{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T23:36:16Z","timestamp":1778715376694,"version":"3.51.4"},"reference-count":47,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["SCHE 341-19\/1-2"],"award-info":[{"award-number":["SCHE 341-19\/1-2"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain, Behavior, and Immunity"],"published-print":{"date-parts":[[2016,1]]},"DOI":"10.1016\/j.bbi.2015.09.005","type":"journal-article","created":{"date-parts":[[2015,9,12]],"date-time":"2015-09-12T07:14:26Z","timestamp":1442042066000},"page":"252-257","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"special_numbering":"C","title":["Pre-exposure to the unconditioned or conditioned stimulus does not affect learned immunosuppression in rats"],"prefix":"10.1016","volume":"51","author":[{"given":"Laura","family":"Lueckemann","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katharina","family":"B\u00f6sche","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harald","family":"Engler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan-Claudius","family":"Schwitalla","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Hadamitzky","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manfred","family":"Schedlowski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"Suppl. 1","key":"10.1016\/j.bbi.2015.09.005_b0005","doi-asserted-by":"crossref","first-page":"S51","DOI":"10.1016\/S0889-1591(02)00067-3","article-title":"Conditioned immunomodulation: research needs and directions","volume":"17","author":"Ader","year":"2003","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.bbi.2015.09.005_b0010","doi-asserted-by":"crossref","first-page":"1534","DOI":"10.1126\/science.7063864","article-title":"Behaviorally conditioned immunosuppression and murine systemic lupus erythematosus","volume":"215","author":"Ader","year":"1982","journal-title":"Science"},{"key":"10.1016\/j.bbi.2015.09.005_b0015","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1097\/PSY.0b013e3181cbd38b","article-title":"Conditioned pharmacotherapeutic effects: a preliminary study","volume":"72","author":"Ader","year":"2010","journal-title":"Psychosom. Med."},{"key":"10.1016\/j.bbi.2015.09.005_b0020","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/0023-9690(89)90009-X","article-title":"With number of preexposures constant latent inhibition increases with preexposure CS duration or total CS exposure","volume":"20","author":"Albert","year":"1989","journal-title":"Learn. Motiv."},{"key":"10.1016\/j.bbi.2015.09.005_b0025","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1038\/clpt.2014.75","article-title":"Preserving learned immunosuppressive placebo response: perspectives for clinical application","volume":"96","author":"Albring","year":"2014","journal-title":"Clin. Pharmacol. Ther."},{"key":"10.1016\/j.bbi.2015.09.005_b0030","first-page":"273","article-title":"Drug-preexposure effects in flavor-aversion learning: associative interference by conditioned environmental stimuli","volume":"5","author":"Batson","year":"1979","journal-title":"J. Exp. Psychol.: Anim. Behav. Process."},{"key":"10.1016\/j.bbi.2015.09.005_b0035","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1038\/nrn1344","article-title":"Molecular mechanisms of taste-recognition memory","volume":"5","author":"Bermudez-Rattoni","year":"2004","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.bbi.2015.09.005_b0045","doi-asserted-by":"crossref","first-page":"111","DOI":"10.4049\/jimmunol.132.1.111","article-title":"Acquisition and extinction of conditioned suppression of a graft-vs-host response in the rat","volume":"132","author":"Bovbjerg","year":"1984","journal-title":"J. Immunol."},{"key":"10.1016\/j.bbi.2015.09.005_b0050","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1111\/j.1749-6632.1987.tb35818.x","article-title":"Conditioned suppression of plaque-forming cell responses with cyclophosphamide. The role of taste aversion","volume":"496","author":"Bovbjerg","year":"1987","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.bbi.2015.09.005_b0055","series-title":"Conditioned Taste Aversion: Memory of a Special Kind","author":"Bures","year":"1998"},{"key":"10.1016\/j.bbi.2015.09.005_b0060","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1007\/s00213-006-0649-z","article-title":"Disruption of the US pre-exposure effect and latent inhibition in two-way active avoidance by systemic amphetamine in C57BL\/6 mice","volume":"191","author":"Chang","year":"2007","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.bbi.2015.09.005_b0065","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1038\/nrn1705","article-title":"Placebos and painkillers: is mind as real as matter?","volume":"6","author":"Colloca","year":"2005","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.bbi.2015.09.005_b0070","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1037\/0097-7403.30.1.58","article-title":"The US-preexposure effect in lithium-induced flavor-aversion conditioning is a consequence of blocking by injection cues","volume":"30","author":"de Brugada","year":"2004","journal-title":"J. Exp. Psychol. Anim. Behav. Process."},{"key":"10.1016\/j.bbi.2015.09.005_b0075","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.tips.2011.12.001","article-title":"Utilizing placebo mechanisms for dose reduction in pharmacotherapy","volume":"33","author":"Doering","year":"2012","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.bbi.2015.09.005_b0080","doi-asserted-by":"crossref","first-page":"205","DOI":"10.3758\/BF03213432","article-title":"Poison-induced neophobia in rats: role of stimulus generalization of conditioned taste aversions","volume":"3","author":"Domjan","year":"1975","journal-title":"Anim. Learn. Behav."},{"key":"10.1016\/j.bbi.2015.09.005_b0085","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/S0091-6773(73)80156-7","article-title":"Attenuation of drug-induced bait shyness to a palatable solution as an increasing function of its availability prior to conditioning","volume":"9","author":"Elkins","year":"1973","journal-title":"Behav. Biol."},{"key":"10.1016\/j.bbi.2015.09.005_b0090","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1038\/nrd3923","article-title":"The placebo response in medicine: minimize, maximize or personalize?","volume":"12","author":"Enck","year":"2013","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.bbi.2015.09.005_b9000","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/S0165-5728(98)00122-2","article-title":"Behaviorally conditioned immunosuppression using cyclosporine A: central nervous system reduces IL-2 production via splenic innervation","volume":"88","author":"Exton","year":"1998","journal-title":"J Neuroimmunol."},{"key":"10.1016\/j.bbi.2015.09.005_b0095","first-page":"R1710","article-title":"Conditioned immunosuppression makes subtherapeutic cyclosporin effective via splenic innervation","volume":"276","author":"Exton","year":"1999","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.bbi.2015.09.005_b0100","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1034\/j.1600-065x.2001.1840120.x","article-title":"Conditioning in the rat: an in vivo model to investigate the molecular mechanisms and clinical implications of brain-immune communication","volume":"184","author":"Exton","year":"2001","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.bbi.2015.09.005_b0105","first-page":"21","article-title":"Behaviorally conditioned immunosuppression in the rat is regulated via noradrenaline and beta-adrenoceptors","volume":"131","author":"Exton","year":"2002","journal-title":"Drug Discov."},{"key":"10.1016\/j.bbi.2015.09.005_b0110","doi-asserted-by":"crossref","first-page":"121","DOI":"10.3758\/BF03328311","article-title":"Learning with prolonged delay of reinforcement","volume":"5","author":"Garcia","year":"1966","journal-title":"Psychon. Sci."},{"key":"10.1016\/j.bbi.2015.09.005_b0115","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1111\/j.1749-6632.1985.tb27060.x","article-title":"A general theory of aversion learning","volume":"443","author":"Garcia","year":"1985","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.bbi.2015.09.005_b0120","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1002\/dev.21263","article-title":"Latent inhibition and facilitation of conditioned taste aversion in preweanling rats","volume":"57","author":"Gaztanaga","year":"2015","journal-title":"Dev. Psychobiol."},{"key":"10.1016\/j.bbi.2015.09.005_b0125","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1007\/s11481-012-9388-6","article-title":"Learned immunosuppression: extinction, renewal, and the challenge of reconsolidation","volume":"8","author":"Hadamitzky","year":"2013","journal-title":"J. Neuroimmune Pharmacol."},{"key":"10.1016\/j.bbi.2015.09.005_b0130","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.neuroscience.2015.06.040","article-title":"Extinction of conditioned taste aversion is related to the aversion strength and associated with c-fos expression in the insular cortex","volume":"303","author":"Hadamitzky","year":"2015","journal-title":"Neuroscience"},{"key":"10.1016\/j.bbi.2015.09.005_b0135","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3758\/BF03199940","article-title":"The effect of nonreinforced stimulus exposure on the strength of a conditioned taste aversion as a function of retention interval: do latent inhibition and extinction involve a shared process?","volume":"20","author":"Kraemer","year":"1992","journal-title":"Anim. Learn. Behav."},{"key":"10.1016\/j.bbi.2015.09.005_b0140","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1037\/h0034425","article-title":"Latent inhibition","volume":"79","author":"Lubow","year":"1973","journal-title":"Psychol. Bull."},{"key":"10.1016\/j.bbi.2015.09.005_b0145","series-title":"Latent Inhibition and Conditioned Attention Theory","author":"Lubow","year":"1989"},{"key":"10.1016\/j.bbi.2015.09.005_b0150","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1037\/h0046700","article-title":"Latent inhibition: the effect of nonreinforced pre-exposure to the conditional stimulus","volume":"52","author":"Lubow","year":"1959","journal-title":"J. Comp. Physiol. Psychol."},{"key":"10.1016\/j.bbi.2015.09.005_b0155","series-title":"Latent Inhibition: Cognition, Neuroscience and Applications to Schizophrenia","author":"Lubow","year":"2010"},{"key":"10.1016\/j.bbi.2015.09.005_b0160","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1038\/nrn1765","article-title":"Central nervous system injury-induced immune deficiency syndrome","volume":"6","author":"Meisel","year":"2005","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.bbi.2015.09.005_b0165","doi-asserted-by":"crossref","first-page":"2140","DOI":"10.1038\/sj.npp.1300522","article-title":"Expression of the CS- and US-pre-exposure effects in the conditioned taste aversion paradigm and their abolition following systemic amphetamine treatment in C57BL6\/J mice","volume":"29","author":"Meyer","year":"2004","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.bbi.2015.09.005_b0170","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1016\/j.biopsych.2014.03.009","article-title":"Calcineurin downregulation in the amygdala is sufficient to induce anxiety-like and depression-like behaviors in C57BL\/6J male mice","volume":"75","author":"Mineur","year":"2014","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.bbi.2015.09.005_b0175","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.jneuroim.2007.05.016","article-title":"Taste-immunosuppression engram: reinforcement and extinction","volume":"188","author":"Niemi","year":"2007","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.bbi.2015.09.005_b0180","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1038\/clpt.2011.214","article-title":"Plasma noradrenaline and state anxiety levels predict placebo response in learned immunosuppression","volume":"91","author":"Ober","year":"2012","journal-title":"Clin. Pharmacol. Ther."},{"key":"10.1016\/j.bbi.2015.09.005_b0185","doi-asserted-by":"crossref","first-page":"2330","DOI":"10.1523\/JNEUROSCI.4230-04.2005","article-title":"Neural substrates for behaviorally conditioned immunosuppression in the rat","volume":"25","author":"Pacheco-Lopez","year":"2005","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bbi.2015.09.005_b0190","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1096\/fj.08-115683","article-title":"Calcineurin inhibition in splenocytes induced by pavlovian conditioning","volume":"23","author":"Pacheco-Lopez","year":"2009","journal-title":"FASEB J."},{"key":"10.1016\/j.bbi.2015.09.005_b0195","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1017\/S1461145711001799","article-title":"Neurobehavioural activation during peripheral immunosuppression","volume":"16","author":"Pacheco-Lopez","year":"2013","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"10.1016\/j.bbi.2015.09.005_b0200","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1037\/0033-2909.86.3.523","article-title":"Associative and nonassociative theories of the UCS preexposure phenomenon: implications for Pavlovian conditioning","volume":"86","author":"Randich","year":"1979","journal-title":"Psychol. Bull."},{"key":"10.1016\/j.bbi.2015.09.005_b0205","series-title":"Handbook of Contemporary Learning Theories","first-page":"505","article-title":"The attenuating effects of drug preexposure on taste aversion conditioning: generality, experimental parameters, underlying mechanisms, and implications for drug use and abuse","author":"Riley","year":"2001"},{"key":"10.1016\/j.bbi.2015.09.005_b0210","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1097\/01.tp.0000263332.65519.1f","article-title":"Impact of cyclosporine upon emotional and social behavior in mice","volume":"83","author":"Sato","year":"2007","journal-title":"Transplantation"},{"key":"10.1016\/j.bbi.2015.09.005_b0215","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.bbi.2009.08.007","article-title":"The learned immune response: pavlov and beyond","volume":"24","author":"Schedlowski","year":"2010","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.bbi.2015.09.005_b0220","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1124\/pr.114.009423","article-title":"Neuro-bio-behavioral mechanisms of placebo and nocebo responses: implications for clinical trials and clinical practice","volume":"67","author":"Schedlowski","year":"2015","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.bbi.2015.09.005_b0225","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1038\/ni0710-561","article-title":"Understanding immunity requires more than immunology","volume":"11","author":"Tracey","year":"2010","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.bbi.2015.09.005_b0230","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/S0165-5728(98)00011-3","article-title":"Behaviorally conditioned effects of cyclosporine A on the immune system of rats: specific alterations of blood leukocyte numbers and decrease of granulocyte function","volume":"85","author":"von Horsten","year":"1998","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.bbi.2015.09.005_b0235","doi-asserted-by":"crossref","first-page":"1444","DOI":"10.1016\/j.bbi.2011.05.011","article-title":"Repeated recall of learned immunosuppression: evidence from rats and men","volume":"25","author":"Wirth","year":"2011","journal-title":"Brain Behav. Immun."}],"container-title":["Brain, Behavior, and Immunity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0889159115300143?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0889159115300143?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T07:41:01Z","timestamp":1760168461000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0889159115300143"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,1]]},"references-count":47,"alternative-id":["S0889159115300143"],"URL":"https:\/\/doi.org\/10.1016\/j.bbi.2015.09.005","relation":{},"ISSN":["0889-1591"],"issn-type":[{"value":"0889-1591","type":"print"}],"subject":[],"published":{"date-parts":[[2016,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Pre-exposure to the unconditioned or conditioned stimulus does not affect learned immunosuppression in rats","name":"articletitle","label":"Article Title"},{"value":"Brain, Behavior, and Immunity","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbi.2015.09.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}