{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T19:27:57Z","timestamp":1789586877056,"version":"build-2803163510"},"reference-count":113,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,3,1]],"date-time":"2017-03-01T00:00:00Z","timestamp":1488326400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,3,1]],"date-time":"2017-03-01T00:00:00Z","timestamp":1488326400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2016,12,20]],"date-time":"2016-12-20T00:00:00Z","timestamp":1482192000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain, Behavior, and Immunity"],"published-print":{"date-parts":[[2017,3]]},"DOI":"10.1016\/j.bbi.2016.12.016","type":"journal-article","created":{"date-parts":[[2016,12,20]],"date-time":"2016-12-20T11:20:24Z","timestamp":1482232824000},"page":"80-95","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":47,"special_numbering":"C","title":["Prenatal alcohol exposure potentiates chronic neuropathic pain, spinal glial and immune cell activation and alters sciatic nerve and DRG cytokine levels"],"prefix":"10.1016","volume":"61","author":[{"given":"Shahani","family":"Noor","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua J.","family":"Sanchez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arden G.","family":"Vanderwall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melody S.","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessie R.","family":"Maxwell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzy","family":"Davies","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren L.","family":"Jantzie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy R.","family":"Petersen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel D.","family":"Savage","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erin D.","family":"Milligan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.bbi.2016.12.016_b0005","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/S0741-8329(00)00076-8","article-title":"Alcohol modulates cytokine secretion and synthesis in human fetus: an in vivo and in vitro study","volume":"21","author":"Ahluwalia","year":"2000","journal-title":"Alcohol"},{"key":"10.1016\/j.bbi.2016.12.016_b0010","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1186\/1756-6606-4-29","article-title":"Fetal alcohol exposure leads to abnormal olfactory bulb development and impaired odor discrimination in adult mice","volume":"4","author":"Akers","year":"2011","journal-title":"Mol. Brain"},{"issue":"24","key":"10.1016\/j.bbi.2016.12.016_b0015","doi-asserted-by":"crossref","first-page":"8285","DOI":"10.1523\/JNEUROSCI.0976-10.2010","article-title":"Pivotal role of TLR4 receptors in alcohol-induced neuroinflammation and brain damage","volume":"30","author":"Alfonso-Loeches","year":"2010","journal-title":"J. Neurosci."},{"issue":"1\u20132","key":"10.1016\/j.bbi.2016.12.016_b0020","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1007\/s11064-015-1760-5","article-title":"Ethanol-induced TLR4\/NLRP3 neuroinflammatory response in microglial cells promotes leukocyte infiltration across the BBB","volume":"41","author":"Alfonso-Loeches","year":"2016","journal-title":"Neurochem. Res."},{"issue":"12","key":"10.1016\/j.bbi.2016.12.016_b0025","doi-asserted-by":"crossref","first-page":"2009","DOI":"10.1097\/01.ALC.0000100940.95053.72","article-title":"A mouse model of prenatal ethanol exposure using a voluntary drinking paradigm","volume":"27","author":"Allan","year":"2003","journal-title":"Alcohol. Clin. Exp. Res."},{"issue":"3","key":"10.1016\/j.bbi.2016.12.016_b0030","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1002\/jnr.22533","article-title":"Endogenous microglia regulate development of embryonic cortical precursor cells","volume":"89","author":"Antony","year":"2011","journal-title":"J. Neurosci. Res."},{"issue":"19","key":"10.1016\/j.bbi.2016.12.016_b0035","doi-asserted-by":"crossref","first-page":"16555","DOI":"10.1074\/jbc.M009068200","article-title":"Distinct signaling pathways for MCP-1-dependent integrin activation and chemotaxis","volume":"276","author":"Ashida","year":"2001","journal-title":"J. Biol. Chem."},{"issue":"9","key":"10.1016\/j.bbi.2016.12.016_b0040","doi-asserted-by":"crossref","first-page":"1916","DOI":"10.1016\/j.pain.2012.06.005","article-title":"Regulatory T cells attenuate neuropathic pain following peripheral nerve injury and experimental autoimmune neuritis","volume":"153","author":"Austin","year":"2012","journal-title":"Pain"},{"issue":"4","key":"10.1016\/j.bbi.2016.12.016_b0045","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1007\/BF02172128","article-title":"Tactile defensiveness in children with developmental disabilities: responsiveness and habituation","volume":"24","author":"Baranek","year":"1994","journal-title":"J. Autism Dev. Disord."},{"issue":"7","key":"10.1016\/j.bbi.2016.12.016_b0050","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.1111\/j.1530-0277.1998.tb03942.x","article-title":"Chronic and acute prenatal and postnatal ethanol exposure on lymphocyte subsets from offspring thymic, splenic, and intestinal intraepithelial sources","volume":"22","author":"Basham","year":"1998","journal-title":"Alcohol. Clin. Exp. Res."},{"issue":"1","key":"10.1016\/j.bbi.2016.12.016_b0055","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/0304-3959(88)90209-6","article-title":"A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man","volume":"33","author":"Bennett","year":"1988","journal-title":"Pain"},{"key":"10.1016\/j.bbi.2016.12.016_b0060","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.bbi.2016.05.022","article-title":"Evidence for an immune signature of prenatal alcohol exposure in female rats","volume":"58","author":"Bodnar","year":"2016","journal-title":"Brain Behav. Immun."},{"issue":"2","key":"10.1016\/j.bbi.2016.12.016_b0065","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.ijpsycho.2009.02.006","article-title":"The acute effect of low-dose alcohol on working memory during mental arithmetic: I. Behavioral measures and EEG theta band spectral characteristics","volume":"73","author":"Boha","year":"2009","journal-title":"Int. J. Psychophysiol."},{"key":"10.1016\/j.bbi.2016.12.016_b0070","doi-asserted-by":"crossref","first-page":"900","DOI":"10.3389\/fmicb.2015.00900","article-title":"Phenotypic changes in the brain of SIV-infected macaques exposed to methamphetamine parallel macrophage activation patterns induced by the common gamma-chain cytokine system","volume":"6","author":"Bortell","year":"2015","journal-title":"Front. Microbiol."},{"issue":"3","key":"10.1016\/j.bbi.2016.12.016_b0075","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1111\/j.1530-0277.2011.01644.x","article-title":"A limited access mouse model of prenatal alcohol exposure that produces long-lasting deficits in hippocampal-dependent learning and memory","volume":"36","author":"Brady","year":"2012","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"10.1016\/j.bbi.2016.12.016_b0080","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/j.expneurol.2014.05.014","article-title":"Chemokine CXCL1 enhances inflammatory pain and increases NMDA receptor activity and COX-2 expression in spinal cord neurons via activation of CXCR2","volume":"261","author":"Cao","year":"2014","journal-title":"Exp. Neurol."},{"issue":"2","key":"10.1016\/j.bbi.2016.12.016_b0085","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1002\/eji.200737485","article-title":"CNS-infiltrating CD4+ T lymphocytes contribute to murine spinal nerve transection-induced neuropathic pain","volume":"38","author":"Cao","year":"2008","journal-title":"Eur. J. Immunol."},{"issue":"1\u20132","key":"10.1016\/j.bbi.2016.12.016_b0090","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/S0022-1759(00)00249-0","article-title":"Flow cytometric analysis of intracellular IFN-gamma, IL-4 and IL-10 in CD3(+)4(+) T-cells from rat spleen","volume":"244","author":"Caraher","year":"2000","journal-title":"J. Immunol. Methods"},{"issue":"4","key":"10.1016\/j.bbi.2016.12.016_b0095","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/0192-0561(94)90010-8","article-title":"Mechanism of the impaired T-cell proliferation in adult rats exposed to alcohol in utero","volume":"16","author":"Chang","year":"1994","journal-title":"Int. J. Immunopharmacol."},{"issue":"11","key":"10.1016\/j.bbi.2016.12.016_b0100","doi-asserted-by":"crossref","first-page":"2053","DOI":"10.1097\/01.alc.0000187037.02670.59","article-title":"Moderate fetal alcohol exposure impairs the neurogenic response to an enriched environment in adult mice","volume":"29","author":"Choi","year":"2005","journal-title":"Alcohol. Clin. Exp. Res."},{"issue":"10","key":"10.1016\/j.bbi.2016.12.016_b0105","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1016\/j.bbadis.2009.10.012","article-title":"Murine models of human neuropathic pain","volume":"1802","author":"Colleoni","year":"2010","journal-title":"Biochim. Biophys. Acta"},{"issue":"46","key":"10.1016\/j.bbi.2016.12.016_b0110","doi-asserted-by":"crossref","first-page":"14415","DOI":"10.1523\/JNEUROSCI.4569-09.2009","article-title":"T-cell infiltration and signaling in the adult dorsal spinal cord is a major contributor to neuropathic pain-like hypersensitivity","volume":"29","author":"Costigan","year":"2009","journal-title":"J. Neurosci."},{"issue":"9","key":"10.1016\/j.bbi.2016.12.016_b0115","doi-asserted-by":"crossref","first-page":"5771","DOI":"10.4049\/jimmunol.180.9.5771","article-title":"IL-10: the master regulator of immunity to infection","volume":"180","author":"Couper","year":"2008","journal-title":"J. Immunol."},{"issue":"10","key":"10.1016\/j.bbi.2016.12.016_b0120","doi-asserted-by":"crossref","first-page":"4216","DOI":"10.1523\/JNEUROSCI.3441-12.2013","article-title":"Microglia regulate the number of neural precursor cells in the developing cerebral cortex","volume":"33","author":"Cunningham","year":"2013","journal-title":"J. Neurosci."},{"issue":"9","key":"10.1016\/j.bbi.2016.12.016_b0125","doi-asserted-by":"crossref","first-page":"2480","DOI":"10.1002\/eji.200425274","article-title":"Interleukin-2 is essential for CD4+CD25+ regulatory T cell function","volume":"34","author":"de la Rosa","year":"2004","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.bbi.2016.12.016_b0130","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1186\/1742-2094-11-92","article-title":"Improvement of spinal non-viral IL-10 gene delivery by D-mannose as a transgene adjuvant to control chronic neuropathic pain","volume":"11","author":"Dengler","year":"2014","journal-title":"J. Neuroinflamm."},{"issue":"1","key":"10.1016\/j.bbi.2016.12.016_b0135","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/S0741-8329(01)00161-6","article-title":"Prenatal exposure to ethanol alters the neuroimmune response to a central nervous system wound in the adult rat","volume":"25","author":"DeVito","year":"2001","journal-title":"Alcohol"},{"issue":"3","key":"10.1016\/j.bbi.2016.12.016_b0140","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1111\/acer.12639","article-title":"Pioglitazone blocks ethanol induction of microglial activation and immune responses in the hippocampus, cerebellum, and cerebral cortex in a mouse model of fetal alcohol spectrum disorders","volume":"39","author":"Drew","year":"2015","journal-title":"Alcohol. Clin. Exp. Res."},{"issue":"30","key":"10.1016\/j.bbi.2016.12.016_b0145","doi-asserted-by":"crossref","first-page":"10819","DOI":"10.1523\/JNEUROSCI.1642-11.2011","article-title":"Peripheral nerve injury alters blood-spinal cord barrier functional and molecular integrity through a selective inflammatory pathway","volume":"31","author":"Echeverry","year":"2011","journal-title":"J. Neurosci."},{"issue":"Pt 2","key":"10.1016\/j.bbi.2016.12.016_b0150","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1242\/jcs.019117","article-title":"Integrins in immunity","volume":"122","author":"Evans","year":"2009","journal-title":"J. Cell Sci."},{"issue":"7","key":"10.1016\/j.bbi.2016.12.016_b0155","doi-asserted-by":"crossref","first-page":"4733","DOI":"10.4049\/jimmunol.0803590","article-title":"Critical role of TLR4 response in the activation of microglia induced by ethanol","volume":"183","author":"Fernandez-Lizarbe","year":"2009","journal-title":"J. Immunol."},{"issue":"1","key":"10.1016\/j.bbi.2016.12.016_b0160","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1111\/j.1365-2567.2004.01852.x","article-title":"Conventional protein kinase C and atypical protein kinase Czeta differentially regulate macrophage production of tumour necrosis factor-alpha and interleukin-10","volume":"112","author":"Foey","year":"2004","journal-title":"Immunology"},{"issue":"9","key":"10.1016\/j.bbi.2016.12.016_b0165","doi-asserted-by":"crossref","first-page":"4309","DOI":"10.4049\/jimmunol.154.9.4309","article-title":"Normal adult ramified microglia separated from other central nervous system macrophages by flow cytometric sorting. Phenotypic differences defined and direct ex vivo antigen presentation to myelin basic protein-reactive CD4+ T cells compared","volume":"154","author":"Ford","year":"1995","journal-title":"J. Immunol."},{"issue":"3","key":"10.1016\/j.bbi.2016.12.016_b0170","doi-asserted-by":"crossref","first-page":"265","DOI":"10.5014\/ajot.62.3.265","article-title":"Children with fetal alcohol spectrum disorders: problem behaviors and sensory processing","volume":"62","author":"Franklin","year":"2008","journal-title":"Am. J. Occup. Ther."},{"issue":"7","key":"10.1016\/j.bbi.2016.12.016_b0175","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1016\/j.alcohol.2010.10.007","article-title":"Impaired perceptual judgment at low blood alcohol concentrations","volume":"45","author":"Friedman","year":"2011","journal-title":"Alcohol"},{"issue":"13","key":"10.1016\/j.bbi.2016.12.016_b0180","doi-asserted-by":"crossref","first-page":"2969","DOI":"10.1038\/npp.2015.151","article-title":"Low doses of ethanol enhance LTD-like plasticity in human motor cortex","volume":"40","author":"Fuhl","year":"2015","journal-title":"Neuropsychopharmacology"},{"issue":"3","key":"10.1016\/j.bbi.2016.12.016_b0185","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1002\/cyto.990110317","article-title":"Logarithmic amplifiers","volume":"11","author":"Gandler","year":"1990","journal-title":"Cytometry"},{"issue":"1","key":"10.1016\/j.bbi.2016.12.016_b0190","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.pharmthera.2010.01.002","article-title":"Chemokines, neuronal-glial interactions, and central processing of neuropathic pain","volume":"126","author":"Gao","year":"2010","journal-title":"Pharmacol. Ther."},{"issue":"3","key":"10.1016\/j.bbi.2016.12.016_b0195","doi-asserted-by":"crossref","first-page":"352","DOI":"10.3390\/ijms17030352","article-title":"Spinal cord T-cell infiltration in the rat spared nerve injury model: a time course study","volume":"17","author":"Gattlen","year":"2016","journal-title":"Int. J. Mol. Sci."},{"issue":"3","key":"10.1016\/j.bbi.2016.12.016_b0200","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1002\/jnr.490260307","article-title":"Prenatal alcohol exposure alters the development of sympathetic synaptic components and of nerve growth factor receptor expression selectivity in lymphoid organs","volume":"26","author":"Gottesfeld","year":"1990","journal-title":"J. Neurosci. Res."},{"issue":"3","key":"10.1016\/j.bbi.2016.12.016_b0205","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/0192-0561(94)00099-A","article-title":"Prenatal alcohol exposure selectively suppresses cell-mediated but not humoral immune responsiveness","volume":"17","author":"Gottesfeld","year":"1995","journal-title":"Int. J. Immunopharmacol."},{"issue":"7","key":"10.1016\/j.bbi.2016.12.016_b0210","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.1016\/j.bbi.2011.04.003","article-title":"Peripheral immune contributions to the maintenance of central glial activation underlying neuropathic pain","volume":"25","author":"Grace","year":"2011","journal-title":"Brain Behav. Immun."},{"issue":"2","key":"10.1016\/j.bbi.2016.12.016_b0215","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/j.bbr.2009.10.012","article-title":"Prenatal exposure to moderate levels of ethanol alters social behavior in adult rats: relationship to structural plasticity and immediate early gene expression in frontal cortex","volume":"207","author":"Hamilton","year":"2010","journal-title":"Behav. Brain Res."},{"issue":"4","key":"10.1016\/j.bbi.2016.12.016_b0220","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1111\/j.1365-3083.1991.tb01787.x","article-title":"Mechanism of calcium ionophore and phorbol ester-induced T-cell activation. Accessory cell requirement for T-cell activation","volume":"33","author":"Hashimoto","year":"1991","journal-title":"Scand. J. Immunol."},{"issue":"6","key":"10.1016\/j.bbi.2016.12.016_b0225","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1016\/j.neubiorev.2009.06.004","article-title":"Prenatal alcohol exposure: fetal programming and later life vulnerability to stress, depression and anxiety disorders","volume":"34","author":"Hellemans","year":"2010","journal-title":"Neurosci. Biobehav. Rev."},{"issue":"8","key":"10.1016\/j.bbi.2016.12.016_b0230","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1038\/ni.2638","article-title":"Origin of monocytes and macrophages in a committed progenitor","volume":"14","author":"Hettinger","year":"2013","journal-title":"Nat. Immunol."},{"issue":"4","key":"10.1016\/j.bbi.2016.12.016_b0235","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1016\/j.neubiorev.2009.10.011","article-title":"The mirror-image pain: an unclered phenomenon and its possible mechanism","volume":"34","author":"Huang","year":"2010","journal-title":"Neurosci. Biobehav. Rev."},{"issue":"3","key":"10.1016\/j.bbi.2016.12.016_b0240","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1124\/pr.110.004135","article-title":"Exploring the neuroimmunopharmacology of opioids: an integrative review of mechanisms of central immune signaling and their implications for opioid analgesia","volume":"63","author":"Hutchinson","year":"2011","journal-title":"Pharmacol. Rev."},{"issue":"1","key":"10.1016\/j.bbi.2016.12.016_b0245","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1472-8206.2009.00801.x","article-title":"Animal models of neuropathic pain","volume":"25","author":"Jaggi","year":"2011","journal-title":"Fundam. Clin. Pharmacol."},{"issue":"3","key":"10.1016\/j.bbi.2016.12.016_b0250","doi-asserted-by":"crossref","first-page":"123","DOI":"10.5214\/ans.0972.7531.11183010","article-title":"Signaling mechanisms in mirror image pain pathogenesis","volume":"18","author":"Jancalek","year":"2011","journal-title":"Ann. Neurosci."},{"key":"10.1016\/j.bbi.2016.12.016_b0255","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1146\/annurev.immunol.25.022106.141623","article-title":"Regulatory T cells: mechanisms of differentiation and function","volume":"30","author":"Josefowicz","year":"2012","journal-title":"Annu. Rev. Immunol."},{"issue":"7","key":"10.1016\/j.bbi.2016.12.016_b0260","doi-asserted-by":"crossref","first-page":"3513","DOI":"10.4049\/jimmunol.160.7.3513","article-title":"IL-17 stimulates the production and expression of proinflammatory cytokines, IL-beta and TNF-alpha, by human macrophages","volume":"160","author":"Jovanovic","year":"1998","journal-title":"J. Immunol."},{"issue":"10","key":"10.1016\/j.bbi.2016.12.016_b0265","doi-asserted-by":"crossref","first-page":"1302","DOI":"10.1002\/dneu.22035","article-title":"Neuroimmune mechanisms in fetal alcohol spectrum disorder","volume":"72","author":"Kane","year":"2012","journal-title":"Dev. Neurobiol."},{"key":"10.1016\/j.bbi.2016.12.016_b0270","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.brainres.2011.06.022","article-title":"Detailed characterization of neuro-immune responses following neuropathic injury in mice","volume":"1405","author":"Kim","year":"2011","journal-title":"Brain Res."},{"issue":"1\u20132","key":"10.1016\/j.bbi.2016.12.016_b0275","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.jneuroim.2003.12.013","article-title":"The extent of cytokine induction in peripheral nerve lesions depends on the mode of injury and NMDA receptor signaling","volume":"149","author":"Kleinschnitz","year":"2004","journal-title":"J. Neuroimmunol."},{"issue":"2","key":"10.1016\/j.bbi.2016.12.016_b0280","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1016\/j.expneurol.2006.03.014","article-title":"T cell infiltration after chronic constriction injury of mouse sciatic nerve is associated with interleukin-17 expression","volume":"200","author":"Kleinschnitz","year":"2006","journal-title":"Exp. Neurol."},{"issue":"1","key":"10.1016\/j.bbi.2016.12.016_b0285","first-page":"29","article-title":"Focus on: epigenetics and fetal alcohol spectrum disorders","volume":"34","author":"Kobor","year":"2011","journal-title":"Alcohol Res. Health"},{"issue":"3","key":"10.1016\/j.bbi.2016.12.016_b0290","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/S0166-2236(98)01302-2","article-title":"Does the right side know what the left is doing?","volume":"22","author":"Koltzenburg","year":"1999","journal-title":"Trends Neurosci."},{"issue":"1","key":"10.1016\/j.bbi.2016.12.016_b0295","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1007\/s004010000257","article-title":"Prenatal exposure to ethanol induces leptomeningeal heterotopia in the cerebral cortex of the rat fetus","volume":"101","author":"Komatsu","year":"2001","journal-title":"Acta Neuropathol."},{"issue":"1","key":"10.1016\/j.bbi.2016.12.016_b0300","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.immuni.2013.01.004","article-title":"Interleukin-2 at the crossroads of effector responses, tolerance, and immunotherapy","volume":"38","author":"Liao","year":"2013","journal-title":"Immunity"},{"issue":"10","key":"10.1016\/j.bbi.2016.12.016_b0305","doi-asserted-by":"crossref","first-page":"4917","DOI":"10.1016\/j.bbagen.2013.06.033","article-title":"CCL2 increases alphavbeta3 integrin expression and subsequently promotes prostate cancer migration","volume":"1830","author":"Lin","year":"2013","journal-title":"Biochim. Biophys. Acta"},{"issue":"1","key":"10.1016\/j.bbi.2016.12.016_b0310","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1177\/0300985813506918","article-title":"Multispectral imaging: a review of its technical aspects and applications in anatomic pathology","volume":"51","author":"Mansfield","year":"2014","journal-title":"Vet. Pathol."},{"issue":"12","key":"10.1016\/j.bbi.2016.12.016_b0315","doi-asserted-by":"crossref","first-page":"1378","DOI":"10.1016\/j.placenta.2015.10.009","article-title":"Combined in utero hypoxia-ischemia and lipopolysaccharide administration in rats induces chorioamnionitis and a fetal inflammatory response syndrome","volume":"36","author":"Maxwell","year":"2015","journal-title":"Placenta"},{"issue":"8","key":"10.1016\/j.bbi.2016.12.016_b0320","doi-asserted-by":"crossref","first-page":"2808","DOI":"10.1523\/JNEUROSCI.21-08-02808.2001","article-title":"Intrathecal HIV-1 envelope glycoprotein gp120 induces enhanced pain states mediated by spinal cord proinflammatory cytokines","volume":"21","author":"Milligan","year":"2001","journal-title":"J. Neurosci."},{"issue":"1","key":"10.1016\/j.bbi.2016.12.016_b0325","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1038\/nrn2533","article-title":"Pathological and protective roles of glia in chronic pain","volume":"10","author":"Milligan","year":"2009","journal-title":"Nat. Rev. Neurosci."},{"issue":"7","key":"10.1016\/j.bbi.2016.12.016_b0330","doi-asserted-by":"crossref","first-page":"3850","DOI":"10.4049\/jimmunol.170.7.3850","article-title":"The extracellular matrix and cytokines regulate microglial integrin expression and activation","volume":"170","author":"Milner","year":"2003","journal-title":"J. Immunol."},{"key":"10.1016\/j.bbi.2016.12.016_b0335","doi-asserted-by":"crossref","DOI":"10.1111\/acer.13208","article-title":"Impact of the innate immune response in the actions of ethanol on the central nervous system","author":"Montesinos","year":"2016","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"10.1016\/j.bbi.2016.12.016_b0340","doi-asserted-by":"crossref","DOI":"10.1002\/0471142735.im1402s83","article-title":"Activation of murine macrophages","author":"Mosser","year":"2008","journal-title":"Curr. Protoc. Immunol."},{"issue":"1","key":"10.1016\/j.bbi.2016.12.016_b0345","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.neulet.2006.10.062","article-title":"Involvement of microglia in the ethanol-induced neuropathic pain-like state in the rat","volume":"414","author":"Narita","year":"2007","journal-title":"Neurosci. Lett."},{"issue":"3","key":"10.1016\/j.bbi.2016.12.016_b0350","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1111\/j.1530-0277.1991.tb00541.x","article-title":"Changes with age in the proliferative response of splenic T cells from rats exposed to ethanol in utero","volume":"15","author":"Norman","year":"1991","journal-title":"Alcohol. Clin. Exp. Res."},{"issue":"3","key":"10.1016\/j.bbi.2016.12.016_b0355","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1016\/S0306-4522(00)00396-1","article-title":"Hyperalgesia due to nerve injury: role of neutrophils","volume":"101","author":"Perkins","year":"2000","journal-title":"Neuroscience"},{"issue":"Pt 4","key":"10.1016\/j.bbi.2016.12.016_b0360","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1093\/brain\/awh407","article-title":"Involvement of monocyte chemoattractant protein-1, macrophage inflammatory protein-1alpha and interleukin-1beta in Wallerian degeneration","volume":"128","author":"Perrin","year":"2005","journal-title":"Brain"},{"key":"10.1016\/j.bbi.2016.12.016_b0365","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1186\/s13072-016-0074-4","article-title":"DNA methylation signature of human fetal alcohol spectrum disorder","volume":"9","author":"Portales-Casamar","year":"2016","journal-title":"Epigenetics Chromatin"},{"key":"10.1016\/j.bbi.2016.12.016_b0370","series-title":"Introduction to Biophotonics","author":"Prasad","year":"2004"},{"issue":"7","key":"10.1016\/j.bbi.2016.12.016_b0375","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1038\/nri1130","article-title":"Three or more routes for leukocyte migration into the central nervous system","volume":"3","author":"Ransohoff","year":"2003","journal-title":"Nat. Rev. Immunol."},{"issue":"3","key":"10.1016\/j.bbi.2016.12.016_b0380","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1111\/j.1530-0277.1989.tb00350.x","article-title":"Alcohol exposure in utero results in diminished T-cell function and alterations in brain corticotropin-releasing factor and ACTH content","volume":"13","author":"Redei","year":"1989","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"10.1016\/j.bbi.2016.12.016_b0385","article-title":"Microstructural and microglial changes after repetitive mild traumatic brain injury in mice","author":"Robinson","year":"2016","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.bbi.2016.12.016_b0390","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.brainres.2008.05.004","article-title":"A comparison of spinal Iba1 and GFAP expression in rodent models of acute and chronic pain","volume":"1219","author":"Romero-Sandoval","year":"2008","journal-title":"Brain Res."},{"issue":"7","key":"10.1016\/j.bbi.2016.12.016_b0395","first-page":"726","article-title":"Neuroimmune interactions and pain: focus on glial-modulating targets","volume":"9","author":"Romero-Sandoval","year":"2008","journal-title":"Curr. Opin. Investig. Drugs"},{"issue":"12","key":"10.1016\/j.bbi.2016.12.016_b0400","doi-asserted-by":"crossref","first-page":"2465","DOI":"10.1084\/jem.20110434","article-title":"Th17 lymphocytes traffic to the central nervous system independently of alpha4 integrin expression during EAE","volume":"208","author":"Rothhammer","year":"2011","journal-title":"J. Exp. Med."},{"issue":"1\u20132","key":"10.1016\/j.bbi.2016.12.016_b0405","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/S0165-5728(02)00281-3","article-title":"Contralateral non-operated nerve to transected rat sciatic nerve shows increased expression of IL-1beta, TGF-beta1, TNF-alpha, and IL-10","volume":"132","author":"Ruohonen","year":"2002","journal-title":"J. Neuroimmunol."},{"issue":"5","key":"10.1016\/j.bbi.2016.12.016_b0410","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.cytogfr.2010.09.002","article-title":"Biology of interleukin-10","volume":"21","author":"Sabat","year":"2010","journal-title":"Cytokine Growth Factor Rev."},{"issue":"10","key":"10.1016\/j.bbi.2016.12.016_b0415","doi-asserted-by":"crossref","first-page":"1793","DOI":"10.1111\/j.1530-0277.2010.01266.x","article-title":"Effects of a novel cognition-enhancing agent on fetal ethanol-induced learning deficits","volume":"34","author":"Savage","year":"2010","journal-title":"Alcohol. Clin. Exp. Res."},{"issue":"7","key":"10.1016\/j.bbi.2016.12.016_b0420","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1016\/j.jflm.2013.06.023","article-title":"Saccadic eye movements after low-dose oral alcohol exposure","volume":"20","author":"Schmitt","year":"2013","journal-title":"J. Forensic Leg. Med."},{"issue":"2","key":"10.1016\/j.bbi.2016.12.016_b0425","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1007\/s11065-011-9168-8","article-title":"The effects of prenatal alcohol exposure on behavior: rodent and primate studies","volume":"21","author":"Schneider","year":"2011","journal-title":"Neuropsychol. Rev."},{"issue":"9","key":"10.1016\/j.bbi.2016.12.016_b0430","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.1097\/01.alc.0000179409.80370.25","article-title":"Moderate-level prenatal alcohol exposure alters striatal dopamine system function in rhesus monkeys","volume":"29","author":"Schneider","year":"2005","journal-title":"Alcohol. Clin. Exp. Res."},{"issue":"1","key":"10.1016\/j.bbi.2016.12.016_b0435","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1111\/j.1467-8624.2007.01113.x","article-title":"Sensory processing disorder in a primate model: evidence from a longitudinal study of prenatal alcohol and prenatal stress effects","volume":"79","author":"Schneider","year":"2008","journal-title":"Child Dev."},{"issue":"11","key":"10.1016\/j.bbi.2016.12.016_b0440","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1038\/nn1992","article-title":"The neuropathic pain triad: neurons, immune cells and glia","volume":"10","author":"Scholz","year":"2007","journal-title":"Nat. Neurosci."},{"issue":"3","key":"10.1016\/j.bbi.2016.12.016_b0445","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1002\/cyto.1102","article-title":"Evaluation of monensin and brefeldin A for flow cytometric determination of interleukin-1 beta, interleukin-6, and tumor necrosis factor-alpha in monocytes","volume":"46","author":"Schuerwegh","year":"2001","journal-title":"Cytometry"},{"issue":"1","key":"10.1016\/j.bbi.2016.12.016_b0450","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1002\/jbm.a.31863","article-title":"Cytokine profiling using monocytes\/macrophages cultured on common biomaterials with a range of surface chemistries","volume":"88","author":"Schutte","year":"2009","journal-title":"J. Biomed. Mater. Res. A"},{"issue":"16","key":"10.1016\/j.bbi.2016.12.016_b0455","doi-asserted-by":"crossref","first-page":"7438","DOI":"10.1073\/pnas.88.16.7438","article-title":"Isolation and direct characterization of resident microglial cells from the normal and inflamed central nervous system","volume":"88","author":"Sedgwick","year":"1991","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"issue":"5","key":"10.1016\/j.bbi.2016.12.016_b0460","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1007\/s11095-010-0077-y","article-title":"Release of plasmid DNA-encoding IL-10 from PLGA microparticles facilitates long-term reversal of neuropathic pain following a single intrathecal administration","volume":"27","author":"Soderquist","year":"2010","journal-title":"Pharm. Res."},{"issue":"8","key":"10.1016\/j.bbi.2016.12.016_b0465","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1038\/nn.4053","article-title":"Different immune cells mediate mechanical pain hypersensitivity in male and female mice","volume":"18","author":"Sorge","year":"2015","journal-title":"Nat. Neurosci."},{"issue":"7","key":"10.1016\/j.bbi.2016.12.016_b0470","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1016\/j.jpain.2004.06.006","article-title":"Spinal gap junctions: potential involvement in pain facilitation","volume":"5","author":"Spataro","year":"2004","journal-title":"J. Pain"},{"issue":"5","key":"10.1016\/j.bbi.2016.12.016_b0475","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1016\/j.celrep.2014.07.042","article-title":"Microglia modulate wiring of the embryonic forebrain","volume":"8","author":"Squarzoni","year":"2014","journal-title":"Cell Rep."},{"issue":"8","key":"10.1016\/j.bbi.2016.12.016_b0480","doi-asserted-by":"crossref","first-page":"4137","DOI":"10.4049\/jimmunol.167.8.4137","article-title":"Cutting edge: IL-17F, a novel cytokine selectively expressed in activated T cells and monocytes, regulates angiogenesis and endothelial cell cytokine production","volume":"167","author":"Starnes","year":"2001","journal-title":"J. Immunol."},{"issue":"1\u20132","key":"10.1016\/j.bbi.2016.12.016_b0485","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/S0165-5728(02)00036-X","article-title":"The differential role of spinal MHC class II and cellular adhesion molecules in peripheral inflammatory versus neuropathic pain in rodents","volume":"125","author":"Sweitzer","year":"2002","journal-title":"J. Neuroimmunol."},{"issue":"2","key":"10.1016\/j.bbi.2016.12.016_b0490","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1046\/j.1529-8027.2000.00009.x","article-title":"Increased expression of chemokines (MCP-1, MIP-1alpha, RANTES) after peripheral nerve transection","volume":"5","author":"Taskinen","year":"2000","journal-title":"J. Peripher. Nerv. Syst."},{"issue":"2","key":"10.1016\/j.bbi.2016.12.016_b0495","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.bbi.2006.07.001","article-title":"Efficacy of propentofylline, a glial modulating agent, on existing mechanical allodynia following peripheral nerve injury","volume":"21","author":"Tawfik","year":"2007","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.bbi.2016.12.016_b0500","doi-asserted-by":"crossref","DOI":"10.1007\/s11481-016-9691-8","article-title":"Effects of moderate prenatal alcohol exposure during early gestation in rats on inflammation across the maternal-fetal-immune interface and later-life immune function in the offspring","author":"Terasaki","year":"2016","journal-title":"J. Neuroimm. Pharmacol."},{"issue":"3","key":"10.1016\/j.bbi.2016.12.016_b0505","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1111\/j.1530-0277.1992.tb01396.x","article-title":"Alterations in brain polyribosomal RNA translation and lymphocyte proliferation in prenatal ethanol-exposed rats","volume":"16","author":"Tewari","year":"1992","journal-title":"Alcohol. Clin. Exp. Res."},{"issue":"4","key":"10.1016\/j.bbi.2016.12.016_b0510","first-page":"678","article-title":"Resveratrol prevents alcohol-induced cognitive deficits and brain damage by blocking inflammatory signaling and cell death cascade in neonatal rat brain","volume":"117","author":"Tiwari","year":"2011","journal-title":"J. Neurochem."},{"key":"10.1016\/j.bbi.2016.12.016_b0515","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1186\/s12974-015-0382-9","article-title":"Exposure of neonatal rats to alcohol has differential effects on neuroinflammation and neuronal survival in the cerebellum and hippocampus","volume":"12","author":"Topper","year":"2015","journal-title":"J. Neuroinflam."},{"issue":"5","key":"10.1016\/j.bbi.2016.12.016_b0520","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/j.tins.2012.01.006","article-title":"Does moderate drinking harm the fetal brain? Insights from animal models","volume":"35","author":"Valenzuela","year":"2012","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.bbi.2016.12.016_b0525","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.jim.2014.07.012","article-title":"Blockade of LFA-1 augments in vitro differentiation of antigen-induced Foxp3(+) Treg cells","volume":"414","author":"Verhagen","year":"2014","journal-title":"J. Immunol. Methods"},{"issue":"4","key":"10.1016\/j.bbi.2016.12.016_b0530","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1002\/1521-4141(200104)31:4<1173::AID-IMMU1173>3.0.CO;2-9","article-title":"The complement receptor 3, CR3 (CD11b\/CD18), on T lymphocytes: activation-dependent up-regulation and regulatory function","volume":"31","author":"Wagner","year":"2001","journal-title":"Eur. J. Immunol."},{"issue":"6","key":"10.1016\/j.bbi.2016.12.016_b0535","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1007\/BF02151901","article-title":"Tyrosine hydroxylase-containing neurons in the spinal cord of the chicken. I. Development and analysis of catecholamine synthesis capabilities","volume":"16","author":"Wallace","year":"1996","journal-title":"Cell. Mol. Neurobiol."},{"issue":"4","key":"10.1016\/j.bbi.2016.12.016_b0540","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1016\/j.bbrc.2006.12.104","article-title":"A critical role of LFA-1 in the development of Th17 cells and induction of experimental autoimmune encephalomyelytis","volume":"353","author":"Wang","year":"2007","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"4","key":"10.1016\/j.bbi.2016.12.016_b0545","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1111\/j.1365-2826.2008.01669.x","article-title":"Prenatal alcohol exposure: foetal programming, the hypothalamic-pituitary-adrenal axis and sex differences in outcome","volume":"20","author":"Weinberg","year":"2008","journal-title":"J. Neuroendocrinol."},{"issue":"5","key":"10.1016\/j.bbi.2016.12.016_b0550","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1016\/j.pain.2012.02.015","article-title":"Intrathecal cannabilactone CB(2)R agonist, AM1710, controls pathological pain and restores basal cytokine levels","volume":"153","author":"Wilkerson","year":"2012","journal-title":"Pain"},{"issue":"2","key":"10.1016\/j.bbi.2016.12.016_b0555","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1002\/brb3.44","article-title":"Immunofluorescent spectral analysis reveals the intrathecal cannabinoid agonist, AM1241, produces spinal anti-inflammatory cytokine responses in neuropathic rats exhibiting relief from allodynia","volume":"2","author":"Wilkerson","year":"2012","journal-title":"Brain Behav."},{"issue":"4","key":"10.1016\/j.bbi.2016.12.016_b0560","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1111\/j.1365-2567.2011.03549.x","article-title":"Integrin signalling and function in immune cells","volume":"135","author":"Zhang","year":"2012","journal-title":"Immunology"},{"issue":"10","key":"10.1016\/j.bbi.2016.12.016_b0565","doi-asserted-by":"crossref","first-page":"2185","DOI":"10.1016\/j.pain.2013.07.002","article-title":"Chemokine contribution to neuropathic pain: respective induction of CXCL1 and CXCR2 in spinal cord astrocytes and neurons","volume":"154","author":"Zhang","year":"2013","journal-title":"Pain"}],"container-title":["Brain, Behavior, and Immunity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0889159116305621?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0889159116305621?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T07:46:19Z","timestamp":1760168779000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0889159116305621"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3]]},"references-count":113,"alternative-id":["S0889159116305621"],"URL":"https:\/\/doi.org\/10.1016\/j.bbi.2016.12.016","relation":{},"ISSN":["0889-1591"],"issn-type":[{"value":"0889-1591","type":"print"}],"subject":[],"published":{"date-parts":[[2017,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Prenatal alcohol exposure potentiates chronic neuropathic pain, spinal glial and immune cell activation and alters sciatic nerve and DRG cytokine levels","name":"articletitle","label":"Article Title"},{"value":"Brain, Behavior, and Immunity","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbi.2016.12.016","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}