{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T04:46:09Z","timestamp":1791089169934,"version":"4.1.0"},"reference-count":43,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2014,5,1]],"date-time":"2014-05-01T00:00:00Z","timestamp":1398902400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,5,1]],"date-time":"2014-05-01T00:00:00Z","timestamp":1398902400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"Hungarian Research Fund OTKA","award":["109622"],"award-info":[{"award-number":["109622"]}]},{"name":"Hungarian Research Fund OTKA","award":["109744"],"award-info":[{"award-number":["109744"]}]},{"name":"Hungarian Research Fund OTKA","award":["109743"],"award-info":[{"award-number":["109743"]}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain, Behavior, and Immunity"],"published-print":{"date-parts":[[2014,5]]},"DOI":"10.1016\/j.bbi.2014.01.010","type":"journal-article","created":{"date-parts":[[2014,1,21]],"date-time":"2014-01-21T01:30:24Z","timestamp":1390267824000},"page":"25-35","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":43,"special_numbering":"C","title":["The fractalkine\/Cx3CR1 system is implicated in the development of metabolic visceral adipose tissue inflammation in obesity"],"prefix":"10.1016","volume":"38","author":[{"given":"\u00c1gnes","family":"Poly\u00e1k","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Szilam\u00e9r","family":"Ferenczi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c1d\u00e1m","family":"D\u00e9nes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zsuzsanna","family":"Winkler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R\u00f3kus","family":"Kriszt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernadett","family":"Pint\u00e9r-K\u00fcbler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krisztina J.","family":"Kov\u00e1cs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbi.2014.01.010_b0005","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/S1043-2760(00)00301-5","article-title":"Adipose tissue as an endocrine organ","volume":"11","author":"Ahima","year":"2000","journal-title":"Trends Endocrinol. Metab."},{"key":"10.1016\/j.bbi.2014.01.010_b0010","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1006\/frne.2000.0197","article-title":"Leptin regulation of neuroendocrine systems","volume":"21","author":"Ahima","year":"2000","journal-title":"Front. Neuroendocrinol."},{"key":"10.1016\/j.bbi.2014.01.010_b0015","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1055\/s-0031-1291305","article-title":"Effects of high fat diet on the Basal activity of the hypothalamus\u2013pituitary\u2013adrenal axis in mice: a systematic review","volume":"43","author":"Auvinen","year":"2011","journal-title":"Horm. Metab. Res."},{"key":"10.1016\/j.bbi.2014.01.010_b0020","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.physbeh.2004.02.006","article-title":"Genetic vulnerability to diet-induced obesity in the C57BL\/6J mouse: physiological and molecular characteristics","volume":"81","author":"Collins","year":"2004","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.bbi.2014.01.010_b0025","doi-asserted-by":"crossref","first-page":"23799","DOI":"10.1074\/jbc.273.37.23799","article-title":"Identification of CX3CR1. A chemotactic receptor for the human CX3C chemokine fractalkine and a fusion coreceptor for HIV-1","volume":"273","author":"Combadiere","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbi.2014.01.010_b0030","doi-asserted-by":"crossref","first-page":"4645","DOI":"10.1210\/jc.2009-1412","article-title":"11Beta-hydroxysteroid dehydrogenase type 1 and its role in the hypothalamus\u2013pituitary\u2013adrenal axis, metabolic syndrome, and inflammation","volume":"94","author":"Cooper","year":"2009","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.bbi.2014.01.010_b0035","doi-asserted-by":"crossref","first-page":"11696","DOI":"10.1073\/pnas.1934666100","article-title":"Chronic stress and obesity: a new view of \u201ccomfort food\u201d","volume":"100","author":"Dallman","year":"2003","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.bbi.2014.01.010_b0040","doi-asserted-by":"crossref","first-page":"e002006","DOI":"10.1161\/JAHA.112.002006","article-title":"Interleukin-1 mediates neuroinflammatory changes associated with diet-induced atherosclerosis","volume":"1","author":"Denes","year":"2012","journal-title":"J. Am. Heart Assoc."},{"key":"10.1016\/j.bbi.2014.01.010_b0045","first-page":"R328","article-title":"Neuropeptide Y suppresses sympathetic activity to interscapular brown adipose tissue in rats","volume":"260","author":"Egawa","year":"1991","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.bbi.2014.01.010_b0050","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1084\/jem.188.8.1413","article-title":"Fractalkine and CX3CR1 mediate a novel mechanism of leukocyte capture, firm adhesion, and activation under physiologic flow","volume":"188","author":"Fong","year":"1998","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.bbi.2014.01.010_b0055","doi-asserted-by":"crossref","first-page":"2325","DOI":"10.1210\/en.2008-1426","article-title":"Palatable foods, stress, and energy stores sculpt corticotropin-releasing factor, adrenocorticotropin, and corticosterone concentrations after restraint","volume":"150","author":"Foster","year":"2009","journal-title":"Endocrinology"},{"key":"10.1016\/j.bbi.2014.01.010_b0060","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1017\/S0954422410000168","article-title":"High-fat diet-induced obesity in animal models","volume":"23","author":"Hariri","year":"2010","journal-title":"Nutr. Res. Rev."},{"key":"10.1016\/j.bbi.2014.01.010_b0065","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1016\/j.nutres.2010.09.003","article-title":"A highly saturated fat-rich diet is more obesogenic than diets with lower saturated fat content","volume":"30","author":"Hariri","year":"2010","journal-title":"Nutr. Res."},{"key":"10.1016\/j.bbi.2014.01.010_b0070","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/S0092-8674(00)80438-9","article-title":"Identification and molecular characterization of fractalkine receptor CX3CR1, which mediates both leukocyte migration and adhesion","volume":"91","author":"Imai","year":"1997","journal-title":"Cell"},{"key":"10.1016\/j.bbi.2014.01.010_b0075","first-page":"270","article-title":"Adipose tissue is a regulated source of interleukin-10","volume":"29","author":"Juge-Aubry","year":"2005","journal-title":"Cytokine"},{"key":"10.1016\/j.bbi.2014.01.010_b0080","doi-asserted-by":"crossref","first-page":"4106","DOI":"10.1128\/MCB.20.11.4106-4114.2000","article-title":"Analysis of fractalkine receptor CX(3)CR1 function by targeted deletion and green fluorescent protein reporter gene insertion","volume":"20","author":"Jung","year":"2000","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.bbi.2014.01.010_b0085","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.2337\/diabetes.54.4.1023","article-title":"Adipocyte-specific glucocorticoid inactivation protects against diet-induced obesity","volume":"54","author":"Kershaw","year":"2005","journal-title":"Diabetes"},{"key":"10.1016\/j.bbi.2014.01.010_b0090","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/0006-8993(88)90435-0","article-title":"Corticosterone and dexamethasone act at different brain sites to inhibit adrenalectomy-induced adrenocorticotropin hypersecretion","volume":"474","author":"Kovacs","year":"1988","journal-title":"Brain Res."},{"key":"10.1016\/j.bbi.2014.01.010_b0095","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/j.cell.2013.03.001","article-title":"The fractalkine\/CX3CR1 system regulates beta cell function and insulin secretion","volume":"153","author":"Lee","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.bbi.2014.01.010_b0100","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1172\/JCI15555","article-title":"Decreased atherosclerosis in CX3CR1\u2212\/\u2212 mice reveals a role for fractalkine in atherogenesis","volume":"111","author":"Lesnik","year":"2003","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bbi.2014.01.010_b0105","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1161\/ATVBAHA.107.158675","article-title":"CX3CR1 deficiency impairs dendritic cell accumulation in arterial intima and reduces atherosclerotic burden","volume":"28","author":"Liu","year":"2008","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.bbi.2014.01.010_b0110","doi-asserted-by":"crossref","first-page":"16","DOI":"10.2337\/db06-1076","article-title":"Increased inflammatory properties of adipose tissue macrophages recruited during diet-induced obesity","volume":"56","author":"Lumeng","year":"2007","journal-title":"Diabetes"},{"key":"10.1016\/j.bbi.2014.01.010_b0115","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1172\/JCI29881","article-title":"Obesity induces a phenotypic switch in adipose tissue macrophage polarization","volume":"117","author":"Lumeng","year":"2007","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bbi.2014.01.010_b0120","doi-asserted-by":"crossref","first-page":"E1076","DOI":"10.1152\/ajpendo.00531.2010","article-title":"Dietary manipulation reveals an unexpected inverse relationship between fat mass and adipose 11beta-hydroxysteroid dehydrogenase type 1","volume":"300","author":"Man","year":"2011","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.bbi.2014.01.010_b0125","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1038\/oby.2012.7","article-title":"CX3CR1 deficiency does not influence trafficking of adipose tissue macrophages in mice with diet-induced obesity","volume":"20","author":"Morris","year":"2012","journal-title":"Obesity (Silver Spring)"},{"key":"10.1016\/j.bbi.2014.01.010_b0130","doi-asserted-by":"crossref","first-page":"3754","DOI":"10.1210\/en.2004-0305","article-title":"Chronic stress promotes palatable feeding, which reduces signs of stress: feedforward and feedback effects of chronic stress","volume":"145","author":"Pecoraro","year":"2004","journal-title":"Endocrinology"},{"key":"10.1016\/j.bbi.2014.01.010_b0135","first-page":"E333","article-title":"Thermogenesis and BAT activity in hypophysectomized rats with and without corticotropin replacement","volume":"249","author":"Rothwell","year":"1985","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.bbi.2014.01.010_b0140","doi-asserted-by":"crossref","first-page":"1642","DOI":"10.1161\/CIRCULATIONAHA.107.743872","article-title":"Fractalkine deficiency markedly reduces macrophage accumulation and atherosclerotic lesion formation in CCR2\u2212\/\u2212 mice: evidence for independent chemokine functions in atherogenesis","volume":"117","author":"Saederup","year":"2008","journal-title":"Circulation"},{"key":"10.1016\/j.bbi.2014.01.010_b0145","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1038\/oby.2011.18","article-title":"Cafeteria diet is a robust model of human metabolic syndrome with liver and adipose inflammation: comparison to high-fat diet","volume":"19","author":"Sampey","year":"2011","journal-title":"Obesity (Silver Spring)"},{"key":"10.1016\/j.bbi.2014.01.010_b0150","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/S0304-3940(98)00401-7","article-title":"Satiety effect and sympathetic activation of leptin are mediated by hypothalamic melanocortin system","volume":"249","author":"Satoh","year":"1998","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.bbi.2014.01.010_b0155","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1038\/35007534","article-title":"Central nervous system control of food intake","volume":"404","author":"Schwartz","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.bbi.2014.01.010_b0160","doi-asserted-by":"crossref","first-page":"1512","DOI":"10.2337\/db10-0956","article-title":"Fractalkine is a novel human adipochemokine associated with type 2 diabetes","volume":"60","author":"Shah","year":"2011","journal-title":"Diabetes"},{"key":"10.1016\/j.bbi.2014.01.010_b0165","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.cmet.2013.01.006","article-title":"Arcuate NPY controls sympathetic output and BAT function via a relay of tyrosine hydroxylase neurons in the PVN","volume":"17","author":"Shi","year":"2013","journal-title":"Cell Metab."},{"key":"10.1016\/j.bbi.2014.01.010_b0170","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1186\/1476-511X-10-99","article-title":"Analysis of time-dependent adaptations in whole-body energy balance in obesity induced by high-fat diet in rats","volume":"10","author":"So","year":"2011","journal-title":"Lipids Health Dis."},{"key":"10.1016\/j.bbi.2014.01.010_b0175","doi-asserted-by":"crossref","first-page":"15324","DOI":"10.1073\/pnas.1100255108","article-title":"Inflammasome is a central player in the induction of obesity and insulin resistance","volume":"108","author":"Stienstra","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.bbi.2014.01.010_b0180","doi-asserted-by":"crossref","first-page":"22620","DOI":"10.1074\/jbc.M710314200","article-title":"Peroxisome proliferator-activated receptor gamma activation promotes infiltration of alternatively activated macrophages into adipose tissue","volume":"283","author":"Stienstra","year":"2008","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbi.2014.01.010_b0185","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.vph.2009.12.004","article-title":"The role of chemokines in recruitment of immune cells to the artery wall and adipose tissue","volume":"52","author":"Surmi","year":"2010","journal-title":"Vascul. Pharmacol."},{"key":"10.1016\/j.bbi.2014.01.010_b0190","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1172\/JCI59660","article-title":"Obesity is associated with hypothalamic injury in rodents and humans","volume":"122","author":"Thaler","year":"2012","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bbi.2014.01.010_b0195","first-page":"772","article-title":"Adipocytokines: mediators linking adipose tissue, inflammation and immunity","volume":"6","author":"Tilg","year":"2006","journal-title":"Nat. Rev."},{"key":"10.1016\/j.bbi.2014.01.010_b0200","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1038\/nm.2279","article-title":"The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance","volume":"17","author":"Vandanmagsar","year":"2011","journal-title":"Nat. Med."},{"key":"10.1016\/j.bbi.2014.01.010_b0205","doi-asserted-by":"crossref","first-page":"4236","DOI":"10.1210\/en.2009-1235","article-title":"The endogenous actions of hypothalamic peptides on brown adipose tissue thermogenesis in the rat","volume":"151","author":"Verty","year":"2010","journal-title":"Endocrinology"},{"key":"10.1016\/j.bbi.2014.01.010_b0210","doi-asserted-by":"crossref","first-page":"1796","DOI":"10.1172\/JCI200319246","article-title":"Obesity is associated with macrophage accumulation in adipose tissue","volume":"112","author":"Weisberg","year":"2003","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bbi.2014.01.010_b0215","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/j.brainresbull.2004.04.007","article-title":"Effects of repeated restraint stress on hypothalamo\u2013pituitary\u2013adrenocortical function in vasopressin deficient Brattleboro rats","volume":"63","author":"Zelena","year":"2004","journal-title":"Brain Res. Bull."}],"container-title":["Brain, Behavior, and Immunity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0889159114000117?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0889159114000117?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T07:35:13Z","timestamp":1760168113000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0889159114000117"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,5]]},"references-count":43,"alternative-id":["S0889159114000117"],"URL":"https:\/\/doi.org\/10.1016\/j.bbi.2014.01.010","relation":{},"ISSN":["0889-1591"],"issn-type":[{"value":"0889-1591","type":"print"}],"subject":[],"published":{"date-parts":[[2014,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The fractalkine\/Cx3CR1 system is implicated in the development of metabolic visceral adipose tissue inflammation in obesity","name":"articletitle","label":"Article Title"},{"value":"Brain, Behavior, and Immunity","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbi.2014.01.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}