{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T11:47:37Z","timestamp":1790596057332,"version":"4.1.0"},"reference-count":48,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,3,1]],"date-time":"2017-03-01T00:00:00Z","timestamp":1488326400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,3,1]],"date-time":"2017-03-01T00:00:00Z","timestamp":1488326400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain, Behavior, and Immunity"],"published-print":{"date-parts":[[2017,3]]},"DOI":"10.1016\/j.bbi.2016.11.030","type":"journal-article","created":{"date-parts":[[2016,12,1]],"date-time":"2016-12-01T14:31:19Z","timestamp":1480602679000},"page":"228-235","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":36,"special_numbering":"C","title":["Stronger hypothalamus-pituitary-adrenal axis habituation predicts lesser sensitization of inflammatory response to repeated acute stress exposures in healthy young adults"],"prefix":"10.1016","volume":"61","author":[{"given":"Myriam V.","family":"Thoma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danielle","family":"Gianferante","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luke","family":"Hanlin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Fiksdal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuejie","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Rohleder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.bbi.2016.11.030_b0005","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/S0749-3797(18)30622-6","article-title":"Screening for depression in well older adults: evaluation of a short form of the CES-D (Center for Epidemiologic Studies Depression Scale)","volume":"10","author":"Andresen","year":"1994","journal-title":"Am. J. Prev. Med."},{"issue":"7","key":"10.1016\/j.bbi.2016.11.030_b0010","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1093\/eurheartj\/9.7.758","article-title":"Excess fatigue as a precursor of myocardial infarction","volume":"9","author":"Appels","year":"1988","journal-title":"Eur. Heart J."},{"issue":"4","key":"10.1016\/j.bbi.2016.11.030_b0015","doi-asserted-by":"crossref","first-page":"1920","DOI":"10.1073\/pnas.0438019100","article-title":"A mechanism converting psychosocial stress into mononuclear cell activation","volume":"100","author":"Bierhaus","year":"2003","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"5","key":"10.1016\/j.bbi.2016.11.030_b0020","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1097\/PSY.0b013e3181a5a7c0","article-title":"Purpose in life is associated with mortality among community-dwelling older persons","volume":"71","author":"Boyle","year":"2009","journal-title":"Psychosomatic Med."},{"issue":"3","key":"10.1016\/j.bbi.2016.11.030_b0025","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.bbi.2003.09.011","article-title":"Socioeconomic status and stress-induced increases in interleukin-6","volume":"18","author":"Brydon","year":"2004","journal-title":"Brain Behav. Immun."},{"issue":"8","key":"10.1016\/j.bbi.2016.11.030_b0030","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1016\/j.psyneuen.2011.12.010","article-title":"Acute psychosocial stress: does the emotional stress response correspond with physiological responses?","volume":"37","author":"Campbell","year":"2012","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.bbi.2016.11.030_b0035","doi-asserted-by":"crossref","first-page":"385","DOI":"10.2307\/2136404","article-title":"A global measure of perceived stress","volume":"24","author":"Cohen","year":"1983","journal-title":"J. Health Soc. Behav."},{"key":"10.1016\/j.bbi.2016.11.030_b0040","series-title":"The Social Psychology of Health","first-page":"30","article-title":"Perceived stress in a probability sample of the United States","author":"Cohen","year":"1988"},{"issue":"4","key":"10.1016\/j.bbi.2016.11.030_b0045","doi-asserted-by":"crossref","first-page":"e78","DOI":"10.1371\/journal.pmed.0050078","article-title":"Long-term interleukin-6 levels and subsequent risk of coronary heart disease: two new prospective studies and a systematic review","volume":"5","author":"Danesh","year":"2008","journal-title":"PLoS Med."},{"issue":"4","key":"10.1016\/j.bbi.2016.11.030_b0050","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/S0031-9384(96)00465-9","article-title":"Adrenocortical responses to repeated parachute jumping and subsequent h-CRH challenge in inexperienced healthy subjects","volume":"61","author":"Deinzer","year":"1997","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.bbi.2016.11.030_b0055","series-title":"The Hypothalamus-Pituitary-Adrenal Axis","author":"del Rey","year":"2008"},{"issue":"5","key":"10.1016\/j.bbi.2016.11.030_b0060","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1159\/000127196","article-title":"Adaptation to prolonged or repeated stress\u2013comparison between rat strains showing intrinsic differences in reactivity to acute stress","volume":"65","author":"Dhabhar","year":"1997","journal-title":"Neuroendocrinology"},{"key":"10.1016\/j.bbi.2016.11.030_b0065","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1037\/0033-2909.130.3.355","article-title":"Acute stressors and cortisol responses: a theoretical integration and synthesis of laboratory research","volume":"130","author":"Dickerson","year":"2004","journal-title":"Psychol. Bull."},{"issue":"1","key":"10.1016\/j.bbi.2016.11.030_b0070","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1146\/annurev.med.51.1.245","article-title":"Age-associated increased interleukin-6 gene expression, late-life diseases, and frailty","volume":"51","author":"Ershler","year":"2000","journal-title":"Annu. Rev. Med."},{"issue":"12","key":"10.1016\/j.bbi.2016.11.030_b0075","doi-asserted-by":"crossref","first-page":"5249","DOI":"10.1210\/en.2003-0713","article-title":"Stress integration after acute and chronic predator stress: differential activation of central stress circuitry and sensitization of the hypothalamo-pituitary-adrenocortical axis","volume":"144","author":"Figueiredo","year":"2003","journal-title":"Endocrinology"},{"issue":"1","key":"10.1016\/j.bbi.2016.11.030_b0080","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.neubiorev.2010.01.010","article-title":"Human hypothalamus-pituitary-adrenal axis responses to acute psychosocial stress in laboratory settings","volume":"35","author":"Foley","year":"2010","journal-title":"Neurosci. Biobehav. Rev."},{"issue":"1","key":"10.1016\/j.bbi.2016.11.030_b0085","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/S0306-4530(00)00046-9","article-title":"Neuroendocrine responses to experimentally-induced psychological stress in healthy humans","volume":"26","author":"Gerra","year":"2001","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.bbi.2016.11.030_b0090","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/j.psyneuen.2014.07.021","article-title":"Post-stress rumination predicts HPA axis responses to repeated acute stress","volume":"49","author":"Gianferante","year":"2014","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.bbi.2016.11.030_b0095","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1002\/dev.420220304","article-title":"Lack of stability in neonatal adrenocortical reactivity because of rapid habituation of the adrenocortical response","volume":"22","author":"Gunnar","year":"1989","journal-title":"Dev. Psychobiol."},{"issue":"3","key":"10.1016\/j.bbi.2016.11.030_b0100","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1042\/bj2650621","article-title":"Interleukin-6 and the acute phase response","volume":"265","author":"Heinrich","year":"1990","journal-title":"Biochem. J."},{"issue":"2","key":"10.1016\/j.bbi.2016.11.030_b0105","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.ecl.2005.01.003","article-title":"Hypothalamic-pituitary-adrenocortical axis regulation","volume":"34","author":"Jacobson","year":"2005","journal-title":"Endocrinol. Metab. Clin. North Am."},{"issue":"3","key":"10.1016\/j.bbi.2016.11.030_b0110","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/S0306-4530(01)00057-9","article-title":"Prior stressor exposure primes the HPA axis","volume":"27","author":"Johnson","year":"2002","journal-title":"Psychoneuroendocrinology"},{"issue":"2","key":"10.1016\/j.bbi.2016.11.030_b0115","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1097\/00006842-199903000-00006","article-title":"Impact of gender, menstrual cycle phase, and oral contraceptives on the activity of the hypothalamus-pituitary-adrenal axis","volume":"61","author":"Kirschbaum","year":"1999","journal-title":"Psychosomatic Med."},{"issue":"1\u20132","key":"10.1016\/j.bbi.2016.11.030_b0120","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1159\/000119004","article-title":"The \u2018Trier Social Stress Test\u2019\u2013a tool for investigating psychobiological stress responses in a laboratory setting","volume":"28","author":"Kirschbaum","year":"1993","journal-title":"Neuropsychobiology"},{"key":"10.1016\/j.bbi.2016.11.030_b0125","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1097\/00006842-199509000-00009","article-title":"Persistent high cortisol responses to repeated psychological stress in a subpopulation of healthy men","volume":"57","author":"Kirschbaum","year":"1995","journal-title":"Psychosomatic Med."},{"key":"10.1016\/j.bbi.2016.11.030_b0130","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.psyneuen.2008.10.004","article-title":"Why do we respond so differently? Reviewing determinants of human salivary cortisol responses to challenge","volume":"24","author":"Kudielka","year":"2009","journal-title":"Psychoneuroendocrinology"},{"issue":"2","key":"10.1016\/j.bbi.2016.11.030_b0135","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.biopsycho.2005.09.001","article-title":"Exhaustion is associated with reduced habituation of free cortisol responses to repeated acute psychosocial stress","volume":"72","author":"Kudielka","year":"2006","journal-title":"Biol. Psychol."},{"issue":"5","key":"10.1016\/j.bbi.2016.11.030_b0140","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/S0889-1591(03)00029-1","article-title":"Cortisol responses to mild psychological stress are inversely associated with proinflammatory cytokines","volume":"17","author":"Kunz-Ebrecht","year":"2003","journal-title":"Brain Behav. Immun."},{"issue":"Suppl 5","key":"10.1016\/j.bbi.2016.11.030_b0145","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1097\/00006842-196809000-00022","article-title":"A review of psychoendocrine research on the sympathetic-adrenal medullary system","volume":"30","author":"Mason","year":"1968","journal-title":"Psychosomatic Med."},{"issue":"Suppl 5","key":"10.1016\/j.bbi.2016.11.030_b0150","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1097\/00006842-196809000-00021","article-title":"lasma and urinary 17-hydroxycorticosteroid responses to 72-hr. avoidance sessions in the monkey","volume":"30","author":"Mason","year":"1968","journal-title":"Psychosomatic Med."},{"issue":"3","key":"10.1016\/j.bbi.2016.11.030_b0155","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1056\/NEJM199801153380307","article-title":"Protective and damaging effects of stress mediators","volume":"338","author":"McEwen","year":"1998","journal-title":"New Engl. J. Med."},{"key":"10.1016\/j.bbi.2016.11.030_b0160","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.bbi.2014.07.018","article-title":"Measures of adiposity predict interleukin-6 responses to repeated psychosocial stress","volume":"42","author":"McInnis","year":"2014","journal-title":"Brain Behav. Immun."},{"issue":"8","key":"10.1016\/j.bbi.2016.11.030_b0165","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1016\/S0306-4530(97)00072-3","article-title":"Increasing correlations between personality traits and cortisol stress responses obtained by data aggregation","volume":"22","author":"Pruessner","year":"1997","journal-title":"Psychoneuroendocrinology"},{"issue":"3","key":"10.1016\/j.bbi.2016.11.030_b0170","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1097\/PSY.0000000000000049","article-title":"Stimulation of systemic low-grade inflammation by psychosocial stress","volume":"76","author":"Rohleder","year":"2014","journal-title":"Psychosomatic Med."},{"issue":"3","key":"10.1016\/j.bbi.2016.11.030_b0175","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/S0306-4530(02)00019-7","article-title":"Impact of oral contraceptive use on glucocorticoid sensitivity of pro-inflammatory cytokine production after psychosocial stress","volume":"28","author":"Rohleder","year":"2003","journal-title":"Psychoneuroendocrinology"},{"issue":"1","key":"10.1016\/j.bbi.2016.11.030_b0180","first-page":"55","article-title":"How do glucocorticoids influence stress responses? Integrating permissive, suppressive, stimulatory, and preparative actions","volume":"21","author":"Sapolsky","year":"2000","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.bbi.2016.11.030_b0185","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1097\/01.PSY.0000035721.12441.17","article-title":"Dissociation between reactivity of the hypothalamus-pituitary-adrenal axis and the sympathetic-adrenal-medullary system to repeated psychosocial stress","volume":"65","author":"Schommer","year":"2003","journal-title":"Psychosomatic Med."},{"issue":"4","key":"10.1016\/j.bbi.2016.11.030_b0190","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1037\/0033-2909.130.4.601","article-title":"Psychological stress and the human immune system: a meta-analytic study of 30 years of inquiry","volume":"130","author":"Segerstrom","year":"2004","journal-title":"Psychol. Bull."},{"issue":"7","key":"10.1016\/j.bbi.2016.11.030_b0195","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1016\/j.bbi.2007.03.011","article-title":"The effects of acute psychological stress on circulating inflammatory factors in humans: a review and meta-analysis","volume":"21","author":"Steptoe","year":"2007","journal-title":"Brain Behav. Immun."},{"issue":"2","key":"10.1016\/j.bbi.2016.11.030_b0200","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1042\/cs1010185","article-title":"Acute mental stress elicits delayed increases in circulating inflammatory cytokine levels","volume":"101","author":"Steptoe","year":"2001","journal-title":"Clin. Sci. (Lond.)"},{"key":"10.1016\/j.bbi.2016.11.030_b0205","series-title":"Handbook of Life Stress. Cognition, and Health","first-page":"629","article-title":"Allostasis: a new paradigm to explain arousal pathology","author":"Sterling","year":"1988"},{"key":"10.1016\/j.bbi.2016.11.030_b0210","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.bbi.2014.07.014","article-title":"Acute psychosocial stress induces differential short-term changes in catecholamine sensitivity of stimulated inflammatory cytokine production","volume":"43","author":"Strahler","year":"2015","journal-title":"Brain Behav. Immun."},{"issue":"6","key":"10.1016\/j.bbi.2016.11.030_b0215","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1159\/000097185","article-title":"Immobilization stress may increase plasma interleukin-6 via central and peripheral catecholamines","volume":"1","author":"Takaki","year":"1994","journal-title":"NeuroImmunoModulation"},{"key":"10.1016\/j.bbi.2016.11.030_b0220","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1016\/S0022-3999(02)00429-4","article-title":"Hypothalamic-pituitary-adrenal axis, neuroendocrine factors and stress","volume":"53","author":"Tsigos","year":"2002","journal-title":"J. Psychosomatic Res."},{"issue":"2","key":"10.1016\/j.bbi.2016.11.030_b0225","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/0090-1229(90)90034-N","article-title":"The relation among stress, adrenalin, interleukin 6 and acute phase proteins in the rat","volume":"57","author":"van Gool","year":"1990","journal-title":"Clin. Immunol. Immunopathol."},{"key":"10.1016\/j.bbi.2016.11.030_b0230","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.bbi.2005.03.013","article-title":"Delayed response and lack of habituation in plasma interleukin-6 to acute mental stress in men","volume":"20","author":"von Kanel","year":"2006","journal-title":"Brain Behav. Immun."},{"issue":"6","key":"10.1016\/j.bbi.2016.11.030_b0235","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1016\/j.bbi.2008.09.009","article-title":"Determinants of the NF-\u03baB response to acute psychosocial stress in humans","volume":"23","author":"Wolf","year":"2009","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.bbi.2016.11.030_b0240","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.psyneuen.2004.07.002","article-title":"Habituation of cortisol responses to repeated psychosocial stress-further characterization and impact of genetic factors","volume":"30","author":"Wust","year":"2005","journal-title":"Psychoneuroendokrinology"}],"container-title":["Brain, Behavior, and Immunity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0889159116305396?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0889159116305396?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T07:47:45Z","timestamp":1760168865000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0889159116305396"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3]]},"references-count":48,"alternative-id":["S0889159116305396"],"URL":"https:\/\/doi.org\/10.1016\/j.bbi.2016.11.030","relation":{},"ISSN":["0889-1591"],"issn-type":[{"value":"0889-1591","type":"print"}],"subject":[],"published":{"date-parts":[[2017,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Stronger hypothalamus-pituitary-adrenal axis habituation predicts lesser sensitization of inflammatory response to repeated acute stress exposures in healthy young adults","name":"articletitle","label":"Article Title"},{"value":"Brain, Behavior, and Immunity","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbi.2016.11.030","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}