{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T03:00:38Z","timestamp":1780542038693,"version":"3.54.1"},"reference-count":39,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,5,1]],"date-time":"2017-05-01T00:00:00Z","timestamp":1493596800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,5,1]],"date-time":"2017-05-01T00:00:00Z","timestamp":1493596800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain, Behavior, and Immunity"],"published-print":{"date-parts":[[2017,5]]},"DOI":"10.1016\/j.bbi.2017.02.014","type":"journal-article","created":{"date-parts":[[2017,2,22]],"date-time":"2017-02-22T01:15:27Z","timestamp":1487726127000},"page":"291-305","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":34,"special_numbering":"C","title":["Activation of NLRP3 inflammasome by cholesterol crystals in alcohol consumption induces atherosclerotic lesions"],"prefix":"10.1016","volume":"62","author":[{"given":"P.M.","family":"Abdul Muneer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saleena","family":"Alikunju","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vikas","family":"Mishra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heather","family":"Schuetz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam M.","family":"Szlachetka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellen L.","family":"Burnham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Haorah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbi.2017.02.014_b0005","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/1750-1326-6-23","article-title":"Impairment of brain endothelial glucose transporter by methamphetamine causes blood-brain barrier dysfunction","volume":"6","author":"Abdul Muneer","year":"2011","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.bbi.2017.02.014_b0010","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1161\/ATVBAHA.112.247668","article-title":"The mechanisms of cerebral vascular dysfunction and neuroinflammation by MMP-mediated degradation of VEGFR-2 in alcohol ingestion","volume":"32","author":"Abdul Muneer","year":"2012","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.bbi.2017.02.014_b0015","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.jacl.2010.03.003","article-title":"Cholesterol crystals piercing the arterial plaque and intima trigger local and systemic inflammation","volume":"4","author":"Abela","year":"2010","journal-title":"J. Clin. Lipidol."},{"issue":"Suppl 1","key":"10.1016\/j.bbi.2017.02.014_b0020","doi-asserted-by":"crossref","first-page":"S129","DOI":"10.1016\/j.bbi.2011.01.007","article-title":"The inflammatory footprints of alcohol-induced oxidative damage in neurovascular components","volume":"25","author":"Alikunju","year":"2011","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.bbi.2017.02.014_b0025","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1161\/STROKEAHA.109.564781","article-title":"Coronary heart disease risk in patients with stroke or transient ischemic attack and no known coronary heart disease: findings from the Stroke Prevention by Aggressive Reduction in Cholesterol Levels (SPARCL) trial","volume":"41","author":"Amarenco","year":"2010","journal-title":"Stroke"},{"key":"10.1016\/j.bbi.2017.02.014_b0030","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1093\/oxfordjournals.aje.a114141","article-title":"Alcohol consumption and high density lipoprotein cholesterol concentration among alcoholics","volume":"122","author":"Dai","year":"1985","journal-title":"Am. J. Epidemiol."},{"key":"10.1016\/j.bbi.2017.02.014_b0035","doi-asserted-by":"crossref","first-page":"1612","DOI":"10.1016\/S0140-6736(08)60694-7","article-title":"Stroke","volume":"371","author":"Donnan","year":"2008","journal-title":"Lancet"},{"key":"10.1016\/j.bbi.2017.02.014_b0040","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1038\/nature08938","article-title":"NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals","volume":"464","author":"Duewell","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.bbi.2017.02.014_b0045","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1007\/978-1-60761-247-6_6","article-title":"Ischemic stroke in mice and rats","volume":"573","author":"Durukan","year":"2009","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.bbi.2017.02.014_b0050","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1007\/s11481-010-9213-z","article-title":"Alcohol-induced interactive phosphorylation of Src and toll-like receptor regulates the secretion of inflammatory mediators by human astrocytes","volume":"5","author":"Floreani","year":"2010","journal-title":"J. Neuroimmune Pharmacol."},{"key":"10.1016\/j.bbi.2017.02.014_b0055","doi-asserted-by":"crossref","first-page":"2040","DOI":"10.1002\/eji.201041316","article-title":"Nrf2 is essential for cholesterol crystal-induced inflammasome activation and exacerbation of atherosclerosis","volume":"41","author":"Freigang","year":"2011","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.bbi.2017.02.014_b0060","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1161\/01.ATV.16.8.1000","article-title":"Interleukin-1 beta in coronary arteries of patients with ischemic heart disease","volume":"16","author":"Galea","year":"1996","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.bbi.2017.02.014_b0065","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1146\/annurev.immunol.021908.132620","article-title":"Immune and inflammatory mechanisms of atherosclerosis (\u2217)","volume":"27","author":"Galkina","year":"2009","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.bbi.2017.02.014_b0070","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1111\/j.1471-4159.2006.04393.x","article-title":"Oxidative stress activates protein tyrosine kinase and matrix metalloproteinases leading to blood-brain barrier dysfunction","volume":"101","author":"Haorah","year":"2007","journal-title":"J. Neurochem."},{"key":"10.1016\/j.bbi.2017.02.014_b0075","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1111\/j.1471-4159.2006.04245.x","article-title":"Alcohol-induced blood-brain barrier dysfunction is mediated via inositol 1,4,5-triphosphate receptor (IP3R)-gated intracellular calcium release","volume":"100","author":"Haorah","year":"2007","journal-title":"J. Neurochem."},{"key":"10.1016\/j.bbi.2017.02.014_b0080","doi-asserted-by":"crossref","first-page":"1542","DOI":"10.1016\/j.freeradbiomed.2008.08.030","article-title":"Mechanism of alcohol-induced oxidative stress and neuronal injury","volume":"45","author":"Haorah","year":"2008","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.bbi.2017.02.014_b0085","doi-asserted-by":"crossref","first-page":"1601","DOI":"10.1016\/j.freeradbiomed.2011.06.020","article-title":"Stabilization of superoxide dismutase by acetyl-l-carnitine in human brain endothelium during alcohol exposure: novel protective approach","volume":"51","author":"Haorah","year":"2011","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.bbi.2017.02.014_b0090","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1161\/01.STR.0000053849.09308.B2","article-title":"Interleukin-6 promoter polymorphism modulates the effects of heavy alcohol consumption on early carotid artery atherosclerosis: the Carotid Atherosclerosis Progression Study (CAPS)","volume":"34","author":"Jerrard-Dunne","year":"2003","journal-title":"Stroke"},{"key":"10.1016\/j.bbi.2017.02.014_b0095","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1161\/01.STR.29.5.900","article-title":"Alcohol consumption and atherosclerosis: what is the relation? Prospective results from the Bruneck Study","volume":"29","author":"Kiechl","year":"1998","journal-title":"Stroke"},{"issue":"III","key":"10.1016\/j.bbi.2017.02.014_b0100","first-page":"67","article-title":"The relationship between alcohol consumption, liver enzymes and high-density lipoprotein cholesterol","volume":"64","author":"LaPorte","year":"1981","journal-title":"Circulation"},{"key":"10.1016\/j.bbi.2017.02.014_b0105","doi-asserted-by":"crossref","first-page":"3385","DOI":"10.1039\/c2cc17852d","article-title":"Synthesis of beta-cyclodextrin conjugated superparamagnetic iron oxide nanoparticles for selective binding and detection of cholesterol crystals","volume":"48","author":"Li","year":"2012","journal-title":"Chem. Commun. (Camb)"},{"key":"10.1016\/j.bbi.2017.02.014_b0110","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/S1097-2765(02)00599-3","article-title":"The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta","volume":"10","author":"Martinon","year":"2002","journal-title":"Mol. Cell"},{"key":"10.1016\/j.bbi.2017.02.014_b0115","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1146\/annurev.immunol.021908.132715","article-title":"The inflammasomes: guardians of the body","volume":"27","author":"Martinon","year":"2009","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.bbi.2017.02.014_b0120","doi-asserted-by":"crossref","first-page":"1845","DOI":"10.1161\/STROKEAHA.110.580092","article-title":"Alcohol and acute ischemic stroke onset: the stroke onset study","volume":"41","author":"Mostofsky","year":"2010","journal-title":"Stroke"},{"key":"10.1016\/j.bbi.2017.02.014_b0125","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/0361-9230(81)90085-X","article-title":"Alcohol's effect on body temperature: hypothermia, hyperthermia or poikilothermia?","volume":"7","author":"Myers","year":"1981","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.bbi.2017.02.014_b0130","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1186\/1471-2458-10-258","article-title":"Alcohol consumption and the risk of morbidity and mortality for different stroke types\u2013a systematic review and meta-analysis","volume":"10","author":"Patra","year":"2010","journal-title":"BMC Public Health"},{"key":"10.1016\/j.bbi.2017.02.014_b0135","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1038\/sj.mp.4000805","article-title":"Acetyl-L-carnitine physical-chemical, metabolic, and therapeutic properties: relevance for its mode of action in Alzheimer's disease and geriatric depression","volume":"5","author":"Pettegrew","year":"2000","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.bbi.2017.02.014_b0140","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1111\/j.1464-5491.2004.01384.x","article-title":"The J-shape effect of alcohol intake on the risk of developing acute coronary syndromes in diabetic subjects: the CARDIO2000 II Study","volume":"22","author":"Pitsavos","year":"2005","journal-title":"Diabetes Med."},{"key":"10.1016\/j.bbi.2017.02.014_b0145","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1111\/acer.12250","article-title":"Alcohol consumption, heavy drinking, and mortality: rethinking the j-shaped curve","volume":"38","author":"Plunk","year":"2014","journal-title":"Alcohol Clin. Exp. Res."},{"key":"10.1016\/j.bbi.2017.02.014_b0150","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1161\/STROKEAHA.110.580811","article-title":"Atorvastatin reduces macrophage accumulation in atherosclerotic plaques: a comparison of a nonstatin-based regimen in patients undergoing carotid endarterectomy","volume":"41","author":"Puato","year":"2010","journal-title":"Stroke"},{"key":"10.1016\/j.bbi.2017.02.014_b0155","doi-asserted-by":"crossref","first-page":"e11765","DOI":"10.1371\/journal.pone.0011765","article-title":"Cholesterol crystals activate the NLRP3 inflammasome in human macrophages: a novel link between cholesterol metabolism and inflammation","volume":"5","author":"Rajamaki","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.bbi.2017.02.014_b0160","doi-asserted-by":"crossref","first-page":"2354","DOI":"10.1161\/STROKEAHA.107.496737","article-title":"Microemboli composed of cholesterol crystals disrupt the blood-brain barrier and reduce cognition","volume":"39","author":"Rapp","year":"2008","journal-title":"Stroke"},{"key":"10.1016\/j.bbi.2017.02.014_b0165","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1186\/1476-511X-9-86","article-title":"Interactions of the apolipoprotein C-III 3238C>G polymorphism and alcohol consumption on serum triglyceride levels","volume":"9","author":"Ruixing","year":"2010","journal-title":"Lipids Health Dis."},{"key":"10.1016\/j.bbi.2017.02.014_b0170","doi-asserted-by":"crossref","first-page":"1494","DOI":"10.1016\/j.freeradbiomed.2010.08.011","article-title":"Acetyl-L-carnitine protects neuronal function from alcohol-induced oxidative damage in the brain","volume":"49","author":"Rump","year":"2010","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.bbi.2017.02.014_b0175","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/0021-9150(84)90194-1","article-title":"Accelerated turnover of very low density lipoprotein triglycerides in chronic alcohol users. A possible mechanism for the up-regulation of high density lipoprotein by ethanol","volume":"53","author":"Sane","year":"1984","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.bbi.2017.02.014_b0180","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1161\/01.STR.11.2.184","article-title":"Cholesterol crystal embolization in rat brain: a model for atheroembolic cerebral infarction","volume":"11","author":"Steiner","year":"1980","journal-title":"Stroke"},{"key":"10.1016\/j.bbi.2017.02.014_b0185","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1152\/physrev.00024.2005","article-title":"Cytokines in atherosclerosis: pathogenic and regulatory pathways","volume":"86","author":"Tedgui","year":"2006","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.bbi.2017.02.014_b0190","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1038\/356768a0","article-title":"A novel heterodimeric cysteine protease is required for interleukin-1 beta processing in monocytes","volume":"356","author":"Thornberry","year":"1992","journal-title":"Nature"},{"key":"10.1016\/j.bbi.2017.02.014_b0195","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1038\/nri2725","article-title":"NLRP3 inflammasome activation: the convergence of multiple signalling pathways on ROS production?","volume":"10","author":"Tschopp","year":"2010","journal-title":"Nat. Rev. Immunol."}],"container-title":["Brain, Behavior, and Immunity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0889159117300569?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0889159117300569?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,2,24]],"date-time":"2025-02-24T21:27:57Z","timestamp":1740432477000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0889159117300569"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,5]]},"references-count":39,"alternative-id":["S0889159117300569"],"URL":"https:\/\/doi.org\/10.1016\/j.bbi.2017.02.014","relation":{},"ISSN":["0889-1591"],"issn-type":[{"value":"0889-1591","type":"print"}],"subject":[],"published":{"date-parts":[[2017,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Activation of NLRP3 inflammasome by cholesterol crystals in alcohol consumption induces atherosclerotic lesions","name":"articletitle","label":"Article Title"},{"value":"Brain, Behavior, and Immunity","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbi.2017.02.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}