{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T15:15:25Z","timestamp":1790262925479,"version":"4.1.0"},"reference-count":69,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,5,1]],"date-time":"2018-05-01T00:00:00Z","timestamp":1525132800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,5,1]],"date-time":"2018-05-01T00:00:00Z","timestamp":1525132800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001779","name":"Monash University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001779","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006369","name":"Mason","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006369","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain, Behavior, and Immunity"],"published-print":{"date-parts":[[2018,5]]},"DOI":"10.1016\/j.bbi.2018.03.007","type":"journal-article","created":{"date-parts":[[2018,3,12]],"date-time":"2018-03-12T13:33:24Z","timestamp":1520861604000},"page":"36-47","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":45,"special_numbering":"C","title":["Cognitive benefits of lithium chloride in APP\/PS1 mice are associated with enhanced brain clearance of \u03b2-amyloid"],"prefix":"10.1016","volume":"70","author":[{"given":"Yijun","family":"Pan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer L.","family":"Short","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie A.","family":"Newman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kwok H.C.","family":"Choy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Durgesh","family":"Tiwari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Yap","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danielle","family":"Senyschyn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William A.","family":"Banks","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph A.","family":"Nicolazzo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbi.2018.03.007_b0005","doi-asserted-by":"crossref","first-page":"3375","DOI":"10.1097\/00001756-200110290-00045","article-title":"NMDA and muscarinic blockade in the perirhinal cortex impairs object discrimination in rats","volume":"12","author":"Abe","year":"2001","journal-title":"Neuroreport"},{"key":"10.1016\/j.bbi.2018.03.007_b0010","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1007\/s10339-011-0430-z","article-title":"The novel object recognition memory: neurobiology, test procedure, and its modifications","volume":"13","author":"Antunes","year":"2012","journal-title":"Cogn. Process"},{"key":"10.1016\/j.bbi.2018.03.007_b0015","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/S0306-4522(03)00474-3","article-title":"Efflux of human and mouse amyloid beta proteins 1\u201340 and 1\u201342 from brain: impairment in a mouse model of Alzheimer's disease","volume":"12","author":"Banks","year":"2003","journal-title":"Neuroscience"},{"key":"10.1016\/j.bbi.2018.03.007_b0020","doi-asserted-by":"crossref","DOI":"10.1126\/science.aaa5694","article-title":"Gating of hippocampal activity, plasticity, and memory by entorhinal cortex long-range inhibition","volume":"351","author":"Basu","year":"2016","journal-title":"Science"},{"key":"10.1016\/j.bbi.2018.03.007_b0025","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1038\/sj.jcbfm.9600419","article-title":"Transport pathways for clearance of human Alzheimer's amyloid beta-peptide and apolipoproteins E and J in the mouse central nervous system","volume":"27","author":"Bell","year":"2007","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.bbi.2018.03.007_b0030","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1001\/archneur.61.3.378","article-title":"Neurofibrillary tangles mediate the association of amyloid load with clinical Alzheimer disease and level of cognitive function","volume":"61","author":"Bennett","year":"2004","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.bbi.2018.03.007_b0035","doi-asserted-by":"crossref","first-page":"3285","DOI":"10.1172\/JCI25247","article-title":"P-glycoprotein deficiency at the blood-brain barrier increases amyloid-\u03b2 deposition in an Alzheimer disease mouse model","volume":"115","author":"Cirrito","year":"2005","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bbi.2018.03.007_b0040","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/S0165-0173(01)00067-4","article-title":"Applications of the Morris water maze in the study of learning and memory","volume":"36","author":"D'Hooge","year":"2001","journal-title":"Brain Res. Rev."},{"key":"10.1016\/j.bbi.2018.03.007_b0045","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.neuron.2004.07.017","article-title":"LRP\/amyloid \u03b2-peptide interaction mediates differential brain efflux of A\u03b2 isoforms","volume":"43","author":"Deane","year":"2004","journal-title":"Neuron"},{"key":"10.1016\/j.bbi.2018.03.007_b0050","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/0197-4580(95)00013-5","article-title":"Correlations of synaptic and pathological markers with cognition of the elderly","volume":"16","author":"Dickson","year":"1995","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.bbi.2018.03.007_b0055","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1007\/BF00587383","article-title":"Effects of changes in serum osmolarity on bulk flow of fluid into cerebral ventricles and on brain water content","volume":"359","author":"DiMattio","year":"1975","journal-title":"Pfl\u00fcgers Archiv."},{"key":"10.1016\/j.bbi.2018.03.007_b0060","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1007\/s00401-006-0115-3","article-title":"RAGE, LRP-1, and amyloid-beta protein in Alzheimer's disease","volume":"112","author":"Donahue","year":"2006","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.bbi.2018.03.007_b0065","doi-asserted-by":"crossref","first-page":"191","DOI":"10.3389\/fncel.2015.00191","article-title":"Soluble amyloid-beta oligomers as synaptotoxins leading to cognitive impairment in Alzheimer's disease","volume":"9","author":"Ferreira","year":"2015","journal-title":"Front. Cell Neurosci."},{"key":"10.1016\/j.bbi.2018.03.007_b0070","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1192\/bjp.bp.110.080044","article-title":"Disease-modifying properties of long-term lithium treatment for amnestic mild cognitive impairment: randomised controlled trial","volume":"198","author":"Forlenza","year":"2011","journal-title":"Br. J. Psychiat."},{"key":"10.1016\/j.bbi.2018.03.007_b0075","doi-asserted-by":"crossref","first-page":"17","DOI":"10.3389\/fncel.2015.00017","article-title":"Choroid plexus dysfunction impairs beta-amyloid clearance in a triple transgenic mouse model of Alzheimer's disease","volume":"9","author":"Gonzalez-Marrero","year":"2015","journal-title":"Front. Cell Neurosci."},{"key":"10.1016\/j.bbi.2018.03.007_b0080","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.bbr.2008.09.002","article-title":"Validation of a 2-day water maze protocol in mice","volume":"196","author":"Gulinello","year":"2009","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.bbi.2018.03.007_b0085","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/0304-3940(92)90774-2","article-title":"Glycogen synthase kinase-3 induces Alzheimer's disease-like phosphorylation of tau: generation of paired helical filament epitopes and neuronal localisation of the kinase","volume":"147","author":"Hanger","year":"1992","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.bbi.2018.03.007_b0090","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1124\/mol.109.061754","article-title":"Restoring blood-brain barrier P-glycoprotein reduces brain A\u03b2 in a mouse model of Alzheimer's disease","volume":"77","author":"Hartz","year":"2010","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.bbi.2018.03.007_b0095","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1111\/j.1365-2125.1977.tb00694.x","article-title":"Age as a factor affecting lithium therapy","volume":"4","author":"Hewick","year":"1977","journal-title":"Br. J. Clin. Pharmacol."},{"key":"10.1016\/j.bbi.2018.03.007_b0100","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1038\/nm0198-097","article-title":"Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenes","volume":"4","author":"Holcomb","year":"1998","journal-title":"Nat. Med."},{"key":"10.1016\/j.bbi.2018.03.007_b0105","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1007\/s11357-016-9929-7","article-title":"Characterization of AD-like phenotype in aged APPSwe\/PS1dE9 mice","volume":"38","author":"Huang","year":"2016","journal-title":"Age"},{"key":"10.1016\/j.bbi.2018.03.007_b0110","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1126\/scitranslmed.3003748","article-title":"A paravascular pathway facilitates CSF flow through the brain parenchyma and the clearance of interstitial solutes, including amyloid beta","volume":"4","author":"Iliff","year":"2012","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.bbi.2018.03.007_b0115","doi-asserted-by":"crossref","first-page":"553","DOI":"10.3233\/JAD-2009-1074","article-title":"Testing the neurovascular hypothesis of Alzheimer's disease: LRP-1 antisense reduces blood-brain barrier clearance and increases brain levels of amyloid-\u03b2 protein and impairs cognition","volume":"17","author":"Jaeger","year":"2009","journal-title":"J. Alzheim. Dis."},{"key":"10.1016\/j.bbi.2018.03.007_b0120","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/j.bbi.2009.01.017","article-title":"Lipopolysaccharide alters the blood-brain barrier transport of amyloid beta protein: a mechanism for inflammation in the progression of Alzheimer's disease","volume":"23","author":"Jaeger","year":"2009","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.bbi.2018.03.007_b0125","doi-asserted-by":"crossref","first-page":"19276","DOI":"10.1523\/JNEUROSCI.3487-13.2013","article-title":"Neuronal clearance of amyloid-\u03b2 by endocytic receptor LRP1","volume":"33","author":"Kanekiyo","year":"2013","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bbi.2018.03.007_b0130","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1172\/JCI11013","article-title":"Modulation of amyloid beta-protein clearance and Alzheimer's disease susceptibility by the LDL receptor-related protein pathway","volume":"106","author":"Kang","year":"2000","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bbi.2018.03.007_b0135","doi-asserted-by":"crossref","first-page":"8455","DOI":"10.1073\/pnas.93.16.8455","article-title":"A molecular mechanism for the effect of lithium on development","volume":"93","author":"Klein","year":"1996","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.bbi.2018.03.007_b0140","doi-asserted-by":"crossref","first-page":"1855","DOI":"10.1111\/j.1471-4159.2008.05537.x","article-title":"Activation of \u03b2-catenin signalling by GSK-3 inhibition increases p-glycoprotein expression in brain endothelial cells","volume":"106","author":"Lim","year":"2008","journal-title":"J. Neurochem."},{"key":"10.1016\/j.bbi.2018.03.007_b0145","doi-asserted-by":"crossref","first-page":"4023","DOI":"10.1523\/JNEUROSCI.3442-16.2017","article-title":"Astrocytic LRP1 mediates brain A\u03b2 clearance and impacts amyloid deposition","volume":"37","author":"Liu","year":"2017","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bbi.2018.03.007_b0150","first-page":"333","article-title":"Copper complexing decreases the ability of amyloid beta peptide to cross the BBB and enter brain parenchyma","volume":"43","author":"Mare","year":"2004","journal-title":"Peptides"},{"key":"10.1016\/j.bbi.2018.03.007_b0155","doi-asserted-by":"crossref","first-page":"18","DOI":"10.18773\/austprescr.2013.008","article-title":"Safe and effective use of lithium","volume":"36","author":"Manlhi","year":"2013","journal-title":"Aust. Prescr."},{"key":"10.1016\/j.bbi.2018.03.007_b0160","first-page":"1293","article-title":"Diffuse plaques do not accentuate synapse loss in Alzheimer's disease","volume":"137","author":"Masliah","year":"1990","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.bbi.2018.03.007_b0165","doi-asserted-by":"crossref","first-page":"1774","DOI":"10.1126\/science.1197623","article-title":"Decreased clearance of CNS \u03b2-amyloid in Alzheimer's disease","volume":"330","author":"Mawuenyega","year":"2010","journal-title":"Science"},{"key":"10.1016\/j.bbi.2018.03.007_b0170","doi-asserted-by":"crossref","first-page":"2868","DOI":"10.1007\/s11095-013-1116-2","article-title":"Altered brain uptake of therapeutics in a triple transgenic mouse model of Alzheimer's disease","volume":"30","author":"Mehta","year":"2013","journal-title":"Pharm. Res."},{"key":"10.1016\/j.bbi.2018.03.007_b0175","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1017\/S1461145711001611","article-title":"The effect of rosiglitazone on LRP1 expression and amyloid \u03b2 uptake in human brain microvascular endothelial cells: a possible role of a low-dose thiazolidinedione for dementia treatment","volume":"15","author":"Moon","year":"2012","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"10.1016\/j.bbi.2018.03.007_b0180","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1038\/297681a0","article-title":"Place navigation impaired in rats with hippocampal lesions","volume":"297","author":"Morris","year":"1982","journal-title":"Nature"},{"key":"10.1016\/j.bbi.2018.03.007_b9000","first-page":"135","article-title":"Inconsistencies and controversies surrounding the amyloid hypothesis of Alzheimer\u2019s disease","volume":"2","author":"Morris","year":"2014","journal-title":"Acta Neuropathol. Commun."},{"key":"10.1016\/j.bbi.2018.03.007_b0185","doi-asserted-by":"crossref","first-page":"3916","DOI":"10.1523\/JNEUROSCI.13-09-03916.1993","article-title":"Spatial learning impairment parallels the magnitude of dorsal hippocampal lesions, but is hardly present following ventral lesions","volume":"13","author":"Moser","year":"1993","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bbi.2018.03.007_b9010","doi-asserted-by":"crossref","first-page":"311","DOI":"10.3233\/JAD-2010-1221","article-title":"J Alzheimer\u2019s disease and the amyloid-beta peptide","volume":"19","author":"Murphy","year":"2010","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.bbi.2018.03.007_b0190","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1111\/j.1749-6632.2000.tb06725.x","article-title":"The parahippocampal region and object identification","volume":"911","author":"Murray","year":"2000","journal-title":"Ann. NY. Acad. Sci."},{"key":"10.1016\/j.bbi.2018.03.007_b0195","doi-asserted-by":"crossref","first-page":"6568","DOI":"10.1523\/JNEUROSCI.18-16-06568.1998","article-title":"Object recognition and location memory in monkeys with excitotoxic lesions of the amygdala and hippocampus","volume":"18","author":"Murray","year":"1998","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bbi.2018.03.007_b9005","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1097\/NEN.0b013e31825018f7","article-title":"Correlation of Alzheimer disease neuropathologic changes with cognitive status: a review of the literature","volume":"71","author":"Nelson","year":"2012","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.bbi.2018.03.007_b0200","doi-asserted-by":"crossref","first-page":"2625","DOI":"10.1016\/j.xphs.2017.01.013","article-title":"Assessing the impact of lithium chloride on the expression of P-glycoprotein at the blood-brain barrier","volume":"106","author":"Newman","year":"2017","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.bbi.2018.03.007_b0205","doi-asserted-by":"crossref","first-page":"6990","DOI":"10.1073\/pnas.0500466102","article-title":"Inhibition of glycogen synthase kinase-3 by lithium correlates with reduced tauopathy and degeneration in vivo","volume":"102","author":"Noble","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.bbi.2018.03.007_b0210","first-page":"104","article-title":"Microdose lithium treatment stabilized cognitive impairment in patients with Alzheimer's disease","volume":"10","author":"Nunes","year":"2013","journal-title":"Curr. Alzheim. Res."},{"key":"10.1016\/j.bbi.2018.03.007_b0215","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1192\/bjp.bp.106.029868","article-title":"Lithium and risk for Alzheimer's disease in elderly patients with bipolar disorder","volume":"190","author":"Nunes","year":"2007","journal-title":"Br. J. Psychiat."},{"key":"10.1016\/j.bbi.2018.03.007_b0220","doi-asserted-by":"crossref","first-page":"11755","DOI":"10.1523\/JNEUROSCI.1583-16.2016","article-title":"Fatty acid-binding protein 5 at the blood-brain barrier regulates endogenous brain docosahexaenoic acid levels and cognitive function","volume":"36","author":"Pan","year":"2016","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bbi.2018.03.007_b0225","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1186\/2045-8118-8-21","article-title":"Amyloid-beta transporter expression at the blood-CSF barrier is age-dependent","volume":"8","author":"Pascale","year":"2011","journal-title":"Fluids Barr. CNS"},{"key":"10.1016\/j.bbi.2018.03.007_b0230","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1038\/nature01640","article-title":"GSK-3\u03b1 regulates production of Alzheimer's disease amyloid-\u03b2 peptides","volume":"423","author":"Phiel","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.bbi.2018.03.007_b0235","doi-asserted-by":"crossref","first-page":"F538","DOI":"10.1152\/ajprenal.1987.253.3.F538","article-title":"Bulk flow of cerebrospinal fluid into brain in response to acute hyperosmolality","volume":"253","author":"Pullen","year":"1987","journal-title":"Am. J. Physiol. Renal Physiol."},{"key":"10.1016\/j.bbi.2018.03.007_b0240","doi-asserted-by":"crossref","first-page":"1849","DOI":"10.1021\/acschemneuro.5b00190","article-title":"Oleocanthal enhances amyloid-beta clearance from the brains of TgSwDI mice and in vitro across a human blood-brain barrier model","volume":"6","author":"Qosa","year":"2015","journal-title":"ACS Chem. Neurosci."},{"key":"10.1016\/j.bbi.2018.03.007_b0245","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1038\/sj.embor.7400784","article-title":"A\u03b242-driven cerebral amyloidosis in transgenic mice reveals early and robust pathology","volume":"7","author":"Radde","year":"2006","journal-title":"EMBO Rep."},{"key":"10.1016\/j.bbi.2018.03.007_b0250","doi-asserted-by":"crossref","first-page":"1981","DOI":"10.1523\/JNEUROSCI.4321-06.2007","article-title":"Neuroprotective effects of regulators of the glycogen synthase kinase-3beta signaling pathway in a transgenic model of Alzheimer's disease are associated with reduced amyloid precursor protein phosphorylation","volume":"27","author":"Rockenstein","year":"2007","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bbi.2018.03.007_b0255","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1186\/1750-1326-7-28","article-title":"Transgenic APP expression during postnatal development causes persistent locomotor hyperactivity in the adult","volume":"7","author":"Rodgers","year":"2012","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.bbi.2018.03.007_b0260","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1152\/physrev.2001.81.2.741","article-title":"Alzheimer's disease: genes, proteins, and therapy","volume":"81","author":"Selkoe","year":"2001","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.bbi.2018.03.007_b0265","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1007\/s13318-017-0412-3","article-title":"Effect of long-term in vitro lithium exposure on mRNA levels of claudin-3, CYP1A1, ABCG2 and GSTM3 Genes in the hCMEC\/D3 human brain endothelial cell line","volume":"42","author":"Shawahna","year":"2017","journal-title":"Eur. J. Drug Metab. Pharmacokinet."},{"key":"10.1016\/j.bbi.2018.03.007_b0270","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.1172\/JCI10498","article-title":"Clearance of Alzheimer's amyloid1-40 peptide from brain by LDL receptor-related protein-1 at the blood-brain barrier","volume":"106","author":"Shibata","year":"2000","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bbi.2018.03.007_b0275","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1016\/S1474-4422(03)00487-3","article-title":"Alzheimer's disease, normal-pressure hydrocephalus, and senescent changes in CSF circulatory physiology: a hypothesis","volume":"2","author":"Silverberg","year":"2003","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.bbi.2018.03.007_b0280","doi-asserted-by":"crossref","first-page":"1664","DOI":"10.1016\/S0960-9822(02)70790-2","article-title":"Lithium inhibits glycogen synthase kinase-3 activity and mimics wingless signalling in intact cells","volume":"6","author":"Stambolic","year":"1996","journal-title":"Curr. Biol."},{"key":"10.1016\/j.bbi.2018.03.007_b0285","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1172\/JCI81108","article-title":"Endothelial LRP1 transports amyloid-beta(1\u201342) across the blood-brain barrier","volume":"126","author":"Storck","year":"2016","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bbi.2018.03.007_b0290","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/0006-8993(95)01589-2","article-title":"Effects of discrete kainic acid-induced hippocampal lesions on spatial and contextual learning and memory in rats","volume":"716","author":"Stubley-Weatherly","year":"1996","journal-title":"Brain Res."},{"key":"10.1016\/j.bbi.2018.03.007_b0295","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1093\/brain\/awt062","article-title":"Brain amyloid-\u03b2 oligomers in ageing and Alzheimer\u2019s disease","volume":"136","author":"Lesn\u00e9","year":"2013","journal-title":"Brain"},{"key":"10.1016\/j.bbi.2018.03.007_b0300","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1038\/nrneurol.2015.119","article-title":"Clearance systems in the brain - implications for Alzheimer disease","volume":"11","author":"Tarasoff-Conway","year":"2015","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.bbi.2018.03.007_b0305","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.bbr.2011.01.052","article-title":"Effects of the cognition impairer MK-801 on learning and memory in mice and rats","volume":"220","author":"van der Staay","year":"2011","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.bbi.2018.03.007_b0310","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/7603975","article-title":"Improvement of electroacupuncture on APP\/PS1 transgenic mice in spatial learning and memory probably due to expression of A\u03b2 and LRP1 in hippocampus","author":"Wang","year":"2016","journal-title":"Evid. Based Compl. Alternat. Med."},{"key":"10.1016\/j.bbi.2018.03.007_b0315","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1111\/bpa.12152","article-title":"The pericyte: a forgotten cell type with important implications for Alzheimer\u2019s disease?","volume":"24","author":"Winkler","year":"2014","journal-title":"Brain Pathol."},{"key":"10.1016\/j.bbi.2018.03.007_b0320","doi-asserted-by":"crossref","first-page":"2263","DOI":"10.1111\/j.1460-9568.2005.04055.x","article-title":"Removal of cholinergic input to perirhinal cortex disrupts object recognition but not spatial working memory in the rat","volume":"21","author":"Winters","year":"2005","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.bbi.2018.03.007_b0325","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1016\/0028-3908(86)90149-8","article-title":"The pharmacokinetic profile of lithium in rat and mouse; an important factor in psychopharmacological investigation of the drug","volume":"25","author":"Wood","year":"1986","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.bbi.2018.03.007_b0330","doi-asserted-by":"crossref","first-page":"2736","DOI":"10.1016\/j.neurobiolaging.2014.06.003","article-title":"Beneficial synergistic effects of microdose lithium with pyrroloquinoline quinone in an Alzheimer's disease mouse model","volume":"35","author":"Zhao","year":"2014","journal-title":"Neurobiol. Aging"}],"container-title":["Brain, Behavior, and Immunity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0889159118300552?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0889159118300552?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T07:49:11Z","timestamp":1760168951000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0889159118300552"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,5]]},"references-count":69,"alternative-id":["S0889159118300552"],"URL":"https:\/\/doi.org\/10.1016\/j.bbi.2018.03.007","relation":{},"ISSN":["0889-1591"],"issn-type":[{"value":"0889-1591","type":"print"}],"subject":[],"published":{"date-parts":[[2018,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cognitive benefits of lithium chloride in APP\/PS1 mice are associated with enhanced brain clearance of \u03b2-amyloid","name":"articletitle","label":"Article Title"},{"value":"Brain, Behavior, and Immunity","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbi.2018.03.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Crown Copyright \u00a9 2018 Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}