{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T11:00:08Z","timestamp":1783076408896,"version":"3.54.6"},"reference-count":68,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,2,1]],"date-time":"2015-02-01T00:00:00Z","timestamp":1422748800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,2,1]],"date-time":"2015-02-01T00:00:00Z","timestamp":1422748800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain, Behavior, and Immunity"],"published-print":{"date-parts":[[2015,2]]},"DOI":"10.1016\/j.bbi.2014.10.009","type":"journal-article","created":{"date-parts":[[2014,10,22]],"date-time":"2014-10-22T15:01:45Z","timestamp":1413990105000},"page":"213-220","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"special_numbering":"C","title":["Acute increases in intramuscular inflammatory cytokines are necessary for the development of mechanical hypersensitivity in a mouse model of musculoskeletal sensitization"],"prefix":"10.1016","volume":"44","author":[{"given":"Blair C.","family":"Sutton","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark R.","family":"Opp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbi.2014.10.009_b0005","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1172\/JCI30556","article-title":"Interplay of IKK\/NF-kappaB signaling in macrophages and myofibers promotes muscle degeneration in Duchenne muscular dystrophy","volume":"117","author":"Acharyya","year":"2007","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bbi.2014.10.009_b0010","doi-asserted-by":"crossref","DOI":"10.1007\/s10072-011-0599-z","article-title":"Role of TNF-alpha during central sensitization in preclinical studies","author":"Andrade","year":"2011","journal-title":"Neurol. Sci."},{"key":"10.1016\/j.bbi.2014.10.009_b0015","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1111\/j.1476-5381.1992.tb14503.x","article-title":"The pivotal role of tumour necrosis factor alpha in the development of inflammatory hyperalgesia","volume":"107","author":"Cunha","year":"1992","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.bbi.2014.10.009_b0020","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1016\/j.jpain.2009.04.012","article-title":"Role of NFkappaB in an animal model of complex regional pain syndrome-type I (CRPS-I)","volume":"10","author":"de Mos","year":"2009","journal-title":"J. Pain"},{"key":"10.1016\/j.bbi.2014.10.009_b0025","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/S0034-7094(11)70029-0","article-title":"Cytokines and pain","volume":"61","author":"de Oliveira","year":"2011","journal-title":"Rev. Bras. Anesthesiol."},{"key":"10.1016\/j.bbi.2014.10.009_b0030","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/j.pharmthera.2010.08.006","article-title":"Acid-sensing ion channels (ASICs): pharmacology and implication in pain","volume":"128","author":"Deval","year":"2010","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.bbi.2014.10.009_b0035","doi-asserted-by":"crossref","first-page":"1687","DOI":"10.1093\/rheumatology\/kes125","article-title":"Continuous efficacy of etanercept in severe and advanced ankylosing spondylitis: results from a 12-week open-label extension of the SPINE study","volume":"51","author":"Dougados","year":"2012","journal-title":"Rheumatology (Oxford)"},{"key":"10.1016\/j.bbi.2014.10.009_b0040","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1038\/334698a0","article-title":"Interleukin-1 beta as a potent hyperalgesic agent antagonized by a tripeptide analogue","volume":"334","author":"Ferreira","year":"1988","journal-title":"Nature"},{"key":"10.1016\/j.bbi.2014.10.009_b0045","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.pain.2008.08.014","article-title":"Acidic buffer induced muscle pain evokes referred pain and mechanical hyperalgesia in humans","volume":"140","author":"Frey Law","year":"2008","journal-title":"Pain"},{"key":"10.1016\/j.bbi.2014.10.009_b0050","first-page":"817347","article-title":"ASICs do not play a role in maintaining hyperalgesia induced by repeated intramuscular acid injections","volume":"2012","author":"Gautam","year":"2012","journal-title":"Pain Res. Treat."},{"key":"10.1016\/j.bbi.2014.10.009_b0055","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.jss.2010.08.005","article-title":"Tumor necrosis factor expression is ameliorated after exposure to an acidic environment","volume":"173","author":"Grabowski","year":"2012","journal-title":"J. Surg. Res."},{"key":"10.1016\/j.bbi.2014.10.009_b0060","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.pain.2004.12.020","article-title":"Excitatory and modulatory effects of inflammatory cytokines and neurotrophins on mechanosensitive group IV muscle afferents in the rat","volume":"114","author":"Hoheisel","year":"2005","journal-title":"Pain"},{"key":"10.1016\/j.bbi.2014.10.009_b0065","first-page":"F479","article-title":"Effect of systemic pH on pHi and lactic acid generation in exhaustive forearm exercise","volume":"255","author":"Hood","year":"1988","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.bbi.2014.10.009_b0070","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/0304-3940(96)12576-3","article-title":"Pain due to tissue acidosis: a mechanism for inflammatory and ischemic myalgia?","volume":"208","author":"Issberner","year":"1996","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.bbi.2014.10.009_b0075","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/j.cyto.2011.11.013","article-title":"Low extracellular pH stimulates the production of IL-1beta by human monocytes","volume":"57","author":"Jancic","year":"2012","journal-title":"Cytokine"},{"key":"10.1016\/j.bbi.2014.10.009_b0080","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1002\/j.1532-2149.2011.00103.x","article-title":"Diverse sensory inputs permit priming in the acidic saline model of hyperalgesia","volume":"16","author":"Jasper","year":"2012","journal-title":"Eur. J. Pain"},{"issue":"Pt 1","key":"10.1016\/j.bbi.2014.10.009_b0085","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1111\/j.1469-7793.2000.00157.x","article-title":"Muscle contractions induce interleukin-6 mRNA production in rat skeletal muscles","volume":"528","author":"Jonsdottir","year":"2000","journal-title":"J. Physiol."},{"key":"10.1016\/j.bbi.2014.10.009_b0090","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1111\/j.1476-5381.2010.00918.x","article-title":"Reversal of acid-induced and inflammatory pain by the selective ASIC3 inhibitor, APETx2","volume":"161","author":"Karczewski","year":"2010","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.bbi.2014.10.009_b0095","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.cellimm.2012.12.009","article-title":"Extracellular acidosis modulates the endocytosis and maturation of macrophages","volume":"281","author":"Kong","year":"2013","journal-title":"Cell. Immunol."},{"key":"10.1016\/j.bbi.2014.10.009_b0100","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1038\/368339a0","article-title":"Impaired immune and acute-phase responses in interleukin-6-deficient mice","volume":"368","author":"Kopf","year":"1994","journal-title":"Nature"},{"key":"10.1016\/j.bbi.2014.10.009_b0105","doi-asserted-by":"crossref","first-page":"1977","DOI":"10.1111\/j.1460-9568.2005.04379.x","article-title":"Involvement of spinal cord nuclear factor kappaB activation in rat models of proinflammatory cytokine-mediated pain facilitation","volume":"22","author":"Ledeboer","year":"2005","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.bbi.2014.10.009_b0110","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1016\/j.jpain.2006.04.001","article-title":"Spinal cord glia and interleukin-1 do not appear to mediate persistent allodynia induced by intramuscular acidic saline in rats","volume":"7","author":"Ledeboer","year":"2006","journal-title":"J. Pain"},{"key":"10.1016\/j.bbi.2014.10.009_b0115","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1186\/1744-8069-7-57","article-title":"Behavioral evidence for the differential regulation of p-p38 MAPK and p-NF-kappaB in rats with trigeminal neuropathic pain","volume":"7","author":"Lee","year":"2011","journal-title":"Mol. Pain"},{"key":"10.1016\/j.bbi.2014.10.009_b0120","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1006\/bbrc.1996.1754","article-title":"Down-regulation of transcription factors AP-1, Sp-1, and NF-kappa B precedes myocyte differentiation","volume":"229","author":"Lehtinen","year":"1996","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbi.2014.10.009_b0125","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1186\/1742-2094-7-27","article-title":"TNF-alpha and neuropathic pain \u2013 a review","volume":"7","author":"Leung","year":"2010","journal-title":"J. Neuroinflamm."},{"key":"10.1016\/j.bbi.2014.10.009_b0130","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1006\/bbrc.1993.2380","article-title":"Lipopolysaccharide treatment in vivo induces widespread tissue expression of inducible nitric oxide synthase mRNA","volume":"196","author":"Liu","year":"1993","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbi.2014.10.009_b0135","doi-asserted-by":"crossref","first-page":"S32","DOI":"10.1016\/j.jpainsymman.2005.01.008","article-title":"Bone cancer pain: from model to mechanism to therapy","volume":"29","author":"Luger","year":"2005","journal-title":"J. Pain Symptom Manage."},{"key":"10.1016\/j.bbi.2014.10.009_b0140","doi-asserted-by":"crossref","first-page":"10662","DOI":"10.1523\/JNEUROSCI.22-24-10662.2002","article-title":"Proinflammatory mediators, stimulators of sensory neuron excitability via the expression of acid-sensing ion channels","volume":"22","author":"Mamet","year":"2002","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bbi.2014.10.009_b0145","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1038\/nrn1700","article-title":"Role of the immune system in chronic pain","volume":"6","author":"Marchand","year":"2005","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.bbi.2014.10.009_b0150","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1523\/JNEUROSCI.23-03-01026.2003","article-title":"Spinal glia and proinflammatory cytokines mediate mirror-image neuropathic pain in rats","volume":"23","author":"Milligan","year":"2003","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bbi.2014.10.009_b0155","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1016\/S0140-6736(12)62192-8","article-title":"Rheumatoid arthritis: still a chronic disease","volume":"381","author":"Miossec","year":"2013","journal-title":"Lancet"},{"key":"10.1016\/j.bbi.2014.10.009_b0160","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1212\/01.WNL.0000049913.27181.51","article-title":"Activation of nuclear factor-kappaB in inflammatory myopathies and Duchenne muscular dystrophy","volume":"60","author":"Monici","year":"2003","journal-title":"Neurology"},{"key":"10.1016\/j.bbi.2014.10.009_b0165","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.bbi.2004.04.001","article-title":"Diurnal variation of lipopolysaccharide-induced alterations in sleep and body temperature of interleukin-6-deficient mice","volume":"19","author":"Morrow","year":"2005","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.bbi.2014.10.009_b0170","series-title":"Health, United States, 2006, With Chartbook on Trends in the Health of Americans","first-page":"559","author":"National Center for Health Statistics","year":"2006"},{"key":"10.1016\/j.bbi.2014.10.009_b0175","series-title":"Relieving Pain in America: A Blueprint for Transforming Prevention, Care, Education, and Research","author":"National Research Council","year":"2011"},{"key":"10.1016\/j.bbi.2014.10.009_b0180","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1016\/j.biocel.2006.11.016","article-title":"Pain signalling pathways: from cytokines to ion channels","volume":"39","author":"Okuse","year":"2007","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.bbi.2014.10.009_b0185","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1016\/j.neuroscience.2008.02.008","article-title":"Effects of i.c.v. administration of interleukin-1 on sleep and body temperature of interleukin-6-deficient mice","volume":"153","author":"Olivadoti","year":"2008","journal-title":"Neuroscience"},{"key":"10.1016\/j.bbi.2014.10.009_b0190","doi-asserted-by":"crossref","first-page":"6853","DOI":"10.1038\/sj.onc.1203239","article-title":"Activators and target genes of Rel\/NF-kappaB transcription factors","volume":"18","author":"Pahl","year":"1999","journal-title":"Oncogene"},{"key":"10.1016\/j.bbi.2014.10.009_b0195","doi-asserted-by":"crossref","first-page":"6025","DOI":"10.2174\/138161212803582450","article-title":"Non-analgesic effects of opioids: opioids\u2019 effects on sleep (including sleep apnea)","volume":"18","author":"Panagiotou","year":"2012","journal-title":"Curr. Pharma. Des."},{"key":"10.1016\/j.bbi.2014.10.009_b0200","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1152\/physrev.90100.2007","article-title":"Muscle as an endocrine organ: focus on muscle-derived interleukin-6","volume":"88","author":"Pedersen","year":"2008","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.bbi.2014.10.009_b0205","first-page":"18","article-title":"Exercise and cytokines with particular focus on muscle-derived IL-6","volume":"7","author":"Pedersen","year":"2001","journal-title":"Exerc. Immunol. Rev."},{"key":"10.1016\/j.bbi.2014.10.009_b0210","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1152\/japplphysiol.00164.2004","article-title":"The anti-inflammatory effect of exercise","volume":"98","author":"Petersen","year":"2005","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.bbi.2014.10.009_b0215","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/S0079-6123(08)61085-7","article-title":"Tissue acidosis in nociception and pain","volume":"113","author":"Reeh","year":"1996","journal-title":"Prog. Brain Res."},{"key":"10.1016\/j.bbi.2014.10.009_b0220","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1111\/j.1749-6632.2012.06634.x","article-title":"Role of interleukin-6 in stress, sleep, and fatigue","volume":"1261","author":"Rohleder","year":"2012","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.bbi.2014.10.009_b0225","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1016\/S0002-9440(10)62357-7","article-title":"Therapeutic effect of topical administration of SN50, an inhibitor of nuclear factor-kappaB, in treatment of corneal alkali burns in mice","volume":"166","author":"Saika","year":"2005","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.bbi.2014.10.009_b0230","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1016\/S0304-3959(03)00115-5","article-title":"Intramuscular injection of tumor necrosis factor-alpha induces muscle hyperalgesia in rats","volume":"104","author":"Schafers","year":"2003","journal-title":"Pain"},{"key":"10.1016\/j.bbi.2014.10.009_b0235","doi-asserted-by":"crossref","first-page":"2517","DOI":"10.1523\/JNEUROSCI.23-07-02517.2003","article-title":"Tumor necrosis factor-alpha induces mechanical allodynia after spinal nerve ligation by activation of p38 MAPK in primary sensory neurons","volume":"23","author":"Schafers","year":"2003","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bbi.2014.10.009_b0240","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1111\/j.1749-6632.2009.05301.x","article-title":"The role of proinflammatory cytokines in the generation and maintenance of joint pain","volume":"1193","author":"Schaible","year":"2010","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.bbi.2014.10.009_b0245","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.pain.2009.06.002","article-title":"Experimental arthritis causes tumor necrosis factor-alpha-dependent infiltration of macrophages into rat dorsal root ganglia which correlates with pain-related behavior","volume":"145","author":"Segond von Banchet","year":"2009","journal-title":"Pain"},{"key":"10.1016\/j.bbi.2014.10.009_b0250","doi-asserted-by":"crossref","first-page":"1977","DOI":"10.1152\/japplphysiol.00419.2005","article-title":"An in vivo microanalytical technique for measuring the local biochemical milieu of human skeletal muscle","volume":"99","author":"Shah","year":"2005","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.bbi.2014.10.009_b0255","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1016\/j.jpain.2009.04.014","article-title":"Acidic saline-induced primary and secondary mechanical hyperalgesia in mice","volume":"10","author":"Sharma","year":"2009","journal-title":"J. Pain"},{"key":"10.1016\/j.bbi.2014.10.009_b0260","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1002\/1097-4598(200101)24:1<37::AID-MUS4>3.0.CO;2-8","article-title":"Unilateral intramuscular injections of acidic saline produce a bilateral, long-lasting hyperalgesia","volume":"24","author":"Sluka","year":"2001","journal-title":"Muscle Nerve"},{"key":"10.1016\/j.bbi.2014.10.009_b0265","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/S0304-3959(03)00269-0","article-title":"Chronic hyperalgesia induced by repeated acid injections in muscle is abolished by the loss of ASIC3, but not ASIC1","volume":"106","author":"Sluka","year":"2003","journal-title":"Pain"},{"key":"10.1016\/j.bbi.2014.10.009_b0270","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.1124\/jpet.102.033167","article-title":"Chronic muscle pain induced by repeated acid Injection is reversed by spinally administered mu- and delta-, but not kappa-, opioid receptor agonists","volume":"302","author":"Sluka","year":"2002","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.bbi.2014.10.009_b0275","doi-asserted-by":"crossref","first-page":"2593","DOI":"10.1016\/j.lfs.2004.01.002","article-title":"Paclitaxel-induced neuropathic hypersensitivity in mice: responses in 10 inbred mouse strains","volume":"74","author":"Smith","year":"2004","journal-title":"Life Sci."},{"key":"10.1016\/j.bbi.2014.10.009_b0280","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1111\/j.1529-8027.2001.01010.x","article-title":"Etanercept reduces hyperalgesia in experimental painful neuropathy","volume":"6","author":"Sommer","year":"2001","journal-title":"J. Peripher. Nerv. Syst."},{"key":"10.1016\/j.bbi.2014.10.009_b0285","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1017\/S0317167100013937","article-title":"Sensory neurons, ion channels, inflammation and the onset of neuropathic pain","volume":"39","author":"Stemkowski","year":"2012","journal-title":"Can. J. Neurol. Sci."},{"key":"10.1016\/j.bbi.2014.10.009_b0290","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/S1357-4310(99)01615-9","article-title":"Causes and consequences of tumour acidity and implications for treatment","volume":"6","author":"Stubbs","year":"2000","journal-title":"Mol. Med. Today"},{"key":"10.1016\/j.bbi.2014.10.009_b0295","doi-asserted-by":"crossref","first-page":"505","DOI":"10.5665\/sleep.3486","article-title":"Musculoskeletal sensitization and sleep: chronic muscle pain fragments sleep of mice without altering its duration","volume":"37","author":"Sutton","year":"2014","journal-title":"Sleep"},{"key":"10.1016\/j.bbi.2014.10.009_b0300","doi-asserted-by":"crossref","first-page":"515","DOI":"10.5665\/sleep.3488","article-title":"Sleep fragmentation exacerbates mechanical hypersensitivity and alters subsequent sleep\u2013wake behavior in a mouse model of musculoskeletal sensitization","volume":"37","author":"Sutton","year":"2014","journal-title":"Sleep"},{"key":"10.1016\/j.bbi.2014.10.009_b0305","doi-asserted-by":"crossref","first-page":"1602","DOI":"10.1136\/ard.2009.109355","article-title":"Hyperalgesia, synovitis and multiple biomarkers of inflammation are suppressed by interleukin 1 inhibition in a novel animal model of gouty arthritis","volume":"68","author":"Torres","year":"2009","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.bbi.2014.10.009_b0310","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.neulet.2008.03.050","article-title":"Cytokine regulation in animal models of neuropathic pain and in human diseases","volume":"437","author":"Uceyler","year":"2008","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.bbi.2014.10.009_b0315","doi-asserted-by":"crossref","first-page":"8026","DOI":"10.1523\/JNEUROSCI.21-20-08026.2001","article-title":"Nonsteroid anti-inflammatory drugs inhibit both the activity and the inflammation-induced expression of acid-sensing ion channels in nociceptors","volume":"21","author":"Voilley","year":"2001","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bbi.2014.10.009_b0320","doi-asserted-by":"crossref","first-page":"20975","DOI":"10.1074\/jbc.272.34.20975","article-title":"Molecular cloning of a non-inactivating proton-gated Na+ channel specific for sensory neurons","volume":"272","author":"Waldmann","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbi.2014.10.009_b0325","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.trsl.2011.10.003","article-title":"Chronic inflammation and pain in a tumor necrosis factor receptor (TNFR) (p55\/p75\u2212\/\u2212) dual deficient murine model","volume":"160","author":"Westlund","year":"2012","journal-title":"Transl. Res."},{"key":"10.1016\/j.bbi.2014.10.009_b0330","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1159\/000087655","article-title":"Central proinflammatory cytokines and pain enhancement","volume":"14","author":"Weiseler-Frank","year":"2005","journal-title":"Neurosignals"},{"key":"10.1016\/j.bbi.2014.10.009_b0335","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1097\/SPC.0b013e3283460b3a","article-title":"Overcoming pain as a barrier to work","volume":"5","author":"Wynne-Jones","year":"2011","journal-title":"Curr. Opin. Support. Palliat. Care"},{"key":"10.1016\/j.bbi.2014.10.009_b0340","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1006\/cyto.1997.0243","article-title":"Nociceptive responses in interleukin-6-deficient mice to peripheral inflammation and peripheral nerve section","volume":"9","author":"Xu","year":"1997","journal-title":"Cytokine"}],"container-title":["Brain, Behavior, and Immunity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0889159114005066?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0889159114005066?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T07:36:58Z","timestamp":1760168218000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0889159114005066"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,2]]},"references-count":68,"alternative-id":["S0889159114005066"],"URL":"https:\/\/doi.org\/10.1016\/j.bbi.2014.10.009","relation":{},"ISSN":["0889-1591"],"issn-type":[{"value":"0889-1591","type":"print"}],"subject":[],"published":{"date-parts":[[2015,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Acute increases in intramuscular inflammatory cytokines are necessary for the development of mechanical hypersensitivity in a mouse model of musculoskeletal sensitization","name":"articletitle","label":"Article Title"},{"value":"Brain, Behavior, and Immunity","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbi.2014.10.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}