{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T12:34:36Z","timestamp":1770813276605,"version":"3.50.1"},"reference-count":33,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T00:00:00Z","timestamp":1561939200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T00:00:00Z","timestamp":1561939200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,2,15]],"date-time":"2019-02-15T00:00:00Z","timestamp":1550188800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Dementia Research Institute"},{"name":"Dementia Project UK"},{"name":"MRC Centre for Neuropsychiatric Genetics and Genomics","award":["G0801418"],"award-info":[{"award-number":["G0801418"]}]},{"name":"MRC Centre for Neuropsychiatric Genetics and Genomics","award":["G0800509"],"award-info":[{"award-number":["G0800509"]}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["513688"],"award-info":[{"award-number":["513688"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Welsh European Funding Office","award":["PN 80762-CU-149"],"award-info":[{"award-number":["PN 80762-CU-149"]}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain, Behavior, and Immunity"],"published-print":{"date-parts":[[2019,7]]},"DOI":"10.1016\/j.bbi.2019.02.011","type":"journal-article","created":{"date-parts":[[2019,2,15]],"date-time":"2019-02-15T11:41:08Z","timestamp":1550230868000},"page":"267-273","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":24,"special_numbering":"C","title":["Microglia \u2013 mediated immunity partly contributes to the genetic association between Alzheimer\u2019s disease and hippocampal volume"],"prefix":"10.1016","volume":"79","author":[{"given":"T.M.","family":"Lancaster","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.J.","family":"Hill","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Sims","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Williams","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbi.2019.02.011_b0005","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1002\/(SICI)1098-2396(200002)35:2<151::AID-SYN8>3.0.CO;2-P","article-title":"Evidence for the involvement of TNF and NF-kappaB in hippocampal synaptic plasticity","volume":"35","author":"Albensi","year":"2000","journal-title":"Synapse"},{"key":"10.1016\/j.bbi.2019.02.011_b0010","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1176\/appi.ajp.2017.17050529","article-title":"Polygenic risk score for Alzheimer's disease: implications for memory performance and hippocampal volumes in early life","volume":"175","author":"Axelrud","year":"2018","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.bbi.2019.02.011_b0015","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1001\/archneurol.2010.108","article-title":"Genetic variation and neuroimaging measures in Alzheimer disease","volume":"67","author":"Biffi","year":"2010","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.bbi.2019.02.011_b0020","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1534\/g3.112.002618","article-title":"Uncovering networks from genome-wide association studies via circular genomic permutation","volume":"2","author":"Cabrera","year":"2012","journal-title":"G3"},{"key":"10.1016\/j.bbi.2019.02.011_b0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.neurobiolaging.2014.12.028","article-title":"Association of Alzheimer's disease GWAS loci with MRI markers of brain aging","volume":"36","author":"Chauhan","year":"2015","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.bbi.2019.02.011_b0030","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pcbi.1004219","article-title":"MAGMA: generalized gene-set analysis of GWAS data","volume":"11","author":"de Leeuw","year":"2015","journal-title":"PLoS Comput. Biol."},{"key":"10.1016\/j.bbi.2019.02.011_b0035","doi-asserted-by":"crossref","first-page":"745","DOI":"10.3233\/JAD-170834","article-title":"Assessment of the genetic architecture of Alzheimer's disease risk in rate of memory decline","volume":"62","author":"Del-Aguila","year":"2018","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.bbi.2019.02.011_b0040","doi-asserted-by":"crossref","DOI":"10.1371\/annotation\/b91ba224-10be-409d-93f4-7423d502cba0","article-title":"Power and predictive accuracy of polygenic risk scores","volume":"9","author":"Dudbridge","year":"2013","journal-title":"PLoS Genet."},{"key":"10.1016\/j.bbi.2019.02.011_b0045","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1038\/s41586-018-0571-7","article-title":"Genome-wide association studies of brain imaging phenotypes in UK Biobank","volume":"562","author":"Elliott","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.bbi.2019.02.011_b0050","doi-asserted-by":"crossref","first-page":"1466","DOI":"10.1093\/bioinformatics\/btu848","article-title":"PRSice: polygenic risk score software","volume":"31","author":"Euesden","year":"2015","journal-title":"Bioinformatics"},{"key":"10.1016\/j.bbi.2019.02.011_b0055","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1186\/s13024-018-0272-6","article-title":"Polygenic analysis of inflammatory disease variants and effects on microglia in the aging brain","volume":"13","author":"Felsky","year":"2018","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.bbi.2019.02.011_b0060","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.biopsych.2016.02.033","article-title":"Multimodal brain imaging reveals structural differences in Alzheimer's disease polygenic risk carriers: a study in healthy young adults","volume":"81","author":"Foley","year":"2017","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.bbi.2019.02.011_b0065","doi-asserted-by":"crossref","first-page":"e1605","DOI":"10.1212\/WNL.0000000000005415","article-title":"Dissociable influences of APOE epsilon4 and polygenic risk of AD dementia on amyloid and cognition","volume":"90","author":"Ge","year":"2018","journal-title":"Neurology"},{"key":"10.1016\/j.bbi.2019.02.011_b0070","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0198187","article-title":"Genetic risk for neurodegenerative disorders, and its overlap with cognitive ability and physical function","volume":"13","author":"Hagenaars","year":"2018","journal-title":"PLoS One"},{"key":"10.1016\/j.bbi.2019.02.011_b0075","doi-asserted-by":"crossref","DOI":"10.1523\/ENEURO.0098-16.2016","article-title":"An Alzheimer's disease genetic risk score predicts longitudinal thinning of hippocampal complex subregions in healthy older adults","volume":"3","author":"Harrison","year":"2016","journal-title":"eNeuro"},{"key":"10.1016\/j.bbi.2019.02.011_b0080","doi-asserted-by":"crossref","first-page":"13624","DOI":"10.1038\/ncomms13624","article-title":"Novel genetic loci associated with hippocampal volume","volume":"8","author":"Hibar","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bbi.2019.02.011_b0085","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1038\/nature14101","article-title":"Common genetic variants influence human subcortical brain structures","volume":"520","author":"Hibar","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.bbi.2019.02.011_b0090","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1016\/j.jalz.2014.05.1757","article-title":"Convergent genetic and expression data implicate immunity in Alzheimer's disease","volume":"11","author":"International Genomics of Alzheimer's Disease","year":"2015","journal-title":"Alzheimer's Dementia"},{"key":"10.1016\/j.bbi.2019.02.011_b0095","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1038\/nature08185","article-title":"Common polygenic variation contributes to risk of schizophrenia and bipolar disorder","volume":"460","author":"International Schizophrenia","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.bbi.2019.02.011_b0100","doi-asserted-by":"crossref","first-page":"1452","DOI":"10.1038\/ng.2802","article-title":"Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease","volume":"45","author":"Lambert","year":"2013","journal-title":"Nat. Genet."},{"key":"10.1016\/j.bbi.2019.02.011_b0105","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.neurobiolaging.2017.12.022","article-title":"Polygenic risk for Alzheimer\u2019s disease influences precuneal volume in two independent general populations","volume":"64","author":"Li","year":"2018","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.bbi.2019.02.011_b0110","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1016\/j.jalz.2016.01.006","article-title":"Alzheimer's disease risk variants modulate endophenotypes in mild cognitive impairment","volume":"12","author":"Louwersheimer","year":"2016","journal-title":"Alzheimer\u2019s Dementia"},{"key":"10.1016\/j.bbi.2019.02.011_b0115","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.neurobiolaging.2015.12.023","article-title":"The effect of increased genetic risk for Alzheimer's disease on hippocampal and amygdala volume","volume":"40","author":"Lupton","year":"2016","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.bbi.2019.02.011_b0120","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1038\/nn1110","article-title":"NF-kappa B functions in synaptic signaling and behavior","volume":"6","author":"Meffert","year":"2003","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.bbi.2019.02.011_b0125","doi-asserted-by":"crossref","first-page":"25","DOI":"10.3233\/JAD-160889","article-title":"The correlation between inflammatory biomarkers and polygenic risk score in Alzheimer's disease","volume":"56","author":"Morgan","year":"2017","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.bbi.2019.02.011_b0130","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1212\/WNL.0000000000002922","article-title":"Polygenic risk of Alzheimer disease is associated with early- and late-life processes","volume":"87","author":"Mormino","year":"2016","journal-title":"Neurology"},{"key":"10.1016\/j.bbi.2019.02.011_b0135","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1038\/nn.3922","article-title":"Psychiatric genome-wide association study analyses implicate neuronal, immune and histone pathways","volume":"18","author":"Network","year":"2015","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.bbi.2019.02.011_b0140","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.neurobiolaging.2015.10.037","article-title":"Common variants in ABCA7 and MS4A6A are associated with cortical and hippocampal atrophy","volume":"39","author":"Ramirez","year":"2016","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.bbi.2019.02.011_b0145","doi-asserted-by":"crossref","first-page":"2653","DOI":"10.1093\/cercor\/bhr348","article-title":"The association between a polygenic Alzheimer score and cortical thickness in clinically normal subjects","volume":"22","author":"Sabuncu","year":"2012","journal-title":"Cereb. Cortex"},{"key":"10.1016\/j.bbi.2019.02.011_b0150","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1038\/ng.3916","article-title":"Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease","volume":"49","author":"Sims","year":"2017","journal-title":"Nat. Genet."},{"key":"10.1016\/j.bbi.2019.02.011_b0155","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/s13073-018-0523-8","article-title":"Genetic risk for Alzheimer's disease is concentrated in specific macrophage and microglial transcriptional networks","volume":"10","author":"Tansey","year":"2018","journal-title":"Genome Med."},{"key":"10.1016\/j.bbi.2019.02.011_b0160","doi-asserted-by":"crossref","first-page":"1","DOI":"10.18637\/jss.v036.i03","article-title":"Conducting meta-analyses in R with the metafor package","volume":"36","author":"Viechtbauer","year":"2010","journal-title":"J. Stat. Software"},{"key":"10.1016\/j.bbi.2019.02.011_b0165","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1007\/s12035-016-9718-4","article-title":"Impacts of CD33 genetic variations on the atrophy rates of hippocampus and parahippocampal gyrus in normal aging and mild cognitive impairment","volume":"54","author":"Wang","year":"2017","journal-title":"Mol. Neurobiol."}],"container-title":["Brain, Behavior, and Immunity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0889159118305543?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0889159118305543?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T07:55:02Z","timestamp":1760169302000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0889159118305543"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7]]},"references-count":33,"alternative-id":["S0889159118305543"],"URL":"https:\/\/doi.org\/10.1016\/j.bbi.2019.02.011","relation":{},"ISSN":["0889-1591"],"issn-type":[{"value":"0889-1591","type":"print"}],"subject":[],"published":{"date-parts":[[2019,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Microglia \u2013 mediated immunity partly contributes to the genetic association between Alzheimer\u2019s disease and hippocampal volume","name":"articletitle","label":"Article Title"},{"value":"Brain, Behavior, and Immunity","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbi.2019.02.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}