{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T21:16:54Z","timestamp":1790889414680,"version":"4.1.0"},"reference-count":171,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,9,30]],"date-time":"2019-09-30T00:00:00Z","timestamp":1569801600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000837","name":"University of Nottingham","doi-asserted-by":"publisher","award":["UNICAS-A2B177"],"award-info":[{"award-number":["UNICAS-A2B177"]}],"id":[{"id":"10.13039\/501100000837","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000837","name":"University of Nottingham","doi-asserted-by":"publisher","award":["CiC2014029"],"award-info":[{"award-number":["CiC2014029"]}],"id":[{"id":"10.13039\/501100000837","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain, Behavior, and Immunity"],"published-print":{"date-parts":[[2020,1]]},"DOI":"10.1016\/j.bbi.2019.09.019","type":"journal-article","created":{"date-parts":[[2019,9,24]],"date-time":"2019-09-24T19:36:03Z","timestamp":1569353763000},"page":"87-111","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":41,"special_numbering":"C","title":["Sex-specific hippocampal metabolic signatures at the onset of systemic inflammation with lipopolysaccharide in the APPswe\/PS1dE9 mouse model of Alzheimer\u2019s disease"],"prefix":"10.1016","volume":"83","author":[{"given":"Alessandra","family":"Agostini","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ding","family":"Yuchun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bai","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David A.","family":"Kendall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Christine","family":"Pardon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbi.2019.09.019_b0005","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1002\/iub.278","article-title":"Metabolic characteristics and importance of the universal methionine salvage pathway recycling methionine from 5\u2032-methylthioadenosine","volume":"61","author":"Albers","year":"2009","journal-title":"IUBMB Life"},{"key":"10.1016\/j.bbi.2019.09.019_b0010","first-page":"9","article-title":"Methylglyoxal, the dark side of glycolysis","author":"Allaman","year":"2015","journal-title":"Front. Neurosci-Switz"},{"key":"10.1016\/j.bbi.2019.09.019_b0015","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/238485","article-title":"Role of methylglyoxal in Alzheimer's disease","volume":"2014","author":"Angeloni","year":"2014","journal-title":"Biomed. Res. Int."},{"key":"10.1016\/j.bbi.2019.09.019_b0020","doi-asserted-by":"crossref","first-page":"4479","DOI":"10.1007\/s12035-018-1388-y","article-title":"The possibility of an infectious etiology of Alzheimer disease","volume":"56","author":"Ashraf","year":"2019","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.bbi.2019.09.019_b0025","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.bbi.2009.09.001","article-title":"Minimal penetration of lipopolysaccharide across the murine blood-brain barrier","volume":"24","author":"Banks","year":"2010","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.bbi.2019.09.019_b0030","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.exger.2016.12.006","article-title":"A state of delirium: deciphering the effect of inflammation on tau pathology in Alzheimer's disease","volume":"94","author":"Barron","year":"2017","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.bbi.2019.09.019_b0035","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/j.mad.2011.10.007","article-title":"Serum concentration of an inflammatory glycotoxin, methylglyoxal, is associated with increased cognitive decline in elderly individuals","volume":"132","author":"Beeri","year":"2011","journal-title":"Mech. Ageing Dev."},{"key":"10.1016\/j.bbi.2019.09.019_b0040","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1038\/clpt.2014.147","article-title":"Longitudinal inflammation, cognitive decline, and Alzheimer's disease: a mini-review","volume":"96","author":"Bettcher","year":"2014","journal-title":"Clin. Pharmacol. Ther."},{"key":"10.1016\/j.bbi.2019.09.019_b0045","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1016\/0306-3623(95)02141-8","article-title":"Hypothermia as an indicator of the acute effects of lipopolysaccharides: comparison with serum levels of IL1 beta, IL6 and TNF alpha","volume":"27","author":"Blanque","year":"1996","journal-title":"Gen. Pharmacol."},{"key":"10.1016\/j.bbi.2019.09.019_b0050","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.bbr.2011.03.041","article-title":"A detailed analysis of the early context extinction deficits seen in APPswe\/PS1dE9 female mice and their relevance to preclinical Alzheimer's disease","volume":"222","author":"Bonardi","year":"2011","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.bbi.2019.09.019_b0055","doi-asserted-by":"crossref","first-page":"775","DOI":"10.3233\/JAD-160926","article-title":"Altered gut microbiome composition and tryptic activity of the 5xFAD Alzheimer's mouse model","volume":"56","author":"Brandscheid","year":"2017","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.bbi.2019.09.019_b0060","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/S0022-3565(25)27496-1","article-title":"Application of steady state kinetics to the estimation of synthesis rate and turnover time of tissue catecholamines","volume":"154","author":"Brodie","year":"1966","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.bbi.2019.09.019_b0065","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1007\/s11357-006-9003-y","article-title":"Longevity in mice: is stress resistance a common factor?","volume":"28","author":"Brown-Borg","year":"2006","journal-title":"Age"},{"key":"10.1016\/j.bbi.2019.09.019_b0070","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.bbi.2016.08.002","article-title":"Age and sex differences in immune response following LPS treatment in mice","volume":"58","author":"Cai","year":"2016","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.bbi.2019.09.019_b0075","doi-asserted-by":"crossref","first-page":"621","DOI":"10.4049\/jimmunol.177.1.621","article-title":"Gender differences in murine airway responsiveness and lipopolysaccharide-induced inflammation","volume":"177","author":"Card","year":"2006","journal-title":"J. Immunol."},{"key":"10.1016\/j.bbi.2019.09.019_b0080","doi-asserted-by":"crossref","DOI":"10.1186\/s12974-017-0963-x","article-title":"Homocysteine exaggerates microglia activation and neuroinflammation through microglia localized STAT3 overactivation following ischemic stroke","volume":"14","author":"Chen","year":"2017","journal-title":"J. Neuroinflamm."},{"key":"10.1016\/j.bbi.2019.09.019_b0085","doi-asserted-by":"crossref","first-page":"96924","DOI":"10.18632\/oncotarget.19661","article-title":"Comparative study of macrophages in naked mole rats and ICR mice","volume":"8","author":"Cheng","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.bbi.2019.09.019_b0090","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/0006-291X(86)90952-6","article-title":"Salvage of 5\u2032-deoxy-5\u2032-methylthioadenosine and L-homocysteine into methionine in cells cultured in a methionine-free medium \u2013 a study of methionine-dependence","volume":"135","author":"Christa","year":"1986","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbi.2019.09.019_b0095","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1177\/0269881111420313","article-title":"A comparison of InVivoStat with other statistical software packages for analysis of data generated from animal experiments","volume":"26","author":"Clark","year":"2012","journal-title":"J. Psychopharmacol."},{"key":"10.1016\/j.bbi.2019.09.019_b0100","doi-asserted-by":"crossref","first-page":"8703","DOI":"10.1021\/ac2021823","article-title":"Toward global metabolomics analysis with hydrophilic interaction liquid chromatography-mass spectrometry: improved metabolite identification by retention time prediction","volume":"83","author":"Creek","year":"2011","journal-title":"Anal. Chem."},{"key":"10.1016\/j.bbi.2019.09.019_b0105","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1093\/bioinformatics\/bts069","article-title":"IDEOM: an Excel interface for analysis of LC\u2013MS-based metabolomics data","volume":"28","author":"Creek","year":"2012","journal-title":"Bioinformatics"},{"key":"10.1016\/j.bbi.2019.09.019_b0110","doi-asserted-by":"crossref","DOI":"10.1186\/s13195-015-0117-2","article-title":"Co-morbidity and systemic inflammation as drivers of cognitive decline: new experimental models adopting a broader paradigm in dementia research","volume":"7","author":"Cunningham","year":"2015","journal-title":"Alzheimers Res. Ther."},{"key":"10.1016\/j.bbi.2019.09.019_b0115","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1016\/j.bbi.2008.05.007","article-title":"Malaise in the water maze: untangling the effects of LPS and IL-1beta on learning and memory","volume":"22","author":"Cunningham","year":"2008","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.bbi.2019.09.019_b0120","first-page":"Ra79-Ra84","article-title":"Pyruvate is an endogenous anti-inflammatory and anti-oxidant molecule","volume":"12","author":"Das","year":"2006","journal-title":"Med. Sci. Monitor"},{"key":"10.1016\/j.bbi.2019.09.019_b0125","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1586\/14737175.2015.1049999","article-title":"What is the tryptophan kynurenine pathway and why is it important to neurotherapeutics?","volume":"15","author":"Davis","year":"2015","journal-title":"Expert Rev. Neurother."},{"key":"10.1016\/j.bbi.2019.09.019_b0130","doi-asserted-by":"crossref","DOI":"10.3791\/2607","article-title":"Assessing burrowing, nest construction, and hoarding in mice","author":"Deacon","year":"2012","journal-title":"Jove J. Visual. Exp."},{"key":"10.1016\/j.bbi.2019.09.019_b0135","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/S0166-4328(01)00401-6","article-title":"Hippocampal cytotoxic lesion effects on species-typical behaviours in mice","volume":"132","author":"Deacon","year":"2002","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.bbi.2019.09.019_b0140","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1139\/Y10-001","article-title":"Oxidative stress and aging: is methylglyoxal the hidden enemy?","volume":"88","author":"Desai","year":"2010","journal-title":"Can. J. Physiol. Pharm."},{"key":"10.1016\/j.bbi.2019.09.019_b0145","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1016\/j.exger.2007.04.004","article-title":"Circulating blood leukocyte gene expression profiles: effects of the Ames dwarf mutation on pathways related to immunity and inflammation","volume":"42","author":"Dhahbi","year":"2007","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.bbi.2019.09.019_b0150","article-title":"Novel methods for microglia segmentation, feature extraction and classification","author":"Ding","year":"2016","journal-title":"IEEE\/ACM Trans. Comput. Biol. Bioinform."},{"key":"10.1016\/j.bbi.2019.09.019_b0155","first-page":"7","article-title":"Serotonin drives the acquisition of a profibrotic and anti-inflammatory gene profile through the 5-HT7R-PKA signaling axis","author":"Dominguez-Soto","year":"2017","journal-title":"Sci. Rep.-Uk"},{"key":"10.1016\/j.bbi.2019.09.019_b0160","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms14556","article-title":"Sex differences in microglial CX3CR1 signalling determine obesity susceptibility in mice","volume":"8","author":"Dorfman","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bbi.2019.09.019_b0165","doi-asserted-by":"crossref","DOI":"10.1186\/alzrt118","article-title":"Whether, when and how chronic inflammation increases the risk of developing late-onset Alzheimer's disease","volume":"4","author":"Eikelenboom","year":"2012","journal-title":"Alzheimers Res. Ther."},{"key":"10.1016\/j.bbi.2019.09.019_b0170","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.neulet.2008.02.070","article-title":"Taurine improves learning and retention in aged mice","volume":"436","author":"El Idrissi","year":"2008","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.bbi.2019.09.019_b0175","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.diabres.2014.04.006","article-title":"Inflammation as a link between obesity, metabolic syndrome and type 2 diabetes","volume":"105","author":"Esser","year":"2014","journal-title":"Diabetes Res. Clin. Pract."},{"key":"10.1016\/j.bbi.2019.09.019_b0180","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1089\/ars.2014.6022","article-title":"Methionine sulfoxide reductase A negatively controls microglia-mediated neuroinflammation via inhibiting ROS\/MAPKs\/NF-kappa B signaling pathways through a catalytic antioxidant function","volume":"22","author":"Fan","year":"2015","journal-title":"Antioxid. Redox. Signal."},{"key":"10.1016\/j.bbi.2019.09.019_b0185","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1038\/s41582-018-0032-9","article-title":"Sex differences in Alzheimer disease \u2013 the gateway to precision medicine","volume":"14","author":"Ferretti","year":"2018","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.bbi.2019.09.019_b0190","first-page":"400","article-title":"Enzymatic synthesis of homocysteine or methionine directly from O-succinyl-homoserine","volume":"132","author":"Flavin","year":"1967","journal-title":"BBA"},{"key":"10.1016\/j.bbi.2019.09.019_b0195","doi-asserted-by":"crossref","first-page":"2537","DOI":"10.1105\/tpc.17.00256","article-title":"The photorespiratory metabolite 2-phosphoglycolate regulates photosynthesis and starch accumulation in arabidopsis","volume":"29","author":"Flugel","year":"2017","journal-title":"Plant Cell"},{"key":"10.1016\/j.bbi.2019.09.019_b0200","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1023\/B:NERE.0000010439.99991.cf","article-title":"Antioxidant properties of sulfinates: protective effect of hypotaurine on peroxynitrite-dependent damage","volume":"29","author":"Fontana","year":"2004","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.bbi.2019.09.019_b0205","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1016\/j.celrep.2019.03.099","article-title":"The major risk factors for Alzheimer's disease: age, sex, and genes modulate the microglia response to a beta plaques","volume":"27","author":"Frigerio","year":"2019","journal-title":"Cell Rep."},{"key":"10.1016\/j.bbi.2019.09.019_b0210","doi-asserted-by":"crossref","first-page":"1903","DOI":"10.4155\/bio-2016-0111","article-title":"LC\u2013MS\/MS-based quantification of kynurenine metabolites, tryptophan, monoamines and neopterin in plasma, cerebrospinal fluid and brain","volume":"8","author":"Fuertig","year":"2016","journal-title":"Bioanalysis"},{"key":"10.1016\/j.bbi.2019.09.019_b0215","first-page":"3","article-title":"Nutritional aspect of tryptophan metabolism","volume":"6","author":"Fukuwatari","year":"2013","journal-title":"Int. J. Tryptophan Res."},{"key":"10.1016\/j.bbi.2019.09.019_b0220","doi-asserted-by":"crossref","first-page":"2893","DOI":"10.1210\/en.2014-1913","article-title":"Effect of sex differences on brain mitochondrial function and its suppression by ovariectomy and in aged mice","volume":"156","author":"Gaignard","year":"2015","journal-title":"Endocrinology"},{"key":"10.1016\/j.bbi.2019.09.019_b0225","first-page":"103","volume":"16","author":"Ge","year":"2018","journal-title":"Exp. Ther. Med."},{"key":"10.1016\/j.bbi.2019.09.019_b0230","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.neuroscience.2016.05.004","article-title":"Impaired burrowing is the most prominent behavioral deficit of aging Htau mice","volume":"329","author":"Geiszler","year":"2016","journal-title":"Neuroscience"},{"key":"10.1016\/j.bbi.2019.09.019_b0235","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1002\/glia.23271","article-title":"Bioenergetic regulation of microglia","volume":"66","author":"Ghosh","year":"2018","journal-title":"Glia"},{"key":"10.1016\/j.bbi.2019.09.019_b0240","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2019.00122","article-title":"Infection-induced systemic inflammation is a potential driver of Alzheimer\u2019s disease progression","volume":"11","author":"Giridharan","year":"2019","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.bbi.2019.09.019_b0245","first-page":"2395","article-title":"Region-specific metabolic alterations in the brain of the APP\/PS1 transgenic mice of Alzheimer's disease","volume":"1842","author":"Gonzalez-Dominguez","year":"2014","journal-title":"BBA"},{"key":"10.1016\/j.bbi.2019.09.019_b0250","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0158772","article-title":"Biomarkers of environmental enteropathy, inflammation, stunting, and impaired growth in children in Northeast Brazil","volume":"11","author":"Guerrant","year":"2016","journal-title":"PLoS ONE"},{"key":"10.1016\/j.bbi.2019.09.019_b0255","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2018.08.001","article-title":"Transcriptional and translational differences of microglia from male and female brains","volume":"24","author":"Guneykaya","year":"2018","journal-title":"Cell Rep."},{"key":"10.1016\/j.bbi.2019.09.019_b0260","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.jneuroim.2016.04.006","article-title":"Quantitative profiling of neurotransmitter abnormalities in the hippocampus of rats treated with lipopolysaccharide: focusing on kynurenine pathway and implications for depression","volume":"295","author":"Guo","year":"2016","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.bbi.2019.09.019_b0265","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1042\/CS20110164","article-title":"Toll-like receptors in health and disease in the brain: mechanisms and therapeutic potential","volume":"121","author":"Hanke","year":"2011","journal-title":"Clin. Sci. (Lond.)"},{"key":"10.1016\/j.bbi.2019.09.019_b0270","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1083\/jcb.201709069","article-title":"Microglia in Alzheimer's disease","volume":"217","author":"Hansen","year":"2018","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.bbi.2019.09.019_b0275","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.physbeh.2016.05.046","article-title":"Methylglyoxal can mediate behavioral and neurochemical alterations in rat brain","volume":"164","author":"Hansen","year":"2016","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.bbi.2019.09.019_b0280","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1007\/s00726-011-1094-9","article-title":"Antinociceptive effect of intrathecal administration of hypotaurine in rat models of inflammatory and neuropathic pain","volume":"43","author":"Hara","year":"2012","journal-title":"Amino Acids"},{"key":"10.1016\/j.bbi.2019.09.019_b0285","first-page":"7","article-title":"Reduction of Abeta amyloid pathology in APPPS1 transgenic mice in the absence of gut microbiota","author":"Harach","year":"2017","journal-title":"Sci. Rep.-Uk"},{"key":"10.1016\/j.bbi.2019.09.019_b0290","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1016\/j.bbi.2011.11.006","article-title":"Age related changes in microglial phenotype vary between CNS regions: grey versus white matter differences","volume":"26","author":"Hart","year":"2012","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.bbi.2019.09.019_b0295","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1002\/hep.20154","article-title":"5\u2032-Methylthioadenosine modulates the inflammatory response to endotoxin in mice and in rat hepatocytes","volume":"39","author":"Hevia","year":"2004","journal-title":"Hepatology"},{"key":"10.1016\/j.bbi.2019.09.019_b0300","doi-asserted-by":"crossref","first-page":"158","DOI":"10.3389\/fendo.2019.00158","article-title":"Tryptophan metabolic pathways and brain serotonergic activity: a comparative review","volume":"10","author":"Hoglund","year":"2019","journal-title":"Front. Endocrinol. (Lausanne)"},{"key":"10.1016\/j.bbi.2019.09.019_b0305","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1111\/jcpe.13016","article-title":"Association between periodontitis and risk of Alzheimer's disease, mild cognitive impairment and subjective cognitive decline: a case-control study","volume":"45","author":"Holmer","year":"2018","journal-title":"J. Clin. Periodontol."},{"key":"10.1016\/j.bbi.2019.09.019_b0310","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1212\/WNL.0b013e3181b6bb95","article-title":"Systemic inflammation and disease progression in Alzheimer disease","volume":"73","author":"Holmes","year":"2009","journal-title":"Neurology"},{"key":"10.1016\/j.bbi.2019.09.019_b0315","doi-asserted-by":"crossref","DOI":"10.1186\/s12974-015-0332-6","article-title":"Systemic inflammation and microglial activation: systematic review of animal experiments","volume":"12","author":"Hoogland","year":"2015","journal-title":"J. Neuroinflamm."},{"key":"10.1016\/j.bbi.2019.09.019_b0320","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1469-7793.2001.0001j.x","article-title":"Regulation of cell function by methionine oxidation and reduction","volume":"531","author":"Hoshi","year":"2001","journal-title":"J. Physiol."},{"key":"10.1016\/j.bbi.2019.09.019_b0325","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0151081","article-title":"Periodontitis and cognitive decline in Alzheimer's disease","volume":"11","author":"Ide","year":"2016","journal-title":"PLoS ONE"},{"key":"10.1016\/j.bbi.2019.09.019_b0330","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1097\/00024382-199404000-00010","article-title":"Comparison of plasma reduced glutathione and oxidized glutathione with lung and liver-tissue oxidant and antioxidant activity during acute-inflammation","volume":"1","author":"Ikegami","year":"1994","journal-title":"Shock"},{"key":"10.1016\/j.bbi.2019.09.019_b0335","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1016\/j.lfs.2006.12.008","article-title":"Oxalomalate affects the inducible nitric oxide synthase expression and activity","volume":"80","author":"Irace","year":"2007","journal-title":"Life Sci."},{"key":"10.1016\/j.bbi.2019.09.019_b0340","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.nbd.2014.11.013","article-title":"Pyruvate prevents the development of age-dependent cognitive deficits in a mouse model of Alzheimer's disease without reducing amyloid and tau pathology","volume":"81","author":"Isopi","year":"2015","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.bbi.2019.09.019_b0345","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1093\/hmg\/ddh019","article-title":"Mutant presenilins specifically elevate the levels of the 42 residue beta-amyloid peptide in vivo: evidence for augmentation of a 42-specific gamma secretase","volume":"13","author":"Jankowsky","year":"2004","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.bbi.2019.09.019_b0350","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1146\/annurev-nutr-071813-105654","article-title":"Sulfur as a signaling nutrient through hydrogen sulfide","volume":"34","author":"Kabil","year":"2014","journal-title":"Annu. Rev. Nutr."},{"key":"10.1016\/j.bbi.2019.09.019_b0355","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.biopsych.2014.05.006","article-title":"Alzheimer's disease risk genes and mechanisms of disease pathogenesis","volume":"77","author":"Karch","year":"2015","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.bbi.2019.09.019_b0360","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.1000412","article-title":"Improving bioscience research reporting: the ARRIVE guidelines for reporting animal research","volume":"8","author":"Kilkenny","year":"2010","journal-title":"PLoS Biol."},{"key":"10.1016\/j.bbi.2019.09.019_b0365","doi-asserted-by":"crossref","first-page":"574","DOI":"10.2174\/1570159X15666170913110426","article-title":"Neuroinflammation and the immune-kynurenine pathway in anxiety disorders","volume":"16","author":"Kim","year":"2018","journal-title":"Curr. Neuropharmacol."},{"key":"10.1016\/j.bbi.2019.09.019_b0370","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1136\/jnnp-2017-317134","article-title":"Peripheral inflammation in prodromal Alzheimer's and Lewy body dementias","volume":"89","author":"King","year":"2018","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.bbi.2019.09.019_b0375","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1038\/nri.2016.90","article-title":"Sex differences in immune responses","volume":"16","author":"Klein","year":"2016","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.bbi.2019.09.019_b0380","doi-asserted-by":"crossref","first-page":"41","DOI":"10.3389\/fnagi.2016.00041","article-title":"Chronic pyruvate supplementation increases exploratory activity and brain energy reserves in young and middle-aged mice","volume":"8","author":"Koivisto","year":"2016","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.bbi.2019.09.019_b0385","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1002\/jnr.23864","article-title":"Sex differences in hippocampal function","volume":"95","author":"Koss","year":"2017","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.bbi.2019.09.019_b0390","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1093\/gerona\/gls187","article-title":"The role of peripheral inflammatory markers in dementia and Alzheimer's disease: a meta-analysis","volume":"68","author":"Koyama","year":"2013","journal-title":"J. Gerontol. A Biol. Sci. Med. Sci."},{"key":"10.1016\/j.bbi.2019.09.019_b0395","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0031814","article-title":"An automated method to quantify microglia morphology and application to monitor activation state longitudinally in vivo","volume":"7","author":"Kozlowski","year":"2012","journal-title":"PLoS ONE"},{"key":"10.1016\/j.bbi.2019.09.019_b0400","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1038\/mp.2013.155","article-title":"Dynamic microglial alterations underlie stress-induced depressive-like behavior and suppressed neurogenesis","volume":"19","author":"Kreisel","year":"2014","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.bbi.2019.09.019_b0405","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1196\/annals.1333.026","article-title":"Methylglyoxal, glyoxal, and their detoxification in Alzheimer's disease","volume":"1043","author":"Kuhla","year":"2005","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.bbi.2019.09.019_b0410","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1007\/978-1-4615-0135-0_14","article-title":"Neurokynurenines (NEKY) as common neurochemical links of stress and anxiety","volume":"527","author":"Lapin","year":"2003","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.bbi.2019.09.019_b0415","doi-asserted-by":"crossref","first-page":"42891","DOI":"10.1038\/srep42891","article-title":"Anti-inflammatory and anti-excitoxic effects of diethyl oxopropanamide, an ethyl pyruvate bioisoster, exert robust neuroprotective effects in the postischemic brain","volume":"7","author":"Lee","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbi.2019.09.019_b0420","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.brainres.2013.06.026","article-title":"Anti-inflammatory effects of OBA-09, a salicylic acid\/pyruvate ester, in the postischemic brain","volume":"1528","author":"Lee","year":"2013","journal-title":"Brain Res."},{"key":"10.1016\/j.bbi.2019.09.019_b0425","first-page":"8","article-title":"N-methyl-2-pyridone-5-carboxamide (2PY)-major metabolite of nicotinamide: an update on an old uremic","author":"Lenglet","year":"2016","journal-title":"Toxin. Toxins"},{"key":"10.1016\/j.bbi.2019.09.019_b0430","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1007\/s11357-018-0023-1","article-title":"A window into extreme longevity; the circulating metabolomic signature of the naked mole-rat, a mammal that shows negligible senescence (vol 40 pg 105, 2018)","volume":"40","author":"Lewis","year":"2018","journal-title":"Geroscience"},{"key":"10.1016\/j.bbi.2019.09.019_b0435","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1177\/0023677215615269","article-title":"Sex differences between APPswePS1dE9 mice in A-beta accumulation and pancreatic islet function during the development of Alzheimer's disease","volume":"50","author":"Li","year":"2016","journal-title":"Lab. Anim.-Uk"},{"key":"10.1016\/j.bbi.2019.09.019_b0440","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1093\/femsre\/fuw007","article-title":"Lipopolysaccharide modification in Gram-negative bacteria during chronic infection","volume":"40","author":"Maldonado","year":"2016","journal-title":"FEMS Microbiol. Rev."},{"key":"10.1016\/j.bbi.2019.09.019_b0445","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1186\/s13024-015-0048-1","article-title":"Genetics ignite focus on microglial inflammation in Alzheimer's disease","volume":"10","author":"Malik","year":"2015","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.bbi.2019.09.019_b0450","article-title":"Utilization of APPswe\/PS1dE9 transgenic mice in research of Alzheimer's disease: focus on gene therapy and cell-based therapy applications","volume":"2011","author":"Malm","year":"2011","journal-title":"Int. J. Alzheimers Dis."},{"key":"10.1016\/j.bbi.2019.09.019_b0455","doi-asserted-by":"crossref","first-page":"227","DOI":"10.3233\/JAD-131961","article-title":"Reductions in endocannabinoid levels and enhanced coupling of cannabinoid receptors in the striatum are accompanied by cognitive impairments in the A beta PPswe\/PS1 delta E9 mouse model of Alzheimer\u2019s disease","volume":"42","author":"Maroof","year":"2014","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.bbi.2019.09.019_b0460","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1111\/acel.12522","article-title":"Distinct inflammatory phenotypes of microglia and monocyte-derived macrophages in Alzheimer's disease models: effects of aging and amyloid pathology","volume":"16","author":"Martin","year":"2017","journal-title":"Aging Cell"},{"key":"10.1016\/j.bbi.2019.09.019_b0465","doi-asserted-by":"crossref","first-page":"2091","DOI":"10.1007\/s00726-017-2494-2","article-title":"The role of methionine on metabolism, oxidative stress, and diseases","volume":"49","author":"Martinez","year":"2017","journal-title":"Amino Acids"},{"key":"10.1016\/j.bbi.2019.09.019_b0470","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1007\/s12020-012-9795-8","article-title":"Methylglyoxal, obesity, and diabetes","volume":"43","author":"Matafome","year":"2013","journal-title":"Endocrine"},{"key":"10.1016\/j.bbi.2019.09.019_b0475","doi-asserted-by":"crossref","first-page":"19780","DOI":"10.1038\/srep19780","article-title":"Urinary N-methylnicotinamide and beta-aminoisobutyric acid predict catch-up growth in undernourished Brazilian children","volume":"6","author":"Mayneris-Perxachs","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbi.2019.09.019_b0480","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.brainres.2008.07.074","article-title":"Diet and the epigenetic (re)programming of phenotypic differences in behavior","volume":"1237","author":"McGowan","year":"2008","journal-title":"Brain Res."},{"key":"10.1016\/j.bbi.2019.09.019_b0485","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1002\/ana.20895","article-title":"Methylthioadenosine reverses brain autoimmune disease","volume":"60","author":"Moreno","year":"2006","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.bbi.2019.09.019_b0490","doi-asserted-by":"crossref","first-page":"1328","DOI":"10.1046\/j.1471-4159.1996.67031328.x","article-title":"Brain S-adenosylmethionine levels are severely decreased in Alzheimer's disease","volume":"67","author":"Morrison","year":"1996","journal-title":"J. Neurochem."},{"key":"10.1016\/j.bbi.2019.09.019_b0495","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.mcn.2017.11.014","article-title":"Peroxisomes contribute to oxidative stress in neurons during doxorubicin-based chemotherapy","volume":"86","author":"Moruno-Manchon","year":"2018","journal-title":"Mol. Cell. Neurosci."},{"key":"10.1016\/j.bbi.2019.09.019_b0500","doi-asserted-by":"crossref","first-page":"E388","DOI":"10.1152\/ajpendo.00453.2015","article-title":"Methionine sulfoxide reductase A affects beta-amyloid solubility and mitochondrial function in a mouse model of Alzheimer's disease","volume":"310","author":"Moskovitz","year":"2016","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.bbi.2019.09.019_b0505","doi-asserted-by":"crossref","DOI":"10.1186\/1742-2094-8-50","article-title":"Exacerbation of CNS inflammation and neurodegeneration by systemic LPS treatment is independent of circulating IL-1 beta and IL-6","volume":"8","author":"Murray","year":"2011","journal-title":"J. Neuroinflamm."},{"key":"10.1016\/j.bbi.2019.09.019_b0510","doi-asserted-by":"crossref","DOI":"10.1186\/s12974-015-0291-y","article-title":"Rodent models of neuroinflammation for Alzheimer's disease","volume":"12","author":"Nazem","year":"2015","journal-title":"J. Neuroinflamm."},{"key":"10.1016\/j.bbi.2019.09.019_b0515","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1111\/j.1399-6576.1975.tb05241.x","article-title":"Effects of hypothermia and hyperthermia on brain energy metabolism","volume":"19","author":"Nilsson","year":"1975","journal-title":"Acta Anaesthesiol. Scand."},{"key":"10.1016\/j.bbi.2019.09.019_b0520","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1007\/s007020070003","article-title":"Lipopolysaccharide administration produces time-dependent and region-specific alterations in tryptophan and tyrosine hydroxylase activities in rat brain","volume":"107","author":"Nolan","year":"2000","journal-title":"J. Neural. Transm. (Vienna)"},{"key":"10.1016\/j.bbi.2019.09.019_b0525","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1038\/sj.mp.4002148","article-title":"Lipopolysaccharide-induced depressive-like behavior is mediated by indoleamine 2,3-dioxygenase activation in mice","volume":"14","author":"O'Connor","year":"2009","journal-title":"Mol. Psychiatr."},{"key":"10.1016\/j.bbi.2019.09.019_b0530","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1038\/labinvest.2015.110","article-title":"Attenuation of methylglyoxal-induced peritoneal fibrosis: immunomodulation by interleukin-10","volume":"95","author":"Onishi","year":"2015","journal-title":"Lab. Invest."},{"key":"10.1016\/j.bbi.2019.09.019_b0535","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/B978-0-12-800101-1.00011-9","article-title":"The impact of dietary methionine restriction on biomarkers of metabolic health","volume":"121","author":"Orgeron","year":"2014","journal-title":"Prog. Mol. Biol. Transl. Sci."},{"key":"10.1016\/j.bbi.2019.09.019_b0540","doi-asserted-by":"crossref","first-page":"19880","DOI":"10.1038\/srep19880","article-title":"Magnetic Resonance Spectroscopy discriminates the response to microglial stimulation of wild type and Alzheimer's disease models","volume":"6","author":"Pardon","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbi.2019.09.019_b0545","doi-asserted-by":"crossref","DOI":"10.1186\/s12974-016-0590-y","article-title":"Kynurenine metabolic balance is disrupted in the hippocampus following peripheral lipopolysaccharide challenge","volume":"13","author":"Parrott","year":"2016","journal-title":"J. Neuroinflamm."},{"key":"10.1016\/j.bbi.2019.09.019_b0550","doi-asserted-by":"crossref","DOI":"10.3389\/fncel.2018.00172","article-title":"The role of microglia in the spread of tau: relevance for tauopathies","volume":"12","author":"Perea","year":"2018","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.bbi.2019.09.019_b0555","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1007\/s11306-009-0188-9","article-title":"Development and validation of a UPLC\/MS method for a nutritional metabolomic study of human plasma","volume":"6","author":"Pereira","year":"2010","journal-title":"Metabolomics"},{"key":"10.1016\/j.bbi.2019.09.019_b0560","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/S0147-6513(78)80009-8","article-title":"The acute toxicity of methylglyoxal in rats: the influence of age, sex, and pregnancy","volume":"2","author":"Peters","year":"1978","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.bbi.2019.09.019_b0565","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1152\/physiolgenomics.00056.2014","article-title":"S-adenosylmethionine mediates inhibition of inflammatory response and changes in DNA methylation in human macrophages","volume":"46","author":"Pfalzer","year":"2014","journal-title":"Physiol. Genomics"},{"key":"10.1016\/j.bbi.2019.09.019_b0570","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1093\/nutrit\/nuw023","article-title":"Role of gut microbiota and nutrients in amyloid formation and pathogenesis of Alzheimer disease","volume":"74","author":"Pistollato","year":"2016","journal-title":"Nutr. Rev."},{"key":"10.1016\/j.bbi.2019.09.019_b0575","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1016\/j.neuroscience.2009.01.072","article-title":"Neurochemical and behavioral alterations in an inflammatory model of depression: sex differences exposed","volume":"159","author":"Pitychoutis","year":"2009","journal-title":"Neuroscience"},{"key":"10.1016\/j.bbi.2019.09.019_b0580","doi-asserted-by":"crossref","first-page":"437","DOI":"10.31887\/DCNS.2016.18.4\/cepperson","article-title":"Considering sex and gender in Alzheimer disease and other dementias","volume":"18","author":"Podcasy","year":"2016","journal-title":"Dial. Clin. Neurosci."},{"key":"10.1016\/j.bbi.2019.09.019_b0585","doi-asserted-by":"crossref","first-page":"1806","DOI":"10.1111\/j.1582-4934.2009.00803.x","article-title":"Methylglyoxal modulates immune responses: relevance to diabetes","volume":"14","author":"Price","year":"2010","journal-title":"J. Cell Mol. Med."},{"key":"10.1016\/j.bbi.2019.09.019_b0590","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1053\/jhep.2003.50417","article-title":"Oxidative stress-mediated down-regulation of rat hydroxyacid oxidase 1, a liver-specific peroxisomal enzyme","volume":"38","author":"Recalcati","year":"2003","journal-title":"Hepatology"},{"key":"10.1016\/j.bbi.2019.09.019_b0595","doi-asserted-by":"crossref","first-page":"2193","DOI":"10.2741\/1690","article-title":"Fever and hypothermia in systemic inflammation: Recent discoveries and revisions","volume":"10","author":"Romanovsky","year":"2005","journal-title":"Front. Biosci.-Landmrk"},{"key":"10.1016\/j.bbi.2019.09.019_b0600","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.yhbeh.2016.11.017","article-title":"Sex differences in immune responses: hormonal effects, antagonistic selection, and evolutionary consequences","volume":"88","author":"Roved","year":"2017","journal-title":"Horm. Behav."},{"key":"10.1016\/j.bbi.2019.09.019_b0605","doi-asserted-by":"crossref","first-page":"531","DOI":"10.2174\/156720509790147070","article-title":"Amyloid deposition and inflammation in APPswe\/PS1dE9 mouse model of Alzheimer's disease","volume":"6","author":"Ruan","year":"2009","journal-title":"Curr. Alzheimer Res."},{"key":"10.1016\/j.bbi.2019.09.019_b0610","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1111\/acel.12382","article-title":"Growth hormone modulates hypothalamic inflammation in long-lived pituitary dwarf mice","volume":"14","author":"Sadagurski","year":"2015","journal-title":"Aging Cell"},{"key":"10.1016\/j.bbi.2019.09.019_b0615","doi-asserted-by":"crossref","first-page":"225","DOI":"10.4062\/biomolther.2017.251","article-title":"Effects and mechanisms of taurine as a therapeutic agent","volume":"26","author":"Schaffer","year":"2018","journal-title":"Biomol. Ther."},{"key":"10.1016\/j.bbi.2019.09.019_b0620","doi-asserted-by":"crossref","first-page":"2786","DOI":"10.1021\/ac2000994","article-title":"PeakML\/mzMatch: a file format, Java library, R library, and tool-chain for mass spectrometry data analysis","volume":"83","author":"Scheltema","year":"2011","journal-title":"Anal. Chem."},{"key":"10.1016\/j.bbi.2019.09.019_b0625","doi-asserted-by":"crossref","first-page":"1755","DOI":"10.1016\/j.bbamcr.2006.09.006","article-title":"Peroxisomes and oxidative stress","volume":"1763","author":"Schrader","year":"2006","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bbi.2019.09.019_b0630","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1002\/embj.201386609","article-title":"The resolution of neuroinflammation in neurodegeneration: leukocyte recruitment via the choroid plexus","volume":"33","author":"Schwartz","year":"2014","journal-title":"EMBO J."},{"key":"10.1016\/j.bbi.2019.09.019_b0635","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1186\/s12929-017-0370-8","article-title":"Comprehensive comparison of three different animal models for systemic inflammation","volume":"24","author":"Seemann","year":"2017","journal-title":"J. Biomed. Sci."},{"key":"10.1016\/j.bbi.2019.09.019_b0640","first-page":"6","article-title":"An essential developmental function for murine phosphoglycolate phosphatase in safeguarding cell proliferation","author":"Segerer","year":"2016","journal-title":"Sci. Rep.-Uk"},{"key":"10.1016\/j.bbi.2019.09.019_b0645","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.pbb.2016.12.016","article-title":"Lipopolysaccharide administration induces sex-dependent behavioural and serotonergic neurochemical signatures in mice","volume":"153","author":"Sens","year":"2017","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.bbi.2019.09.019_b0650","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1093\/jn\/120.10.1191","article-title":"Effect of dietary tryptophan levels on the urinary excretion of nicotinamide and its metabolites in rats fed a niacin-free diet or a constant total protein level","volume":"120","author":"Shibata","year":"1990","journal-title":"J. Nutr."},{"key":"10.1016\/j.bbi.2019.09.019_b0655","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1016\/j.cmet.2014.03.017","article-title":"Methionine metabolism regulates maintenance and differentiation of human pluripotent stem cells","volume":"19","author":"Shiraki","year":"2014","journal-title":"Cell Metab."},{"key":"10.1016\/j.bbi.2019.09.019_b0660","doi-asserted-by":"crossref","DOI":"10.1371\/annotation\/90c76048-2edd-4315-8404-4d9d8cbd411e","article-title":"A systematic analysis of the peripheral and CNS effects of systemic LPS, IL-1beta, [corrected] TNF-alpha and IL-6 challenges in C57BL\/6 mice","volume":"8","author":"Skelly","year":"2013","journal-title":"PLoS ONE"},{"key":"10.1016\/j.bbi.2019.09.019_b0665","doi-asserted-by":"crossref","first-page":"561","DOI":"10.3233\/JAD-171042","article-title":"Homocysteine and dementia: an international consensus statement","volume":"62","author":"Smith","year":"2018","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.bbi.2019.09.019_b0670","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.nbd.2017.05.007","article-title":"Molecular imaging of serotonin degeneration in mild cognitive impairment","volume":"105","author":"Smith","year":"2017","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.bbi.2019.09.019_b0675","doi-asserted-by":"crossref","first-page":"1841","DOI":"10.1007\/s12035-018-1188-4","article-title":"The gut microbiome alterations and inflammation-driven pathogenesis of alzheimer's diseasea critical review","volume":"56","author":"Sochocka","year":"2019","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.bbi.2019.09.019_b0680","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1073\/pnas.1717507115","article-title":"Pyruvate induces torpor in obese mice","volume":"115","author":"Soto","year":"2018","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.bbi.2019.09.019_b0685","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.bbapap.2004.08.010","article-title":"Methionine oxidation and aging","volume":"1703","author":"Stadtman","year":"2005","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bbi.2019.09.019_b0690","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1007\/s10545-009-9006-9","article-title":"Dealing with methionine\/homocysteine sulfur: cysteine metabolism to taurine and inorganic sulfur","volume":"34","author":"Stipanuk","year":"2011","journal-title":"J. Inherit. Metab. Dis."},{"key":"10.1016\/j.bbi.2019.09.019_b0695","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1007\/s11306-007-0082-2","article-title":"Proposed minimum reporting standards for chemical analysis Chemical Analysis Working Group (CAWG) Metabolomics Standards Initiative (MSI)","volume":"3","author":"Sumner","year":"2007","journal-title":"Metabolomics"},{"key":"10.1016\/j.bbi.2019.09.019_b0700","doi-asserted-by":"crossref","first-page":"3776","DOI":"10.1039\/C6AN00170J","article-title":"Non-destructive characterisation of mesenchymal stem cell differentiation using LC\u2013MS-based metabolite footprinting","volume":"141","author":"Surrati","year":"2016","journal-title":"Analyst"},{"key":"10.1016\/j.bbi.2019.09.019_b0705","doi-asserted-by":"crossref","first-page":"273","DOI":"10.3233\/JAD-131685","article-title":"Methylglyoxal produced by amyloid-beta peptide-induced nitrotyrosination of triosephosphate isomerase triggers neuronal death in Alzheimer's disease","volume":"41","author":"Tajes","year":"2014","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.bbi.2019.09.019_b0710","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1186\/s13024-015-0057-0","article-title":"Is L-methionine a trigger factor for Alzheimer's-like neurodegeneration?: Changes in Abeta oligomers, tau phosphorylation, synaptic proteins, Wnt signaling and behavioral impairment in wild-type mice","volume":"10","author":"Tapia-Rojas","year":"2015","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.bbi.2019.09.019_b0715","first-page":"9","article-title":"Highly sensitive feature detection for high resolution LC\/MS","author":"Tautenhahn","year":"2008","journal-title":"BMCBioinformatics"},{"key":"10.1016\/j.bbi.2019.09.019_b0720","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1016\/j.bbi.2007.01.012","article-title":"Sub-pyrogenic systemic inflammation impacts on brain and behavior, independent of cytokines","volume":"21","author":"Teeling","year":"2007","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.bbi.2019.09.019_b0725","doi-asserted-by":"crossref","first-page":"93","DOI":"10.4331\/wjbc.v3.i5.93","article-title":"Peroxisomes, oxidative stress, and inflammation","volume":"3","author":"Terlecky","year":"2012","journal-title":"World J. Biol. Chem."},{"key":"10.1016\/j.bbi.2019.09.019_b0730","doi-asserted-by":"crossref","first-page":"782","DOI":"10.2741\/4616","article-title":"Immune response to systemic inflammation in the intestinal microcirculation","volume":"23","author":"Thorburn","year":"2018","journal-title":"Front. Biosci. (Landmark Ed)"},{"key":"10.1016\/j.bbi.2019.09.019_b0735","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1159\/000322092","article-title":"Systemic inflammation is associated with MCI and its subtypes: the Sydney memory and aging study","volume":"30","author":"Trollor","year":"2010","journal-title":"Dement Geriatr. Cogn."},{"key":"10.1016\/j.bbi.2019.09.019_b0740","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1089\/neu.2015.3977","article-title":"Performance of male and female C57BL\/6J mice on motor and cognitive tasks commonly used in pre-clinical traumatic brain injury research","volume":"33","author":"Tucker","year":"2016","journal-title":"J. Neurotraum."},{"key":"10.1016\/j.bbi.2019.09.019_b0745","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/S0531-5565(03)00008-1","article-title":"Altered methionine metabolism in long living Ames dwarf mice","volume":"38","author":"Uthus","year":"2003","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.bbi.2019.09.019_b0750","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.bbi.2016.03.010","article-title":"The blood-brain barrier in systemic inflammation","volume":"60","author":"Varatharaj","year":"2017","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.bbi.2019.09.019_b0755","article-title":"Sexual differentiation of microglia","author":"Villa","year":"2018","journal-title":"Front. Neuroendocrinol."},{"key":"10.1016\/j.bbi.2019.09.019_b0760","doi-asserted-by":"crossref","first-page":"3501","DOI":"10.1016\/j.celrep.2018.05.048","article-title":"Sex-specific features of microglia from adult mice","volume":"23","author":"Villa","year":"2018","journal-title":"Cell Rep."},{"key":"10.1016\/j.bbi.2019.09.019_b0765","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1002\/glia.23171","article-title":"Sexual dimorphism in the inflammatory response to traumatic brain injury","volume":"65","author":"Villapol","year":"2017","journal-title":"Glia"},{"key":"10.1016\/j.bbi.2019.09.019_b0770","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.ijpddr.2013.11.002","article-title":"Untargeted metabolomic analysis of miltefosine action in Leishmania infantum reveals changes to the internal lipid metabolism","volume":"4","author":"Vincent","year":"2014","journal-title":"Int. J. Parasitol. Drugs Drug Resist."},{"key":"10.1016\/j.bbi.2019.09.019_b0775","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.mad.2013.05.004","article-title":"Sulfur-based redox alterations in long-lived Snell dwarf mice","volume":"134","author":"Vitvitsky","year":"2013","journal-title":"Mech. Ageing Dev."},{"key":"10.1016\/j.bbi.2019.09.019_b0780","doi-asserted-by":"crossref","first-page":"1699","DOI":"10.2337\/db15-0568","article-title":"Methylglyoxal-induced endothelial cell loss and inflammation contribute to the development of diabetic cardiomyopathy","volume":"65","author":"Vulesevic","year":"2016","journal-title":"Diabetes"},{"key":"10.1016\/j.bbi.2019.09.019_b0785","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1089\/089771504322778596","article-title":"Relationships between cerebrospinal fluid markers of excitotoxicity, ischemia, and oxidative damage after severe TBI: the impact of gender, age, and hypothermia","volume":"21","author":"Wagner","year":"2004","journal-title":"J. Neurotraum."},{"key":"10.1016\/j.bbi.2019.09.019_b0790","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.nbd.2003.08.009","article-title":"Gender differences in the amount and deposition of amyloidbeta in APPswe and PS1 double transgenic mice","volume":"14","author":"Wang","year":"2003","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.bbi.2019.09.019_b0795","article-title":"Human genetic and metabolite variation reveals that methylthioadenosine is a prognostic biomarker and an inflammatory regulator in sepsis","volume":"3","author":"Wang","year":"2017","journal-title":"Sci. Adv."},{"key":"10.1016\/j.bbi.2019.09.019_b0800","doi-asserted-by":"crossref","first-page":"467","DOI":"10.3233\/JAD-2003-5607","article-title":"Advanced glycation endproduct precursor alters intracellular amyloid-beta\/A beta PP carboxy-terminal fragment aggregation and cytotoxicity","volume":"5","author":"Woltjer","year":"2003","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.bbi.2019.09.019_b0805","article-title":"Expression of tryptophan 2,3-dioxygenase and production of kynurenine pathway metabolites in triple transgenic mice and human Alzheimer's disease brain","volume":"8","author":"Wu","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.bbi.2019.09.019_b0810","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.arr.2018.05.006","article-title":"NAD metabolism: Implications in aging and longevity","volume":"47","author":"Yaku","year":"2018","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.bbi.2019.09.019_b0815","article-title":"Differential general anesthetic effects on microglial cytokine expression","volume":"8","author":"Ye","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.bbi.2019.09.019_b0820","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1001\/jamaneurol.2016.0150","article-title":"Association between genetic traits for immune-mediated diseases and Alzheimer disease","volume":"73","author":"Yokoyama","year":"2016","journal-title":"JAMA Neurol."},{"key":"10.1016\/j.bbi.2019.09.019_b0825","doi-asserted-by":"crossref","unstructured":"Young, K., Rothers, J., Castaneda, S., Ritchie, J., E Pottenger, A., Morrison, H., 2018. Sex and regional differences in microglia morphology and complement receptor 3 are independent of constitutive neuroinflammatory protein concentrations in healthy mice.","DOI":"10.7287\/peerj.preprints.26937v1"},{"key":"10.1016\/j.bbi.2019.09.019_b0830","doi-asserted-by":"crossref","first-page":"42","DOI":"10.3389\/fnagi.2018.00042","article-title":"Lipopolysaccharide associates with amyloid plaques, neurons and oligodendrocytes in Alzheimer's disease brain: a review","volume":"10","author":"Zhan","year":"2018","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.bbi.2019.09.019_b0835","doi-asserted-by":"crossref","first-page":"2324","DOI":"10.1212\/WNL.0000000000003391","article-title":"Gram-negative bacterial molecules associate with Alzheimer disease pathology","volume":"87","author":"Zhan","year":"2016","journal-title":"Neurology"},{"key":"10.1016\/j.bbi.2019.09.019_b0840","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.3233\/JAD-170020","article-title":"Altered gut microbiota in a mouse model of Alzheimer's disease","volume":"60","author":"Zhang","year":"2017","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.bbi.2019.09.019_b0845","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.jneuroim.2008.09.017","article-title":"Circulating endotoxin and systemic immune activation in sporadic amyotrophic lateral sclerosis (sALS)","volume":"206","author":"Zhang","year":"2009","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.bbi.2019.09.019_b0850","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.neurobiolaging.2016.02.011","article-title":"Sex differences in metabolic aging of the brain: insights into female susceptibility to Alzheimer's disease","volume":"42","author":"Zhao","year":"2016","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.bbi.2019.09.019_b0855","first-page":"8","article-title":"Microbiome-derived lipopolysaccharide enriched in the perinuclear region of Alzheimer's disease","author":"Zhao","year":"2017","journal-title":"Brain. Front Immunol"}],"container-title":["Brain, Behavior, and Immunity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0889159119303757?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0889159119303757?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T23:55:42Z","timestamp":1778543742000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0889159119303757"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1]]},"references-count":171,"alternative-id":["S0889159119303757"],"URL":"https:\/\/doi.org\/10.1016\/j.bbi.2019.09.019","relation":{},"ISSN":["0889-1591"],"issn-type":[{"value":"0889-1591","type":"print"}],"subject":[],"published":{"date-parts":[[2020,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Sex-specific hippocampal metabolic signatures at the onset of systemic inflammation with lipopolysaccharide in the APPswe\/PS1dE9 mouse model of Alzheimer\u2019s disease","name":"articletitle","label":"Article Title"},{"value":"Brain, Behavior, and Immunity","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbi.2019.09.019","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}