{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T05:00:13Z","timestamp":1792731613820,"version":"4.5.0"},"reference-count":36,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2014,8,1]],"date-time":"2014-08-01T00:00:00Z","timestamp":1406851200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,8,1]],"date-time":"2014-08-01T00:00:00Z","timestamp":1406851200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain, Behavior, and Immunity"],"published-print":{"date-parts":[[2014,8]]},"DOI":"10.1016\/j.bbi.2014.05.019","type":"journal-article","created":{"date-parts":[[2014,6,6]],"date-time":"2014-06-06T12:30:50Z","timestamp":1402057850000},"page":"55-60","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["SOD1G93A transgenic mouse CD4+ T cells mediate neuroprotection after facial nerve axotomy when removed from a suppressive peripheral microenvironment"],"prefix":"10.1016","volume":"40","author":[{"given":"Nichole A.","family":"Mesnard-Hoaglin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junping","family":"Xin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa M.","family":"Haulcomb","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard J.","family":"Batka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virginia M.","family":"Sanders","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathryn J.","family":"Jones","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbi.2014.05.019_b0010","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.it.2009.09.003","article-title":"T cell-microglial dialogue in Parkinson\u2019s disease and amyotrophic lateral sclerosis: are we listening?","volume":"31","author":"Appel","year":"2010","journal-title":"Trends Immunol."},{"key":"10.1016\/j.bbi.2014.05.019_b0015","doi-asserted-by":"crossref","first-page":"e2740","DOI":"10.1371\/journal.pone.0002740","article-title":"Adaptive immune neuroprotection in G93A-SOD1 amyotrophic lateral sclerosis mice","volume":"3","author":"Banerjee","year":"2008","journal-title":"PLoS ONE"},{"key":"10.1016\/j.bbi.2014.05.019_b0020","doi-asserted-by":"crossref","first-page":"15558","DOI":"10.1073\/pnas.0807419105","article-title":"CD4+ T cells support glial neuroprotection, slow disease progression, and modify glial morphology in an animal model of inherited ALS","volume":"105","author":"Beers","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.bbi.2014.05.019_b0025","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1016\/j.bbi.2010.12.008","article-title":"Neuroinflammation modulates distinct regional and temporal clinical responses in ALS mice","volume":"25","author":"Beers","year":"2011","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.bbi.2014.05.019_b0030","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/S0889-1591(03)00089-8","article-title":"Natural killer cells do not mediate facial motoneuron survival after facial nerve transection","volume":"17","author":"Byram","year":"2003","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.bbi.2014.05.019_b0035","doi-asserted-by":"crossref","first-page":"4333","DOI":"10.1523\/JNEUROSCI.5276-03.2004","article-title":"CD4-positive T cell-mediated neuroprotection requires dual compartment antigen presentation","volume":"24","author":"Byram","year":"2004","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bbi.2014.05.019_b0040","doi-asserted-by":"crossref","first-page":"17913","DOI":"10.1073\/pnas.0804610105","article-title":"T lymphocytes potentiate endogenous neuroprotective inflammation in a mouse model of ALS","volume":"105","author":"Chiu","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.bbi.2014.05.019_b0045","doi-asserted-by":"crossref","first-page":"20960","DOI":"10.1073\/pnas.0911405106","article-title":"Activation of innate and humoral immunity in the peripheral nervous system of ALS transgenic mice","volume":"106","author":"Chiu","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.bbi.2014.05.019_b0050","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.jneuroim.2006.04.006","article-title":"CD4+CD25+ regulatory T cells and CD1-restricted NKT cells do not mediate facial motoneuron survival after axotomy","volume":"176","author":"DeBoy","year":"2006","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.bbi.2014.05.019_b0055","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.expneurol.2006.04.028","article-title":"Immune-mediated neuroprotection of axotomized mouse facial motoneurons is dependent on the IL-4\/STAT6 signaling pathway in CD4(+) T cells","volume":"201","author":"Deboy","year":"2006","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.bbi.2014.05.019_b0060","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.expneurol.2003.10.004","article-title":"Amyotrophic lateral sclerosis is a distal axonopathy: evidence in mice and man","volume":"185","author":"Fischer","year":"2004","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.bbi.2014.05.019_b0065","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1080\/14660820410020286","article-title":"Inflammation in amyotrophic lateral sclerosis spinal cord and brain is mediated by activated macrophages, mast cells and T cells","volume":"5","author":"Graves","year":"2004","journal-title":"Amyotroph. Lateral Scler. Other Motor Neuron Disord."},{"key":"10.1016\/j.bbi.2014.05.019_b0070","doi-asserted-by":"crossref","first-page":"1721","DOI":"10.1056\/NEJM199412223312516","article-title":"Transgenic-mouse model of amyotrophic lateral sclerosis","volume":"331","author":"Gurney","year":"1994","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.bbi.2014.05.019_b0075","doi-asserted-by":"crossref","first-page":"1772","DOI":"10.1126\/science.8209258","article-title":"Motor neuron degeneration in mice that express a human Cu, Zn superoxide dismutase mutation","volume":"264","author":"Gurney","year":"1994","journal-title":"Science"},{"issue":"10","key":"10.1016\/j.bbi.2014.05.019_b0080","doi-asserted-by":"crossref","first-page":"2349","DOI":"10.1002\/cne.23538","article-title":"Axotomy-induced target disconnection promotes an additional death mechanism involved in motoneuron degeneration in ALS transgenic mice","volume":"522","author":"Haulcomb","year":"2014","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.bbi.2014.05.019_b0085","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.nbd.2007.07.003","article-title":"Time course of preferential motor unit loss in the SOD1 G93A mouse model of amyotrophic lateral sclerosis","volume":"28","author":"Hegedus","year":"2007","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.bbi.2014.05.019_b0090","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1002\/ana.10805","article-title":"Presence of dendritic cells, MCP-1, and activated microglia\/macrophages in amyotrophic lateral sclerosis spinal cord tissue","volume":"55","author":"Henkel","year":"2004","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.bbi.2014.05.019_b0100","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1017\/S1740925X11000135","article-title":"Using comparative anatomy in the axotomy model to identify distinct roles for microglia and astrocytes in synaptic stripping","volume":"7","author":"Jinno","year":"2011","journal-title":"Neuron Glia Biol."},{"key":"10.1016\/j.bbi.2014.05.019_b0105","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/0165-3806(85)90212-3","article-title":"Changes in nuclear envelope invaginations in axotomized immature and mature hamster facial motoneurons","volume":"353","author":"Jones","year":"1985","journal-title":"Brain Res."},{"key":"10.1016\/j.bbi.2014.05.019_b0110","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.bbi.2004.05.004","article-title":"Role of the immune system in the maintenance of mouse facial motoneuron viability after nerve injury","volume":"19","author":"Jones","year":"2005","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.bbi.2014.05.019_b0120","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1097\/00001756-199605310-00021","article-title":"Neuromuscular function impairment is not caused by motor neurone loss in FALS mice. An electromyographic study","volume":"7","author":"Kennel","year":"1996","journal-title":"NeuroReport"},{"key":"10.1016\/j.bbi.2014.05.019_b0130","doi-asserted-by":"crossref","first-page":"3488","DOI":"10.1002\/cne.22718","article-title":"Differential gene expression in the axotomized facial motor nucleus of presymptomatic SOD1 mice","volume":"519","author":"Mesnard","year":"2011","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.bbi.2014.05.019_b0135","first-page":"21","article-title":"Delayed functional recovery in presymptomatic mSOD1-G93A mice following facial nerve crush axotomy","volume":"4","author":"Mesnard","year":"2013","journal-title":"J. Neurodegen. Regen."},{"key":"10.1016\/j.bbi.2014.05.019_b0140","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.brainresrev.2003.11.004","article-title":"The facial nerve axotomy model","volume":"44","author":"Moran","year":"2004","journal-title":"Brain Res. Brain Res. Rev."},{"key":"10.1016\/j.bbi.2014.05.019_b0145","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/0014-4886(95)90042-X","article-title":"Motor neuron\u2013astrocyte interactions and levels of Cu, Zn superoxide dismutase in sporadic amyotrophic lateral sclerosis","volume":"131","author":"O\u2019Reilly","year":"1995","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.bbi.2014.05.019_b0150","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/S1474-4422(11)70015-1","article-title":"Neuroinflammation in amyotrophic lateral sclerosis: role of glial activation in motor neuron disease","volume":"10","author":"Philips","year":"2011","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.bbi.2014.05.019_b0155","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1179\/174313209X414542","article-title":"Is the spinal cord motoneuron exclusively a target in ALS? Comparison between astroglial reactivity in a rat model of familial ALS and in human sporadic ALS cases","volume":"32","author":"Rafalowska","year":"2010","journal-title":"Neurol. Res."},{"key":"10.1016\/j.bbi.2014.05.019_b0160","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1038\/362059a0","article-title":"Mutations in Cu\/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis","volume":"362","author":"Rosen","year":"1993","journal-title":"Nature"},{"key":"10.1016\/j.bbi.2014.05.019_b0165","doi-asserted-by":"crossref","first-page":"2736","DOI":"10.1002\/jnr.22424","article-title":"Appearance of phagocytic microglia adjacent to motoneurons in spinal cord tissue from a presymptomatic transgenic rat model of amyotrophic lateral sclerosis","volume":"88","author":"Sanagi","year":"2010","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.bbi.2014.05.019_b0170","doi-asserted-by":"crossref","first-page":"RC7","DOI":"10.1523\/JNEUROSCI.19-11-j0004.1999","article-title":"Exacerbation of facial motoneuron loss after facial nerve transection in severe combined immunodeficient (scid) mice","volume":"19","author":"Serpe","year":"1999","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bbi.2014.05.019_b0175","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1002\/1097-4547(20001015)62:2<273::AID-JNR11>3.0.CO;2-C","article-title":"Kinetics of facial motoneuron loss following facial nerve transection in severe combined immunodeficient mice","volume":"62","author":"Serpe","year":"2000","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.bbi.2014.05.019_b0180","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1016\/S0889-1591(02)00017-X","article-title":"Functional recovery after facial nerve crush is delayed in severe combined immunodeficient mice","volume":"16","author":"Serpe","year":"2002","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.bbi.2014.05.019_b0185","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/S0889-1591(03)00028-X","article-title":"CD4+ T, but not CD8+ or B, lymphocytes mediate facial motoneuron survival after facial nerve transection","volume":"17","author":"Serpe","year":"2003","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.bbi.2014.05.019_b0190","first-page":"115","article-title":"Immunohistological alterations in muscle of patients with amyotrophic lateral sclerosis: mononuclear cell phenotypes and expression of MHC products","volume":"11","author":"Troost","year":"1992","journal-title":"Clin. Neuropathol."},{"key":"10.1016\/j.bbi.2014.05.019_b0195","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1016\/j.nbd.2003.12.012","article-title":"Evidence of widespread cerebral microglial activation in amyotrophic lateral sclerosis: an [11C](R)-PK11195 positron emission tomography study","volume":"15","author":"Turner","year":"2004","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.bbi.2014.05.019_b0200","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1002\/jnr.20379","article-title":"Loss of synaptophysin-positive boutons on lumbar motor neurons innervating the medial gastrocnemius muscle of the SOD1G93A G1H transgenic mouse model of ALS","volume":"79","author":"Zang","year":"2005","journal-title":"J. Neurosci. Res."}],"container-title":["Brain, Behavior, and Immunity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0889159114001627?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0889159114001627?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T07:35:47Z","timestamp":1760168147000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0889159114001627"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,8]]},"references-count":36,"alternative-id":["S0889159114001627"],"URL":"https:\/\/doi.org\/10.1016\/j.bbi.2014.05.019","relation":{},"ISSN":["0889-1591"],"issn-type":[{"value":"0889-1591","type":"print"}],"subject":[],"published":{"date-parts":[[2014,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"SOD1G93A transgenic mouse CD4+ T cells mediate neuroprotection after facial nerve axotomy when removed from a suppressive peripheral microenvironment","name":"articletitle","label":"Article Title"},{"value":"Brain, Behavior, and Immunity","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbi.2014.05.019","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}