{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T06:52:35Z","timestamp":1778309555813,"version":"3.51.4"},"reference-count":73,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81371477"],"award-info":[{"award-number":["81371477"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005089","name":"Beijing Municipal Natural Science Foundation","doi-asserted-by":"publisher","award":["7132063"],"award-info":[{"award-number":["7132063"]}],"id":[{"id":"10.13039\/501100005089","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005089","name":"Beijing Municipal Natural Science Foundation","doi-asserted-by":"publisher","award":["7072035"],"award-info":[{"award-number":["7072035"]}],"id":[{"id":"10.13039\/501100005089","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009670","name":"National Alliance for Research on Schizophrenia and Depression","doi-asserted-by":"publisher","award":["20314"],"award-info":[{"award-number":["20314"]}],"id":[{"id":"10.13039\/100009670","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007123","name":"Stanley Medical Research Institute","doi-asserted-by":"publisher","award":["03T-459"],"award-info":[{"award-number":["03T-459"]}],"id":[{"id":"10.13039\/100007123","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007123","name":"Stanley Medical Research Institute","doi-asserted-by":"publisher","award":["05T-726"],"award-info":[{"award-number":["05T-726"]}],"id":[{"id":"10.13039\/100007123","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain, Behavior, and Immunity"],"published-print":{"date-parts":[[2016,1]]},"DOI":"10.1016\/j.bbi.2015.09.014","type":"journal-article","created":{"date-parts":[[2015,9,25]],"date-time":"2015-09-25T22:34:06Z","timestamp":1443220446000},"page":"169-175","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":69,"special_numbering":"C","title":["Interaction of BDNF with cytokines in chronic schizophrenia"],"prefix":"10.1016","volume":"51","author":[{"given":"Xiang Yang","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yun-Long","family":"Tan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Da-Chun","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shu-Ping","family":"Tan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fu-De","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hanjing Emily","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovana B.","family":"Zunta-Soares","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xu-Feng","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas R.","family":"Kosten","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jair C.","family":"Soares","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.bbi.2015.09.014_b0005","doi-asserted-by":"crossref","first-page":"409","DOI":"10.4331\/wjbc.v5.i4.409","article-title":"New insight in expression, transport, and secretion of brain-derived neurotrophic factor: implications in brain-related diseases","volume":"5","author":"Adachi","year":"2014","journal-title":"World J. Biol. Chem."},{"issue":"2","key":"10.1016\/j.bbi.2015.09.014_b0010","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1177\/0960327113493305","article-title":"Inflammation and schizophrenia: alterations in cytokine levels and perturbation in antioxidative defense systems","volume":"33","author":"Al-Asmari","year":"2014","journal-title":"Hum. Exp. Toxicol."},{"key":"10.1016\/j.bbi.2015.09.014_b0015","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.pnpbp.2012.08.015","article-title":"Neurodevelopment and inflammatory patterns in schizophrenia in relation to pathophysiology","volume":"42","author":"Altamura","year":"2013","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.bbi.2015.09.014_b0020","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.pnpbp.2012.06.014","article-title":"Schizophrenia: linking prenatal infection to cytokines, the tryptophan catabolite (TRYCAT) pathway, NMDA receptor hypofunction, neurodevelopment and neuroprogression","volume":"42","author":"Anderson","year":"2013","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"issue":"1","key":"10.1016\/j.bbi.2015.09.014_b9020","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1002\/jnr.10440","article-title":"Expression of brain-derived neurotrophic factor mRNA in rat hippocampus after treatment with antipsychotic drugs","volume":"71","author":"Bai","year":"2003","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.bbi.2015.09.014_b0030","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/0920-9964(95)00089-5","article-title":"Serum cytokine concentrations in patients with schizophrenia","volume":"20","author":"Baker","year":"1996","journal-title":"Schizophr. Res."},{"issue":"8","key":"10.1016\/j.bbi.2015.09.014_b0035","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1016\/j.biopsych.2012.04.002","article-title":"Tumor necrosis factor gene variation predicts hippocampus volume in healthy individuals","volume":"72","author":"Baune","year":"2012","journal-title":"Biol. Psychiatry"},{"issue":"11","key":"10.1016\/j.bbi.2015.09.014_b0040","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.1016\/j.jpsychires.2012.08.016","article-title":"Elevated serum level of type-2 cytokine and low IL-17 in first episode psychosis and schizophrenia in relapse","volume":"46","author":"Borovcanin","year":"2012","journal-title":"J. Psychiatr. Res."},{"issue":"1","key":"10.1016\/j.bbi.2015.09.014_b0045","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.schres.2013.03.027","article-title":"Antipsychotics can modulate the cytokine profile in schizophrenia: attenuation of the type-2 inflammatory response","volume":"147","author":"Borovcanin","year":"2013","journal-title":"Schizophr. Res."},{"issue":"5","key":"10.1016\/j.bbi.2015.09.014_b0050","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1176\/appi.ajp.161.5.889","article-title":"Elevated maternal interleukin-8 levels and risk of schizophrenia in adult off spring","volume":"161","author":"Brown","year":"2004","journal-title":"Am. J. Psychiatry"},{"issue":"1\u20133","key":"10.1016\/j.bbi.2015.09.014_b0055","first-page":"1","article-title":"Brain derived neurotropic factor in first-episode psychosis","volume":"91","author":"Buckley","year":"2007","journal-title":"Schizophr. Res."},{"issue":"2","key":"10.1016\/j.bbi.2015.09.014_b0060","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1097\/YCO.0b013e3283436eb7","article-title":"Brain-derived neurotrophic factor: findings in schizophrenia","volume":"24","author":"Buckley","year":"2011","journal-title":"Curr. Opin. Psychiatry"},{"key":"10.1016\/j.bbi.2015.09.014_b0065","doi-asserted-by":"crossref","first-page":"430","DOI":"10.3389\/fncel.2014.00430","article-title":"Brain-derived neurotrophic factor: a bridge between inflammation and neuroplasticity","volume":"8","author":"Calabrese","year":"2014","journal-title":"Front. Cell. Neurosci."},{"issue":"4","key":"10.1016\/j.bbi.2015.09.014_b0070","doi-asserted-by":"crossref","first-page":"320","DOI":"10.2478\/s13380-012-0045-6","article-title":"Prenatal infection, maternal immune activation, and risk for schizophrenia","volume":"3","author":"Canetta","year":"2012","journal-title":"Transl. Neurosci."},{"issue":"1","key":"10.1016\/j.bbi.2015.09.014_b0075","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1002\/ana.10764","article-title":"Multiple sclerosis: cytokine receptors on oligodendrocytes predict innate regulation","volume":"55","author":"Cannella","year":"2004","journal-title":"Ann. Neurol."},{"issue":"3","key":"10.1016\/j.bbi.2015.09.014_b0080","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1007\/s00213-009-1665-6","article-title":"Decreased levels of serum brain-derived neurotrophic factor in drug-na\u00efve first-episode schizophrenia: relationship to clinical phenotypes","volume":"207","author":"Chen","year":"2009","journal-title":"Psychopharmacology"},{"issue":"6","key":"10.1016\/j.bbi.2015.09.014_b9005","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1016\/j.bbi.2006.02.002","article-title":"Cytokines in schizophrenia and the effects of antipsychotic drugs","volume":"20","author":"Drzyzga","year":"2006","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.bbi.2015.09.014_b0095","first-page":"55","article-title":"Serum levels of interleukin-6 and tumor necrosis factor-alpha in exacerbation and remission phase of schizophrenia","volume":"25","author":"Dunjic-Kostic","year":"2013","journal-title":"Psychiat. Danub."},{"issue":"1","key":"10.1016\/j.bbi.2015.09.014_b0110","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jpsychires.2011.09.022","article-title":"The role of BDNF in the pathophysiology and treatment of schizophrenia","volume":"46","author":"Favalli","year":"2012","journal-title":"J. Psychiatr. Res."},{"issue":"9","key":"10.1016\/j.bbi.2015.09.014_b0115","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/j.tins.2005.06.008","article-title":"IL-18: a key player in neuroinflammation and neurodegeneration?","volume":"28","author":"Felderhoff-Mueser","year":"2005","journal-title":"Trends Neurosci."},{"issue":"10","key":"10.1016\/j.bbi.2015.09.014_b0120","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1016\/j.biopsych.2013.01.001","article-title":"Inflammatory cytokines and neurological and neurocognitive alterations in the course of schizophrenia","volume":"73","author":"Fineberg","year":"2013","journal-title":"Biol. Psychiatry"},{"issue":"3","key":"10.1016\/j.bbi.2015.09.014_b0125","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.neulet.2011.06.042","article-title":"Increased annexin-V and decreased TNF-\u03b1 serum levels in chronic-medicated patients withschizophrenia","volume":"502","author":"Francesconi","year":"2011","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.bbi.2015.09.014_b0130","doi-asserted-by":"crossref","first-page":"136","DOI":"10.3389\/fnsyn.2010.00136","article-title":"Novel roles for immune molecules in neural development: implications for neurodevelopmental disorders","volume":"2","author":"Garay","year":"2010","journal-title":"Front. Synaptic Neurosci."},{"issue":"9","key":"10.1016\/j.bbi.2015.09.014_b0140","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1038\/mp.2010.88","article-title":"Brain-derived neurotrophic factor levels in schizophrenia: a systematic review with meta-analysis","volume":"16","author":"Green","year":"2011","journal-title":"Mol. Psychiatry"},{"issue":"2","key":"10.1016\/j.bbi.2015.09.014_b0145","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1046\/j.1471-4159.1998.70020699.x","article-title":"Inflammatory signals induce neurotrophin expression in human microglial cells","volume":"70","author":"Heese","year":"1998","journal-title":"J. Neurochem."},{"issue":"5","key":"10.1016\/j.bbi.2015.09.014_b0150","doi-asserted-by":"crossref","first-page":"e96021","DOI":"10.1371\/journal.pone.0096021","article-title":"Relationship between interleukin-6 gene polymorphism and hippocampal volume in antipsychotic-na\u00efve schizophrenia: evidence for differential susceptibility?","volume":"9","author":"Kalmady","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.bbi.2015.09.014_b0155","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1093\/schbul\/13.2.261","article-title":"The Positive and Negative Syndrome Scale (PANSS) for schizophrenia","volume":"13","author":"Kay","year":"1987","journal-title":"Schizophr. Bull."},{"issue":"6","key":"10.1016\/j.bbi.2015.09.014_b0160","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/S0022-3956(99)00033-3","article-title":"Development, disease and degeneration in schizophrenia: a unitary pathophysiological model","volume":"33","author":"Keshavan","year":"1999","journal-title":"J. Psychiatr. Res."},{"issue":"2","key":"10.1016\/j.bbi.2015.09.014_b0165","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1159\/000213565","article-title":"Cytokine changes and tryptophan metabolites in medication-na\u00efve and medication-free schizophrenic patients","volume":"59","author":"Kim","year":"2009","journal-title":"Neuropsychobiology"},{"issue":"3","key":"10.1016\/j.bbi.2015.09.014_b0170","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1017\/S1461145710000738","article-title":"Blood BDNF concentrations reflect brain-tissue BDNF levels across species","volume":"14","author":"Klein","year":"2011","journal-title":"Int. J. Neuropsychopharmacol."},{"issue":"Suppl 1","key":"10.1016\/j.bbi.2015.09.014_b0175","first-page":"S153","article-title":"Increased interleukin-6 and tumor necrosis factor alpha in first episode schizophrenia patients versus healthy controls","volume":"24","author":"Kubistova","year":"2012","journal-title":"Psychiat. Danub."},{"issue":"Pt 8","key":"10.1016\/j.bbi.2015.09.014_b0180","first-page":"2248","volume":"133","author":"Linker","year":"2010","journal-title":"Functional role of brain-derived neurotrophic factor in neuroprotective autoimmunity: therapeutic implications in a model of multiple sclerosis."},{"issue":"3","key":"10.1016\/j.bbi.2015.09.014_b0190","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/S0920-9964(00)00094-3","article-title":"Increased serum interleukin-8 and interleukin-10 in schizophrenic patients resistant to treatment with neuroleptics and the stimulatory effects of clozapine on serum leukemia inhibitory factor receptor","volume":"54","author":"Maes","year":"2002","journal-title":"Schizophr. Res."},{"issue":"7","key":"10.1016\/j.bbi.2015.09.014_b0195","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/j.biopsych.2011.04.013","article-title":"Meta-analysis of cytokine alterations in schizophrenia: clinical status and antipsychotic effects","volume":"70","author":"Miller","year":"2011","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.bbi.2015.09.014_b0200","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.pnpbp.2012.03.010","article-title":"Prenatal inflammation and neurodevelopment in schizophrenia: a review of human studies","volume":"42","author":"Miller","year":"2013","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"issue":"2\u20133","key":"10.1016\/j.bbi.2015.09.014_b0205","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1159\/000356538","article-title":"Immunology of schizophrenia","volume":"21","author":"M\u00fcller","year":"2014","journal-title":"NeuroImmunoModulation"},{"key":"10.1016\/j.bbi.2015.09.014_b0210","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.pnpbp.2012.10.022","article-title":"The role of pro-inflammatory cytokines in the neuroinflammation and neurogenesis of schizophrenia","volume":"48","author":"Na","year":"2014","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"issue":"3","key":"10.1016\/j.bbi.2015.09.014_b0215","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1038\/nrd3366","article-title":"Potential therapeutic uses of BDNF in neurological and psychiatric disorders","volume":"10","author":"Nagahara","year":"2011","journal-title":"Nat. Rev. Drug Discov."},{"issue":"6","key":"10.1016\/j.bbi.2015.09.014_b0220","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1038\/sj.mp.4000730","article-title":"Cytokine and growth factor involvement in schizophrenia \u2013 support for the developmental model","volume":"5","author":"Nawa","year":"2000","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.bbi.2015.09.014_b9000","doi-asserted-by":"crossref","first-page":"45","DOI":"10.3389\/fpsyt.2013.00045","article-title":"BDNF and schizophrenia: from neurodevelopment to neuronal plasticity, learning, and memory","volume":"4","author":"Nieto","year":"2013","journal-title":"Front. Psychiatry"},{"issue":"2","key":"10.1016\/j.bbi.2015.09.014_b0230","doi-asserted-by":"crossref","first-page":"61","DOI":"10.9758\/cpn.2012.10.2.61","article-title":"A review of brain-derived neurotrophic factor as a candidate biomarker in schizophrenia","volume":"10","author":"Nurjono","year":"2012","journal-title":"Clin. Psychopharmacol. Neurosci."},{"issue":"3","key":"10.1016\/j.bbi.2015.09.014_b0235","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.psychres.2007.11.014","article-title":"Increased tumor necrosis factor-alpha concentrations with interleukin-4 concentrations in exacerbations of schizophrenia","volume":"160","author":"O\u2019Brien","year":"2008","journal-title":"Psychiatry Res."},{"key":"10.1016\/j.bbi.2015.09.014_b0240","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.bbi.2013.10.007","article-title":"Association between serum brain-derived neurotrophic factor and plasma interleukin-6 in major depressive disorder with melancholic features","volume":"36","author":"Patas","year":"2014","journal-title":"Brain Behav. Immun."},{"issue":"3","key":"10.1016\/j.bbi.2015.09.014_b0245","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.neulet.2011.01.039","article-title":"Serum brain-derived neurotrophic factor and clozapine daily dose in patients with schizophrenia: a positive correlation","volume":"491","author":"Pedrini","year":"2011","journal-title":"Neurosci. Lett."},{"issue":"4","key":"10.1016\/j.bbi.2015.09.014_b0250","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1017\/S1461145709991015","article-title":"Decreased BDNF levels in CSF of drug-naive first-episode psychotic subjects: correlation with plasma BDNF and psychopathology","volume":"13","author":"Pillai","year":"2010","journal-title":"Int. J. Neuropsychopharmacol."},{"issue":"4","key":"10.1016\/j.bbi.2015.09.014_b9025","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/j.pnpbp.2004.05.008","article-title":"Low serum levels of brain-derived neurotrophic factor in patients with schizophrenia do not elevate after antipsychotic treatment","volume":"28","author":"Pirildar","year":"2004","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"issue":"8","key":"10.1016\/j.bbi.2015.09.014_b0260","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1016\/j.biopsych.2007.09.024","article-title":"Inflammatory cytokine alterations in schizophrenia: a systematic quantitative review","volume":"63","author":"Potvin","year":"2008","journal-title":"Biol. Psychiatry"},{"issue":"4","key":"10.1016\/j.bbi.2015.09.014_b0265","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1007\/BF02602952","article-title":"The role of chemokines in inflammation","volume":"26","author":"Proost","year":"1996","journal-title":"Int. J. Clin. Lab. Res."},{"issue":"12","key":"10.1016\/j.bbi.2015.09.014_b0270","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1038\/mp.2012.23","article-title":"Neurodevelopmental model of schizophrenia: update 2012","volume":"17","author":"Rapoport","year":"2012","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.bbi.2015.09.014_b0275","doi-asserted-by":"crossref","first-page":"e389","DOI":"10.1038\/tp.2014.26","article-title":"Decreased BDNF and TrkB mRNA expression in multiple cortical areas of patients with schizophrenia and mood disorders","volume":"4","author":"Ray","year":"2014","journal-title":"Transl. Psychiatry"},{"issue":"1\u20133","key":"10.1016\/j.bbi.2015.09.014_b0280","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/S0920-9964(08)70630-3","article-title":"Decreased serum levels of BDNF in first episode patients with schizophrenia and its psychopathological correlations","volume":"102","author":"Rizos","year":"2008","journal-title":"Schizophr. Res."},{"issue":"2 Pt 2","key":"10.1016\/j.bbi.2015.09.014_b0285","doi-asserted-by":"crossref","first-page":"251","DOI":"10.3109\/15622970802182733","article-title":"Reduced serum BDNF levels in patients with chronic schizophrenic disorder in relapse, who were treated with typical or atypical antipsychotics","volume":"11","author":"Rizos","year":"2010","journal-title":"World J. Biol. Psychiatry"},{"issue":"1","key":"10.1016\/j.bbi.2015.09.014_b0290","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.schres.2012.10.020","article-title":"Cognition and the five-factor model of the Positive and Negative Syndrome Scale in schizophrenia","volume":"143","author":"Rodriguez-Jimenez","year":"2013","journal-title":"Schizophr. Res."},{"issue":"3","key":"10.1016\/j.bbi.2015.09.014_b0295","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/j.jpsychires.2012.12.001","article-title":"Increased cerebrospinal fluid interleukin-6 levels in patients with schizophrenia and those with major depressive disorder","volume":"47","author":"Sasayama","year":"2013","journal-title":"J. Psychiatr. Res."},{"issue":"1\u20132","key":"10.1016\/j.bbi.2015.09.014_b0300","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.jneuroim.2005.01.023","article-title":"A role for brain-derived neurotrophic factor in B cell development","volume":"163","author":"Schuhmann","year":"2005","journal-title":"J. Neuroimmunol."},{"issue":"1\u20132","key":"10.1016\/j.bbi.2015.09.014_b0305","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.jneuroim.2004.10.026","article-title":"Tumor necrosis factor-alpha and interleukin-6 regulate secretion of brain-derived neurotrophic factor in human monocytes","volume":"160","author":"Schulte-Herbr\u00fcggen","year":"2005","journal-title":"J. Neuroimmunol."},{"issue":"1","key":"10.1016\/j.bbi.2015.09.014_b0310","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.cyto.2009.05.005","article-title":"Decreased serum levels of interleukin-2 and interleukin-6 in Indian Bengalee schizophrenic patients","volume":"47","author":"Singh","year":"2009","journal-title":"Cytokine"},{"key":"10.1016\/j.bbi.2015.09.014_b9010","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1186\/1742-2094-10-59","article-title":"Acute and subacute IL-1\u03b2 administrations differentially modulate neuroimmune and neurotrophicsystems: possible implications for neuroprotection and neurodegeneration","volume":"10","author":"Song","year":"2013","journal-title":"J. Neuroinflammation"},{"issue":"7","key":"10.1016\/j.bbi.2015.09.014_b0315","doi-asserted-by":"crossref","first-page":"546","DOI":"10.3109\/15622975.2014.922699","article-title":"Prolactin serum levels correlate with inflammatory status in drug-na\u00efve first-episode schizophrenia","volume":"15","author":"Song","year":"2014","journal-title":"World J. Biol. Psychiatry"},{"key":"10.1016\/j.bbi.2015.09.014_b0320","doi-asserted-by":"crossref","unstructured":"Sperner-Unterweger, B., Fuchs, D., 2015. Schizophrenia and psychoneuroimmunology: an integrative view. Curr. Opin. Psychiatry [Epub ahead of print].","DOI":"10.1097\/YCO.0000000000000153"},{"issue":"1\u20133","key":"10.1016\/j.bbi.2015.09.014_b0325","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.schres.2013.10.011","article-title":"Antipsychotics\u2019 effects on blood levels of cytokines in schizophrenia: a meta-analysis","volume":"151","author":"Tourjman","year":"2013","journal-title":"Schizophr. Res."},{"issue":"1\u20133","key":"10.1016\/j.bbi.2015.09.014_b0330","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.schres.2014.03.005","article-title":"Cytokine function in medication-naive first episode psychosis: a systematic review and meta-analysis","volume":"155","author":"Upthegrove","year":"2014","journal-title":"Schizophr. Res."},{"issue":"1\u20133","key":"10.1016\/j.bbi.2015.09.014_b0335","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.schres.2012.01.031","article-title":"Searching for a consensus five-factor model of the Positive and Negative Syndrome Scale for schizophrenia","volume":"137","author":"Wallwork","year":"2012","journal-title":"Schizophr. Res."},{"issue":"5","key":"10.1016\/j.bbi.2015.09.014_b0340","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.1046\/j.1460-9568.1999.00567.x","article-title":"Mutual regulation between the intercellular messengers nitric oxide and brain-derived neurotrophic factor in rodent neocortical neurons","volume":"11","author":"Xiong","year":"1999","journal-title":"Eur. J. Neurosci."},{"issue":"8","key":"10.1016\/j.bbi.2015.09.014_b0345","doi-asserted-by":"crossref","first-page":"1508","DOI":"10.1016\/j.pnpbp.2009.08.011","article-title":"Decreased serum BDNF levels in chronic institutionalized schizophrenia on long-term treatment with typical and atypical antipsychotics","volume":"33","author":"Xiu","year":"2009","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"issue":"1","key":"10.1016\/j.bbi.2015.09.014_b0350","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.neulet.2011.07.020","article-title":"Decreased serum brain-derived neurotrophic factor levels in schizophrenic patients with tardive dyskinesia","volume":"502","author":"Yang","year":"2011","journal-title":"Neurosci. Lett."},{"issue":"9","key":"10.1016\/j.bbi.2015.09.014_b0360","doi-asserted-by":"crossref","first-page":"5483","DOI":"10.1007\/s11033-013-2648-6","article-title":"BDNF and TNF-\u03b1 polymorphisms in memory","volume":"40","author":"Yogeetha","year":"2013","journal-title":"Mol. Biol. Rep."},{"issue":"5","key":"10.1016\/j.bbi.2015.09.014_b9030","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1016\/j.pnpbp.2007.03.010","article-title":"Treatment with risperidone for 4 weeks increased plasma 3-methoxy-4-hydroxypnenylglycol (MHPG) levels, but did not alter plasma brain-derived neurotrophic factor (BDNF) levels in schizophrenic patients","volume":"31","author":"Yoshimura","year":"2007","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"issue":"3","key":"10.1016\/j.bbi.2015.09.014_b0365","doi-asserted-by":"crossref","first-page":"174","DOI":"10.3109\/15622975.2013.830774","article-title":"Inflammatory cytokine network in schizophrenia","volume":"15","author":"Zakharyan","year":"2014","journal-title":"World J. Biol. Psychiatry"},{"issue":"2\u20133","key":"10.1016\/j.bbi.2015.09.014_b0370","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/S0920-9964(01)00296-1","article-title":"Elevated interleukin-2, interleukin-6 and interleukin-8 serum levels in neuroleptic-free schizophrenia: association with psychopathology","volume":"57","author":"Zhang","year":"2002","journal-title":"Schizophr. Res."},{"issue":"7","key":"10.1016\/j.bbi.2015.09.014_b0375","doi-asserted-by":"crossref","first-page":"940","DOI":"10.4088\/JCP.v65n0710","article-title":"Changes in serum interleukin-2, -6, and -8 levels before and during treatment with risperidone and haloperidol: relationship to outcome in schizophrenia","volume":"65","author":"Zhang","year":"2004","journal-title":"J. Clin. Psychiatry"},{"issue":"2","key":"10.1016\/j.bbi.2015.09.014_b0380","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1007\/s00213-012-2643-y","article-title":"Low BDNF is associated with cognitive impairment in chronic patients with schizophrenia","volume":"222","author":"Zhang","year":"2012","journal-title":"Psychopharmacology"},{"issue":"8","key":"10.1016\/j.bbi.2015.09.014_b0385","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1016\/j.biopsych.2012.04.032","article-title":"Brain-derived neurotrophic factor levels and its Val66Met gene polymorphism predict tardive dyskinesia treatment response to ginkgo biloba","volume":"72","author":"Zhang","year":"2012","journal-title":"Biol. Psychiatry"}],"container-title":["Brain, Behavior, and Immunity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0889159115300210?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0889159115300210?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T07:42:02Z","timestamp":1760168522000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0889159115300210"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,1]]},"references-count":73,"alternative-id":["S0889159115300210"],"URL":"https:\/\/doi.org\/10.1016\/j.bbi.2015.09.014","relation":{},"ISSN":["0889-1591"],"issn-type":[{"value":"0889-1591","type":"print"}],"subject":[],"published":{"date-parts":[[2016,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Interaction of BDNF with cytokines in chronic schizophrenia","name":"articletitle","label":"Article Title"},{"value":"Brain, Behavior, and Immunity","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbi.2015.09.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}