{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T11:08:35Z","timestamp":1783163315341,"version":"3.54.6"},"reference-count":148,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain, Behavior, and Immunity"],"published-print":{"date-parts":[[2020,10]]},"DOI":"10.1016\/j.bbi.2020.05.076","type":"journal-article","created":{"date-parts":[[2020,5,30]],"date-time":"2020-05-30T19:39:38Z","timestamp":1590867578000},"page":"100-117","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":33,"special_numbering":"C","title":["Gestational poly(I:C) attenuates, not exacerbates, the behavioral, cytokine and mTOR changes caused by isolation rearing in a rat \u2018dual-hit\u2019 model for neurodevelopmental disorders"],"prefix":"10.1016","volume":"89","author":[{"given":"Jen-Yin","family":"Goh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saoirse E.","family":"O'Sullivan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sinead E.","family":"Shortall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"Zordan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna M.","family":"Piccinini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harry G.","family":"Potter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin C.F.","family":"Fone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madeleine V.","family":"King","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbi.2020.05.076_b0005","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/j.schres.2013.12.007","article-title":"DNA hypermethylation of serotonin transporter gene promoter in drug na\u00efve patients with schizophrenia","volume":"152","author":"Abdolmaleky","year":"2014","journal-title":"Schizophr. Res."},{"key":"10.1016\/j.bbi.2020.05.076_b0010","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1001\/archpsyc.60.6.565","article-title":"Sex differences in the risk of schizophrenia: evidence from meta-analysis","volume":"60","author":"Aleman","year":"2003","journal-title":"Arch. Gen. Psychiatry"},{"key":"10.1016\/j.bbi.2020.05.076_b0015","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.pnpbp.2017.02.022","article-title":"Oxytocin mitigated the depressive-like behaviors of maternal separation stress through modulating mitochondrial function and neuroinflammation","volume":"76","author":"Amini-Khoei","year":"2017","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.bbi.2020.05.076_b0020","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.nbd.2019.01.025","article-title":"Maternal immune activation impairs cognitive flexibility and alters transcription in frontal cortex","volume":"125","author":"Amodeo","year":"2019","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.bbi.2020.05.076_b0025","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.ijdevneu.2016.03.001","article-title":"Early life adversities or high fat diet intake reduce cognitive function and alter BDNF signaling in adult rats: Interplay of these factors changes these effects","volume":"50","author":"Arcego","year":"2016","journal-title":"Int. J. Dev. Neurosci."},{"key":"10.1016\/j.bbi.2020.05.076_b0030","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.bbr.2010.03.041","article-title":"Subchronic MK-801 treatment and post-weaning social isolation in rats: differential effects on locomotor activity and hippocampal long-term potentiation","volume":"212","author":"Ashby","year":"2010","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.bbi.2020.05.076_b0035","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.pnpbp.2014.11.002","article-title":"Behavioral alterations in rat offspring following maternal immune activation and ELR-CXC chemokine receptor antagonism during pregnancy: implications for neurodevelopmental psychiatric disorders","volume":"57","author":"Ballendine","year":"2015","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.bbi.2020.05.076_b0045","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1037\/bne0000230","article-title":"Spared motivational modulation of cognitive effort in a maternal immune activation model of schizophrenia risk","volume":"132","author":"Bates","year":"2018","journal-title":"Behav. Neurosci."},{"key":"10.1016\/j.bbi.2020.05.076_b0050","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1111\/nyas.13712","article-title":"Inflammation in psychiatric disorders: what comes first?","volume":"1437","author":"Bauer","year":"2019","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.bbi.2020.05.076_b0055","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1097\/00008877-199306000-00005","article-title":"Social isolation attenuates rat forebrain 5-HT release induced by KCl stimulation and exposure to a novel environment","volume":"4","author":"Bickerdike","year":"1993","journal-title":"Behav. Pharmacol."},{"key":"10.1016\/j.bbi.2020.05.076_b0060","doi-asserted-by":"crossref","first-page":"4320","DOI":"10.1523\/JNEUROSCI.20-11-04320.2000","article-title":"Medial frontal cortex mediates perceptual attentional set shifting in the rat","volume":"20","author":"Birrell","year":"2000","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bbi.2020.05.076_b0065","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.bbr.2010.12.040","article-title":"Individual differences in maternal response to immune challenge predict offspring behavior: contribution of environmental factors","volume":"220","author":"Bronson","year":"2011","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.bbi.2020.05.076_b0070","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.1002\/dneu.22024","article-title":"Epidemiologic studies of exposure to prenatal infection and risk of schizophrenia and autism","volume":"72","author":"Brown","year":"2012","journal-title":"Dev. Neurobiol."},{"key":"10.1016\/j.bbi.2020.05.076_b0075","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.neubiorev.2017.01.018","article-title":"Impact of adolescent social experiences on behavior and neural circuits implicated in mental illnesses","volume":"76","author":"Burke","year":"2017","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.bbi.2020.05.076_b0080","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.jneuroim.2018.06.014","article-title":"Variability in PolyIC induced immune response: implications for preclinical maternal immune activation models","volume":"323","author":"Careaga","year":"2018","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.bbi.2020.05.076_b0085","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.jad.2009.11.006","article-title":"Genetic and environmental influences on psychiatric comorbidity: a systematic review","volume":"126","author":"Cerd\u00e1","year":"2010","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.bbi.2020.05.076_b0090","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuint.2019.104473","article-title":"Behavioral alterations induced by post-weaning isolation rearing of rats are accompanied by reduced VGF\/BDNF\/TrkB signaling in the hippocampus","volume":"129","author":"Chmelova","year":"2019","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.bbi.2020.05.076_b0095","doi-asserted-by":"crossref","DOI":"10.1111\/gbb.12535","article-title":"Oxytocin and vasopressin in the rodent hippocampus","volume":"18","author":"Cilz","year":"2019","journal-title":"Genes Brain Behav."},{"key":"10.1016\/j.bbi.2020.05.076_b0100","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1093\/cercor\/bhj120","article-title":"Cognitive inflexibility after prefrontal serotonin depletion is behaviorally and neurochemically specific","volume":"17","author":"Clarke","year":"2007","journal-title":"Cereb. Cortex"},{"key":"10.1016\/j.bbi.2020.05.076_b0105","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/j.pnpbp.2018.09.011","article-title":"Maternal immune activation in rats blunts brain cytokine and kynurenine pathway responses to a second immune challenge in early adulthood","volume":"89","author":"Clark","year":"2019","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.bbi.2020.05.076_b0115","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1111\/j.1365-2826.2010.02003.x","article-title":"Hippocampal microinfusion of oxytocin attenuates the behavioural response to stress by means of dynamic interplay with the glucocorticoid-catecholamine responses","volume":"22","author":"Cohen","year":"2010","journal-title":"J. Neuroendocrinol."},{"key":"10.1016\/j.bbi.2020.05.076_b0120","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1038\/nrn3729","article-title":"Nuclear and cytosolic JNK signalling in neurons","volume":"15","author":"Coffey","year":"2014","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.bbi.2020.05.076_b0125","doi-asserted-by":"crossref","DOI":"10.5402\/2012\/451865","article-title":"Synergistic effect between maternal infection and adolescent cannabinoid exposure on serotonin 5HT1A receptor binding in the hippocampus: testing the \u201ctwo hit\u201d hypothesis for the development of schizophrenia","volume":"2012","author":"Dalton","year":"2012","journal-title":"ISRN Psychiatry"},{"key":"10.1016\/j.bbi.2020.05.076_b0130","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1016\/j.physbeh.2012.01.015","article-title":"Testing the cumulative stress and mismatch hypotheses of psychopathology in a rat model of early-life adversity","volume":"106","author":"Daskalakis","year":"2012","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.bbi.2020.05.076_b0135","doi-asserted-by":"crossref","first-page":"1858","DOI":"10.1016\/j.psyneuen.2013.06.008","article-title":"The three-hit concept of vulnerability and resilience: toward understanding adaptation to early-life adversity outcome","volume":"38","author":"Daskalakis","year":"2013","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.bbi.2020.05.076_b0145","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1038\/nature12518","article-title":"Social reward requires coordinated activity of nucleus accumbens oxytocin and serotonin","volume":"501","author":"D\u00f6len","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.bbi.2020.05.076_b0150","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.brainresbull.2017.11.008","article-title":"Poly(I:C) model of schizophrenia in rats induces sex-dependent functional brain changes detected by MRI that are not reversed by aripiprazole treatment","volume":"137","author":"Drazanova","year":"2018","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.bbi.2020.05.076_b0155","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.bbi.2017.10.024","article-title":"Post-weaning social isolation of rats leads to long-term disruption of the gut microbiota-immune-brain axis","volume":"68","author":"Dunphy-Doherty","year":"2018","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.bbi.2020.05.076_b0160","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.bbr.2009.11.017","article-title":"Fluoxetine improves the memory deficits caused by the chemotherapy agent 5-fluorouracil","volume":"208","author":"ElBeltagy","year":"2010","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.bbi.2020.05.076_b0165","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/S0091-3057(02)00794-3","article-title":"Early maternal deprivation and prepulse inhibition: the role of the postdeprivation environment","volume":"73","author":"Ellenbroek","year":"2002","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.bbi.2020.05.076_b0170","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.yfrne.2004.09.001","article-title":"The hypothalamic-neurohypophysial system regulates the hypothalamic-pituitary-adrenal axis under stress: an old concept revisited","volume":"25","author":"Engelmann","year":"2004","journal-title":"Front. Neuroendocrinol."},{"key":"10.1016\/j.bbi.2020.05.076_b0175","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.neuroscience.2019.07.002","article-title":"Interleukin 6 dependent synaptic plasticity in a social defeat-susceptible prefrontal cortex circuit","volume":"414","author":"Esquivel-Rend\u00f3n","year":"2019","journal-title":"Neuroscience"},{"key":"10.1016\/j.bbi.2020.05.076_b0180","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1126\/science.aag3194","article-title":"Maternal immune activation: Implications for neuropsychiatric disorders","volume":"353","author":"Estes","year":"2016","journal-title":"Science"},{"key":"10.1016\/j.bbi.2020.05.076_b0185","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.brainres.2010.05.040","article-title":"Stereological brain volume changes in post-weaned socially isolated rats","volume":"1345","author":"Fabricius","year":"2010","journal-title":"Brain Res."},{"key":"10.1016\/j.bbi.2020.05.076_b0190","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.ijdevneu.2010.09.003","article-title":"Socially isolated rats exhibit changes in dopamine homeostasis pertinent to schizophrenia","volume":"29","author":"Fabricius","year":"2011","journal-title":"Int. J. Dev. Neurosci."},{"key":"10.1016\/j.bbi.2020.05.076_b0195","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/j.diabet.2017.10.004","article-title":"Inhibitory role of oxytocin on TNF\u03b1 expression assessed in vitro and in vivo","volume":"44","author":"Garrido-Urbani","year":"2018","journal-title":"Diabetes Metab."},{"key":"10.1016\/j.bbi.2020.05.076_b0200","doi-asserted-by":"crossref","first-page":"2533","DOI":"10.1007\/s00213-013-3424-y","article-title":"Neonatal phencyclidine administration and post-weaning social isolation as a dual-hit model of 'schizophrenia-like' behaviour in the rat","volume":"231","author":"Gaskin","year":"2014","journal-title":"Psychopharmacology (Berl)."},{"key":"10.1016\/j.bbi.2020.05.076_b0205","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/ijnp\/pyw062","article-title":"Down-regulation of hippocampal genes regulating dopaminergic, GABAergic, and glutamatergic function following combined neonatal phencyclidine and post-weaning social isolation of rats as a neurodevelopmental model for schizophrenia","volume":"19","author":"Gaskin","year":"2016","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"10.1016\/j.bbi.2020.05.076_b0210","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.bbr.2017.03.036","article-title":"Effects of social deprivation on social and depressive-like behaviors and the numbers of oxytocin expressing neurons in rats","volume":"328","author":"Gilles","year":"2017","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.bbi.2020.05.076_b0215","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.jneuroim.2004.10.008","article-title":"Maternal poly I: C exposure during pregnancy regulates TNF alpha, BDNF, and NGF expression in neonatal brain and the maternal-fetal unit of the rat","volume":"159","author":"Gilmore","year":"2005","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.bbi.2020.05.076_b0220","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/j.bbr.2018.08.016","article-title":"Maternal immune activation in mid-late gestation alters amphetamine sensitivity and object recognition, but not other schizophrenia-related behaviours in adult rats","volume":"356","author":"Gray","year":"2019","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.bbi.2020.05.076_b0225","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1111\/jnc.12622","article-title":"Is the mTOR-signalling cascade disrupted in Schizophrenia?","volume":"129","author":"Gururajan","year":"2014","journal-title":"J. Neurochem."},{"key":"10.1016\/j.bbi.2020.05.076_b0230","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.schres.2015.05.010","article-title":"Using a maternal immune stimulation model of schizophrenia to study behavioral and neurobiological alterations over the developmental course","volume":"166","author":"Hadar","year":"2015","journal-title":"Schizophr. Res."},{"key":"10.1016\/j.bbi.2020.05.076_b0235","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1038\/s41398-019-0457-y","article-title":"Sex-dependent behavioral deficits and neuropathology in a maternal immune activation model of autism","volume":"9","author":"Haida","year":"2019","journal-title":"Transl. Psychiatry."},{"key":"10.1016\/j.bbi.2020.05.076_b0240","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1007\/s00702-007-0627-6","article-title":"Deficits in parvalbumin and calbindin immunoreactive cells in the hippocampus of isolation reared rats","volume":"114","author":"Harte","year":"2007","journal-title":"J. Neural. Transm. (Vienna)"},{"key":"10.1016\/j.bbi.2020.05.076_b0245","doi-asserted-by":"crossref","first-page":"1767","DOI":"10.1016\/j.neuropharm.2011.11.022","article-title":"A stereological comparison of GAD67 and reelin expression in the hippocampal stratum oriens of offspring from two mouse models of maternal inflammation during pregnancy","volume":"62","author":"Harvey","year":"2012","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.bbi.2020.05.076_b0250","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1177\/0269881119826783","article-title":"Social isolation rearing-induced anxiety and response to agomelatine in male and female rats: Role of corticosterone, oxytocin, and vasopressin","volume":"33","author":"Harvey","year":"2019","journal-title":"J. Psychopharmacol."},{"key":"10.1016\/j.bbi.2020.05.076_b0255","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1097\/FBP.0b013e32835a5184","article-title":"Low maternal care exacerbates adult stress susceptibility in the chronic mild stress rat model of depression","volume":"23","author":"Henningsen","year":"2012","journal-title":"Behav. Pharmacol."},{"key":"10.1016\/j.bbi.2020.05.076_b0260","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1016\/j.physbeh.2010.12.019","article-title":"Post-weaning chronic social isolation produces profound behavioral dysregulation with decreases in prefrontal cortex synaptic-associated protein expression in female rats","volume":"104","author":"Hermes","year":"2011","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.bbi.2020.05.076_b0265","doi-asserted-by":"crossref","first-page":"2126","DOI":"10.1016\/j.bbadis.2014.08.009","article-title":"Long-term effects of combined neonatal and adolescent stress on brain-derived neurotrophic factor and dopamine receptor expression in the rat forebrain","volume":"1842","author":"Hill","year":"2014","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bbi.2020.05.076_b0270","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1111\/bph.13368","article-title":"Cannabidiol protects an in vitro model of the blood-brain barrier from oxygen-glucose deprivation via PPAR\u03b3 and 5-HT1A receptors","volume":"173","author":"Hind","year":"2016","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.bbi.2020.05.076_b0275","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1146\/annurev-pharmtox-010716-104624","article-title":"CNS Target identification and validation: avoiding the valley of death or naive optimism?","volume":"57","author":"Hutson","year":"2017","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"10.1016\/j.bbi.2020.05.076_b0280","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1038\/mp.2013.66","article-title":"Reelin, an extracellular matrix protein linked to early onset psychiatric diseases, drives postnatal development of the prefrontal cortex via GluN2B-NMDARs and the mTOR pathway","volume":"19","author":"Iafrati","year":"2014","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.bbi.2020.05.076_b0285","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.neuropharm.2016.04.020","article-title":"Behavioral, neurochemical and molecular changes after acute deep brain stimulation of the infralimbic prefrontal cortex","volume":"108","author":"Jim\u00e9nez-S\u00e1nchez","year":"2016","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.bbi.2020.05.076_b0290","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1017\/neu.2014.20","article-title":"Oxytocin and vasopressin levels are decreased in the plasma of male schizophrenia patients","volume":"26","author":"Jobst","year":"2014","journal-title":"Acta Neuropsychiatr."},{"key":"10.1016\/j.bbi.2020.05.076_b0295","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1111\/j.1476-5381.2011.01386.x","article-title":"Animal models of schizophrenia","volume":"164","author":"Jones","year":"2011","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.bbi.2020.05.076_b0300","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1042\/BST20130032","article-title":"Immune responses of macrophages and dendritic cells regulated by mTOR signalling","volume":"41","author":"Katholnig","year":"2013","journal-title":"Biochem. Soc. Trans."},{"key":"10.1016\/j.bbi.2020.05.076_b0305","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1038\/s41386-018-0185-7","article-title":"Maternal immune activation: reporting guidelines to improve the rigor, reproducibility, and transparency of the model","volume":"44","author":"Kentner","year":"2019","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.bbi.2020.05.076_b0310","doi-asserted-by":"crossref","unstructured":"Kilkenny, C., Browne, W., Cuthill, I.C., Emerson, M., Altman, D.G., NC3Rs Reporting Guidelines Working Group, 2010. Animal research: reporting in vivo experiments: the ARRIVE guidelines. Br. J. Pharmacol. 160, 1577-1579.","DOI":"10.1111\/j.1476-5381.2010.00872.x"},{"key":"10.1016\/j.bbi.2020.05.076_b0320","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1038\/nrneurol.2014.187","article-title":"Maternal immune activation and abnormal brain development across CNS disorders","volume":"10","author":"Knuesel","year":"2014","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.bbi.2020.05.076_b0325","doi-asserted-by":"crossref","first-page":"41","DOI":"10.3389\/fncir.2017.00041","article-title":"Neuroanatomical substrates of rodent social behavior: the medial prefrontal cortex and its projection patterns","volume":"11","author":"Ko","year":"2017","journal-title":"Front. Neural Circuits"},{"key":"10.1016\/j.bbi.2020.05.076_b0330","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.psyneuen.2015.02.007","article-title":"Isolation rearing impaired sensorimotor gating but increased pro-inflammatory cytokines and disrupted metabolic parameters in both sexes of rats","volume":"55","author":"Ko","year":"2015","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.bbi.2020.05.076_b0335","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1038\/s41386-018-0171-0","article-title":"Oxytocin attenuates phencyclidine hyperactivity and increases social interaction and nucleus accumbens dopamine release in rats","volume":"44","author":"Kohli","year":"2019","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.bbi.2020.05.076_b0345","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1002\/syn.890010204","article-title":"The serotoninergic innervation of cerebral cortex: different classes of axon terminals arise from dorsal and median raphe nuclei","volume":"1","author":"Kosofsky","year":"1987","journal-title":"Synapse"},{"key":"10.1016\/j.bbi.2020.05.076_b0350","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.bbi.2019.08.006","article-title":"Poly(I:C) source, molecular weight and endotoxin contamination affect dam and prenatal outcomes, implications for models of maternal immune activation","volume":"82","author":"Kowash","year":"2019","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.bbi.2020.05.076_b0355","doi-asserted-by":"crossref","first-page":"18540","DOI":"10.1038\/srep18540","article-title":"Oxytocin Protects Hippocampal Memory and Plasticity from Uncontrollable Stress","volume":"5","author":"Lee","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbi.2020.05.076_b0360","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1177\/0269881111430751","article-title":"A two-hit model: behavioural investigation of the effect of combined neonatal MK-801 administration and isolation rearing in the rat","volume":"26","author":"Lim","year":"2012","journal-title":"J. Psychopharmacol."},{"key":"10.1016\/j.bbi.2020.05.076_b0365","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.jchemneu.2012.12.006","article-title":"Pattern of distribution of serotonergic fibers to the orbitomedial and insular cortex in the rat","volume":"48\u201349","author":"Linley","year":"2013","journal-title":"J. Chem. Neuroanat."},{"key":"10.1016\/j.bbi.2020.05.076_b0370","doi-asserted-by":"crossref","unstructured":"Lins, B.R., Hurtubise, J.L., Roebuck, A.J., Marks, W.N., Zabder, N.K., Scott, G.A., Greba, Q., Dawicki, W., Zhang, X., Rudulier, C.D., et al., 2018. Prospective analysis of the effects of maternal immune activation on rat cytokines during pregnancy and behavior of the male offspring relevant to schizophrenia. eNeuro 5, e0249-18.2018.","DOI":"10.1523\/ENEURO.0249-18.2018"},{"key":"10.1016\/j.bbi.2020.05.076_b0375","doi-asserted-by":"crossref","unstructured":"Lins, B.R., Marks, W.N., Zabder, N.K., Greba, Q., Howland, J.G., 2019. Maternal immune activation during pregnancy alters the behavior profile of female offspring of Sprague Dawley rats. eNeuro 6, e0437-18.2019.","DOI":"10.1523\/ENEURO.0437-18.2019"},{"key":"10.1016\/j.bbi.2020.05.076_b0380","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1038\/77702","article-title":"Maternal care, hippocampal synaptogenesis and cognitive development in rats","volume":"3","author":"Liu","year":"2000","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.bbi.2020.05.076_b0385","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.bbi.2012.09.011","article-title":"Peripubertal viral-like challenge and social isolation mediate overlapping but distinct effects on behaviour and brain interferon regulatory factor 7 expression in the adult Wistar rat","volume":"27","author":"Lukasz","year":"2013","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.bbi.2020.05.076_b0390","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1590\/S0100-879X2012007500031","article-title":"Animal models of prenatal immune challenge and their contribution to the study of schizophrenia: a systematic review","volume":"45","author":"Mac\u00eado","year":"2012","journal-title":"Braz. J. Med. Biol. Res."},{"key":"10.1016\/j.bbi.2020.05.076_b0395","first-page":"17","article-title":"Pharmaceutical innovation in the treatment of schizophrenia and mental disorders compared with other diseases","volume":"13","author":"MacEwan","year":"2016","journal-title":"Innov. Clin. Neurosci."},{"key":"10.1016\/j.bbi.2020.05.076_b0400","doi-asserted-by":"crossref","first-page":"2381","DOI":"10.1113\/jphysiol.2012.248575","article-title":"The amygdala and medial prefrontal cortex: partners in the fear circuit","volume":"591","author":"Marek","year":"2013","journal-title":"J. Physiol."},{"key":"10.1016\/j.bbi.2020.05.076_b0405","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1111\/j.1749-6632.1998.tb09546.x","article-title":"Stress, adaptation, and disease. Allostasis and allostatic load","volume":"840","author":"McEwen","year":"1998","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.bbi.2020.05.076_b0410","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1038\/s41537-017-0032-6","article-title":"Abnormalities of signal transduction networks in chronic schizophrenia","volume":"3","author":"McGuire","year":"2017","journal-title":"NPJ Schizophr."},{"key":"10.1016\/j.bbi.2020.05.076_b0420","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.bbr.2007.12.029","article-title":"A preliminary investigation into the effects of antipsychotics on sub-chronic phencyclidine-induced deficits in attentional set-shifting in female rats","volume":"189","author":"McLean","year":"2008","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.bbi.2020.05.076_b0425","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1177\/0269881108093842","article-title":"Isolation rearing impairs novel object recognition and attentional set shifting performance in female rats","volume":"24","author":"McLean","year":"2010","journal-title":"J. Psychopharmacol."},{"key":"10.1016\/j.bbi.2020.05.076_b0430","doi-asserted-by":"crossref","unstructured":"J. Mairesse M. Zinni J. Pansiot R. Hassan-Abdi C. Demene M. Colella C. Charriaut-Marlangue Rideau Batista Novais A., Tanter, M., Maccari, S., et al. Oxytocin receptor agonist reduces perinatal brain damage by targeting microglia Glia 67 2019 345 359.","DOI":"10.1002\/glia.23546"},{"key":"10.1016\/j.bbi.2020.05.076_b0435","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/j.bbr.2015.11.009","article-title":"Alterations to prepulse inhibition magnitude and latency in adult rats following neonatal treatment with domoic acid and social isolation rearing","volume":"298","author":"Marriott","year":"2016","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.bbi.2020.05.076_b0440","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.bbi.2014.01.019","article-title":"Minocycline rescues decrease in neurogenesis, increase in microglia cytokines and deficits in sensorimotor gating in an animal model of schizophrenia","volume":"38","author":"Mattei","year":"2014","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.bbi.2020.05.076_b0445","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1002\/emmm.201201410","article-title":"5-HT6 receptor recruitment of mTOR as a mechanism for perturbed cognition in schizophrenia","volume":"4","author":"Meffre","year":"2012","journal-title":"EMBO Mol. Med."},{"key":"10.1016\/j.bbi.2020.05.076_b0450","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1016\/j.tins.2019.08.001","article-title":"Neurodevelopmental Resilience and Susceptibility to Maternal Immune Activation","volume":"42","author":"Meyer","year":"2019","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.bbi.2020.05.076_b0455","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1038\/sj.npp.1301413","article-title":"Relative prenatal and postnatal maternal contributions to schizophrenia-related neurochemical dysfunction after in utero immune challenge","volume":"33","author":"Meyer","year":"2008","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.bbi.2020.05.076_b0460","doi-asserted-by":"crossref","first-page":"1308","DOI":"10.1016\/j.neuropharm.2011.01.009","article-title":"To poly(I:C) or not to poly(I:C): advancing preclinical schizophrenia research through the use of prenatal immune activation models","volume":"62","author":"Meyer","year":"2012","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.bbi.2020.05.076_b0465","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1189\/jlb.0312125","article-title":"Length of dsRNA (poly I:C) drives distinct innate immune responses, depending on the cell type","volume":"94","author":"Mian","year":"2013","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.bbi.2020.05.076_b0470","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1038\/nrd3628","article-title":"Cognitive dysfunction in psychiatric disorders: characteristics, causes and the quest for improved therapy","volume":"11","author":"Millan","year":"2012","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.bbi.2020.05.076_b0475","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/j.euroneuro.2010.09.006","article-title":"Isolation rearing-induced deficits in sensorimotor gating and social interaction in rats are related to cortico-striatal oxidative stress, and reversed by sub-chronic clozapine administration","volume":"21","author":"M\u00f6ller","year":"2011","journal-title":"Eur. Neuropsychopharmacol."},{"key":"10.1016\/j.bbi.2020.05.076_b0480","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.bbi.2012.12.011","article-title":"Social isolation rearing induces mitochondrial, immunological, neurochemical and behavioural deficits in rats, and is reversed by clozapine or N-acetyl cysteine","volume":"30","author":"M\u00f6ller","year":"2013","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.bbi.2020.05.076_b0485","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1146\/annurev-clinpsy-050718-095539","article-title":"Prenatal Developmental Origins of Future Psychopathology: Mechanisms and Pathways","volume":"15","author":"Monk","year":"2019","journal-title":"Annu. Rev. Clin. Psychol."},{"key":"10.1016\/j.bbi.2020.05.076_b0490","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.bbr.2017.04.057","article-title":"Two-hit model of schizophrenia induced by neonatal immune activation and peripubertal stress in rats: Study of sex differences and brain oxidative alterations","volume":"331","author":"Monte","year":"2017","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.bbi.2020.05.076_b0495","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1111\/cge.12485","article-title":"Novel treatment strategies for schizophrenia from improved understanding of genetic risk","volume":"86","author":"Morris","year":"2014","journal-title":"Clin. Genet."},{"key":"10.1016\/j.bbi.2020.05.076_b0500","first-page":"643","article-title":"Mouse models of maternal immune activation: mind your caging system! Brain Behav","volume":"73","author":"Mueller","year":"2018","journal-title":"Immun."},{"key":"10.1016\/j.bbi.2020.05.076_b0505","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1016\/j.bbi.2019.04.019","article-title":"Influence of poly(I:C) variability on thermoregulation, immune responses and pregnancy outcomes in mouse models of maternal immune activation","volume":"80","author":"Mueller","year":"2019","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.bbi.2020.05.076_b0510","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1111\/j.1471-4159.2010.06617.x","article-title":"Temporal dysregulation of cortical gene expression in the isolation reared Wistar rat","volume":"113","author":"Murphy","year":"2010","journal-title":"J. Neurochem."},{"key":"10.1016\/j.bbi.2020.05.076_b0520","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.bbi.2018.09.005","article-title":"Evolution of a maternal immune activation (mIA) model in rats: early developmental effects","volume":"75","author":"Murray","year":"2019","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.bbi.2020.05.076_b0530","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1093\/cercor\/bhw364","article-title":"GRK5 regulates social behavior via suppression of mTORC1 signaling in medial prefrontal cortex","volume":"28","author":"Niu","year":"2018","journal-title":"Cereb. Cortex"},{"key":"10.1016\/j.bbi.2020.05.076_b0535","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.ijdevneu.2013.01.001","article-title":"Postnatal maternal deprivation and pubertal stress have additive effects on dopamine D2 receptor and CaMKII beta expression in the striatum","volume":"31","author":"Novak","year":"2013","journal-title":"Int. J. Dev. Neurosci."},{"key":"10.1016\/j.bbi.2020.05.076_b0545","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuropharm.2019.01.019","article-title":"Post-weaning social isolation exacerbates aggression in both sexes and affects the vasopressin and oxytocin system in a sex-specific manner","volume":"156","author":"Oliveira","year":"2019","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.bbi.2020.05.076_b0550","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.1038\/npp.2017.40","article-title":"Improved social interaction, recognition and working memory with cannabidiol treatment in a prenatal infection (poly I:C) rat model","volume":"42","author":"Osborne","year":"2017","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.bbi.2020.05.076_b0555","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.bbi.2015.08.021","article-title":"Maturation- and sex-sensitive depression of hippocampal excitatory transmission in a rat schizophrenia model","volume":"51","author":"Patrich","year":"2016","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.bbi.2020.05.076_b0560","series-title":"The Rat Brain in Stereotaxic Coordinates","author":"Paxinos","year":"1998"},{"key":"10.1016\/j.bbi.2020.05.076_b0570","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1016\/j.biopsych.2011.06.007","article-title":"Abnormal trajectories of neurodevelopment and behavior following in utero insult in the rat","volume":"70","author":"Piontkewitz","year":"2011","journal-title":"Biol. Psychiatry."},{"key":"10.1016\/j.bbi.2020.05.076_b0575","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.neuroscience.2016.02.009","article-title":"Sex differences in the outcome of juvenile social isolation on HPA axis function in rats","volume":"320","author":"Pisu","year":"2016","journal-title":"Neuroscience"},{"key":"10.1016\/j.bbi.2020.05.076_b0580","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1159\/000430091","article-title":"Early Adolescent emergence of reversal learning impairments in isolation-reared rats","volume":"37","author":"Powell","year":"2015","journal-title":"Dev. Neurosci."},{"key":"10.1016\/j.bbi.2020.05.076_b0585","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.mcn.2016.06.004","article-title":"Valproic acid exposure sequentially activates Wnt and mTOR pathways in rats","volume":"75","author":"Qin","year":"2016","journal-title":"Mol. Cell Neurosci."},{"key":"10.1016\/j.bbi.2020.05.076_b0590","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.bbi.2013.07.006","article-title":"Prenatal versus postnatal maternal factors in the development of infection-induced working memory impairments in mice","volume":"33","author":"Richetto","year":"2013","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.bbi.2020.05.076_b0595","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1007\/s00213-012-2646-8","article-title":"Effects of prenatal immune activation and peri-adolescent stress on amphetamine-induced conditioned place preference in the rat","volume":"222","author":"Richtand","year":"2012","journal-title":"Psychopharmacology (Berl)."},{"key":"10.1016\/j.bbi.2020.05.076_b0600","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.physbeh.2012.02.004","article-title":"Fluoxetine and aripiprazole treatment following prenatal immune activation exert longstanding effects on rat locomotor response","volume":"106","author":"Richtand","year":"2012","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.bbi.2020.05.076_b0605","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.bbi.2018.10.011","article-title":"Building a framework to optimize animal models of maternal immune activation: like your ongoing home improvements, it's a work in progress","volume":"75","author":"Roderick","year":"2019","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.bbi.2020.05.076_b0615","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.brainresbull.2019.02.005","article-title":"Cumulative multiple early life hits- a potent threat leading to neurological disorders","volume":"147","author":"Sarkar","year":"2019","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.bbi.2020.05.076_b0620","doi-asserted-by":"crossref","first-page":"35","DOI":"10.30802\/AALAS-CM-18-000025","article-title":"Immunomodulatory Effects of Stress and Environmental Enrichment in Long-Evans Rats (Rattus norvegicus)","volume":"69","author":"Scarola","year":"2019","journal-title":"Comp. Med."},{"key":"10.1016\/j.bbi.2020.05.076_b0625","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1038\/nmeth.2019","article-title":"Fiji: an open-source platform for biological-image analysis","volume":"9","author":"Schindelin","year":"2012","journal-title":"Nat. Methods"},{"key":"10.1016\/j.bbi.2020.05.076_b0635","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1007\/s11689-008-9000-9","article-title":"Deficient maternal care resulting from immunological stress during pregnancy is associated with a sex-dependent enhancement of conditioned fear in the offspring","volume":"1","author":"Schwendener","year":"2009","journal-title":"J. Neurodev. Disord."},{"key":"10.1016\/j.bbi.2020.05.076_b0640","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1177\/0956797612469210","article-title":"An upside to adversity?: moderate cumulative lifetime adversity is associated with resilient responses in the face of controlled stressors","volume":"24","author":"Seery","year":"2013","journal-title":"Psychol. Sci."},{"key":"10.1016\/j.bbi.2020.05.076_b0645","doi-asserted-by":"crossref","first-page":"7413","DOI":"10.1007\/s12035-018-0940-0","article-title":"Characterization of behavioral, signaling and cytokine alterations in a rat neurodevelopmental model for schizophrenia, and their reversal by the 5-HT6 receptor antagonist SB-399885","volume":"55","author":"Shortall","year":"2018","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.bbi.2020.05.076_b0650","doi-asserted-by":"crossref","DOI":"10.1007\/s12035-020-01938-x","article-title":"Calbindin deficits may underlie dissociable effects of 5-HT6 and mGlu7 antagonists on glutamate and cognition in a dual-hit neurodevelopmental model for schizophrenia","author":"Shortall","year":"2020","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.bbi.2020.05.076_b0655","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.bbi.2017.02.007","article-title":"Perinatal programming by inflammation","volume":"63","author":"Spencer","year":"2017","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.bbi.2020.05.076_b0660","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1002\/dev.21182","article-title":"Natural variation in maternal care shapes adult social behavior in rats","volume":"56","author":"Starr-Phillips","year":"2014","journal-title":"Dev. Psychobiol."},{"key":"10.1016\/j.bbi.2020.05.076_b0665","doi-asserted-by":"crossref","first-page":"305","DOI":"10.31887\/DCNS.2010.12.3\/sstilo","article-title":"The epidemiology of schizophrenia: replacing dogma with knowledge","volume":"12","author":"Stilo","year":"2010","journal-title":"Dialogues Clin. Neurosci"},{"key":"10.1016\/j.bbi.2020.05.076_b0670","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.schres.2018.02.009","article-title":"Associations of independent living and labor force participation with impairment indicators in schizophrenia and bipolar disorder at 20-year follow-up","volume":"197","author":"Strassnig","year":"2018","journal-title":"Schizophr. Res."},{"key":"10.1016\/j.bbi.2020.05.076_b0680","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1002937","article-title":"A role for microRNA-155 modulation in the anti-HIV-1 effects of Toll-like receptor 3 stimulation in macrophages","volume":"8","author":"Swaminathan","year":"2012","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.bbi.2020.05.076_b0690","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1016\/j.neuroscience.2010.01.029","article-title":"Juvenile social experience regulates central neuropeptides relevant to emotional and social behaviors","volume":"166","author":"Tanaka","year":"2010","journal-title":"Neuroscience"},{"key":"10.1016\/j.bbi.2020.05.076_b0695","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.schres.2016.04.019","article-title":"Reduced oxytocin receptor gene expression and binding sites in different brain regions in schizophrenia: a post-mortem study","volume":"177","author":"Uhrig","year":"2016","journal-title":"Schizophr. Res."},{"key":"10.1016\/j.bbi.2020.05.076_b0700","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0162665","article-title":"Early life stress increases metabolic risk, HPA axis reactivity, and depressive-like behavior when combined with postweaning social isolation in rats","volume":"11","author":"Vargas","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.bbi.2020.05.076_b0705","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.pnpbp.2013.04.001","article-title":"The TRIPS (Toll-like receptors in immuno-inflammatory pathogenesis) hypothesis: a novel postulate to understand schizophrenia","volume":"44","author":"Venkatasubramanian","year":"2013","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.bbi.2020.05.076_b0710","doi-asserted-by":"crossref","first-page":"2210","DOI":"10.1016\/j.euroneuro.2015.09.022","article-title":"Longitudinal in vivo maturational changes of metabolites in the prefrontal cortex of rats exposed to polyinosinic-polycytidylic acid in utero","volume":"25","author":"Vernon","year":"2015","journal-title":"Eur. Neuropsychopharmacol."},{"key":"10.1016\/j.bbi.2020.05.076_b0715","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1002\/syn.21561","article-title":"Prenatal immune challenge in rats: altered responses to dopaminergic and glutamatergic agents, prepulse inhibition of acoustic startle, and reduced route-based learning as a function of maternal body weight gain after prenatal exposure to poly IC","volume":"66","author":"Vorhees","year":"2012","journal-title":"Synapse"},{"key":"10.1016\/j.bbi.2020.05.076_b0720","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.ntt.2014.10.007","article-title":"Prenatal immune challenge in rats: effects of polyinosinic-polycytidylic acid on spatial learning, prepulse inhibition, conditioned fear, and responses to MK-801 and amphetamine","volume":"47","author":"Vorhees","year":"2015","journal-title":"Neurotoxicol. Teratol."},{"key":"10.1016\/j.bbi.2020.05.076_b0725","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1016\/j.euroneuro.2013.12.005","article-title":"Evidence that aetiological risk factors for psychiatric disorders cause distinct patterns of cognitive deficits","volume":"24","author":"Wallace","year":"2014","journal-title":"Eur. Neuropsychopharmacol."},{"key":"10.1016\/j.bbi.2020.05.076_b0730","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.jneuroim.2015.11.001","article-title":"Oxytocin-secreting system: A major part of the neuroendocrine center regulating immunologic activity","volume":"289","author":"Wang","year":"2015","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.bbi.2020.05.076_b0740","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.euroneuro.2015.12.020","article-title":"The dopamine D3-preferring D2\/D3 dopamine receptor partial agonist, cariprazine, reverses behavioural changes in a rat neurodevelopmental model for schizophrenia","volume":"26","author":"Watson","year":"2016","journal-title":"Eur. Neuropsychopharmacol."},{"key":"10.1016\/j.bbi.2020.05.076_b0745","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/S0166-4328(01)00166-8","article-title":"Dissociation between the effects of pre-weaning and\/or post-weaning social isolation on prepulse inhibition and latent inhibition in adult Sprague-Dawley rats","volume":"121","author":"Weiss","year":"2001","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.bbi.2020.05.076_b0750","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.bbr.2003.10.015","article-title":"Effect of social isolation on stress-related behavioural and neuroendocrine state in the rat","volume":"152","author":"Weiss","year":"2004","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.bbi.2020.05.076_b0755","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1097\/WCO.0b013e32835ee548","article-title":"Sex differences in autism spectrum disorders","volume":"26","author":"Werling","year":"2013","journal-title":"Curr. Opin. Neurol."},{"key":"10.1016\/j.bbi.2020.05.076_b0760","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.bbr.2013.02.020","article-title":"The effects of pre-test social deprivation on a natural reward incentive test and concomitant 50 kHz ultrasonic vocalization production in adolescent and adult male Sprague-Dawley rats","volume":"245","author":"Willey","year":"2013","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.bbi.2020.05.076_b0765","doi-asserted-by":"crossref","first-page":"2829","DOI":"10.1210\/endo.138.7.5255","article-title":"Central oxytocin administration reduces stress-induced corticosterone release and anxiety behavior in rats","volume":"138","author":"Windle","year":"1997","journal-title":"Endocrinology"},{"key":"10.1016\/j.bbi.2020.05.076_b0770","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1016\/j.physbeh.2007.11.031","article-title":"Effects of experience and context on 50-kHz vocalizations in rats","volume":"93","author":"W\u00f6hr","year":"2008","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.bbi.2020.05.076_b0775","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/0166-4328(96)00181-7","article-title":"Social isolation increases aggressive behaviour and alters the effects of diazepam in the rat social interaction test","volume":"75","author":"Wongwitdecha","year":"1996","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.bbi.2020.05.076_b0780","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1111\/j.1476-5381.2012.02022.x","article-title":"5-HT6 receptor agonists and antagonists enhance learning and memory in a conditioned emotion response paradigm by modulation of cholinergic and glutamatergic mechanisms","volume":"167","author":"Woods","year":"2012","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.bbi.2020.05.076_b0790","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.bbr.2011.05.040","article-title":"Differential effects of maternal immune activation and juvenile stress on anxiety-like behaviour and physiology in adult rats: no evidence for the \u201cdouble-hit hypothesis\u201d","volume":"224","author":"Yee","year":"2011","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.bbi.2020.05.076_b0795","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.pharmthera.2009.02.004","article-title":"Using the MATRICS to guide development of a preclinical cognitive test battery for research in schizophrenia","volume":"122","author":"Young","year":"2009","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.bbi.2020.05.076_b0800","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.bbi.2014.05.011","article-title":"Effect of maternal immune activation on the kynurenine pathway in preadolescent rat offspring and on MK801-induced hyperlocomotion in adulthood: amelioration by COX-2 inhibition","volume":"41","author":"Zavitsanou","year":"2014","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.bbi.2020.05.076_b0805","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1016\/j.neuropharm.2011.02.022","article-title":"Prenatal exposure to a viral mimetic alters behavioural flexibility in male, but not female, rats","volume":"62","author":"Zhang","year":"2012","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.bbi.2020.05.076_b0810","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1007\/s12264-016-0046-5","article-title":"Plasma oxytocin and arginine-vasopressin levels in children with autism spectrum disorder in China: associations with symptoms","volume":"32","author":"Zhang","year":"2016","journal-title":"Neurosci. Bull."},{"key":"10.1016\/j.bbi.2020.05.076_b0815","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1177\/1753425912459975","article-title":"TLR3 activation efficiency by high or low molecular mass poly I:C","volume":"19","author":"Zhou","year":"2013","journal-title":"Innate Immun."},{"key":"10.1016\/j.bbi.2020.05.076_b0820","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1016\/j.euroneuro.2017.01.011","article-title":"The involvement of cannabinoids and mTOR in the reconsolidation of an emotional memory in the hippocampal-amygdala-insular circuit","volume":"27","author":"Zubedat","year":"2017","journal-title":"Eur. Neuropsychopharmacol."}],"container-title":["Brain, Behavior, and Immunity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0889159120300763?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0889159120300763?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T08:01:28Z","timestamp":1760169688000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0889159120300763"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10]]},"references-count":148,"alternative-id":["S0889159120300763"],"URL":"https:\/\/doi.org\/10.1016\/j.bbi.2020.05.076","relation":{},"ISSN":["0889-1591"],"issn-type":[{"value":"0889-1591","type":"print"}],"subject":[],"published":{"date-parts":[[2020,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Gestational poly(I:C) attenuates, not exacerbates, the behavioral, cytokine and mTOR changes caused by isolation rearing in a rat \u2018dual-hit\u2019 model for neurodevelopmental disorders","name":"articletitle","label":"Article Title"},{"value":"Brain, Behavior, and Immunity","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbi.2020.05.076","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}