{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T21:57:18Z","timestamp":1792879038757,"version":"4.5.0"},"reference-count":35,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T00:00:00Z","timestamp":1596240000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T00:00:00Z","timestamp":1596240000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T00:00:00Z","timestamp":1596240000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T00:00:00Z","timestamp":1596240000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T00:00:00Z","timestamp":1596240000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T00:00:00Z","timestamp":1596240000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T00:00:00Z","timestamp":1596240000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100000923","name":"Australian Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000923","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain, Behavior, and Immunity"],"published-print":{"date-parts":[[2020,8]]},"DOI":"10.1016\/j.bbi.2020.04.009","type":"journal-article","created":{"date-parts":[[2020,4,6]],"date-time":"2020-04-06T11:17:55Z","timestamp":1586171875000},"page":"442-450","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":22,"special_numbering":"C","title":["In vivo intrathecal IL-1\u03b2 quantification in rats: Monitoring the molecular signals of neuropathic pain"],"prefix":"10.1016","volume":"88","author":[{"given":"Azim","family":"Arman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ewa M.","family":"Goldys","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guozhen","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark R.","family":"Hutchinson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.bbi.2020.04.009_b0005","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1016\/j.bbi.2006.10.017","article-title":"Stereological and somatotopic analysis of the spinal microglial response to peripheral nerve injury","volume":"21","author":"Beggs","year":"2007","journal-title":"Brain Behav. Immun."},{"issue":"1","key":"10.1016\/j.bbi.2020.04.009_b0010","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/0304-3959(88)90209-6","article-title":"A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man","volume":"33","author":"Bennett","year":"1988","journal-title":"Pain"},{"issue":"1","key":"10.1016\/j.bbi.2020.04.009_b0015","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1186\/s12974-016-0757-6","article-title":"Cytokine and chemokine alterations in tissue, CSF, and plasma in early presymptomatic phase of experimental allergic encephalomyelitis (EAE), in a rat model of multiple sclerosis","volume":"13","author":"Borjini","year":"2016","journal-title":"J. Neuroinflammation"},{"issue":"1","key":"10.1016\/j.bbi.2020.04.009_b0020","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.neuron.2006.09.021","article-title":"Mechanisms of neuropathic pain","volume":"52","author":"Campbell","year":"2006","journal-title":"Neuron"},{"issue":"7","key":"10.1016\/j.bbi.2020.04.009_b0025","doi-asserted-by":"crossref","first-page":"1212","DOI":"10.1002\/ar.22506","article-title":"Comparison of three methods of drug delivery in the rat lumbar spinal subarachnoid space","volume":"295","author":"Chen","year":"2012","journal-title":"Anat. Rec. (Hoboken)"},{"issue":"23","key":"10.1016\/j.bbi.2020.04.009_b0030","doi-asserted-by":"crossref","first-page":"16214","DOI":"10.1074\/jbc.M114.571505","article-title":"3-Hydroxyl-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor (statin)-induced 28-kDa interleukin-1beta interferes with mature IL-1beta signaling","volume":"289","author":"Davaro","year":"2014","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.bbi.2020.04.009_b0035","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1021\/acsabm.9b00958","article-title":"A method for in vivo quantification of cytokine IL-1\u03b2 In the rat intrathecal space","volume":"3","author":"Deng","year":"2020","journal-title":"ACS Appl. Bio Mater."},{"issue":"19","key":"10.1016\/j.bbi.2020.04.009_b0040","doi-asserted-by":"crossref","first-page":"5682","DOI":"10.1039\/C9AN01300H","article-title":"Polymer brush based fluorescent immunosensor for direct monitoring of interleukin-1beta in rat blood","volume":"144","author":"Deng","year":"2019","journal-title":"Analyst"},{"issue":"1","key":"10.1016\/j.bbi.2020.04.009_b0045","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0006-8993(91)91729-K","article-title":"Staining of glial fibrillary acidic protein (GFAP) in lumbar spinal cord increases following a sciatic nerve constriction injury","volume":"565","author":"Garrison","year":"1991","journal-title":"Brain Res."},{"key":"10.1016\/j.bbi.2020.04.009_b0050","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1186\/1471-2458-11-770","article-title":"Pain as a global public health priority","volume":"11","author":"Goldberg","year":"2011","journal-title":"BMC Public Health"},{"issue":"4","key":"10.1016\/j.bbi.2020.04.009_b0055","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1038\/nri3621","article-title":"Pathological pain and the neuroimmune interface","volume":"14","author":"Grace","year":"2014","journal-title":"Nat. Rev. Immunol."},{"issue":"5","key":"10.1016\/j.bbi.2020.04.009_b0060","first-page":"E615","article-title":"Intrathecal lentivirus-mediated transfer of interleukin-10 attenuates chronic constriction injury-induced neuropathic pain through modulation of spinal high-mobility group box 1 in rats","volume":"16","author":"He","year":"2013","journal-title":"Pain Physician"},{"issue":"1\u20132","key":"10.1016\/j.bbi.2020.04.009_b0065","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/S0300-483X(00)00401-7","article-title":"Cytokine measurement techniques for assessing hypersensitivity","volume":"158","author":"House","year":"2001","journal-title":"Toxicology"},{"issue":"1","key":"10.1016\/j.bbi.2020.04.009_b0070","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1111\/j.1460-9568.2008.06321.x","article-title":"Non-stereoselective reversal of neuropathic pain by naloxone and naltrexone: involvement of toll-like receptor 4 (TLR4)","volume":"28","author":"Hutchinson","year":"2008","journal-title":"Eur. J. Neurosci."},{"issue":"5","key":"10.1016\/j.bbi.2020.04.009_b0075","doi-asserted-by":"crossref","first-page":"2206","DOI":"10.1046\/j.1471-4159.1999.02206.x","article-title":"Interleukin-1beta induces substance P release from primary afferent neurons through the cyclooxygenase-2 system","volume":"73","author":"Inoue","year":"1999","journal-title":"J. Neurochem."},{"issue":"33","key":"10.1016\/j.bbi.2020.04.009_b0080","doi-asserted-by":"crossref","first-page":"7353","DOI":"10.1523\/JNEUROSCI.1850-04.2004","article-title":"A role for proinflammatory cytokines and fractalkine in analgesia, tolerance, and subsequent pain facilitation induced by chronic intrathecal morphine","volume":"24","author":"Johnston","year":"2004","journal-title":"J. Neurosci."},{"issue":"2\u20133","key":"10.1016\/j.bbi.2020.04.009_b0085","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/S0304-3959(99)00195-5","article-title":"Cytokine involvement in dynorphin-induced allodynia","volume":"84","author":"Laughlin","year":"2000","journal-title":"Pain"},{"issue":"18","key":"10.1016\/j.bbi.2020.04.009_b0090","first-page":"2807","article-title":"Temporal expression of cytokines and their receptors mRNAs in a neuropathic pain model","volume":"15","author":"Lee","year":"2004","journal-title":"Neuroreport"},{"issue":"4","key":"10.1016\/j.bbi.2020.04.009_b0095","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.cytogfr.2011.10.001","article-title":"Understanding the mechanism of IL-1beta secretion","volume":"22","author":"Lopez-Castejon","year":"2011","journal-title":"Cytokine Growth Factor Rev."},{"key":"10.1016\/j.bbi.2020.04.009_b0100","doi-asserted-by":"crossref","first-page":"2743","DOI":"10.12688\/f1000research.9621.1","article-title":"Recent advances in understanding neuropathic pain: glia, sex differences, and epigenetics","volume":"5","author":"Machelska","year":"2016","journal-title":"F1000Res"},{"issue":"1","key":"10.1016\/j.bbi.2020.04.009_b0105","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/S0165-0270(99)00075-8","article-title":"A method for increasing the viability of the external portion of lumbar catheters placed in the spinal subarachnoid space of rats","volume":"90","author":"Milligan","year":"1999","journal-title":"J. Neurosci. Methods"},{"issue":"2","key":"10.1016\/j.bbi.2020.04.009_b0110","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1038\/nrd3624","article-title":"The neuropathic pain market","volume":"11","author":"Nightingale","year":"2012","journal-title":"Nat. Rev. Drug Discov."},{"issue":"2","key":"10.1016\/j.bbi.2020.04.009_b0115","doi-asserted-by":"crossref","first-page":"95","DOI":"10.2165\/00019053-200927020-00002","article-title":"Neuropathic pain: quality-of-life impact, costs and cost effectiveness of therapy","volume":"27","author":"O'Connor","year":"2009","journal-title":"Pharmacoeconomics"},{"issue":"48","key":"10.1016\/j.bbi.2020.04.009_b0120","doi-asserted-by":"crossref","first-page":"41659","DOI":"10.1021\/acsami.7b10753","article-title":"Graphene oxide thin film with dual function integrated into a nanosandwich device for in vivo monitoring of interleukin-6","volume":"9","author":"Qi","year":"2017","journal-title":"ACS Appl. Mater. Interfaces"},{"issue":"2","key":"10.1016\/j.bbi.2020.04.009_b0125","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1124\/jpet.103.052407","article-title":"Inhibition of microglial activation attenuates the development but not existing hypersensitivity in a rat model of neuropathy","volume":"306","author":"Raghavendra","year":"2003","journal-title":"J. Pharmacol. Exp. Ther."},{"issue":"1","key":"10.1016\/j.bbi.2020.04.009_b0130","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1590\/S1679-45082013000100016","article-title":"Nitric oxide metabolites in the lumbosacral spinal cord interstice and cerebrospinal fluid in female rats with acute cyclophosphamide-induced cystitis. An in vivo microdialysis study","volume":"11","author":"Rocha","year":"2013","journal-title":"Einstein (Sao Paulo)"},{"key":"10.1016\/j.bbi.2020.04.009_b0135","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.brainres.2008.05.004","article-title":"A comparison of spinal Iba1 and GFAP expression in rodent models of acute and chronic pain","volume":"1219","author":"Romero-Sandoval","year":"2008","journal-title":"Brain Res."},{"key":"10.1016\/j.bbi.2020.04.009_b0140","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharmthera.2019.02.004","article-title":"Potential biomarkers for persistent and neuropathic pain therapy","author":"Sisignano","year":"2019","journal-title":"Pharmacol. Ther."},{"issue":"5","key":"10.1016\/j.bbi.2020.04.009_b0145","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1016\/j.bbi.2006.10.003","article-title":"Early cytokine expression in mouse sciatic nerve after chronic constriction nerve injury depends on calpain","volume":"21","author":"Uceyler","year":"2007","journal-title":"Brain Behav. Immun."},{"issue":"2","key":"10.1016\/j.bbi.2020.04.009_b0150","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/S0006-8993(97)00254-0","article-title":"Increase of interleukin-1beta mRNA and protein in the spinal cord following experimental traumatic injury in the rat","volume":"759","author":"Wang","year":"1997","journal-title":"Brain Res."},{"key":"10.1016\/j.bbi.2020.04.009_b0155","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1146\/annurev.psych.51.1.29","article-title":"The pain of being sick: implications of immune-to-brain communication for understanding pain","volume":"51","author":"Watkins","year":"2000","journal-title":"Annu. Rev. Psychol."},{"issue":"8","key":"10.1016\/j.bbi.2020.04.009_b0160","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/S0166-2236(00)01854-3","article-title":"Glial activation: a driving force for pathological pain","volume":"24","author":"Watkins","year":"2001","journal-title":"Trends Neurosci."},{"issue":"3","key":"10.1016\/j.bbi.2020.04.009_b0165","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.pain.2005.11.011","article-title":"Genetic impairment of interleukin-1 signaling attenuates neuropathic pain, autotomy, and spontaneous ectopic neuronal activity, following nerve injury in mice","volume":"120","author":"Wolf","year":"2006","journal-title":"Pain"},{"key":"10.1016\/j.bbi.2020.04.009_b0170","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.snb.2018.11.054","article-title":"An optical fiber based immunosensor for localized detection of IL-1\u03b2 in rat spinal cord","volume":"282","author":"Zhang","year":"2019","journal-title":"Sens. Actuat. B Chem."},{"key":"10.1016\/j.bbi.2020.04.009_b0175","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.bbi.2018.04.011","article-title":"A novel platform for in vivo detection of cytokine release within discrete brain regions","volume":"71","author":"Zhang","year":"2018","journal-title":"Brain Behav. Immun."}],"container-title":["Brain, Behavior, and Immunity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0889159119315132?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0889159119315132?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T08:11:36Z","timestamp":1760170296000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0889159119315132"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8]]},"references-count":35,"alternative-id":["S0889159119315132"],"URL":"https:\/\/doi.org\/10.1016\/j.bbi.2020.04.009","relation":{},"ISSN":["0889-1591"],"issn-type":[{"value":"0889-1591","type":"print"}],"subject":[],"published":{"date-parts":[[2020,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"In vivo intrathecal IL-1\u03b2 quantification in rats: Monitoring the molecular signals of neuropathic pain","name":"articletitle","label":"Article Title"},{"value":"Brain, Behavior, and Immunity","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbi.2020.04.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}