{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T22:24:24Z","timestamp":1775341464083,"version":"3.50.1"},"reference-count":49,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,2,1]],"date-time":"2017-02-01T00:00:00Z","timestamp":1485907200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,2,1]],"date-time":"2017-02-01T00:00:00Z","timestamp":1485907200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"Spanish Ministry of Economy","award":["PS09\/01313"],"award-info":[{"award-number":["PS09\/01313"]}]},{"name":"Spanish Ministry of Economy","award":["PI12\/01437"],"award-info":[{"award-number":["PI12\/01437"]}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain, Behavior, and Immunity"],"published-print":{"date-parts":[[2017,2]]},"DOI":"10.1016\/j.bbi.2016.10.004","type":"journal-article","created":{"date-parts":[[2016,10,15]],"date-time":"2016-10-15T08:41:47Z","timestamp":1476520907000},"page":"142-150","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":41,"special_numbering":"C","title":["Neuroanatomical correlates of stroke-associated infection and stroke-induced immunodepression"],"prefix":"10.1016","volume":"60","author":[{"given":"Xabier","family":"Urra","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos","family":"Laredo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yashu","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sergio","family":"Amaro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Salvatore","family":"Rudilosso","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arturo","family":"Ren\u00fa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2710-6433","authenticated-orcid":false,"given":"Alberto","family":"Prats-Galino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna M.","family":"Planas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Oleaga","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00c1ngel","family":"Chamorro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbi.2016.10.004_b0005","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1002\/ana.410120111","article-title":"Neuroimmunomodulation: neural anatomical basis for impairment and facilitation","volume":"12","author":"Brooks","year":"1982","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.bbi.2016.10.004_b0010","doi-asserted-by":"crossref","first-page":"2408","DOI":"10.1093\/brain\/awu101","article-title":"Diaschisis: past, present, future","volume":"137","author":"Carrera","year":"2014","journal-title":"Brain"},{"key":"10.1016\/j.bbi.2016.10.004_b0015","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1136\/jnnp.2006.100800","article-title":"Interleukin 10, monocytes and increased risk of early infection in ischaemic stroke","volume":"77","author":"Chamorro","year":"2006","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.bbi.2016.10.004_b0020","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1161\/01.STR.0000258346.68966.9d","article-title":"Infection after acute ischemic stroke: a manifestation of brain-induced immunodepression","volume":"38","author":"Chamorro","year":"2007","journal-title":"Stroke"},{"key":"10.1016\/j.bbi.2016.10.004_b0025","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.jns.2006.10.001","article-title":"Catecholamines, infection, and death in acute ischemic stroke","volume":"252","author":"Chamorro","year":"2007","journal-title":"J. Neurol. Sci."},{"key":"10.1016\/j.bbi.2016.10.004_b0030","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1038\/nrneurol.2012.98","article-title":"The immunology of acute stroke","volume":"8","author":"Chamorro","year":"2012","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.bbi.2016.10.004_b0035","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1016\/j.clnu.2008.06.011","article-title":"Accuracy of the volume-viscosity swallow test for clinical screening of oropharyngeal dysphagia and aspiration","volume":"27","author":"Clav\u00e9","year":"2008","journal-title":"Clin. Nutr."},{"key":"10.1016\/j.bbi.2016.10.004_b0040","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1001\/archneur.62.7.1081","article-title":"Insular cortex infarction in acute middle cerebral artery territory stroke: predictor of stroke severity and vascular lesion","volume":"62","author":"Fink","year":"2005","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.bbi.2016.10.004_b0045","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1016\/j.apmr.2012.10.012","article-title":"Left-sided brain injury associated with more hospital-acquired infections during inpatient rehabilitation","volume":"94","author":"Frisina","year":"2013","journal-title":"Arch. Phys. Med. Rehabil."},{"key":"10.1016\/j.bbi.2016.10.004_b0050","doi-asserted-by":"crossref","first-page":"2760","DOI":"10.1161\/STROKEAHA.113.001690","article-title":"Lesion location predicts transient and extended risk of aspiration after supratentorial ischemic stroke","volume":"44","author":"Galovic","year":"2013","journal-title":"Stroke"},{"key":"10.1016\/j.bbi.2016.10.004_b0055","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/S0006-8993(02)03368-1","article-title":"Temporal effects of left versus right middle cerebral artery occlusion on spleen lymphocyte subsets and mitogenic response in Wistar rats","volume":"955","author":"Gendron","year":"2002","journal-title":"Brain Res."},{"key":"10.1016\/j.bbi.2016.10.004_b0060","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1159\/000111499","article-title":"Cellular immunodepression preceding infectious complications after acute ischemic stroke in humans","volume":"25","author":"Haeusler","year":"2008","journal-title":"Cerebrovasc. Dis."},{"key":"10.1016\/j.bbi.2016.10.004_b0065","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1159\/000331922","article-title":"Influence of stroke localization on autonomic activation, immunodepression, and post-stroke infection","volume":"32","author":"Harms","year":"2011","journal-title":"Cerebrovasc. Dis."},{"key":"10.1016\/j.bbi.2016.10.004_b0070","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/0006-8993(76)90822-2","article-title":"Temporal neocortical afferent connections to the amygdala in the rhesus monkey","volume":"115","author":"Herzog","year":"1976","journal-title":"Brain Res."},{"key":"10.1016\/j.bbi.2016.10.004_b0075","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1002\/hbm.20579","article-title":"Dynamical consequences of lesions in cortical networks","volume":"29","author":"Honey","year":"2008","journal-title":"Hum. Brain Mapp."},{"key":"10.1016\/j.bbi.2016.10.004_b0080","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1016\/j.neuroimage.2007.07.053","article-title":"Tract probability maps in stereotaxic spaces: analyses of white matter anatomy and tract-specific quantification","volume":"39","author":"Hua","year":"2008","journal-title":"Neuroimage"},{"key":"10.1016\/j.bbi.2016.10.004_b0085","doi-asserted-by":"crossref","first-page":"3226","DOI":"10.1161\/STROKEAHA.109.557967","article-title":"Infarct volume is a major determiner of post-stroke immune cell function and susceptibility to infection","volume":"40","author":"Hug","year":"2009","journal-title":"Stroke"},{"key":"10.1016\/j.bbi.2016.10.004_b0090","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1002\/cne.902640306","article-title":"The entorhinal cortex of the monkey: II. Cortical afferents","volume":"264","author":"Insausti","year":"1987","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.bbi.2016.10.004_b0095","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1007\/s00429-012-0498-y","article-title":"Tracing superior longitudinal fasciculus connectivity in the human brain using high resolution diffusion tensor tractography","volume":"219","author":"Kamali","year":"2014","journal-title":"Brain Struct. Funct."},{"key":"10.1016\/j.bbi.2016.10.004_b0100","doi-asserted-by":"crossref","first-page":"e71141","DOI":"10.1371\/journal.pone.0071141","article-title":"Hospital acquired pneumonia is linked to right hemispheric peri-insular stroke","volume":"8","author":"Kemmling","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.bbi.2016.10.004_b0105","doi-asserted-by":"crossref","first-page":"2849","DOI":"10.1161\/STROKEAHA.109.549618","article-title":"The spectrum of systemic immune alterations after murine focal ischemia: immunodepression versus immunomodulation","volume":"40","author":"Liesz","year":"2009","journal-title":"Stroke"},{"key":"10.1016\/j.bbi.2016.10.004_b0110","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1523\/JNEUROSCI.2439-14.2015","article-title":"DAMP signaling is a key pathway inducing immune modulation after brain injury","volume":"35","author":"Liesz","year":"2015","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bbi.2016.10.004_b0115","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1056\/NEJM200103013440908","article-title":"Aspiration pneumonitis and aspiration pneumonia","volume":"344","author":"Marik","year":"2001","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.bbi.2016.10.004_b0120","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1016\/j.bbi.2007.09.008","article-title":"Associations among central nervous, endocrine, and immune activities when positive emotions are elicited by looking at a favorite person","volume":"22","author":"Matsunaga","year":"2008","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.bbi.2016.10.004_b0125","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1002\/ana.20105","article-title":"Role of cerebral lateralization in control of immune processes in humans","volume":"55","author":"Meador","year":"2004","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.bbi.2016.10.004_b0130","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1159\/000338080","article-title":"Predicting post-stroke infections and outcome with blood-based immune and stress markers","volume":"33","author":"Meisel","year":"2012","journal-title":"Cerebrovasc. Dis."},{"key":"10.1016\/j.bbi.2016.10.004_b0135","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1038\/nrn1765","article-title":"Central nervous system injury-induced immune deficiency syndrome","volume":"6","author":"Meisel","year":"2005","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.bbi.2016.10.004_b0140","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1093\/brain\/121.6.1013","article-title":"From sensation to cognition","volume":"121","author":"Mesulam","year":"1998","journal-title":"Brain"},{"key":"10.1016\/j.bbi.2016.10.004_b0145","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1136\/jnnp.2009.182394","article-title":"The impact of lesion location and lesion size on poststroke infection frequency","volume":"81","author":"Minnerup","year":"2010","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.bbi.2016.10.004_b0150","doi-asserted-by":"crossref","first-page":"6762","DOI":"10.1038\/ncomms7762","article-title":"Neural organization of spoken language revealed by lesion-symptom mapping","volume":"6","author":"Mirman","year":"2015","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bbi.2016.10.004_b0155","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/S0074-7742(02)52014-6","article-title":"Cerebral lateralization and the immune system","volume":"52","author":"Neveu","year":"2002","journal-title":"Int. Rev. Neurobiol."},{"key":"10.1016\/j.bbi.2016.10.004_b0160","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1016\/j.neuroimage.2007.08.017","article-title":"Imaging brain and immune association accompanying cognitive appraisal of an acute stressor","volume":"39","author":"Ohira","year":"2008","journal-title":"Neuroimage"},{"key":"10.1016\/j.bbi.2016.10.004_b0165","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1161\/STROKEAHA.110.600940","article-title":"Regional ischemic vulnerability of the brain to hypoperfusion: the need for location specific computed tomography perfusion thresholds in acute stroke patients","volume":"42","author":"Payabvash","year":"2011","journal-title":"Stroke"},{"key":"10.1016\/j.bbi.2016.10.004_b0170","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1084\/jem.20021098","article-title":"Stroke-induced immunodeficiency promotes spontaneous bacterial infections and is mediated by sympathetic activation reversal by poststroke T helper cell type 1-like immunostimulation","volume":"198","author":"Prass","year":"2003","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.bbi.2016.10.004_b0175","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1162\/jocn.2007.19.7.1081","article-title":"Improving lesion-symptom mapping","volume":"19","author":"Rorden","year":"2007","journal-title":"J. Cogn. Neurosci."},{"key":"10.1016\/j.bbi.2016.10.004_b0180","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1038\/nrn1521","article-title":"Using human brain lesions to infer function: a relic from a past era in the fMRI age?","volume":"5","author":"Rorden","year":"2004","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.bbi.2016.10.004_b0185","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1196\/annals.1444.017","article-title":"Cerebral white matter: neuroanatomy, clinical neurology, and neurobehavioral correlates","volume":"1142","author":"Schmahmann","year":"2008","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.bbi.2016.10.004_b0190","doi-asserted-by":"crossref","first-page":"2335","DOI":"10.1161\/STROKEAHA.115.009617","article-title":"Diagnosis of stroke-associated pneumonia: recommendations from the pneumonia in stroke consensus group","volume":"46","author":"Smith","year":"2015","journal-title":"Stroke"},{"key":"10.1016\/j.bbi.2016.10.004_b0195","doi-asserted-by":"crossref","first-page":"1903","DOI":"10.1161\/STROKEAHA.108.535468","article-title":"Swallowing disturbance pattern relates to brain lesion location in acute stroke patients","volume":"40","author":"Steinhagen","year":"2009","journal-title":"Stroke"},{"key":"10.1016\/j.bbi.2016.10.004_b0200","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1126\/science.1213099","article-title":"Immunology. Neuroimmune communication","volume":"334","author":"Trakhtenberg","year":"2011","journal-title":"Science"},{"key":"10.1016\/j.bbi.2016.10.004_b0205","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1006\/nimg.2001.0978","article-title":"Automated anatomical labeling of activations in SPM using a macroscopic anatomical parcellation of the MNI MRI single-subject brain","volume":"15","author":"Tzourio-Mazoyer","year":"2002","journal-title":"Neuroimage"},{"key":"10.1016\/j.bbi.2016.10.004_b0210","doi-asserted-by":"crossref","first-page":"e110","DOI":"10.1161\/STROKEAHA.109.566968","article-title":"Stroke-induced immunodepression is a marker of severe brain damage","volume":"41","author":"Urra","year":"2010","journal-title":"Stroke"},{"key":"10.1016\/j.bbi.2016.10.004_b0215","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1161\/STROKEAHA.108.532085","article-title":"Monocytes are major players in the prognosis and risk of infection after acute stroke","volume":"40","author":"Urra","year":"2009","journal-title":"Stroke"},{"key":"10.1016\/j.bbi.2016.10.004_b0220","doi-asserted-by":"crossref","first-page":"1174","DOI":"10.1016\/j.neuroscience.2008.06.014","article-title":"Harms and benefits of lymphocyte subpopulations in patients with acute stroke","volume":"158","author":"Urra","year":"2009","journal-title":"Neuroscience"},{"key":"10.1016\/j.bbi.2016.10.004_b0225","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1016\/j.tics.2013.09.012","article-title":"Network hubs in the human brain","volume":"17","author":"van den Heuvel","year":"2013","journal-title":"Trends Cogn. Sci."},{"key":"10.1016\/j.bbi.2016.10.004_b0230","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1161\/STROKEAHA.107.493635","article-title":"Analysis of lymphocyte subsets in patients with stroke and their influence on infection after stroke","volume":"39","author":"Vogelgesang","year":"2008","journal-title":"Stroke"},{"key":"10.1016\/j.bbi.2016.10.004_b0235","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1111\/j.1468-1331.2012.03818.x","article-title":"Insular stroke is associated with acute sympathetic hyperactivation and immunodepression","volume":"20","author":"Walter","year":"2013","journal-title":"Eur. J. Neurol."},{"key":"10.1016\/j.bbi.2016.10.004_b0240","first-page":"830614","article-title":"Infection after acute ischemic stroke: risk factors, biomarkers, and outcome","volume":"2011","author":"Wartenberg","year":"2011","journal-title":"Stroke Res. Treat."},{"key":"10.1016\/j.bbi.2016.10.004_b0245","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1111\/j.1468-1331.2008.02512.x","article-title":"A decrease of human leucocyte antigen-DR expression on monocytes in peripheral blood predicts stroke-associated infection in critically-ill patients with acute stroke","volume":"16","author":"Zhang","year":"2009","journal-title":"Eur. J. Neurol."}],"container-title":["Brain, Behavior, and Immunity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0889159116304664?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0889159116304664?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T07:44:05Z","timestamp":1760168645000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0889159116304664"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,2]]},"references-count":49,"alternative-id":["S0889159116304664"],"URL":"https:\/\/doi.org\/10.1016\/j.bbi.2016.10.004","relation":{},"ISSN":["0889-1591"],"issn-type":[{"value":"0889-1591","type":"print"}],"subject":[],"published":{"date-parts":[[2017,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Neuroanatomical correlates of stroke-associated infection and stroke-induced immunodepression","name":"articletitle","label":"Article Title"},{"value":"Brain, Behavior, and Immunity","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbi.2016.10.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}