{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T00:03:51Z","timestamp":1766361831478,"version":"build-2065373602"},"reference-count":77,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,2,1]],"date-time":"2018-02-01T00:00:00Z","timestamp":1517443200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,2,1]],"date-time":"2018-02-01T00:00:00Z","timestamp":1517443200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,1,10]],"date-time":"2019-01-10T00:00:00Z","timestamp":1547078400000},"content-version":"am","delay-in-days":343,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"name":"National Institute of Health","award":["NS40433"],"award-info":[{"award-number":["NS40433"]}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain, Behavior, and Immunity"],"published-print":{"date-parts":[[2018,2]]},"DOI":"10.1016\/j.bbi.2017.10.005","type":"journal-article","created":{"date-parts":[[2017,10,13]],"date-time":"2017-10-13T00:46:11Z","timestamp":1507855571000},"page":"98-110","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Impact of peripheral immune status on central molecular responses to facial nerve axotomy"],"prefix":"10.1016","volume":"68","author":[{"given":"D.O.","family":"Setter","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.M.","family":"Runge","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.D.","family":"Schartz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.M.","family":"Kennedy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.L.","family":"Brown","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.P.","family":"McMillan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W.M.","family":"Miller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.M.","family":"Shah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.M.","family":"Haulcomb","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.M.","family":"Sanders","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.J.","family":"Jones","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"7","key":"10.1016\/j.bbi.2017.10.005_b0005","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1212\/WNL.57.7.1282","article-title":"Immune reactivity in a mouse model of familial ALS correlates with disease progression","volume":"57","author":"Alexianu","year":"2001","journal-title":"Neurology"},{"issue":"7","key":"10.1016\/j.bbi.2017.10.005_b0010","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1002\/glia.22989","article-title":"Connexin 43 in astrocytes contributes to motor neuron toxicity in amyotrophic lateral sclerosis","volume":"64","author":"Almad","year":"2016","journal-title":"Glia"},{"issue":"7","key":"10.1016\/j.bbi.2017.10.005_b0015","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1002\/glia.22668","article-title":"Effects of astrocyte-targeted production of interleukin-6 in the mouse on the host response to nerve injury","volume":"62","author":"Almolda","year":"2014","journal-title":"Glia"},{"issue":"9","key":"10.1016\/j.bbi.2017.10.005_b0020","doi-asserted-by":"crossref","first-page":"2705","DOI":"10.1002\/(SICI)1521-4141(199909)29:09<2705::AID-IMMU2705>3.0.CO;2-1","article-title":"Relative efficiency of microglia, astrocytes, dendritic cells and B cells in naive CD4+ T cell priming and Th1\/Th2 cell restimulation","volume":"29","author":"Aloisi","year":"1999","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.bbi.2017.10.005_b0025","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1007\/978-1-4939-1062-5_27","article-title":"SYBR(R) Green and TaqMan(R) quantitative PCR arrays: expression profile of genes relevant to a pathway or a disease state","volume":"1182","author":"Alvarez","year":"2014","journal-title":"Methods Mol. Biol."},{"issue":"1","key":"10.1016\/j.bbi.2017.10.005_b0030","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.neuroscience.2007.09.084","article-title":"Impaired nerve regeneration and enhanced neuroinflammatory response in mice lacking pituitary adenylyl cyclase activating peptide","volume":"151","author":"Armstrong","year":"2008","journal-title":"Neuroscience"},{"issue":"7","key":"10.1016\/j.bbi.2017.10.005_b0035","doi-asserted-by":"crossref","first-page":"e2740","DOI":"10.1371\/journal.pone.0002740","article-title":"Adaptive immune neuroprotection in G93A-SOD1 amyotrophic lateral sclerosis mice","volume":"3","author":"Banerjee","year":"2008","journal-title":"PLoS One"},{"issue":"9","key":"10.1016\/j.bbi.2017.10.005_b0040","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/S0962-8924(01)02064-5","article-title":"Signal transduction by tumor necrosis factor and its relatives","volume":"11","author":"Baud","year":"2001","journal-title":"Trends Cell Biol."},{"issue":"1","key":"10.1016\/j.bbi.2017.10.005_b0045","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.expneurol.2009.11.003","article-title":"Functional recovery and facial motoneuron survival are influenced by immunodeficiency in crush-axotomized mice","volume":"221","author":"Beahrs","year":"2010","journal-title":"Exp. Neurol."},{"issue":"7","key":"10.1016\/j.bbi.2017.10.005_b0050","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1007\/s00109-006-0065-1","article-title":"Antigen presentation in autoimmunity and CNS inflammation: how T lymphocytes recognize the brain","volume":"84","author":"Becher","year":"2006","journal-title":"J. Mol. Med. (Berl)"},{"issue":"40","key":"10.1016\/j.bbi.2017.10.005_b0055","doi-asserted-by":"crossref","first-page":"15558","DOI":"10.1073\/pnas.0807419105","article-title":"CD4+ T cells support glial neuroprotection, slow disease progression, and modify glial morphology in an animal model of inherited ALS","volume":"105","author":"Beers","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"issue":"2","key":"10.1016\/j.bbi.2017.10.005_b9000","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.jneumeth.2007.04.013","article-title":"Quantification of the rat spinal microglial response to peripheral nerve injury as revealed by immunohistochemical image analysis and flow cytometry","volume":"164","author":"Blackbeard","year":"2007","journal-title":"J. Neurosci. Methods"},{"issue":"4","key":"10.1016\/j.bbi.2017.10.005_b0060","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1002\/cne.20017","article-title":"Microglial major histocompatibility complex glycoprotein-1 in the axotomized facial motor nucleus: regulation and role of tumor necrosis factor receptors 1 and 2","volume":"470","author":"Bohatschek","year":"2004","journal-title":"J. Comp. Neurol."},{"issue":"1\u20132","key":"10.1016\/j.bbi.2017.10.005_b0065","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.jneuroim.2004.07.018","article-title":"B7.2 on activated and phagocytic microglia in the facial axotomy model: regulation by interleukin-1 receptor type 1, tumor necrosis factor receptors 1 and 2 and endotoxin","volume":"156","author":"Bohatschek","year":"2004","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.bbi.2017.10.005_b0070","doi-asserted-by":"crossref","first-page":"151","DOI":"10.3389\/fncel.2016.00151","article-title":"Enhanced immune response in immunodeficient mice improves peripheral nerve regeneration following axotomy","volume":"10","author":"Bombeiro","year":"2016","journal-title":"Front Cell Neurosci."},{"issue":"6","key":"10.1016\/j.bbi.2017.10.005_b0075","doi-asserted-by":"crossref","first-page":"e39216","DOI":"10.1371\/journal.pone.0039216","article-title":"Microglial activation correlates with disease progression and upper motor neuron clinical symptoms in amyotrophic lateral sclerosis","volume":"7","author":"Brettschneider","year":"2012","journal-title":"PLoS One"},{"issue":"4","key":"10.1016\/j.bbi.2017.10.005_b0080","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1001\/archneur.1986.00520040063021","article-title":"Failure of immunosuppression with a ten- to 14-day course of high-dose intravenous cyclophosphamide to alter the progression of amyotrophic lateral sclerosis","volume":"43","author":"Brown","year":"1986","journal-title":"Arch. Neurol."},{"issue":"18","key":"10.1016\/j.bbi.2017.10.005_b0085","doi-asserted-by":"crossref","first-page":"4333","DOI":"10.1523\/JNEUROSCI.5276-03.2004","article-title":"CD4-positive T cell-mediated neuroprotection requires dual compartment antigen presentation","volume":"24","author":"Byram","year":"2004","journal-title":"J. Neurosci."},{"issue":"2","key":"10.1016\/j.bbi.2017.10.005_b0090","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1002\/eji.200737485","article-title":"CNS-infiltrating CD4+ T lymphocytes contribute to murine spinal nerve transection-induced neuropathic pain","volume":"38","author":"Cao","year":"2008","journal-title":"Eur. J. Immunol."},{"issue":"1","key":"10.1016\/j.bbi.2017.10.005_b0095","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1002\/(SICI)1097-4547(19990101)55:1<127::AID-JNR14>3.0.CO;2-2","article-title":"Microglia stimulate naive T-cell differentiation without stimulating T-cell proliferation","volume":"55","author":"Carson","year":"1999","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.bbi.2017.10.005_b0100","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1007\/978-3-319-40764-7_7","article-title":"Purine signaling and microglial wrapping","volume":"949","author":"Castellano","year":"2016","journal-title":"Adv. Exp. Med. Biol."},{"issue":"1\u20132","key":"10.1016\/j.bbi.2017.10.005_b0105","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.jns.2014.09.025","article-title":"Evidence for peripheral immune activation in amyotrophic lateral sclerosis","volume":"347","author":"Chen","year":"2014","journal-title":"J. Neurol. Sci."},{"issue":"3","key":"10.1016\/j.bbi.2017.10.005_b0110","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1080\/14660820410017091","article-title":"Temporal gene expression patterns in G93A\/SOD1 mouse","volume":"5","author":"Chen","year":"2004","journal-title":"Amyotroph. Lateral Scler. Other Motor Neuron Disord."},{"issue":"1","key":"10.1016\/j.bbi.2017.10.005_b0115","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.brainresrev.2003.08.007","article-title":"Fas ligand\/Fas system in the brain: regulator of immune and apoptotic responses","volume":"44","author":"Choi","year":"2004","journal-title":"Brain Res. Rev."},{"key":"10.1016\/j.bbi.2017.10.005_b0120","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.neuroscience.2014.09.027","article-title":"The neuroimmunology of degeneration and regeneration in the peripheral nervous system","volume":"302","author":"DeFrancesco-Lisowitz","year":"2015","journal-title":"Neuroscience"},{"issue":"2","key":"10.1016\/j.bbi.2017.10.005_b0125","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1002\/ana.410350205","article-title":"Trial of immunosuppression in amyotrophic lateral sclerosis using total lymphoid irradiation","volume":"35","author":"Drachman","year":"1994","journal-title":"Ann. Neurol."},{"issue":"3845","key":"10.1016\/j.bbi.2017.10.005_b0130","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1126\/science.161.3845.1027","article-title":"Mice: fighting by neonatally androgenized females","volume":"161","author":"Edwards","year":"1968","journal-title":"Science"},{"issue":"3","key":"10.1016\/j.bbi.2017.10.005_b9005","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1007\/PL00005649","article-title":"A quantitative analysis of the glial cell reaction in primary sensory termination areas following sciatic nerve injury and treatment with nerve growth factor in the adult rat","volume":"114","author":"Eriksson","year":"1997","journal-title":"Exp. Brain Res."},{"issue":"3","key":"10.1016\/j.bbi.2017.10.005_b0135","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1111\/j.1750-3639.2000.tb00267.x","article-title":"Neuronal FasL induces cell death of encephalitogenic T lymphocytes","volume":"10","author":"Flugel","year":"2000","journal-title":"Brain Pathol."},{"issue":"3","key":"10.1016\/j.bbi.2017.10.005_b0140","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/0304-3940(88)90585-X","article-title":"Microglial cells but not astrocytes undergo mitosis following rat facial nerve axotomy","volume":"85","author":"Graeber","year":"1988","journal-title":"Neurosci. Lett."},{"issue":"3 pt. 2","key":"10.1016\/j.bbi.2017.10.005_b0145","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/0014-4886(75)90170-3","article-title":"The nerve cell body response to axotomy","volume":"48","author":"Grafstein","year":"1975","journal-title":"Exp. Neurol."},{"issue":"10","key":"10.1016\/j.bbi.2017.10.005_b0150","doi-asserted-by":"crossref","first-page":"2349","DOI":"10.1002\/cne.23538","article-title":"Axotomy-induced target disconnection promotes an additional death mechanism involved in motoneuron degeneration in amyotrophic lateral sclerosis transgenic mice","volume":"522","author":"Haulcomb","year":"2014","journal-title":"J. Comp. Neurol."},{"issue":"1","key":"10.1016\/j.bbi.2017.10.005_b0155","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/S0969-9961(03)00087-1","article-title":"Message and protein-level elevation of tumor necrosis factor \u03b1 (TNF\u03b1) and TNF\u03b1-modulating cytokines in spinal cords of the G93A-SOD1 mouse model for amyotrophic lateral sclerosis","volume":"14","author":"Hensley","year":"2003","journal-title":"Neurobiol. Dis."},{"issue":"2","key":"10.1016\/j.bbi.2017.10.005_b0160","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1046\/j.1471-4159.2002.00968.x","article-title":"Temporal patterns of cytokine and apoptosis-related gene expression in spinal cords of the G93A-SOD1 mouse model of amyotrophic lateral sclerosis","volume":"82","author":"Hensley","year":"2002","journal-title":"J. Neurochem."},{"issue":"12","key":"10.1016\/j.bbi.2017.10.005_b0165","doi-asserted-by":"crossref","first-page":"1633","DOI":"10.1007\/s00702-015-1444-y","article-title":"Lymphocytes reduce nigrostriatal deficits in the 6-hydroxydopamine mouse model of Parkinson's disease","volume":"122","author":"Ip","year":"2015","journal-title":"J. Neural. Transm. (Vienna)"},{"issue":"3","key":"10.1016\/j.bbi.2017.10.005_b0170","doi-asserted-by":"crossref","DOI":"10.14814\/phy2.12703","article-title":"The effects of group and single housing and automated animal monitoring on urinary corticosterone levels in male C57BL\/6 mice","volume":"4","author":"Kamakura","year":"2016","journal-title":"Physiol. Rep."},{"issue":"2","key":"10.1016\/j.bbi.2017.10.005_b0175","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/j.expneurol.2012.01.015","article-title":"Impaired recruitment of neuroprotective microglia and T cells during acute neuronal injury coincides with increased neuronal vulnerability in an amyotrophic lateral sclerosis model","volume":"234","author":"Kawamura","year":"2012","journal-title":"Exp. Neurol."},{"issue":"12","key":"10.1016\/j.bbi.2017.10.005_b0180","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1001\/archneur.1983.04050110070012","article-title":"Plasmapheresis with immunosuppression in amyotrophic lateral sclerosis","volume":"40","author":"Kelemen","year":"1983","journal-title":"Arch. Neurol."},{"issue":"1\u20132","key":"10.1016\/j.bbi.2017.10.005_b0185","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.jneuroim.2005.11.015","article-title":"Lymphopenia and spontaneous autorosette formation in SOD1 mouse model of ALS","volume":"172","author":"Kuzmenok","year":"2006","journal-title":"J. Neuroimmunol."},{"issue":"8","key":"10.1016\/j.bbi.2017.10.005_b0195","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1007\/BF00179953","article-title":"Changes in glial fibrillary acidic protein immunoreactivity in the rat facial nucleus following various types of nerve lesions","volume":"253","author":"Laskawi","year":"1996","journal-title":"Eur. Arch. Otorhinolaryngol."},{"issue":"7638","key":"10.1016\/j.bbi.2017.10.005_b0200","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1038\/nature21029","article-title":"Neurotoxic reactive astrocytes are induced by activated microglia","volume":"541","author":"Liddelow","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.bbi.2017.10.005_b0205","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/S0074-7742(08)60183-X","article-title":"The axon reaction: a review of the principal features of perikaryal responses to axon injury","volume":"14","author":"Lieberman","year":"1971","journal-title":"Int. Rev. Neurobiol."},{"issue":"2","key":"10.1016\/j.bbi.2017.10.005_b0210","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1001\/archfaci.2010.98","article-title":"Effects of corticosteroids on functional recovery and neuron survival after facial nerve injury in mice","volume":"13","author":"Lieberman","year":"2011","journal-title":"Arch. Facial. Plast. Surg."},{"issue":"1","key":"10.1016\/j.bbi.2017.10.005_b0215","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1002\/ana.21152","article-title":"Fas small interfering RNA reduces motoneuron death in amyotrophic lateral sclerosis mice","volume":"62","author":"Locatelli","year":"2007","journal-title":"Ann. Neurol."},{"issue":"6","key":"10.1016\/j.bbi.2017.10.005_b0220","first-page":"731","article-title":"Effect of enrichment devices on aggression in manipulated nude mice","volume":"54","author":"Lockworth","year":"2015","journal-title":"J. Am. Assoc. Lab. Anim. Sci."},{"issue":"4","key":"10.1016\/j.bbi.2017.10.005_b0225","doi-asserted-by":"crossref","first-page":"e244","DOI":"10.1212\/NXI.0000000000000244","article-title":"Systemic inflammatory response and neuromuscular involvement in amyotrophic lateral sclerosis","volume":"3","author":"Lu","year":"2016","journal-title":"Neurol. Neuroimmunol. Neuroinflamm."},{"issue":"2","key":"10.1016\/j.bbi.2017.10.005_b0230","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/S0306-4522(02)00448-7","article-title":"Altered reaction of facial motoneurons to axonal damage in the presymptomatic phase of a murine model of familial amyotrophic lateral sclerosis","volume":"115","author":"Mariotti","year":"2002","journal-title":"Neuroscience"},{"key":"10.1016\/j.bbi.2017.10.005_b0235","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1186\/1742-2094-5-45","article-title":"TNF signaling inhibition in the CNS: implications for normal brain function and neurodegenerative disease","volume":"5","author":"McCoy","year":"2008","journal-title":"J. Neuroinflamm."},{"issue":"1","key":"10.1016\/j.bbi.2017.10.005_b0240","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.expneurol.2010.05.019","article-title":"Use of laser microdissection in the investigation of facial motoneuron and neuropil molecular phenotypes after peripheral axotomy","volume":"225","author":"Mesnard","year":"2010","journal-title":"Exp. Neurol."},{"issue":"17","key":"10.1016\/j.bbi.2017.10.005_b0245","doi-asserted-by":"crossref","first-page":"3488","DOI":"10.1002\/cne.22718","article-title":"Differential gene expression in the axotomized facial motor nucleus of presymptomatic SOD1 mice","volume":"519","author":"Mesnard","year":"2011","journal-title":"J. Comp. Neurol."},{"issue":"1","key":"10.1016\/j.bbi.2017.10.005_b0250","first-page":"21","article-title":"Delayed functional recovery in presymptomatic mSOD1 mice following facial nerve crush axotomy","volume":"4","author":"Mesnard","year":"2013","journal-title":"J. Neurodegener. Regen."},{"key":"10.1016\/j.bbi.2017.10.005_b0255","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.bbi.2014.05.019","article-title":"SOD1(G93A) transgenic mouse CD4(+) T cells mediate neuroprotection after facial nerve axotomy when removed from a suppressive peripheral microenvironment","volume":"40","author":"Mesnard-Hoaglin","year":"2014","journal-title":"Brain Behav. Immun."},{"issue":"2\u20133","key":"10.1016\/j.bbi.2017.10.005_b0260","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.brainresrev.2003.11.004","article-title":"The facial nerve axotomy model","volume":"44","author":"Moran","year":"2004","journal-title":"Brain Res. Brain Res. Rev."},{"issue":"96","key":"10.1016\/j.bbi.2017.10.005_b0265","first-page":"e52382","article-title":"Facial nerve axotomy in mice: a model to study motoneuron response to injury","author":"Olmstead","year":"2015","journal-title":"J. Vis. Exp."},{"issue":"3\u20134","key":"10.1016\/j.bbi.2017.10.005_b0270","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.applanim.2006.05.022","article-title":"More than numbers matter: the effect of social factors on behaviour and welfare of laboratory rodents and non-human primates","volume":"103","author":"Olsson","year":"2007","journal-title":"Appl. Animal Behav. Sci."},{"issue":"2","key":"10.1016\/j.bbi.2017.10.005_b0275","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1006\/exnr.2002.8024","article-title":"Cytotoxic potential of proinflammatory cytokines: combined deletion of tnf receptors tnfr1 and tnfr2 prevents motoneuron cell death after facial axotomy in adult mouse","volume":"178","author":"Raivich","year":"2002","journal-title":"Exp. Neurol."},{"issue":"15","key":"10.1016\/j.bbi.2017.10.005_b0280","doi-asserted-by":"crossref","first-page":"5804","DOI":"10.1523\/JNEUROSCI.18-15-05804.1998","article-title":"Immune surveillance in the injured nervous system: T-lymphocytes invade the axotomized mouse facial motor nucleus and aggregate around sites of neuronal degeneration","volume":"18","author":"Raivich","year":"1998","journal-title":"J. Neurosci."},{"issue":"6","key":"10.1016\/j.bbi.2017.10.005_b0285","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1016\/S0896-6273(02)00905-4","article-title":"Motoneuron death triggered by a specific pathway downstream of Fas. potentiation by ALS-linked SOD1 mutations","volume":"35","author":"Raoul","year":"2002","journal-title":"Neuron"},{"issue":"15","key":"10.1016\/j.bbi.2017.10.005_b0290","doi-asserted-by":"crossref","first-page":"6007","DOI":"10.1073\/pnas.0508774103","article-title":"Chronic activation in presymptomatic amyotrophic lateral sclerosis (ALS) mice of a feedback loop involving Fas, Daxx, and FasL","volume":"103","author":"Raoul","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"issue":"11","key":"10.1016\/j.bbi.2017.10.005_b0295","doi-asserted-by":"crossref","first-page":"RC7","DOI":"10.1523\/JNEUROSCI.19-11-j0004.1999","article-title":"Exacerbation of facial motoneuron loss after facial nerve transection in severe combined immunodeficient (scid) mice","volume":"19","author":"Serpe","year":"1999","journal-title":"J. Neurosci."},{"issue":"2","key":"10.1016\/j.bbi.2017.10.005_b0300","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1002\/1097-4547(20001015)62:2<273::AID-JNR11>3.0.CO;2-C","article-title":"Kinetics of facial motoneuron loss following facial nerve transection in severe combined immunodeficient mice","volume":"62","author":"Serpe","year":"2000","journal-title":"J. Neurosci. Res."},{"issue":"5","key":"10.1016\/j.bbi.2017.10.005_b0305","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/S0889-1591(03)00028-X","article-title":"CD4+ T, but not CD8+ or B, lymphocytes mediate facial motoneuron survival after facial nerve transection","volume":"17","author":"Serpe","year":"2003","journal-title":"Brain, Behav. Immun."},{"key":"10.1016\/j.bbi.2017.10.005_b0310","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1186\/s40478-015-0251-x","article-title":"Reduced beta-amyloid pathology in an APP transgenic mouse model of Alzheimer's disease lacking functional B and T cells","volume":"3","author":"Spani","year":"2015","journal-title":"Acta Neuropathol. Commun."},{"issue":"4","key":"10.1016\/j.bbi.2017.10.005_b9010","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1002\/cne.10623","article-title":"Ribosomal RNA transcriptional activation and processing in hamster rubrospinal motoneurons: effects of axotomy and testosterone treatment","volume":"458","author":"Storer","year":"2003","journal-title":"J. Comp. Neurol."},{"issue":"1","key":"10.1016\/j.bbi.2017.10.005_b0315","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1002\/1097-4547(20000701)61:1<10::AID-JNR2>3.0.CO;2-E","article-title":"Comparative evaluation of cytokine profiles and reactive gliosis supports a critical role for interleukin-6 in neuron-glia signaling during regeneration","volume":"61","author":"Streit","year":"2000","journal-title":"J. Neurosci. Res."},{"issue":"3\u20134","key":"10.1016\/j.bbi.2017.10.005_b9015","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1016\/0361-9230(93)90284-I","article-title":"The response of central glia to peripheral nerve injury","volume":"30","author":"Svensson","year":"1993","journal-title":"Brain Res. Bull."},{"issue":"9","key":"10.1016\/j.bbi.2017.10.005_b0320","doi-asserted-by":"crossref","first-page":"3443","DOI":"10.1046\/j.1460-9568.2000.00240.x","article-title":"Soluble TNF receptors partially protect injured motoneurons in the postnatal CNS","volume":"12","author":"Terrado","year":"2000","journal-title":"Eur. J. Neurosci."},{"issue":"1","key":"10.1016\/j.bbi.2017.10.005_b0325","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1002\/glia.440010110","article-title":"Increased glial fibrillary acidic protein synthesis in astrocytes during retrograde reaction of the rat facial nucleus","volume":"1","author":"Tetzlaff","year":"1988","journal-title":"Glia"},{"issue":"8","key":"10.1016\/j.bbi.2017.10.005_b0330","doi-asserted-by":"crossref","first-page":"2528","DOI":"10.1523\/JNEUROSCI.11-08-02528.1991","article-title":"Response of facial and rubrospinal neurons to axotomy: changes in mRNA expression for cytoskeletal proteins and GAP-43","volume":"11","author":"Tetzlaff","year":"1991","journal-title":"J. Neurosci."},{"issue":"4","key":"10.1016\/j.bbi.2017.10.005_b0335","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1258\/002367703322389870","article-title":"Male management: coping with aggression problems in male laboratory mice","volume":"37","author":"Van Loo","year":"2003","journal-title":"Lab. Anim."},{"issue":"1","key":"10.1016\/j.bbi.2017.10.005_b0340","first-page":"39","article-title":"Effects of facial nerve axotomy on Th2-associated and Th1-associated chemokine mRNA expression in the facial motor nucleus of wild-type and presymptomatic SOD1 mice","volume":"2","author":"Wainwright","year":"2009","journal-title":"J. Neurodegener. Regen."},{"issue":"5","key":"10.1016\/j.bbi.2017.10.005_b0345","doi-asserted-by":"crossref","first-page":"e00024","DOI":"10.1042\/AN20090017","article-title":"Exacerbation of facial motoneuron loss after facial nerve axotomy in CCR3-deficient mice","volume":"1","author":"Wainwright","year":"2009","journal-title":"ASN Neuro."},{"issue":"1\u20132","key":"10.1016\/j.bbi.2017.10.005_b0350","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.jneuroim.2009.09.009","article-title":"Effects of facial nerve axotomy on Th2- and Th1-associated chemokine expression in the facial motor nucleus of wild-type and presymptomatic mSOD1 mice","volume":"216","author":"Wainwright","year":"2009","journal-title":"J. Neuroimmunol."},{"issue":"6","key":"10.1016\/j.bbi.2017.10.005_b0355","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1111\/j.1742-4658.2011.08015.x","article-title":"TNFR1-induced activation of the classical NF-kappaB pathway","volume":"278","author":"Wajant","year":"2011","journal-title":"FEBS J."},{"issue":"4","key":"10.1016\/j.bbi.2017.10.005_b0360","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1038\/laban.1219","article-title":"Aggression in group-housed laboratory mice: why can't we solve the problem?","volume":"46","author":"Weber","year":"2017","journal-title":"Lab. Anim. (NY)"},{"issue":"2","key":"10.1016\/j.bbi.2017.10.005_b0365","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1111\/j.1600-0404.1990.tb01602.x","article-title":"Immunosuppressive treatment of patients with amyotrophic lateral sclerosis","volume":"82","author":"Werdelin","year":"1990","journal-title":"Acta Neurol. Scand."},{"issue":"18","key":"10.1016\/j.bbi.2017.10.005_b0370","doi-asserted-by":"crossref","first-page":"6391","DOI":"10.1523\/JNEUROSCI.6221-11.2012","article-title":"Genomic analysis of reactive astrogliosis","volume":"32","author":"Zamanian","year":"2012","journal-title":"J. Neurosci."}],"container-title":["Brain, Behavior, and Immunity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0889159117304580?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0889159117304580?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T07:50:15Z","timestamp":1760169015000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0889159117304580"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,2]]},"references-count":77,"alternative-id":["S0889159117304580"],"URL":"https:\/\/doi.org\/10.1016\/j.bbi.2017.10.005","relation":{},"ISSN":["0889-1591"],"issn-type":[{"type":"print","value":"0889-1591"}],"subject":[],"published":{"date-parts":[[2018,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Impact of peripheral immune status on central molecular responses to facial nerve axotomy","name":"articletitle","label":"Article Title"},{"value":"Brain, Behavior, and Immunity","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbi.2017.10.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}