year":"2011","journal-title":"Science"},{"key":"10.1016\/j.bbi.2013.12.005_b0285","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1177\/088307380001500701","article-title":"Short-term benefit from oral vancomycin treatment of regressive-onset autism","volume":"15","author":"Sandler","year":"2000","journal-title":"J. Child. Neurol."},{"key":"10.1016\/j.bbi.2013.12.005_b0290","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1016\/j.psyneuen.2008.02.011","article-title":"Gender-specific behavioral and immunological alterations in an animal model of autism induced by prenatal exposure to valproic acid","volume":"33","author":"Schneider","year":"2008","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.bbi.2013.12.005_b0295","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1126\/science.1138659","article-title":"Strong association of de novo copy number mutations with autism","volume":"316","author":"Sebat","year":"2007","journal-title":"Science"},{"key":"10.1016\/j.bbi.2013.12.005_b0300","doi-asserted-by":"crossref","first-page":"R60","DOI":"10.1186\/gb-2011-12-6-r60","article-title":"Metagenomic biomarker discovery and explanation","volume":"12","author":"Segata","year":"2011","journal-title":"Genome Biol."},{"key":"10.1016\/j.bbi.2013.12.005_b0305","doi-asserted-by":"crossref","first-page":"e32543","DOI":"10.1371\/journal.pone.0032543","article-title":"Improved detection of bifidobacteria with optimised 16S rRNA-gene based pyrosequencing","volume":"7","author":"Sim","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.bbi.2013.12.005_b9075","doi-asserted-by":"crossref","first-page":"1985","DOI":"10.1099\/ijs.0.64318-0","article-title":"Alistipes onderdonkii sp. nov. and Alistipes shahii sp. nov., of human origin","volume":"56","author":"Song","year":"2006","journal-title":"Int. J. Syst. Evol. Micr."},{"key":"10.1016\/j.bbi.2013.12.005_b0310","doi-asserted-by":"crossref","first-page":"6459","DOI":"10.1128\/AEM.70.11.6459-6465.2004","article-title":"Real-Time PCR Quantitation of Clostridia in Feces of Autistic Children","volume":"70","author":"Song","year":"2004","journal-title":"Appl. Environ. Microbiol."},{"key":"10.1016\/j.bbi.2013.12.005_b0315","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1113\/jphysiol.2004.063388","article-title":"Postnatal microbial colonization programs the hypothalamic-pituitary-adrenal system for stress response in mice","volume":"558","author":"Sudo","year":"2004","journal-title":"J. Physiol."},{"key":"10.1016\/j.bbi.2013.12.005_b0320","unstructured":"ter Braak, C.J.F., \u0160milauer, P., 2012. CANOCO reference manual and user\u2019s guide: software for ordination (version 5.0) (Biometris [etc.], Wageningen [etc.])."},{"key":"10.1016\/j.bbi.2013.12.005_b0325","doi-asserted-by":"crossref","first-page":"6718","DOI":"10.1128\/AEM.05212-11","article-title":"Low relative abundances of the mucolytic bacterium Akkermansia muciniphila and Bifidobacterium spp. in feces of children with autism","volume":"77","author":"Wang","year":"2011","journal-title":"Appl. Environ. Microbiol."},{"key":"10.1016\/j.bbi.2013.12.005_b0330","doi-asserted-by":"crossref","first-page":"2096","DOI":"10.1007\/s10620-012-2167-7","article-title":"Elevated fecal short chain fatty acid and ammonia concentrations in children with autism spectrum disorder","volume":"57","author":"Wang","year":"2012","journal-title":"Dig. Dis. Sci."},{"key":"10.1016\/j.bbi.2013.12.005_b0335","doi-asserted-by":"crossref","first-page":"e24585","DOI":"10.1371\/journal.pone.0024585","article-title":"Impaired carbohydrate digestion and transport and mucosal dysbiosis in the intestines of children with autism and gastrointestinal disturbances","volume":"6","author":"Williams","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.bbi.2013.12.005_b0340","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1186\/1476-4598-10-27","article-title":"Short-chain fatty acid level and field cancerization show opposing associations with enteroendocrine cell number and neuropilin expression in patients with colorectal adenoma","volume":"10","author":"Yu","year":"2011","journal-title":"Mol. Cancer"}],"container-title":["Brain, Behavior, and Immunity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0889159113005904?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0889159113005904?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T07:37:09Z","timestamp":1760168229000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0889159113005904"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,3]]},"references-count":73,"alternative-id":["S0889159113005904"],"URL":"https:\/\/doi.org\/10.1016\/j.bbi.2013.12.005","relation":{},"ISSN":["0889-1591"],"issn-type":[{"value":"0889-1591","type":"print"}],"subject":[],"published":{"date-parts":[[2014,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Altered gut microbiota and activity in a murine model of autism spectrum disorders","name":"articletitle","label":"Article Title"},{"value":"Brain, Behavior, and Immunity","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbi.2013.12.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}