{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T17:20:13Z","timestamp":1784308813544,"version":"3.55.0"},"reference-count":55,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,10,1]],"date-time":"2017-10-01T00:00:00Z","timestamp":1506816000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,10,1]],"date-time":"2017-10-01T00:00:00Z","timestamp":1506816000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain, Behavior, and Immunity"],"published-print":{"date-parts":[[2017,10]]},"DOI":"10.1016\/j.bbi.2017.04.018","type":"journal-article","created":{"date-parts":[[2017,4,24]],"date-time":"2017-04-24T22:15:19Z","timestamp":1493072119000},"page":"11-19","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":58,"special_numbering":"C","title":["Mothers\u2019 childhood hardship forecasts adverse pregnancy outcomes: Role of inflammatory, lifestyle, and psychosocial pathways"],"prefix":"10.1016","volume":"65","author":[{"given":"Gregory E.","family":"Miller","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Culhane","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Grobman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyagriv","family":"Simhan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas E.","family":"Williamson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma K.","family":"Adam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Buss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonja","family":"Entringer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kwang-Youn","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Felipe Garcia-Espana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren","family":"Keenan-Devlin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas W.","family":"McDade","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pathik D.","family":"Wadhwa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann","family":"Borders","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbi.2017.04.018_b0005","doi-asserted-by":"crossref","first-page":"1801","DOI":"10.1111\/j.1532-5415.2007.01390.x","article-title":"Three-year change in inflammatory markers in elderly people and mortality: the Invecchiare in Chianti study","volume":"55","author":"Alley","year":"2007","journal-title":"J. Am. Geriatr. Soc."},{"key":"10.1016\/j.bbi.2017.04.018_b0010","series-title":"Trends in Tobacco Use","author":"American Lung Association","year":"2011"},{"key":"10.1016\/j.bbi.2017.04.018_b0015","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1038\/nrn3818","article-title":"Epigenetic and transgenerational reprogramming of brain development","volume":"16","author":"Bale","year":"2015","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.bbi.2017.04.018_b0020","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1038\/nature02725","article-title":"Developmental plasticity and human health","volume":"430","author":"Bateson","year":"2004","journal-title":"Nature"},{"issue":"Suppl. 3","key":"10.1016\/j.bbi.2017.04.018_b0025","doi-asserted-by":"crossref","first-page":"S163","DOI":"10.1542\/peds.2009-1100D","article-title":"Health disparities beginning in childhood: a life-course perspective","volume":"124","author":"Braveman","year":"2009","journal-title":"Pediatrics"},{"key":"10.1016\/j.bbi.2017.04.018_b0030","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1038\/pr.2015.191","article-title":"Epigenetics: linking social and environmental exposures to preterm birth","volume":"79","author":"Burris","year":"2016","journal-title":"Pediatr. Res."},{"key":"10.1016\/j.bbi.2017.04.018_b0035","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1177\/1933719108329095","article-title":"Inflammation and pregnancy","volume":"16","author":"Challis","year":"2009","journal-title":"Reprod. Sci."},{"key":"10.1016\/j.bbi.2017.04.018_b0040","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1037\/0033-2909.128.2.295","article-title":"Socioeconomic differences in children\u2019s health: how and why do these relationships change with age?","volume":"128","author":"Chen","year":"2002","journal-title":"Psychol. Bull."},{"key":"10.1016\/j.bbi.2017.04.018_b0045","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1097\/PSY.0000000000000392","article-title":"Dimensions of socioeconomic status and childhood asthma outcomes: evidence for distinct behavioral and biological associations","volume":"78","author":"Chen","year":"2016","journal-title":"Psychosom. Med."},{"key":"10.1016\/j.bbi.2017.04.018_b0050","article-title":"Parents\u2019 childhood socioeconomic circumstances are associated with their children\u2019s asthma outcomes","author":"Chen","year":"2016","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.bbi.2017.04.018_b0055","doi-asserted-by":"crossref","first-page":"385","DOI":"10.2307\/2136404","article-title":"A global measure of perceived stress","volume":"24","author":"Cohen","year":"1983","journal-title":"J. Health Soc. Behav."},{"key":"10.1016\/j.bbi.2017.04.018_b0060","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1111\/j.1749-6632.2009.05334.x","article-title":"Childhood socioeconomic status and adult health","volume":"1186","author":"Cohen","year":"2010","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.bbi.2017.04.018_b0065","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.bbi.2013.06.009","article-title":"Childhood socioeconomic status, telomere length, and susceptibility to upper respiratory infection","volume":"34","author":"Cohen","year":"2013","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.bbi.2017.04.018_b0070","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1146\/annurev.psych.031809.130727","article-title":"Psychological science on pregnancy: stress processes, biopsychosocial models, and emerging research issues","volume":"62","author":"Dunkel","year":"2011","journal-title":"Annu. Rev. Psychol."},{"key":"10.1016\/j.bbi.2017.04.018_b0075","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1037\/0003-066X.59.2.77","article-title":"The environment of childhood poverty","volume":"59","author":"Evans","year":"2004","journal-title":"Am. Psychol."},{"key":"10.1016\/j.bbi.2017.04.018_b0080","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.bbi.2012.06.014","article-title":"Stressful early life experiences and immune dysregulation across the lifespan","volume":"27","author":"Fagundes","year":"2013","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.bbi.2017.04.018_b0085","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1111\/aji.12265","article-title":"Longitudinal profiling of inflammatory cytokines and C-reactive protein during uncomplicated and preterm pregnancy","volume":"72","author":"Ferguson","year":"2014","journal-title":"Am. J. Reprod. Immunol."},{"key":"10.1016\/j.bbi.2017.04.018_b0090","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1373\/clinchem.2009.135087","article-title":"Comparison of multiplex immunoassay platforms","volume":"56","author":"Fu","year":"2010","journal-title":"Clin. Chem."},{"key":"10.1016\/j.bbi.2017.04.018_b0095","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1136\/jech.2007.065508","article-title":"Is the association between childhood socioeconomic circumstances and cause-specific mortality established? Update of a systematic review","volume":"62","author":"Galobardes","year":"2008","journal-title":"J. Epidemiol. Community Health"},{"key":"10.1016\/j.bbi.2017.04.018_b0100","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1016\/j.mehy.2015.07.026","article-title":"A proposed bio-panel to predict risk for spontaneous preterm birth among African American women","volume":"85","author":"Gillespie","year":"2015","journal-title":"Med. Hypotheses"},{"key":"10.1016\/j.bbi.2017.04.018_b0105","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1152\/physrev.00029.2013","article-title":"Early developmental conditioning of later health and disease: physiology or pathophysiology","volume":"94","author":"Hanson","year":"2014","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.bbi.2017.04.018_b0110","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1111\/j.1469-7610.2004.00218.x","article-title":"Validity of adult retrospective reports of adverse childhood experiences: review of the evidence","volume":"45","author":"Hardt","year":"2004","journal-title":"J. Child Psychol. Psychiatry"},{"key":"10.1016\/j.bbi.2017.04.018_b0115","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1001\/archpediatrics.2010.61","article-title":"Childhood hardship, maternal smoking, and birth outcomes: a prospective cohort study","volume":"164","author":"Harville","year":"2010","journal-title":"Arch. Pediatr. Adolesc. Med."},{"key":"10.1016\/j.bbi.2017.04.018_b0120","series-title":"Introduction to Mediation, Moderation, and Conditional Process Analysis","author":"Hayes","year":"2013"},{"key":"10.1016\/j.bbi.2017.04.018_b0125","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1146\/annurev.publhealth.012809.103538","article-title":"How experience gets under the skin to create gradients in developmental health","volume":"31","author":"Hertzman","year":"2010","journal-title":"Annu. Rev. Public Health"},{"key":"10.1016\/j.bbi.2017.04.018_b0130","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1038\/nature05485","article-title":"Inflammation and metabolic disorders","volume":"444","author":"Hotamisligil","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.bbi.2017.04.018_b0135","doi-asserted-by":"crossref","first-page":"e004017","DOI":"10.1136\/bmjopen-2013-004017","article-title":"Analysis of variation in charges and prices paid for vaginal and caesarean section births: a cross-sectional study","volume":"4","author":"Hsia","year":"2014","journal-title":"BMJ Open"},{"key":"10.1016\/j.bbi.2017.04.018_b0140","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1038\/nri3042","article-title":"Reciprocal regulation of the neural and innate immune systems","volume":"11","author":"Irwin","year":"2011","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.bbi.2017.04.018_b0145","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/S1471-4906(02)00013-3","article-title":"IL-6: a regulator of the transition from neutrophil to monocyte recruitment during inflammation","volume":"24","author":"Kaplanski","year":"2003","journal-title":"Trends Immunol."},{"key":"10.1016\/j.bbi.2017.04.018_b0150","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1038\/npp.2014.140","article-title":"Early-life experience, epigenetics, and the developing brain","volume":"40","author":"Kundakovic","year":"2015","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.bbi.2017.04.018_b0155","series-title":"Human Growth and Development","first-page":"325","article-title":"Early environments, developmental plasticity, and chronic degenerative disease","author":"Kuzawa","year":"2012"},{"key":"10.1016\/j.bbi.2017.04.018_b0160","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.socscimed.2015.01.030","article-title":"Childhood and later life stressors and increased inflammatory gene expression at older ages","volume":"130","author":"Levine","year":"2015","journal-title":"Soc. Sci. Med."},{"key":"10.1016\/j.bbi.2017.04.018_b0165","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.socscimed.2010.03.012","article-title":"Life course socioeconomic position is associated with inflammatory markers: the Framingham Offspring Study","volume":"71","author":"Loucks","year":"2010","journal-title":"Soc. Sci. Med."},{"key":"10.1016\/j.bbi.2017.04.018_b0170","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1146\/annurev.publhealth.26.021304.144505","article-title":"A life course approach to chronic disease epidemiology","volume":"26","author":"Lynch","year":"2005","journal-title":"Annu. Rev. Public Health"},{"key":"10.1016\/j.bbi.2017.04.018_b0175","series-title":"Special Care Nursery Admissions","author":"March of Dimes","year":"2011"},{"key":"10.1016\/j.bbi.2017.04.018_b0180","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.bbi.2013.09.013","article-title":"Child abuse is related to inflammation in mid-life women: role of obesity","volume":"36","author":"Matthews","year":"2014","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.bbi.2017.04.018_b0185","doi-asserted-by":"crossref","first-page":"14716","DOI":"10.1073\/pnas.0902971106","article-title":"Low early-life social class leaves a biological residue manifest by decreased glucocorticoid and increased pro-inflammatory signaling","volume":"106","author":"Miller","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.bbi.2017.04.018_b0190","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1037\/a0024768","article-title":"Psychological stress in childhood and susceptibility to the chronic diseases of aging: moving toward a model of behavioral and biological mechanisms","volume":"137","author":"Miller","year":"2011","journal-title":"Psychol. Bull."},{"key":"10.1016\/j.bbi.2017.04.018_b0195","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1093\/ije\/dyu028","article-title":"Intergenerational determinants of offspring size at birth: a life course and graphical analysis using the Aberdeen Children of the 1950s Study (ACONF)","volume":"43","author":"Morton","year":"2014","journal-title":"Int. J. Epidemiol."},{"key":"10.1016\/j.bbi.2017.04.018_b0200","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1111\/j.1600-0897.2010.00813.x","article-title":"The contribution of macrophages to normal and pathological pregnancies","volume":"63","author":"Nagamatsu","year":"2010","journal-title":"Am. J. Reprod. Immunol."},{"key":"10.1016\/j.bbi.2017.04.018_b0205","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1111\/aji.12477","article-title":"The role of decidual macrophages during normal and pathological pregnancy","volume":"75","author":"Ning","year":"2016","journal-title":"Am. J. Reprod. Immunol."},{"key":"10.1016\/j.bbi.2017.04.018_b0210","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1136\/jmedgenet-2014-102577","article-title":"Human transgenerational responses to early-life experience: potential impact on development, health and biomedical research","volume":"51","author":"Pembrey","year":"2014","journal-title":"J. Med. Genet."},{"key":"10.1016\/j.bbi.2017.04.018_b0215","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1016\/j.bbi.2009.01.008","article-title":"Parental education is related to C-reactive protein among female middle-aged community volunteers","volume":"23","author":"Phillips","year":"2009","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.bbi.2017.04.018_b0220","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1177\/014662167700100306","article-title":"The CES-D scale: a self-report depression scale for research in the general population","volume":"1","author":"Radloff","year":"1977","journal-title":"J. Appl. Psychol. Measur."},{"key":"10.1016\/j.bbi.2017.04.018_b0225","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1037\/0033-2909.128.2.330","article-title":"Risky families: family social environments and the mental and physical health of offspring","volume":"128","author":"Repetti","year":"2002","journal-title":"Psychol. Bull."},{"key":"10.1016\/j.bbi.2017.04.018_b0230","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1161\/CIRCRESAHA.115.306656","article-title":"From C-reactive protein to interleukin-6 to interleukin-1: moving upstream to identify novel targets for atheroprotection","volume":"118","author":"Ridker","year":"2016","journal-title":"Circ. Res."},{"key":"10.1016\/j.bbi.2017.04.018_b0235","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1136\/jech.2009.095109","article-title":"Hypertension in adult survivors of child abuse: observations from the Nurses\u2019 Health Study II","volume":"64","author":"Riley","year":"2010","journal-title":"J. Epidemiol. Community Health"},{"key":"10.1016\/j.bbi.2017.04.018_b0240","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1126\/science.1251816","article-title":"Preterm labor: one syndrome, many causes","volume":"345","author":"Romero","year":"2014","journal-title":"Science"},{"key":"10.1016\/j.bbi.2017.04.018_b0245","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1111\/aji.12563","article-title":"Patterns of peripheral cytokine expression during pregnancy in two cohorts and associations with measures of inflammation in cord blood","volume":"76","author":"Ross","year":"2016","journal-title":"Am. J. Reprod. Immunol."},{"key":"10.1016\/j.bbi.2017.04.018_b0250","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1016\/j.bbi.2010.06.007","article-title":"Socioeconomic status in one\u2019s childhood predicts offspring cardiovascular risk","volume":"24","author":"Schreier","year":"2010","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.bbi.2017.04.018_b0255","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1016\/0277-9536(91)90150-B","article-title":"The MOS social support survey","volume":"32","author":"Sherbourne","year":"1991","journal-title":"Soc. Sci. Med."},{"key":"10.1016\/j.bbi.2017.04.018_b0260","doi-asserted-by":"crossref","first-page":"2252","DOI":"10.1001\/jama.2009.754","article-title":"Neuroscience, molecular biology, and the childhood roots of health disparities: building a new framework for health promotion and disease prevention","volume":"301","author":"Shonkoff","year":"2009","journal-title":"JAMA"},{"key":"10.1016\/j.bbi.2017.04.018_b0265","doi-asserted-by":"crossref","first-page":"967629","DOI":"10.1155\/2012\/967629","article-title":"The Th1:th2 dichotomy of pregnancy and preterm labour","volume":"2012","author":"Sykes","year":"2012","journal-title":"Mediators Inflamm."},{"key":"10.1016\/j.bbi.2017.04.018_b0270","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/j.clp.2011.06.007","article-title":"The contribution of maternal stress to preterm birth: issues and considerations","volume":"38","author":"Wadhwa","year":"2011","journal-title":"Clin. Perinatol."},{"key":"10.1016\/j.bbi.2017.04.018_b0275","doi-asserted-by":"crossref","first-page":"166","DOI":"10.2337\/dc12-0702","article-title":"Inflammatory markers and risk of type 2 diabetes: a systematic review and meta-analysis","volume":"36","author":"Wang","year":"2013","journal-title":"Diabetes Care"}],"container-title":["Brain, Behavior, and Immunity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0889159117301289?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0889159117301289?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T07:47:02Z","timestamp":1760168822000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0889159117301289"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,10]]},"references-count":55,"alternative-id":["S0889159117301289"],"URL":"https:\/\/doi.org\/10.1016\/j.bbi.2017.04.018","relation":{},"ISSN":["0889-1591"],"issn-type":[{"value":"0889-1591","type":"print"}],"subject":[],"published":{"date-parts":[[2017,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mothers\u2019 childhood hardship forecasts adverse pregnancy outcomes: Role of inflammatory, lifestyle, and psychosocial pathways","name":"articletitle","label":"Article Title"},{"value":"Brain, Behavior, and Immunity","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbi.2017.04.018","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}