{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T22:36:56Z","timestamp":1787697416010,"version":"build-2784847793"},"reference-count":82,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,7,1]],"date-time":"2018-07-01T00:00:00Z","timestamp":1530403200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,7,1]],"date-time":"2018-07-01T00:00:00Z","timestamp":1530403200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Bildung und Forschung","doi-asserted-by":"publisher","award":["01EO1004"],"award-info":[{"award-number":["01EO1004"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain, Behavior, and Immunity"],"published-print":{"date-parts":[[2018,7]]},"DOI":"10.1016\/j.bbi.2018.04.002","type":"journal-article","created":{"date-parts":[[2018,4,5]],"date-time":"2018-04-05T23:19:22Z","timestamp":1522970362000},"page":"133-141","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"special_numbering":"C","title":["CRP genetic variants are associated with mortality and depressive symptoms in chronic heart failure patients"],"prefix":"10.1016","volume":"71","author":[{"given":"S.","family":"Kittel-Schneider","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Kaspar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Berliner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Weber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Deckert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Ertl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"St\u00f6rk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Angermann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Reif","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2\u20133","key":"10.1016\/j.bbi.2018.04.002_b0005","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1016\/j.jad.2012.03.033","article-title":"Effect of celecoxib add-on treatment on symptoms and serum IL-6 concentrations in patients with major depressive disorder: randomized double-blind placebo-controlled study","volume":"141","author":"Abbasi","year":"2012","journal-title":"J. Affect. Disord"},{"issue":"1","key":"10.1016\/j.bbi.2018.04.002_b0010","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.ajhg.2016.11.007","article-title":"Genome-wide association study identifies 27 loci influencing concentrations of circulating cytokines and growth factors","volume":"100","author":"Ahola-Olli","year":"2017","journal-title":"Am. J. Hum. Genet."},{"issue":"1","key":"10.1016\/j.bbi.2018.04.002_b0015","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1161\/CIRCHEARTFAILURE.111.962969","article-title":"Mode of action and effects of standardized collaborative disease management on mortality and morbidity in patients with systolic heart failure: the Interdisciplinary Network for Heart Failure (INH) study","volume":"5","author":"Angermann","year":"2012","journal-title":"Circ. Heart Fail."},{"key":"10.1016\/j.bbi.2018.04.002_b0020","article-title":"A functional variant of the neuropeptide S receptor-1 gene modulates clinical outcomes and healthcare utilization in patients with systolic heart failure: results from the Interdisciplinary Network Heart Failure (INH) Study","author":"Angermann","year":"2016","journal-title":"Eur. J. Heart Fail."},{"key":"10.1016\/j.bbi.2018.04.002_b0025","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1186\/1471-2350-12-95","article-title":"Genetic polymorphisms of innate immunity-related inflammatory pathways and their association with factors related to type 2 diabetes","volume":"12","author":"Arora","year":"2011","journal-title":"BMC Med. Genet."},{"key":"10.1016\/j.bbi.2018.04.002_b0030","first-page":"1","article-title":"Testing for BNP and NT-proBNP in the diagnosis and prognosis of heart failure","volume":"142","author":"Balion","year":"2006","journal-title":"Evid. Rep. Technol. Assess. (Full Rep.)"},{"issue":"2","key":"10.1016\/j.bbi.2018.04.002_b0035","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1093\/bioinformatics\/bth457","article-title":"Haploview: analysis and visualization of LD and haplotype maps","volume":"21","author":"Barrett","year":"2005","journal-title":"Bioinformatics"},{"issue":"1","key":"10.1016\/j.bbi.2018.04.002_b0040","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1186\/1742-2094-11-100","article-title":"The association between sex-related interleukin-6 gene polymorphisms and the risk for cerebral palsy","volume":"11","author":"Bi","year":"2014","journal-title":"J. Neuroinflamm."},{"key":"10.1016\/j.bbi.2018.04.002_b0045","doi-asserted-by":"crossref","DOI":"10.1002\/jso.23682","article-title":"Elevated C-reactive protein as a predictor of patient outcomes following palliative surgery","author":"Blakely","year":"2014","journal-title":"J. Surg. Oncol."},{"issue":"5","key":"10.1016\/j.bbi.2018.04.002_b0050","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1038\/mp.2010.38","article-title":"Poor replication of candidate genes for major depressive disorder using genome-wide association data","volume":"16","author":"Bosker","year":"2011","journal-title":"Mol. Psychiatry"},{"issue":"2","key":"10.1016\/j.bbi.2018.04.002_b0055","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1007\/s10741-016-9533-z","article-title":"The role of inflammation and cell death in the pathogenesis, progression and treatment of heart failure","volume":"21","author":"Briasoulis","year":"2016","journal-title":"Heart Fail. Rev."},{"issue":"5","key":"10.1016\/j.bbi.2018.04.002_b0060","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1080\/08870446.2013.869813","article-title":"Depressive symptoms in outpatients with heart failure: importance of inflammatory biomarkers, disease severity and personality","volume":"29","author":"Brouwers","year":"2014","journal-title":"Psychol. Health"},{"key":"10.1016\/j.bbi.2018.04.002_b0065","doi-asserted-by":"crossref","DOI":"10.4088\/JCP.15m10267","article-title":"Depression is associated with high levels of C-reactive protein and low levels of fractional exhaled nitric oxide: results from the 2007\u20132012 national health and nutrition examination surveys","author":"Cepeda","year":"2016","journal-title":"J. Clin. Psychiatry"},{"issue":"Suppl. 1","key":"10.1016\/j.bbi.2018.04.002_b0070","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.archger.2009.09.009","article-title":"308(G\/A) TNF-alpha gene polymorphism and risk of depression late in the life","volume":"49","author":"Cerri","year":"2009","journal-title":"Arch Gerontol. Geriatr."},{"issue":"12","key":"10.1016\/j.bbi.2018.04.002_b0075","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1038\/ajh.2011.141","article-title":"Relationship of plasma interleukin-6 and its genetic variants with hypertension in Hong Kong Chinese","volume":"24","author":"Cheung","year":"2011","journal-title":"Am. J. Hypertens."},{"issue":"7","key":"10.1016\/j.bbi.2018.04.002_b0080","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1161\/CIRCULATIONAHA.110.948570","article-title":"Meta-analysis of genome-wide association studies in >80 000 subjects identifies multiple loci for C-reactive protein levels","volume":"123","author":"Dehghan","year":"2011","journal-title":"Circulation"},{"key":"10.1016\/j.bbi.2018.04.002_b9000","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1177\/1474515113507508","article-title":"Depressive symptoms and inflammatory biomarkers in patients with heart failure","volume":"13","author":"Dekker","year":"2014","journal-title":"Eur. J. Cardiovasc. Nurs."},{"key":"10.1016\/j.bbi.2018.04.002_b0085","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1186\/1475-2840-8-58","article-title":"Elevated plasma levels of TNF-alpha and interleukin-6 in patients with diastolic dysfunction and glucose metabolism disorders","volume":"8","author":"Dinh","year":"2009","journal-title":"Cardiovasc. Diabetol."},{"key":"10.1016\/j.bbi.2018.04.002_b0090","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1007\/7854_2011_185","article-title":"Behavioral genetics of affective and anxiety disorders","volume":"12","author":"Domschke","year":"2012","journal-title":"Curr. Top. Behav. Neurosci."},{"issue":"2","key":"10.1016\/j.bbi.2018.04.002_b0095","doi-asserted-by":"crossref","first-page":"213","DOI":"10.2217\/14622416.10.2.213","article-title":"Genome-wide association studies of coronary artery disease and heart failure: where are we going?","volume":"10","author":"Dorn","year":"2009","journal-title":"Pharmacogenomics"},{"issue":"1","key":"10.1016\/j.bbi.2018.04.002_b0100","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1001\/jama.2009.954","article-title":"Genetic Loci associated with C-reactive protein levels and risk of coronary heart disease","volume":"302","author":"Elliott","year":"2009","journal-title":"JAMA"},{"key":"10.1016\/j.bbi.2018.04.002_b0105","article-title":"The association between diabetes and depression: a very disabling condition","author":"Fiore","year":"2014","journal-title":"Endocrine"},{"issue":"3","key":"10.1016\/j.bbi.2018.04.002_b0110","doi-asserted-by":"crossref","first-page":"2258","DOI":"10.4238\/2012.May.14.5","article-title":"Common variants in the CRP gene are associated with serum C-reactive protein levels and body mass index in healthy individuals in Mexico","volume":"11","author":"Flores-Alfaro","year":"2012","journal-title":"Genet Mol. Res."},{"issue":"6","key":"10.1016\/j.bbi.2018.04.002_b0115","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1089\/gtmb.2010.0001","article-title":"The interleukin 6\u2013572 G>C (rs1800796) polymorphism is associated with the risk of developing acute coronary syndrome","volume":"14","author":"Fragoso","year":"2010","journal-title":"Genet Test Mol. Biomarkers"},{"issue":"8","key":"10.1016\/j.bbi.2018.04.002_b0120","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1007\/s00392-011-0285-4","article-title":"Biological variation of high sensitive Troponin T in stable heart failure patients with ischemic or dilated cardiomyopathy","volume":"100","author":"Frankenstein","year":"2011","journal-title":"Clin. Res. Cardiol."},{"issue":"7164","key":"10.1016\/j.bbi.2018.04.002_b0125","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1038\/nature06258","article-title":"A second generation human haplotype map of over 3.1 million SNPs","volume":"449","author":"Frazer","year":"2007","journal-title":"Nature"},{"issue":"8","key":"10.1016\/j.bbi.2018.04.002_b0130","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1097\/PSY.0000000000000346","article-title":"Major depression and long-term survival of patients with heart failure","volume":"78","author":"Freedland","year":"2016","journal-title":"Psychosom. Med."},{"key":"10.1016\/j.bbi.2018.04.002_b0135","doi-asserted-by":"crossref","DOI":"10.1002\/ejhf.150","article-title":"Effects of structured heart failure disease management on mortality and morbidity depend on patients\u2019 mood: results from the Interdisciplinary Network for Heart Failure Study","author":"Gelbrich","year":"2014","journal-title":"Eur. J. Heart Fail."},{"issue":"5","key":"10.1016\/j.bbi.2018.04.002_b0140","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/j.cardfail.2015.12.014","article-title":"Monocyte subsets and inflammatory cytokines in acute decompensated heart failure","volume":"22","author":"Goonewardena","year":"2016","journal-title":"J. Card. Fail."},{"key":"10.1016\/j.bbi.2018.04.002_b0145","doi-asserted-by":"crossref","DOI":"10.1002\/ejhf.146","article-title":"Impaired fasting glucose: a predictor of reduced survival in patients with heart failure","author":"Gotsman","year":"2014","journal-title":"Eur. J. Heart Fail."},{"key":"10.1016\/j.bbi.2018.04.002_b0150","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.bbi.2013.02.001","article-title":"Central autonomic network mediates cardiovascular responses to acute inflammation: relevance to increased cardiovascular risk in depression?","volume":"31","author":"Harrison","year":"2013","journal-title":"Brain Behav. Immun."},{"issue":"3","key":"10.1016\/j.bbi.2018.04.002_b0155","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1111\/j.1751-7133.2008.00030.x","article-title":"The impact of anemia on the prognosis of chronic heart failure: a meta-analysis and systemic review","volume":"15","author":"He","year":"2009","journal-title":"Congest Heart Fail."},{"issue":"3","key":"10.1016\/j.bbi.2018.04.002_b0160","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1097\/MIB.0000000000000296","article-title":"Serum C-reactive protein and CRP genotype in pediatric inflammatory bowel disease: influence on phenotype, natural history, and response to therapy","volume":"21","author":"Henderson","year":"2015","journal-title":"Inflamm. Bowel Dis."},{"issue":"4","key":"10.1016\/j.bbi.2018.04.002_b0165","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1007\/s10865-013-9510-0","article-title":"C-reactive protein is elevated in atypical but not nonatypical depression: data from the National Health and Nutrition Examination Survey (NHANES) 1999\u20132004","volume":"37","author":"Hickman","year":"2014","journal-title":"J. Behav. Med."},{"issue":"4","key":"10.1016\/j.bbi.2018.04.002_b0170","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1159\/000089003","article-title":"Interleukin-6 genetic polymorphism and Chinese major depression","volume":"52","author":"Hong","year":"2005","journal-title":"Neuropsychobiology"},{"key":"10.1016\/j.bbi.2018.04.002_b0175","article-title":"Role of interleukin-6 in regulation of immune responses to remodeling after myocardial infarction","author":"Huang","year":"2014","journal-title":"Heart Fail. Rev."},{"issue":"10","key":"10.1016\/j.bbi.2018.04.002_b0180","doi-asserted-by":"crossref","first-page":"2915","DOI":"10.2337\/db06-0600","article-title":"IL6 gene promoter polymorphisms and type 2 diabetes: joint analysis of individual participants' data from 21 studies","volume":"55","author":"Huth","year":"2006","journal-title":"Diabetes"},{"issue":"1","key":"10.1016\/j.bbi.2018.04.002_b0185","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.acvd.2011.10.007","article-title":"The role of natriuretic peptide testing in guiding chronic heart failure management: review of available data and recommendations for use","volume":"105","author":"Januzzi","year":"2012","journal-title":"Arch. Cardiovasc. Dis."},{"issue":"5","key":"10.1016\/j.bbi.2018.04.002_b0190","doi-asserted-by":"crossref","first-page":"420","DOI":"10.3343\/alm.2016.36.5.420","article-title":"The prognostic value of serum levels of heart-type fatty acid binding protein and high sensitivity C-reactive protein in patients with increased levels of amino-terminal pro-B type natriuretic peptide","volume":"36","author":"Jeong","year":"2016","journal-title":"Ann. Lab. Med."},{"issue":"6","key":"10.1016\/j.bbi.2018.04.002_b0195","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1016\/j.ahj.2011.03.011","article-title":"Depressive symptoms and inflammation in patients hospitalized for heart failure","volume":"161","author":"Johansson","year":"2011","journal-title":"Am. Heart J."},{"issue":"19","key":"10.1016\/j.bbi.2018.04.002_b0200","doi-asserted-by":"crossref","first-page":"2129","DOI":"10.1016\/j.jacc.2009.12.045","article-title":"Inflammatory markers and incident heart failure risk in older adults: the Health ABC (Health, Aging, and Body Composition) study","volume":"55","author":"Kalogeropoulos","year":"2010","journal-title":"J. Am. Coll. Cardiol."},{"issue":"3 Pt 1","key":"10.1016\/j.bbi.2018.04.002_b0205","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1016\/0002-8703(91)90225-7","article-title":"Epidemiology of heart failure","volume":"121","author":"Kannel","year":"1991","journal-title":"Am. Heart J."},{"issue":"1","key":"10.1016\/j.bbi.2018.04.002_b0210","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1089\/gtmb.2013.0357","article-title":"Association of interleukin-6-174 G>C promoter polymorphism with increased risk of type 2 diabetes mellitus patients with diabetic nephropathy in Turkey","volume":"18","author":"Karadeniz","year":"2014","journal-title":"Genet Test Mol. Biomarkers"},{"issue":"5","key":"10.1016\/j.bbi.2018.04.002_b0215","doi-asserted-by":"crossref","first-page":"353","DOI":"10.3109\/00365513.2011.568123","article-title":"Polymorphism in the C-reactive protein (CRP) gene affects CRP levels in plasma and one early marker of atherosclerosis in men: the Health 2000 Survey","volume":"71","author":"Kettunen","year":"2011","journal-title":"Scand. J. Clin. Lab Invest."},{"key":"10.1016\/j.bbi.2018.04.002_b0220","article-title":"Association between a functional interleukin 6 receptor genetic variant and risk of depression and psychosis in a population-based birth cohort","author":"Khandaker","year":"2017","journal-title":"Brain Behav. Immun."},{"issue":"10","key":"10.1016\/j.bbi.2018.04.002_b0225","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1038\/hr.2012.89","article-title":"C-reactive protein (CRP) gene polymorphisms, CRP levels and risk of incident essential hypertension: findings from an observational cohort of Han Chinese","volume":"35","author":"Kong","year":"2012","journal-title":"Hypertens. Res."},{"issue":"3","key":"10.1016\/j.bbi.2018.04.002_b0230","article-title":"Elevated level of high-sensitivity C-reactive protein is important in determining prognosis in chronic heart failure","volume":"16","author":"Kozdag","year":"2010","journal-title":"Med. Sci. Monit."},{"issue":"9","key":"10.1016\/j.bbi.2018.04.002_b0235","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1046\/j.1525-1497.2001.016009606.x","article-title":"The PHQ-9: validity of a brief depression severity measure","volume":"16","author":"Kroenke","year":"2001","journal-title":"J. Gen. Intern. Med."},{"key":"10.1016\/j.bbi.2018.04.002_b0240","article-title":"Position paper on the importance of psychosocial factors in cardiology: Update 2013","volume":"12","author":"Ladwig","year":"2014","journal-title":"Ger. Med. Sci."},{"issue":"4","key":"10.1016\/j.bbi.2018.04.002_b0245","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.jpsychores.2014.01.004","article-title":"Hemoglobin levels in persons with depressive and\/or anxiety disorders","volume":"76","author":"Lever-van Milligen","year":"2014","journal-title":"J. Psychosom. Res."},{"issue":"2","key":"10.1016\/j.bbi.2018.04.002_b0250","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/S0165-0327(02)00237-9","article-title":"Comparative validity of three screening questionnaires for DSM-IV depressive disorders and physicians\u2019 diagnoses","volume":"78","author":"Lowe","year":"2004","journal-title":"J. Affect. Disord."},{"issue":"7","key":"10.1016\/j.bbi.2018.04.002_b0255","doi-asserted-by":"crossref","first-page":"1717","DOI":"10.1253\/circj.CJ-10-1199","article-title":"Overexpression of human C-reactive protein exacerbates left ventricular remodeling in diabetic cardiomyopathy","volume":"75","author":"Mano","year":"2011","journal-title":"Circ. J."},{"issue":"5","key":"10.1016\/j.bbi.2018.04.002_b0260","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1160\/TH07-03-0231","article-title":"Common haplotypes of the C-reactive protein gene and circulating leptin levels influence the interindividual variability in serum C-reactive protein levels. The Segovia study","volume":"98","author":"Martinez-Calatrava","year":"2007","journal-title":"Thromb. Haemost."},{"issue":"4","key":"10.1016\/j.bbi.2018.04.002_b0265","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1016\/j.ejheart.2008.02.008","article-title":"Prognostic role of pro- and anti-inflammatory cytokines and their polymorphisms in acute decompensated heart failure","volume":"10","author":"Miettinen","year":"2008","journal-title":"Eur. J. Heart Fail."},{"issue":"4","key":"10.1016\/j.bbi.2018.04.002_b0270","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1136\/annrheumdis-2012-202848","article-title":"N-terminal pro-brain-type natriuretic peptide (NT-pro-BNP) and mortality risk in early inflammatory polyarthritis: results from the Norfolk Arthritis Registry (NOAR)","volume":"73","author":"Mirjafari","year":"2014","journal-title":"Ann. Rheum. Dis."},{"issue":"2","key":"10.1016\/j.bbi.2018.04.002_b0275","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1159\/000159775","article-title":"Cytokine Genes TNF, IL1A, IL1B, IL6, IL1RN and IL10, and childhood-onset mood disorders","volume":"58","author":"Misener","year":"2008","journal-title":"Neuropsychobiology"},{"issue":"11","key":"10.1016\/j.bbi.2018.04.002_b0280","doi-asserted-by":"crossref","first-page":"2752","DOI":"10.1172\/JCI119821","article-title":"Retrograde inflammatory signaling from neutrophils to endothelial cells by soluble interleukin-6 receptor alpha","volume":"100","author":"Modur","year":"1997","journal-title":"J. Clin. Invest."},{"issue":"3","key":"10.1016\/j.bbi.2018.04.002_b0285","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1177\/1099800413496454","article-title":"In patients with stable heart failure, soluble TNF-receptor 2 is associated with increased risk for depressive symptoms","volume":"16","author":"Moughrabi","year":"2013","journal-title":"Biol. Res. Nurs."},{"issue":"2\u20133","key":"10.1016\/j.bbi.2018.04.002_b0290","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1159\/000356540","article-title":"Immunology of major depression","volume":"21","author":"Muller","year":"2014","journal-title":"Neuroimmunomodulation"},{"issue":"2","key":"10.1016\/j.bbi.2018.04.002_b0295","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1093\/eurjhf\/hfn032","article-title":"Self-assessment of health status is associated with inflammatory activation and predicts long-term outcomes in chronic heart failure","volume":"11","author":"Parissis","year":"2009","journal-title":"Eur. J. Heart Fail."},{"issue":"3","key":"10.1016\/j.bbi.2018.04.002_b0300","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1161\/CIRCHEARTFAILURE.114.001488","article-title":"Comparative potential of the 2-item versus the 9-item patient health questionnaire to predict death or rehospitalization in heart failure","volume":"8","author":"Piepenburg","year":"2015","journal-title":"Circ. Heart Fail."},{"issue":"9","key":"10.1016\/j.bbi.2018.04.002_b0305","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1016\/j.euroneuro.2012.09.009","article-title":"Tumor necrosis factor and its targets in the inflammatory cytokine pathway are identified as putative transcriptomic biomarkers for escitalopram response","volume":"23","author":"Powell","year":"2013","journal-title":"Eur. Neuropsychopharmacol"},{"issue":"6","key":"10.1016\/j.bbi.2018.04.002_b0310","doi-asserted-by":"crossref","first-page":"e99495","DOI":"10.1371\/journal.pone.0099495","article-title":"Circulating levels of tumor necrosis factor-alpha receptor 2 are increased in heart failure with preserved ejection fraction relative to heart failure with reduced ejection fraction: evidence for a divergence in pathophysiology","volume":"9","author":"Putko","year":"2014","journal-title":"PLoS One"},{"issue":"12","key":"10.1016\/j.bbi.2018.04.002_b0315","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1056\/NEJM200003233421202","article-title":"C-reactive protein and other markers of inflammation in the prediction of cardiovascular disease in women","volume":"342","author":"Ridker","year":"2000","journal-title":"N. Engl. J. Med."},{"issue":"2","key":"10.1016\/j.bbi.2018.04.002_b0320","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1016\/j.atherosclerosis.2009.06.004","article-title":"Interleukin-6 promoter polymorphism and cardiovascular risk factors: the Health 2000 Survey","volume":"207","author":"Riikola","year":"2009","journal-title":"Atherosclerosis"},{"issue":"4","key":"10.1016\/j.bbi.2018.04.002_b0325","article-title":"Diagnosis and treatment of depression in patients with congestive heart failure: a review of the literature","volume":"15","author":"Rustad","year":"2013","journal-title":"Prim Care Companion CNS Disord."},{"issue":"2","key":"10.1016\/j.bbi.2018.04.002_b0330","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1093\/eurjhf\/hfs153","article-title":"Association between diabetes mellitus and post-discharge outcomes in patients hospitalized with heart failure: findings from the EVEREST trial","volume":"15","author":"Sarma","year":"2013","journal-title":"Eur. J. Heart Fail."},{"issue":"1","key":"10.1016\/j.bbi.2018.04.002_b0335","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1001\/archinte.159.1.29","article-title":"Congestive heart failure in the community: trends in incidence and survival in a 10-year period","volume":"159","author":"Senni","year":"1999","journal-title":"Arch. Intern. Med."},{"key":"10.1016\/j.bbi.2018.04.002_b0340","doi-asserted-by":"crossref","DOI":"10.1007\/s11033-014-3459-0","article-title":"A novel haplotype within C-reactive protein gene influences CRP levels and coronary heart disease risk in Northwest Indians","author":"Singh","year":"2014","journal-title":"Mol. Biol. Rep."},{"issue":"11","key":"10.1016\/j.bbi.2018.04.002_b0345","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1093\/ntr\/ntp144","article-title":"Interaction between smoking and the interleukin-6 gene affects systemic levels of inflammatory biomarkers","volume":"11","author":"Sunyer","year":"2009","journal-title":"Nicotine Tob. Res."},{"issue":"3","key":"10.1016\/j.bbi.2018.04.002_b0350","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1016\/j.amjcard.2007.08.038","article-title":"Usefulness of C-reactive protein and left ventricular diastolic performance for prognosis in patients with left ventricular systolic heart failure","volume":"101","author":"Tang","year":"2008","journal-title":"Am. J. Cardiol."},{"issue":"2","key":"10.1016\/j.bbi.2018.04.002_b0355","doi-asserted-by":"crossref","first-page":"e64","DOI":"10.1016\/j.atherosclerosis.2008.10.034","article-title":"Association between C-reactive protein gene haplotypes and C-reactive protein levels in Taiwanese: interaction with obesity","volume":"204","author":"Teng","year":"2009","journal-title":"Atherosclerosis"},{"issue":"3","key":"10.1016\/j.bbi.2018.04.002_b0360","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1016\/j.jad.2013.06.004","article-title":"CRP, IL-6 and depression: a systematic review and meta-analysis of longitudinal studies","volume":"150","author":"Valkanova","year":"2013","journal-title":"J. Affect. Disord."},{"issue":"6","key":"10.1016\/j.bbi.2018.04.002_b0365","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1159\/000332336","article-title":"Mendelian randomization study of interleukin-6 in chronic obstructive pulmonary disease","volume":"82","author":"van Durme","year":"2011","journal-title":"Respiration"},{"issue":"16","key":"10.1016\/j.bbi.2018.04.002_b0370","doi-asserted-by":"crossref","first-page":"1890","DOI":"10.1161\/01.CIR.0000015126.83143.B4","article-title":"Endothelin antagonism and interleukin-6 inhibition attenuate the proatherogenic effects of C-reactive protein","volume":"105","author":"Verma","year":"2002","journal-title":"Circulation"},{"issue":"2","key":"10.1016\/j.bbi.2018.04.002_b0375","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1001\/2013.jamapsychiatry.102","article-title":"Elevated C-reactive protein levels, psychological distress, and depression in 73, 131 individuals","volume":"70","author":"Wium-Andersen","year":"2013","journal-title":"JAMA Psychiatry"},{"key":"10.1016\/j.bbi.2018.04.002_b0380","article-title":"Elevated C-reactive protein, depression, somatic diseases, and all-cause mortality: a mendelian randomization study","author":"Wium-Andersen","year":"2013","journal-title":"Biol. Psychiatry"},{"issue":"4","key":"10.1016\/j.bbi.2018.04.002_b0385","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1172\/JCI67221","article-title":"IL-6 polymorphisms: a useful genetic tool for inflammation research?","volume":"123","author":"Woo","year":"2013","journal-title":"J. Clin. Invest."},{"issue":"Pt 4","key":"10.1016\/j.bbi.2018.04.002_b0390","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1258\/acb.2010.090305","article-title":"The increased plasma C-reactive protein and interleukin-6 levels in patients undergoing coronary artery bypass grafting surgery are associated with the interleukin-6-174G > C gene polymorphism","volume":"47","author":"Wypasek","year":"2010","journal-title":"Ann. Clin. Biochem."},{"key":"10.1016\/j.bbi.2018.04.002_b9005","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1097\/PSY.0000000000000216","article-title":"Inflammation markers and major depressive disorder in patients with chronic heart failure: results from the sertraline against depression and heart disease in chronic heart failure study","volume":"77","author":"Xiong","year":"2015","journal-title":"Psychosom. Med."},{"issue":"2","key":"10.1016\/j.bbi.2018.04.002_b0395","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1111\/ahg.12003","article-title":"Association between the interleukin-6 gene-572 C\/G polymorphism and the risk of type 2 diabetes mellitus: a meta-analysis of 11,681 subjects","volume":"77","author":"Yin","year":"2013","journal-title":"Ann. Hum. Genet."},{"key":"10.1016\/j.bbi.2018.04.002_b0400","doi-asserted-by":"crossref","DOI":"10.2337\/dc16-0710","article-title":"hs-CRP predicts improvement in depression in patients with type 1 diabetes and major depression undergoing depression treatment: results from the diabetes and depression (DAD) study","author":"Zahn","year":"2016","journal-title":"Diabetes Care"}],"container-title":["Brain, Behavior, and Immunity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0889159118300886?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0889159118300886?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T07:48:57Z","timestamp":1760168937000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0889159118300886"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,7]]},"references-count":82,"alternative-id":["S0889159118300886"],"URL":"https:\/\/doi.org\/10.1016\/j.bbi.2018.04.002","relation":{},"ISSN":["0889-1591"],"issn-type":[{"value":"0889-1591","type":"print"}],"subject":[],"published":{"date-parts":[[2018,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"CRP genetic variants are associated with mortality and depressive symptoms in chronic heart failure patients","name":"articletitle","label":"Article Title"},{"value":"Brain, Behavior, and Immunity","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbi.2018.04.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}