{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T17:10:11Z","timestamp":1778692211709,"version":"3.51.4"},"reference-count":41,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,5,1]],"date-time":"2018-05-01T00:00:00Z","timestamp":1525132800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,5,1]],"date-time":"2018-05-01T00:00:00Z","timestamp":1525132800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100007170","name":"Ministry of Economy","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007170","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"ISCIII","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002924","name":"FEDER","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002924","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010669","name":"ICT","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010669","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004543","name":"China Scholarship Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004543","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain, Behavior, and Immunity"],"published-print":{"date-parts":[[2018,5]]},"DOI":"10.1016\/j.bbi.2018.03.018","type":"journal-article","created":{"date-parts":[[2018,3,17]],"date-time":"2018-03-17T00:17:20Z","timestamp":1521245840000},"page":"346-353","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"special_numbering":"C","title":["Adrenal hormones and circulating leukocyte subtypes in stroke patients treated with reperfusion therapy"],"prefix":"10.1016","volume":"70","author":[{"given":"Francesc","family":"Mir\u00f3-Mur","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos","family":"Laredo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arturo","family":"Ren\u00fa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Salvatore","family":"Rudilosso","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yashu","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sergio","family":"Amaro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Llull","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xabier","family":"Urra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna M.","family":"Planas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00c1ngel","family":"Chamorro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbi.2018.03.018_b0005","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1038\/nrneurol.2012.98","article-title":"The immunology of acute stroke","volume":"8","author":"Chamorro","year":"2012","journal-title":"Nat Rev Neurol"},{"key":"10.1016\/j.bbi.2018.03.018_b0010","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1056\/NEJM199505183322008","article-title":"The hypothalamic-pituitary-adrenal axis and immune-mediated inflammation","volume":"332","author":"Chrousos","year":"1995","journal-title":"N Engl J Med"},{"key":"10.1016\/j.bbi.2018.03.018_b0015","first-page":"3009","article-title":"Regional release and removal of catecholamines and extraneuronal metabolism to metanephrines","volume":"80","author":"Eisenhofer","year":"1995","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.bbi.2018.03.018_b0020","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/S0031-6997(24)01470-4","article-title":"The sympathetic nerve\u2014an integrative interface between two supersystems: the brain and the immune system","volume":"52","author":"Elenkov","year":"2000","journal-title":"Pharmacol Rev"},{"key":"10.1016\/j.bbi.2018.03.018_b0025","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1016\/S0167-5699(97)01111-0","article-title":"Glucocorticoids and immune function: unknown dimensions and new frontiers","volume":"18","author":"Wilckens","year":"1997","journal-title":"Immunol Today"},{"key":"10.1016\/j.bbi.2018.03.018_b0030","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1084\/jem.20011629","article-title":"In vitro generation of interleukin 10-producing regulatory CD4+ T cells is induced by immunosuppressive drugs and inhibited by T helper type 1 (Th1)- and Th2-inducing cytokines","volume":"195","author":"Barrat","year":"2002","journal-title":"J Exp Med"},{"key":"10.1016\/j.bbi.2018.03.018_b0035","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.neuron.2009.09.032","article-title":"The stressed CNS: when glucocorticoids aggravate inflammation","volume":"64","author":"Sorrells","year":"2009","journal-title":"Neuron"},{"key":"10.1016\/j.bbi.2018.03.018_b0040","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1007\/s00415-013-7231-5","article-title":"Cortisol levels and the severity and outcomes of acute stroke: a systematic review","volume":"261","author":"Barugh","year":"2014","journal-title":"J Neurol"},{"key":"10.1016\/j.bbi.2018.03.018_b0045","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1161\/01.STR.12.2.200","article-title":"Plasma norepinephrine in stroke","volume":"12","author":"Myers","year":"1981","journal-title":"Stroke."},{"key":"10.1016\/j.bbi.2018.03.018_b0050","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1111\/j.1365-2796.1990.tb00213.x","article-title":"Urinary free cortisol excretion shortly after ischemic stroke","volume":"228","author":"Olsson","year":"1990","journal-title":"J Intern Med"},{"key":"10.1016\/j.bbi.2018.03.018_b0055","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1161\/STROKEAHA.108.532085","article-title":"Monocytes are major players in the prognosis and risk of infection after acute stroke","volume":"40","author":"Urra","year":"2009","journal-title":"Stroke"},{"key":"10.1016\/j.bbi.2018.03.018_b0060","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1161\/01.STR.25.6.1105","article-title":"Pattern of activation of the hypothalamic\u2013pituitary\u2013 adrenal axis in acute stroke. Relation to acute confusional state, extent of brain damage, and clinical outcome","volume":"25","author":"Fassbender","year":"1994","journal-title":"Stroke"},{"key":"10.1016\/j.bbi.2018.03.018_b0065","doi-asserted-by":"crossref","first-page":"1374","DOI":"10.1001\/jama.1977.03280140052016","article-title":"Prognostic value of the stress response following stroke","volume":"238","author":"Feibel","year":"1977","journal-title":"JAMA"},{"key":"10.1016\/j.bbi.2018.03.018_b0070","doi-asserted-by":"crossref","first-page":"170","DOI":"10.2174\/156720207781387169","article-title":"Neurohormonal activation in ischemic stroke: effects of acute phase disturbances on long-term mortality","volume":"4","author":"Anne","year":"2007","journal-title":"Curr Neurovasc Res"},{"key":"10.1016\/j.bbi.2018.03.018_b0075","doi-asserted-by":"crossref","first-page":"e72758","DOI":"10.1371\/journal.pone.0072758","article-title":"Cortisol as a prognostic marker of short-term outcome in chinese patients with acute ischemic stroke","volume":"8","author":"Zi","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.bbi.2018.03.018_b0080","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1161\/01.STR.27.6.1028","article-title":"Effect of malnutrition after acute stroke on clinical outcome","volume":"27","author":"D\u00e1valos","year":"1996","journal-title":"Stroke"},{"key":"10.1016\/j.bbi.2018.03.018_b0085","doi-asserted-by":"crossref","first-page":"3415","DOI":"10.1161\/STROKEAHA.111.627331","article-title":"Plasma alpha-melanocyte stimulating hormone predicts outcome in ischemic stroke","volume":"42","author":"Zierath","year":"2011","journal-title":"Stroke"},{"key":"10.1016\/j.bbi.2018.03.018_b0090","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/0022-510X(94)90234-8","article-title":"Temporal profile of ischemic tissue damage, neutrophil response, and vascular plugging following permanent and transient (2H) middle cerebral artery occlusion in the rat","volume":"125","author":"Zhang","year":"1994","journal-title":"J Neurol Sci"},{"key":"10.1016\/j.bbi.2018.03.018_b0095","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1038\/jcbfm.2013.217","article-title":"Immune cell infiltration in malignant middle cerebral artery infarction: comparison with transient cerebral ischemia","volume":"34","author":"Chu","year":"2014","journal-title":"J Cereb Blood Flow Metab"},{"key":"10.1016\/j.bbi.2018.03.018_b0100","doi-asserted-by":"crossref","first-page":"11636","DOI":"10.1038\/s41598-017-11946-y","article-title":"Complete reperfusion is required for maximal benefits of mechanical thrombectomy in stroke patients","volume":"7","author":"Chamorro","year":"2017","journal-title":"Sci Rep"},{"key":"10.1016\/j.bbi.2018.03.018_b0105","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1161\/01.STR.0000170644.15504.49","article-title":"The Early Systemic Prophylaxis of Infection After Stroke study: a randomized clinical trial","volume":"36","author":"Chamorro","year":"2005","journal-title":"Stroke"},{"key":"10.1016\/j.bbi.2018.03.018_b0110","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1148\/radiol.12120971","article-title":"Perfusion CT in acute stroke: a comprehensive analysis of infarct and penumbra","volume":"267","author":"Bivard","year":"2013","journal-title":"Radiology"},{"key":"10.1016\/j.bbi.2018.03.018_b0115","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1177\/0271678X15621704","article-title":"Brain hemorrhage after endovascular reperfusion therapy of ischemic stroke: a threshold-finding whole-brain perfusion CT study","volume":"37","author":"Ren\u00fa","year":"2017","journal-title":"J Cereb Blood Flow Metab"},{"key":"10.1016\/j.bbi.2018.03.018_b0120","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.jns.2006.10.001","article-title":"Catecholamines, infection, and death in acute ischemic stroke","volume":"252","author":"Chamorro","year":"2007","journal-title":"J Neurol Sci"},{"key":"10.1016\/j.bbi.2018.03.018_b0125","doi-asserted-by":"crossref","first-page":"1174","DOI":"10.1016\/j.neuroscience.2008.06.014","article-title":"Harms and benefits of lymphocyte subpopulations in patients with acute stroke","volume":"158","author":"Urra","year":"2009","journal-title":"Neuroscience"},{"key":"10.1016\/j.bbi.2018.03.018_b0130","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1038\/jcbfm.2009.25","article-title":"Monocyte subtypes predict clinical course and prognosis in human stroke","volume":"29","author":"Urra","year":"2009","journal-title":"J Cereb Blood Flow Metab"},{"key":"10.1016\/j.bbi.2018.03.018_b0135","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1001\/jama.2016.13647","article-title":"HERMES Collaborators. Time to treatment with endovascular thrombectomy and outcomes from ischemic stroke: A meta-analysis","volume":"316","author":"Saver","year":"2016","journal-title":"JAMA"},{"key":"10.1016\/j.bbi.2018.03.018_b0140","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1046\/j.1471-4159.2003.01604.x","article-title":"Novel glucocorticoid effects on acute inflammation in the CNS","volume":"84","author":"Dinkel","year":"2003","journal-title":"J Neurochem"},{"key":"10.1016\/j.bbi.2018.03.018_b0145","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1126\/science.4035356","article-title":"Glucocorticoids potentiate ischemic injury to neurons: therapeutic implications","volume":"229","author":"Sapolsky","year":"1985","journal-title":"Science"},{"key":"10.1016\/j.bbi.2018.03.018_b0150","doi-asserted-by":"crossref","first-page":"e74839","DOI":"10.1371\/journal.pone.0074839","article-title":"Stress mediators and immune dysfunction in patients with acute cerebrovascular diseases","volume":"8","author":"Liesz","year":"2013","journal-title":"PLoS ONE"},{"key":"10.1016\/j.bbi.2018.03.018_b0155","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1007\/s00540-008-0639-x","article-title":"Plasma proinflammatory and anti-inflammatory cytokine and catecholamine concentrations as predictors of neurological outcome in acute stroke patients","volume":"22","author":"Oto","year":"2008","journal-title":"J Anesth"},{"key":"10.1016\/j.bbi.2018.03.018_b0160","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.bbi.2014.05.015","article-title":"Differential effects of sympathetic nervous system and hypothalamic-pituitary-adrenal axis on systemic immune cells after severe experimental stroke","volume":"41","author":"Mracsko","year":"2014","journal-title":"Brain Behav Immun"},{"key":"10.1016\/j.bbi.2018.03.018_b0165","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/S0165-0173(96)00012-4","article-title":"The role of adrenocorticoids as modulators of immune function in health and disease: neural, endocrine and immune interactions","volume":"23","author":"McEwen","year":"1997","journal-title":"Brain Res Brain Res Rev"},{"key":"10.1016\/j.bbi.2018.03.018_b0170","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1146\/annurev.immunol.20.082401.104914","article-title":"Neuroendocrine regulation of immunity","volume":"20","author":"Webster","year":"2002","journal-title":"Annu Rev Immunol"},{"key":"10.1016\/j.bbi.2018.03.018_b0175","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/S0167-5699(00)01747-3","article-title":"Norepinephrine: a messenger from the brain to the immune system","volume":"21","author":"Kohm","year":"2000","journal-title":"Immunol Today"},{"key":"10.1016\/j.bbi.2018.03.018_b0180","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1084\/jem.20021098","article-title":"Stroke induced immunodeficiency promotes spontaneous bacterial infections and is mediated by sympathetic activation reversal by post-stroke T helper cell type 1-like immunostimulation","volume":"198","author":"Prass","year":"2003","journal-title":"J Exp Med"},{"key":"10.1016\/j.bbi.2018.03.018_b0185","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1126\/science.1210301","article-title":"Functional innervation of hepatic iNKT cells is immunosuppressive following stroke","volume":"334","author":"Wong","year":"2011","journal-title":"Science"},{"key":"10.1016\/j.bbi.2018.03.018_b0190","doi-asserted-by":"crossref","first-page":"1638","DOI":"10.4049\/jimmunol.157.4.1638","article-title":"Stress-induced changes in blood leukocyte distribution. Role of adrenal steroid hormones","volume":"157","author":"Dhabhar","year":"1996","journal-title":"J Immunol"},{"key":"10.1016\/j.bbi.2018.03.018_b0195","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1038\/nm.1927","article-title":"Regulatory T cells are key cerebroprotective immunomodulators in acute experimental stroke","volume":"15","author":"Liesz","year":"2009","journal-title":"Nat Med"},{"key":"10.1016\/j.bbi.2018.03.018_b0200","doi-asserted-by":"crossref","first-page":"1571","DOI":"10.1111\/jcmm.12304","article-title":"Regulatory T cells modulate inflammation and reduce infarct volume in experimental brain ischemia","volume":"18","author":"Brea","year":"2014","journal-title":"J Cell Mol Med"},{"key":"10.1016\/j.bbi.2018.03.018_b0205","doi-asserted-by":"crossref","unstructured":"Sandercock PA, Soane T. Corticosteroids for acute ischaemic stroke. Cochrane Database Syst Rev. 2011; 9: CD000064.","DOI":"10.1002\/14651858.CD000064.pub2"}],"container-title":["Brain, Behavior, and Immunity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0889159118300631?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0889159118300631?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T07:53:39Z","timestamp":1760169219000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0889159118300631"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,5]]},"references-count":41,"alternative-id":["S0889159118300631"],"URL":"https:\/\/doi.org\/10.1016\/j.bbi.2018.03.018","relation":{},"ISSN":["0889-1591"],"issn-type":[{"value":"0889-1591","type":"print"}],"subject":[],"published":{"date-parts":[[2018,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Adrenal hormones and circulating leukocyte subtypes in stroke patients treated with reperfusion therapy","name":"articletitle","label":"Article Title"},{"value":"Brain, Behavior, and Immunity","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbi.2018.03.018","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}