{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T05:11:45Z","timestamp":1790831505500,"version":"4.1.0"},"reference-count":93,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,2,28]],"date-time":"2020-02-28T00:00:00Z","timestamp":1582848000000},"content-version":"am","delay-in-days":364,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100006488","name":"Institut National de la Recherche Agronomique","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006488","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008966","name":"Soci\u00e9t\u00e9 Francophone du Diab\u00e8te","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008966","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain, Behavior, and Immunity"],"published-print":{"date-parts":[[2019,3]]},"DOI":"10.1016\/j.bbi.2018.11.316","type":"journal-article","created":{"date-parts":[[2018,11,30]],"date-time":"2018-11-30T12:06:59Z","timestamp":1543579619000},"page":"25-36","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":59,"special_numbering":"C","title":["Brain tumor necrosis factor-\u03b1 mediates anxiety-like behavior in a mouse model of severe obesity"],"prefix":"10.1016","volume":"77","author":[{"given":"C\u00e9lia","family":"Fourrier","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cl\u00e9mentine","family":"Bosch-Bouju","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rapha\u00ebl","family":"Boursereau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Sauvant","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agn\u00e8s","family":"Aubert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucile","family":"Capuron","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillaume","family":"Ferreira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Lay\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalie","family":"Castanon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.bbi.2018.11.316_b0005","doi-asserted-by":"crossref","first-page":"2459","DOI":"10.1038\/s41467-018-04883-5","article-title":"Translational control of depression-like behavior via phosphorylation of eukaryotic translation initiation factor 4E","volume":"9","author":"Aguilar-Valles","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bbi.2018.11.316_b0010","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.physbeh.2016.11.016","article-title":"Behavioral changes in male mice fed a high-fat diet are associated with IL-1beta expression in specific brain regions","volume":"169","author":"Almeida-Suhett","year":"2017","journal-title":"Physiol. Behav."},{"issue":"3","key":"10.1016\/j.bbi.2018.11.316_b0015","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/j.yfrne.2014.05.004","article-title":"Sex differences in anxiety and depression clinical perspectives","volume":"35","author":"Altemus","year":"2014","journal-title":"Front. Neuroendocrinol."},{"key":"10.1016\/j.bbi.2018.11.316_b0020","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.psyneuen.2018.03.005","article-title":"Depression and peripheral inflammatory profile of patients with obesity","volume":"91","author":"Ambrosio","year":"2018","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.bbi.2018.11.316_b0025","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.bbi.2014.03.012","article-title":"Diet-induced obesity progressively alters cognition, anxiety-like behavior and lipopolysaccharide-induced depressive-like behavior: focus on brain indoleamine 2,3-dioxygenase activation","volume":"41","author":"Andr\u00e9","year":"2014","journal-title":"Brain Behav. Immun."},{"issue":"2","key":"10.1016\/j.bbi.2018.11.316_b0030","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/S1056-8727(02)00185-X","article-title":"Leptin treatment ameliorates anxiety in ob\/ob obese mice","volume":"17","author":"Asakawa","year":"2003","journal-title":"J. Diabetes Complications"},{"issue":"5","key":"10.1016\/j.bbi.2018.11.316_b0035","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1037\/0735-7044.116.5.884","article-title":"Double dissociation of function within the hippocampus: spatial memory and hyponeophagia","volume":"116","author":"Bannerman","year":"2002","journal-title":"Behav. Neurosci."},{"issue":"3","key":"10.1016\/j.bbi.2018.11.316_b0040","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.cmet.2005.02.001","article-title":"Roles for leptin receptor\/STAT3-dependent and -independent signals in the regulation of glucose homeostasis","volume":"1","author":"Bates","year":"2005","journal-title":"Cell Metab."},{"issue":"1\u20132","key":"10.1016\/j.bbi.2018.11.316_b0045","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/S0166-4328(01)00291-1","article-title":"Measuring normal and pathological anxiety-like behaviour in mice: a review","volume":"125","author":"Belzung","year":"2001","journal-title":"Behav. Brain Res."},{"issue":"51","key":"10.1016\/j.bbi.2018.11.316_b0050","doi-asserted-by":"crossref","first-page":"15731","DOI":"10.1073\/pnas.1511593112","article-title":"Obesity diminishes synaptic markers, alters microglial morphology, and impairs cognitive function","volume":"112","author":"Bocarsly","year":"2015","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"4","key":"10.1016\/j.bbi.2018.11.316_b0055","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1523\/JNEUROSCI.2277-11.2012","article-title":"Distinct roles for specific leptin receptor signals in the development of hypothalamic feeding circuits","volume":"32","author":"Bouret","year":"2012","journal-title":"J. Neurosci."},{"issue":"9","key":"10.1016\/j.bbi.2018.11.316_b0060","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.1038\/ijo.2012.204","article-title":"The associations of anxiety and depression symptoms with weight change and incident obesity: The HUNT Study","volume":"37","author":"Brumpton","year":"2013","journal-title":"Int. J. Obes. (Lond.)"},{"issue":"4","key":"10.1016\/j.bbi.2018.11.316_b0065","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/j.psym.2011.12.008","article-title":"High preoperative depression, phobic anxiety, and binge eating scores and low medium-term weight loss in sleeve gastrectomy obese patients: a preliminary cohort study","volume":"53","author":"Brunault","year":"2012","journal-title":"Psychosomatics"},{"issue":"2","key":"10.1016\/j.bbi.2018.11.316_b0070","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1038\/npp.2014.199","article-title":"Effects of centrally administered etanercept on behavior, microglia, and astrocytes in mice following a peripheral immune challenge","volume":"40","author":"Camara","year":"2015","journal-title":"Neuropsychopharmacology"},{"issue":"1","key":"10.1016\/j.bbi.2018.11.316_b0075","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1038\/npp.2016.123","article-title":"Role of Adiposity-Driven Inflammation in Depressive Morbidity","volume":"42","author":"Capuron","year":"2017","journal-title":"Neuropsychopharmacology"},{"issue":"7","key":"10.1016\/j.bbi.2018.11.316_b0080","doi-asserted-by":"crossref","first-page":"1517","DOI":"10.1017\/S0033291710001984","article-title":"Relationship between adiposity, emotional status and eating behaviour in obese women: role of inflammation","volume":"41","author":"Capuron","year":"2011","journal-title":"Psychol. Med."},{"key":"10.1016\/j.bbi.2018.11.316_b0085","doi-asserted-by":"crossref","first-page":"74","DOI":"10.3389\/fendo.2014.00074","article-title":"Neuropsychiatric comorbidity in obesity: role of inflammatory processes","volume":"5","author":"Castanon","year":"2014","journal-title":"Front. Endocrinol. (Lausanne)"},{"key":"10.1016\/j.bbi.2018.11.316_b0090","doi-asserted-by":"crossref","first-page":"229","DOI":"10.3389\/fnins.2015.00229","article-title":"Role of neuroinflammation in the emotional and cognitive alterations displayed by animal models of obesity","volume":"9","author":"Castanon","year":"2015","journal-title":"Front. Neurosci."},{"issue":"6","key":"10.1016\/j.bbi.2018.11.316_b0095","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/j.beem.2017.09.003","article-title":"Circadian aspects of adipokine regulation in rodents","volume":"31","author":"Challet","year":"2017","journal-title":"Best Pract. Res. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.bbi.2018.11.316_b0100","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.neulet.2013.02.005","article-title":"The contribution of TNF-alpha in the amygdala to anxiety in mice with persistent inflammatory pain","volume":"541","author":"Chen","year":"2013","journal-title":"Neurosci. Lett."},{"issue":"1","key":"10.1016\/j.bbi.2018.11.316_b0105","doi-asserted-by":"crossref","first-page":"R18","DOI":"10.1152\/ajpregu.00298.2014","article-title":"Genesis of anxiety, depression, and ongoing abdominal discomfort in ulcerative colitis-like colon inflammation","volume":"308","author":"Chen","year":"2015","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"issue":"2","key":"10.1016\/j.bbi.2018.11.316_b0110","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1124\/jpet.107.133181","article-title":"Food restriction alters N'-propyl-4,5,6,7-tetrahydrobenzothiazole-2,6-diamine dihydrochloride (pramipexole)-induced yawning, hypothermia, and locomotor activity in rats: evidence for sensitization of dopamine D2 receptor-mediated effects","volume":"325","author":"Collins","year":"2008","journal-title":"J. Pharmacol. Exp. Ther."},{"issue":"2","key":"10.1016\/j.bbi.2018.11.316_b0115","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1001\/jama.2015.18118","article-title":"Mental Health Conditions Among Patients Seeking and Undergoing Bariatric Surgery: A Meta-analysis","volume":"315","author":"Dawes","year":"2016","journal-title":"JAMA"},{"key":"10.1016\/j.bbi.2018.11.316_b0120","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.bbi.2016.12.022","article-title":"Impact of prebiotics on metabolic and behavioral alterations in a mouse model of metabolic syndrome","volume":"64","author":"de Cossio","year":"2017","journal-title":"Brain Behav. Immun."},{"issue":"5","key":"10.1016\/j.bbi.2018.11.316_b0125","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1016\/S0033-3182(09)70840-0","article-title":"Obesity and quality of life: a controlled study of normal-weight and obese individuals","volume":"50","author":"de Zwaan","year":"2009","journal-title":"Psychosomatics"},{"key":"10.1016\/j.bbi.2018.11.316_b0130","series-title":"Nucleus accumbens inflammation mediates anxiodepressive behavior and compulsive sucrose seeking elicited by saturated dietary fat","author":"Decarie-Spain","year":"2018"},{"issue":"9","key":"10.1016\/j.bbi.2018.11.316_b0135","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0024325","article-title":"Cognitive and emotional alterations are related to hippocampal inflammation in a mouse model of metabolic syndrome","volume":"6","author":"Dinel","year":"2011","journal-title":"PLoS ONE"},{"key":"10.1016\/j.bbi.2018.11.316_b0140","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.psyneuen.2013.10.014","article-title":"Lipopolysaccharide-induced brain activation of the indoleamine 2,3-dioxygenase and depressive-like behavior are impaired in a mouse model of metabolic syndrome","volume":"40","author":"Dinel","year":"2014","journal-title":"Psychoneuroendocrinology"},{"issue":"7","key":"10.1016\/j.bbi.2018.11.316_b0145","doi-asserted-by":"crossref","first-page":"2618","DOI":"10.1523\/JNEUROSCI.4200-13.2014","article-title":"Obesity elicits interleukin 1-mediated deficits in hippocampal synaptic plasticity","volume":"34","author":"Erion","year":"2014","journal-title":"J. Neurosci."},{"issue":"6","key":"10.1016\/j.bbi.2018.11.316_b0155","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1111\/jdv.12909","article-title":"Effect of biologics on depressive symptoms in patients with psoriasis: a systematic review","volume":"29","author":"Fleming","year":"2015","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"issue":"1","key":"10.1016\/j.bbi.2018.11.316_b0160","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1186\/s12974-017-0939-x","article-title":"Docosahexaenoic acid-containing choline phospholipid modulates LPS-induced neuroinflammation in vivo and in microglia in vitro","volume":"14","author":"Fourrier","year":"2017","journal-title":"J. Neuroinflammation"},{"issue":"3","key":"10.1016\/j.bbi.2018.11.316_b0165","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1038\/ijo.2009.252","article-title":"The association between obesity and anxiety disorders in the population: a systematic review and meta-analysis","volume":"34","author":"Gariepy","year":"2010","journal-title":"Int. J. Obes. (Lond.)"},{"issue":"1","key":"10.1016\/j.bbi.2018.11.316_b0170","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1017\/S0033291710000346","article-title":"Symptoms of depression and anxiety, and change in body mass index from adolescence to adulthood: results from a British birth cohort","volume":"41","author":"Gaysina","year":"2011","journal-title":"Psychol. Med."},{"issue":"2","key":"10.1016\/j.bbi.2018.11.316_b0175","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1007\/s00395-010-0146-8","article-title":"Central TNF inhibition results in attenuated neurohumoral excitation in heart failure: a role for superoxide and nitric oxide","volume":"106","author":"Guggilam","year":"2011","journal-title":"Basic Res. Cardiol."},{"key":"10.1016\/j.bbi.2018.11.316_b0180","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.physbeh.2014.02.036","article-title":"Antidepressant effects of insulin in streptozotocin induced diabetic mice: Modulation of brain serotonin system","volume":"129","author":"Gupta","year":"2014","journal-title":"Physiol. Behav."},{"issue":"7","key":"10.1016\/j.bbi.2018.11.316_b0185","doi-asserted-by":"crossref","first-page":"1730","DOI":"10.1016\/j.cell.2015.11.023","article-title":"Neuroinflammatory TNFalpha Impairs Memory via Astrocyte Signaling","volume":"163","author":"Habbas","year":"2015","journal-title":"Cell"},{"issue":"2","key":"10.1016\/j.bbi.2018.11.316_b0190","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/j.expneurol.2012.07.010","article-title":"TNF-alpha-mediated anxiety in a mouse model of multiple sclerosis","volume":"237","author":"Haji","year":"2012","journal-title":"Exp. Neurol."},{"issue":"9492","key":"10.1016\/j.bbi.2018.11.316_b0195","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1016\/S0140-6736(05)67483-1","volume":"366","author":"Haslam","year":"2005","journal-title":"Obesity Lancet"},{"issue":"6","key":"10.1016\/j.bbi.2018.11.316_b0200","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/j.eurpsy.2008.03.013","article-title":"Depression, comorbidities and the TNF-alpha system","volume":"23","author":"Himmerich","year":"2008","journal-title":"Eur. Psychiatry"},{"issue":"2","key":"10.1016\/j.bbi.2018.11.316_b0205","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1111\/asj.12255","article-title":"Effects of chronic mild food restriction on behavior and the hypothalamic malonyl-CoA signaling pathway","volume":"86","author":"Iio","year":"2015","journal-title":"Anim. Sci. J."},{"issue":"1","key":"10.1016\/j.bbi.2018.11.316_b0210","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.neulet.2006.12.032","article-title":"TNF-alpha involves in altered prefrontal synaptic transmission in mice with persistent inflammatory pain","volume":"415","author":"Jia","year":"2007","journal-title":"Neurosci. Lett."},{"issue":"3","key":"10.1016\/j.bbi.2018.11.316_b0215","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.jnutbio.2014.10.007","article-title":"Dietary restriction preserves the mass and function of pancreatic beta cells via cell kinetic regulation and suppression of oxidative\/ER stress in diabetic mice","volume":"26","author":"Kanda","year":"2015","journal-title":"J. Nutr. Biochem."},{"key":"10.1016\/j.bbi.2018.11.316_b0220","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1186\/1750-1326-9-36","article-title":"Diet and exercise orthogonally alter the gut microbiome and reveal independent associations with anxiety and cognition","volume":"9","author":"Kang","year":"2014","journal-title":"Mol. Neurodegener."},{"issue":"2","key":"10.1016\/j.bbi.2018.11.316_b0225","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1093\/rheumatology\/keq327","article-title":"Improvements in patient-reported outcomes, symptoms of depression and anxiety, and their association with clinical remission among patients with moderate-to-severe active early rheumatoid arthritis","volume":"50","author":"Kekow","year":"2011","journal-title":"Rheumatology (Oxford)"},{"issue":"6","key":"10.1016\/j.bbi.2018.11.316_b0230","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1177\/0271678X15606724","article-title":"Caloric restriction improves diabetes-induced cognitive deficits by attenuating neurogranin-associated calcium signaling in high-fat diet-fed mice","volume":"36","author":"Kim","year":"2016","journal-title":"J. Cereb. Blood Flow Metab."},{"issue":"11","key":"10.1016\/j.bbi.2018.11.316_b0235","doi-asserted-by":"crossref","first-page":"2734","DOI":"10.2337\/db11-1621","article-title":"Caloric restriction chronically impairs metabolic programming in mice","volume":"61","author":"Kirchner","year":"2012","journal-title":"Diabetes"},{"key":"10.1016\/j.bbi.2018.11.316_b0240","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/j.bbi.2016.08.001","article-title":"Differential effects of peripheral and brain tumor necrosis factor on inflammation, sickness, emotional behavior and memory in mice","volume":"58","author":"Klaus","year":"2016","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.bbi.2018.11.316_b0245","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.neuroscience.2015.03.068","article-title":"Neurochemical and electrophysiological deficits in the ventral hippocampus and selective behavioral alterations caused by high-fat diet in female C57BL\/6 mice","volume":"297","author":"Krishna","year":"2015","journal-title":"Neuroscience"},{"issue":"4","key":"10.1016\/j.bbi.2018.11.316_b0250","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1038\/sj.jcbfm.9600382","article-title":"Impaired wound healing after cerebral hypoxia-ischemia in the diabetic mouse","volume":"27","author":"Kumari","year":"2007","journal-title":"J. Cereb. Blood Flow Metab."},{"issue":"7","key":"10.1016\/j.bbi.2018.11.316_b0255","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1007\/s11064-014-1322-2","article-title":"Effect of a selective cyclooxygenase type 2 inhibitor celecoxib on depression associated with obesity in mice: an approach using behavioral tests","volume":"39","author":"Kurhe","year":"2014","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.bbi.2018.11.316_b0260","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.3389\/fphys.2018.01047","article-title":"Food for Mood: Relevance of Nutritional Omega-3 Fatty Acids for Depression and Anxiety","volume":"9","author":"Larrieu","year":"2018","journal-title":"Front. Physiol."},{"issue":"1","key":"10.1016\/j.bbi.2018.11.316_b0265","doi-asserted-by":"crossref","first-page":"E53","DOI":"10.1210\/jc.2013-2673","article-title":"Adipose inflammation in obesity: relationship with circulating levels of inflammatory markers and association with surgery-induced weight loss","volume":"99","author":"Lasselin","year":"2014","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"12","key":"10.1016\/j.bbi.2018.11.316_b0270","doi-asserted-by":"crossref","first-page":"3507","DOI":"10.1111\/j.1460-9568.2006.05203.x","article-title":"Homeostatic control of the excitation-inhibition balance in cortical layer 5 pyramidal neurons","volume":"24","author":"Le Roux","year":"2006","journal-title":"Eur. J. Neurosci."},{"issue":"4","key":"10.1016\/j.bbi.2018.11.316_b0275","doi-asserted-by":"crossref","first-page":"357","DOI":"10.4196\/kjpp.2016.20.4.357","article-title":"Effects of systemic administration of ibuprofen on stress response in a rat model of post-traumatic stress disorder","volume":"20","author":"Lee","year":"2016","journal-title":"Korean J. Physiol. Pharmacol."},{"key":"10.1016\/j.bbi.2018.11.316_b0280","doi-asserted-by":"crossref","DOI":"10.1038\/tp.2014.92","article-title":"Peripherally triggered and GSK-3beta-driven brain inflammation differentially skew adult hippocampal neurogenesis, behavioral pattern separation and microglial activation in response to ibuprofen","volume":"4","author":"Llorens-Martin","year":"2014","journal-title":"Transl. Psychiatry"},{"issue":"3","key":"10.1016\/j.bbi.2018.11.316_b0285","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1001\/archgenpsychiatry.2010.2","article-title":"Overweight, obesity, and depression: a systematic review and meta-analysis of longitudinal studies","volume":"67","author":"Luppino","year":"2010","journal-title":"Arch. Gen. Psychiatry"},{"issue":"7","key":"10.1016\/j.bbi.2018.11.316_b0290","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1038\/nn.2139","article-title":"The orexigenic hormone ghrelin defends against depressive symptoms of chronic stress","volume":"11","author":"Lutter","year":"2008","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.bbi.2018.11.316_b0295","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.bbi.2014.01.005","article-title":"Calorie restriction dose-dependently abates lipopolysaccharide-induced fever, sickness behavior, and circulating interleukin-6 while increasing corticosterone","volume":"40","author":"MacDonald","year":"2014","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.bbi.2018.11.316_b0300","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.yhbeh.2015.04.002","article-title":"Sex differences in anxiety disorders: Interactions between fear, stress, and gonadal hormones","volume":"76","author":"Maeng","year":"2015","journal-title":"Horm. Behav."},{"issue":"1","key":"10.1016\/j.bbi.2018.11.316_b0305","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1210\/me.2014-1328","article-title":"Minireview: Food for thought: regulation of synaptic function by metabolic hormones","volume":"29","author":"McGregor","year":"2015","journal-title":"Mol. Endocrinol."},{"issue":"4","key":"10.1016\/j.bbi.2018.11.316_b0310","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1002\/da.22084","article-title":"Cytokine targets in the brain: impact on neurotransmitters and neurocircuits","volume":"30","author":"Miller","year":"2013","journal-title":"Depress Anxiety"},{"issue":"2","key":"10.1016\/j.bbi.2018.11.316_b0315","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1038\/nrn.2017.168","article-title":"Leptin and the maintenance of elevated body weight","volume":"19","author":"Pan","year":"2018","journal-title":"Nat. Rev. Neurosci."},{"issue":"2","key":"10.1016\/j.bbi.2018.11.316_b0320","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1002\/oby.21698","article-title":"Anxiety independently contributes to elevated inflammation in humans with obesity","volume":"25","author":"Pierce","year":"2017","journal-title":"Obesity (Silver Spring)"},{"key":"10.1016\/j.bbi.2018.11.316_b0325","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.bbr.2014.04.049","article-title":"Endotoxaemia resulting from decreased serotonin tranporter (5-HTT) function: a reciprocal risk factor for depression and insulin resistance?","volume":"276","author":"Pomytkin","year":"2015","journal-title":"Behav. Brain Res."},{"issue":"2","key":"10.1016\/j.bbi.2018.11.316_b0330","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1210\/en.2009-0862","article-title":"Plasma transcortin influences endocrine and behavioral stress responses in mice","volume":"151","author":"Richard","year":"2010","journal-title":"Endocrinology"},{"issue":"3","key":"10.1016\/j.bbi.2018.11.316_b0335","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.genhosppsych.2007.12.006","article-title":"Anxiety disorders and comorbid medical illness","volume":"30","author":"Roy-Byrne","year":"2008","journal-title":"Gen. Hosp. Psychiatry"},{"key":"10.1016\/j.bbi.2018.11.316_b0340","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/B978-0-12-398314-5.00001-5","article-title":"Inflammation in anxiety","volume":"88","author":"Salim","year":"2012","journal-title":"Adv. Protein Chem. Struct. Biol."},{"key":"10.1016\/j.bbi.2018.11.316_b0345","first-page":"40","article-title":"Temporal dynamics of anxiety phenotypes in a dental pulp injury model","volume":"11","author":"Shang","year":"2015","journal-title":"Mol. Pain"},{"issue":"3","key":"10.1016\/j.bbi.2018.11.316_b0350","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/j.physbeh.2010.07.002","article-title":"Neurobehavioral deficits in db\/db diabetic mice","volume":"101","author":"Sharma","year":"2010","journal-title":"Physiol. Behav."},{"issue":"4","key":"10.1016\/j.bbi.2018.11.316_b0355","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1158\/1055-9965.EPI-10-0064","article-title":"Comparison of mRNA and protein measures of cytokines following vaccination with human papillomavirus-16 L1 virus-like particles","volume":"19","author":"Shebl","year":"2010","journal-title":"Cancer Epidemiol. Biomarkers Prev."},{"key":"10.1016\/j.bbi.2018.11.316_b0360","doi-asserted-by":"crossref","DOI":"10.1038\/s41380-018-0086-5","article-title":"Gut microbiota modulate neurobehavior through changes in brain insulin sensitivity and metabolism","author":"Soto","year":"2018","journal-title":"Mol. Psychiatry"},{"issue":"12","key":"10.1016\/j.bbi.2018.11.316_b0365","doi-asserted-by":"crossref","first-page":"3219","DOI":"10.1523\/JNEUROSCI.4486-04.2005","article-title":"Differential regulation of AMPA receptor and GABA receptor trafficking by tumor necrosis factor-alpha","volume":"25","author":"Stellwagen","year":"2005","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bbi.2018.11.316_b0370","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.bbi.2012.09.002","article-title":"Inflammation and symptoms of depression and anxiety in patients with acute coronary heart disease","volume":"31","author":"Steptoe","year":"2013","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.bbi.2018.11.316_b0375","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.neuroscience.2015.04.045","article-title":"Models and mechanisms for hippocampal dysfunction in obesity and diabetes","volume":"309","author":"Stranahan","year":"2015","journal-title":"Neuroscience"},{"issue":"3","key":"10.1016\/j.bbi.2018.11.316_b0380","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1038\/nn2055","article-title":"Diabetes impairs hippocampal function through glucocorticoid-mediated effects on new and mature neurons","volume":"11","author":"Stranahan","year":"2008","journal-title":"Nat. Neurosci."},{"issue":"12","key":"10.1016\/j.bbi.2018.11.316_b0385","doi-asserted-by":"crossref","first-page":"2108","DOI":"10.1177\/0271678X16642233","article-title":"Blood-brain barrier breakdown promotes macrophage infiltration and cognitive impairment in leptin receptor-deficient mice","volume":"36","author":"Stranahan","year":"2016","journal-title":"J. Cereb. Blood Flow Metab."},{"issue":"10","key":"10.1016\/j.bbi.2018.11.316_b0390","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1002\/hipo.20577","article-title":"Voluntary exercise and caloric restriction enhance hippocampal dendritic spine density and BDNF levels in diabetic mice","volume":"19","author":"Stranahan","year":"2009","journal-title":"Hippocampus"},{"key":"10.1016\/j.bbi.2018.11.316_b0395","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.psyneuen.2017.02.035","article-title":"Depression and anxiety both associate with serum level of hs-CRP: a gender-stratified analysis in a population-based study","volume":"81","author":"Tayefi","year":"2017","journal-title":"Psychoneuroendocrinology"},{"issue":"9","key":"10.1016\/j.bbi.2018.11.316_b0400","doi-asserted-by":"crossref","first-page":"4109","DOI":"10.1210\/en.2010-0336","article-title":"Minireview: Inflammation and obesity pathogenesis: the hypothalamus heats up","volume":"151","author":"Thaler","year":"2010","journal-title":"Endocrinology"},{"issue":"1","key":"10.1016\/j.bbi.2018.11.316_b0405","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1172\/JCI59660","article-title":"Obesity is associated with hypothalamic injury in rodents and humans","volume":"122","author":"Thaler","year":"2012","journal-title":"J. Clin. Invest"},{"key":"10.1016\/j.bbi.2018.11.316_b0410","doi-asserted-by":"crossref","DOI":"10.1093\/cercor\/bhw052","article-title":"Nutritional n-3 PUFA Deficiency Abolishes Endocannabinoid Gating of Hippocampal Long-Term Potentiation","author":"Thomazeau","year":"2016","journal-title":"Cereb. Cortex"},{"key":"10.1016\/j.bbi.2018.11.316_b0415","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.pbb.2017.10.006","article-title":"The antidepressant- and anxiolytic-like effects of fluoxetine and clozapine in chronically isolated rats involve inhibition of hippocampal TNF-alpha","volume":"163","author":"Todorovic","year":"2017","journal-title":"Pharmacol. Biochem. Behav."},{"issue":"1","key":"10.1016\/j.bbi.2018.11.316_b0420","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1038\/12703","article-title":"Disruption of the glucocorticoid receptor gene in the nervous system results in reduced anxiety","volume":"23","author":"Tronche","year":"1999","journal-title":"Nat. Genet."},{"issue":"9504","key":"10.1016\/j.bbi.2018.11.316_b0425","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/S0140-6736(05)67763-X","article-title":"Etanercept and clinical outcomes, fatigue, and depression in psoriasis: double-blind placebo-controlled randomised phase III trial","volume":"367","author":"Tyring","year":"2006","journal-title":"Lancet"},{"key":"10.1016\/j.bbi.2018.11.316_b0430","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1111\/j.1749-6632.1998.tb09557.x","article-title":"Effects of peripheral administration of LPS on the expression of immunoreactive interleukin-1 alpha, beta, and receptor antagonist in rat brain","volume":"840","author":"van Dam","year":"1998","journal-title":"Ann. N. Y. Acad. Sci."},{"issue":"2","key":"10.1016\/j.bbi.2018.11.316_b0435","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.psyneuen.2012.05.017","article-title":"The impact of stress systems and lifestyle on dyslipidemia and obesity in anxiety and depression","volume":"38","author":"van Reedt Dortland","year":"2013","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.bbi.2018.11.316_b0440","unstructured":"Walfish, S., 2006. A Review of Statistical Outlier Methods. Pharmaceutical Technol. 1\u20135."},{"issue":"3","key":"10.1016\/j.bbi.2018.11.316_b0445","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/S0278-5846(02)00356-1","article-title":"Infralimbic D2 receptor influences on anxiety-like behavior and active memory\/attention in CD-1 mice","volume":"27","author":"Wall","year":"2003","journal-title":"Prog. Neuro-Psychopharmacol. Biol. Psychiatry"},{"issue":"6","key":"10.1016\/j.bbi.2018.11.316_b0450","doi-asserted-by":"crossref","first-page":"4702","DOI":"10.1007\/s12035-017-0663-7","article-title":"FGF21 Attenuates High-Fat Diet-Induced Cognitive Impairment via Metabolic Regulation and Anti-inflammation of Obese Mice","volume":"55","author":"Wang","year":"2018","journal-title":"Mol. Neurobiol."},{"issue":"1","key":"10.1016\/j.bbi.2018.11.316_b0455","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.nbd.2009.04.002","article-title":"Effects of high fat diet on Morris maze performance, oxidative stress, and inflammation in rats: contributions of maternal diet","volume":"35","author":"White","year":"2009","journal-title":"Neurobiol. Dis."},{"issue":"4","key":"10.1016\/j.bbi.2018.11.316_b0460","doi-asserted-by":"crossref","first-page":"2127","DOI":"10.1152\/jn.00107.2006","article-title":"Temporal regulation of the expression locus of homeostatic plasticity","volume":"96","author":"Wierenga","year":"2006","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.bbi.2018.11.316_b0465","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.psyneuen.2014.01.020","article-title":"Glucocorticoid receptor activation impairs hippocampal plasticity by suppressing BDNF expression in obese mice","volume":"42","author":"Wosiski-Kuhn","year":"2014","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.bbi.2018.11.316_b0470","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1186\/1472-6882-12-188","article-title":"Chotosan ameliorates cognitive and emotional deficits in an animal model of type 2 diabetes: possible involvement of cholinergic and VEGF\/PDGF mechanisms in the brain","volume":"12","author":"Zhao","year":"2012","journal-title":"BMC Complement Altern Med"}],"container-title":["Brain, Behavior, and Immunity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0889159118302897?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0889159118302897?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T07:54:31Z","timestamp":1760169271000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0889159118302897"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3]]},"references-count":93,"alternative-id":["S0889159118302897"],"URL":"https:\/\/doi.org\/10.1016\/j.bbi.2018.11.316","relation":{},"ISSN":["0889-1591"],"issn-type":[{"value":"0889-1591","type":"print"}],"subject":[],"published":{"date-parts":[[2019,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Brain tumor necrosis factor-\u03b1 mediates anxiety-like behavior in a mouse model of severe obesity","name":"articletitle","label":"Article Title"},{"value":"Brain, Behavior, and Immunity","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbi.2018.11.316","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}