{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T01:35:56Z","timestamp":1772069756717,"version":"3.50.1"},"reference-count":79,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain, Behavior, and Immunity"],"published-print":{"date-parts":[[2020,10]]},"DOI":"10.1016\/j.bbi.2020.05.078","type":"journal-article","created":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T11:28:16Z","timestamp":1591010896000},"page":"559-568","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":36,"special_numbering":"C","title":["A pharmacological interactome between COVID-19 patient samples and human sensory neurons reveals potential drivers of neurogenic pulmonary dysfunction"],"prefix":"10.1016","volume":"89","author":[{"given":"Pradipta R.","family":"Ray","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andi","family":"Wangzhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nizar","family":"Ghneim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muhammad S.","family":"Yousuf","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Candler","family":"Paige","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diana","family":"Tavares-Ferreira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juliet M.","family":"Mwirigi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephanie","family":"Shiers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ishwarya","family":"Sankaranarayanan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amelia J.","family":"McFarland","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sanjay V.","family":"Neerukonda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steve","family":"Davidson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gregory","family":"Dussor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael D.","family":"Burton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Theodore J.","family":"Price","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbi.2020.05.078_b0005","first-page":"9","article-title":"Translational control of depression-like behavior via phosphorylation of eukaryotic translation initiation factor 4E","author":"Aguilar-Valles","year":"2018","journal-title":"Nature Commun."},{"key":"10.1016\/j.bbi.2020.05.078_b0010","doi-asserted-by":"crossref","first-page":"2118","DOI":"10.1523\/JNEUROSCI.2673-17.2018","article-title":"Loss of eIF4E phosphorylation engenders depression-like behaviors via selective mRNA translation","volume":"38","author":"Amorim","year":"2018","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bbi.2020.05.078_b0015","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1093\/bioinformatics\/btu638","article-title":"HTSeq\u2014a Python framework to work with high-throughput sequencing data","volume":"31","author":"Anders","year":"2015","journal-title":"Bioinformatics"},{"key":"10.1016\/j.bbi.2020.05.078_b0020","doi-asserted-by":"crossref","first-page":"13473","DOI":"10.1523\/JNEUROSCI.1822-09.2009","article-title":"A key role for gp130 expressed on peripheral sensory nerves in pathological pain","volume":"29","author":"Andratsch","year":"2009","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bbi.2020.05.078_b0025","doi-asserted-by":"crossref","first-page":"5937","DOI":"10.1128\/JVI.76.12.5937-5948.2002","article-title":"Murine coronavirus replication-induced p38 mitogen-activated protein kinase activation promotes interleukin-6 production and virus replication in cultured cells","volume":"76","author":"Banerjee","year":"2002","journal-title":"J. Virol."},{"key":"10.1016\/j.bbi.2020.05.078_b0030","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1038\/nm.4501","article-title":"Nociceptor sensory neurons suppress neutrophil and gammadelta T cell responses in bacterial lung infections and lethal pneumonia","volume":"24","author":"Baral","year":"2018","journal-title":"Nat. Med."},{"key":"10.1016\/j.bbi.2020.05.078_b0035","doi-asserted-by":"crossref","first-page":"18381","DOI":"10.1523\/JNEUROSCI.3386-11.2011","article-title":"The chemokine CCL2 increases Nav1.8 sodium channel activity in primary sensory neurons through a Gbetagamma-dependent mechanism","volume":"31","author":"Belkouch","year":"2011","journal-title":"J. Neurosci."},{"issue":"249\u2013261","key":"10.1016\/j.bbi.2020.05.078_b0040","article-title":"Transient receptor potential cation channel, subfamily V, member 4 and airway sensory afferent activation: Role of adenosine triphosphate","volume":"138","author":"Bonvini","year":"2016","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.bbi.2020.05.078_b0045","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/S0022-4804(03)00154-9","article-title":"Capsaicin-sensitive nerves regulate the metabolic response to abdominal sepsis","volume":"112","author":"Bryant","year":"2003","journal-title":"J. Surg. Res."},{"key":"10.1016\/j.bbi.2020.05.078_b0050","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1007\/s11882-002-0021-2","article-title":"Neurology of allergic inflammation and rhinitis","volume":"2","author":"Canning","year":"2002","journal-title":"Curr. Allergy Asthma Rep."},{"key":"10.1016\/j.bbi.2020.05.078_b0055","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/j.pupt.2011.01.008","article-title":"Functional implications of the multiple afferent pathways regulating cough","volume":"24","author":"Canning","year":"2011","journal-title":"Pulm. Pharmacol. Ther."},{"key":"10.1016\/j.bbi.2020.05.078_b0060","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/S0034-5687(00)00208-5","article-title":"Neural regulation of airway smooth muscle tone","volume":"125","author":"Canning","year":"2001","journal-title":"Respir. Physiol."},{"key":"10.1016\/j.bbi.2020.05.078_b0065","series-title":"Sensory nerves and airway irritability","first-page":"139","author":"Canning","year":"2009"},{"key":"10.1016\/j.bbi.2020.05.078_b0070","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1093\/bioinformatics\/btn615","article-title":"AmiGO: online access to ontology and annotation data","volume":"25","author":"Carbon","year":"2009","journal-title":"Bioinformatics"},{"key":"10.1016\/j.bbi.2020.05.078_b0075","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1111\/ajt.14515","article-title":"Neuro-immune interactions in inflammation and host defense: Implications for transplantation","volume":"18","author":"Chavan","year":"2018","journal-title":"Am. J. Transplant."},{"key":"10.1016\/j.bbi.2020.05.078_b0080","doi-asserted-by":"crossref","DOI":"10.1172\/JCI137244","article-title":"Clinical and immunologic features in severe and moderate Coronavirus Disease 2019","author":"Chen","year":"2020","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bbi.2020.05.078_b0085","doi-asserted-by":"crossref","first-page":"7703","DOI":"10.1128\/JVI.02560-09","article-title":"Upregulation of the chemokine (C-C motif) ligand 2 via a severe acute respiratory syndrome coronavirus spike-ACE2 signaling pathway","volume":"84","author":"Chen","year":"2010","journal-title":"J. Virol."},{"key":"10.1016\/j.bbi.2020.05.078_b0090","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1038\/nn.3144","article-title":"Neurogenic inflammation and the peripheral nervous system in host defense and immunopathology","volume":"15","author":"Chiu","year":"2012","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.bbi.2020.05.078_b0095","doi-asserted-by":"crossref","first-page":"D1068","DOI":"10.1093\/nar\/gkx1143","article-title":"DGIdb 3.0: a redesign and expansion of the drug\u2013gene interaction database","volume":"46","author":"Cotto","year":"2018","journal-title":"Nucl. Acids Res."},{"key":"10.1016\/j.bbi.2020.05.078_b0100","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.3389\/fimmu.2019.01473","article-title":"Emerging roles for Eph receptors and ephrin ligands in immunity","volume":"10","author":"Darling","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.bbi.2020.05.078_b0105","first-page":"67","article-title":"Role of the transient receptor potential vanilloid 1 in inflammation and sepsis","volume":"4","author":"Devesa","year":"2011","journal-title":"J. Inflamm. Res."},{"key":"10.1016\/j.bbi.2020.05.078_b0110","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1093\/bioinformatics\/bts635","article-title":"STAR: ultrafast universal RNA-seq aligner","volume":"29","author":"Dobin","year":"2013","journal-title":"Bioinformatics"},{"key":"10.1016\/j.bbi.2020.05.078_b0115","doi-asserted-by":"crossref","first-page":"3760","DOI":"10.1172\/JCI42843","article-title":"Nociceptors: the sensors of the pain pathway","volume":"120","author":"Dubin","year":"2010","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bbi.2020.05.078_b0120","doi-asserted-by":"crossref","first-page":"D766","DOI":"10.1093\/nar\/gky955","article-title":"GENCODE reference annotation for the human and mouse genomes","volume":"47","author":"Frankish","year":"2019","journal-title":"Nucl. Acids Res."},{"key":"10.1016\/j.bbi.2020.05.078_b0125","doi-asserted-by":"crossref","first-page":"14134","DOI":"10.1073\/pnas.1005320107","article-title":"eIF4E phosphorylation promotes tumorigenesis and is associated with prostate cancer progression","volume":"107","author":"Furic","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.bbi.2020.05.078_b0130","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.pupt.2019.03.007","article-title":"BLU-5937: A selective P2X3 antagonist with potent anti-tussive effect and no taste alteration","volume":"56","author":"Garceau","year":"2019","journal-title":"Pulm. Pharmacol. Ther."},{"key":"10.1016\/j.bbi.2020.05.078_b0135","unstructured":"Gordon, D.E., et al., 2020. A SARS-CoV-2-Human Protein-Protein Interaction Map Reveals Drug Targets and Potential Drug-Repurposing. bioRxiv:2020.2003.2022.002386."},{"key":"10.1016\/j.bbi.2020.05.078_b0140","doi-asserted-by":"crossref","first-page":"1190","DOI":"10.1097\/ALN.0b013e318212515b","article-title":"Disruption of the transient receptor potential vanilloid 1 can affect survival, bacterial clearance, and cytokine gene expression during murine sepsis","volume":"114","author":"Guptill","year":"2011","journal-title":"Anesthesiology"},{"key":"10.1016\/j.bbi.2020.05.078_b0145","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1124\/mol.113.091272","article-title":"Sensory nerve terminal mitochondrial dysfunction induces hyperexcitability in airway nociceptors via protein kinase C","volume":"85","author":"Hadley","year":"2014","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.bbi.2020.05.078_b0150","unstructured":"Han, Y., Zhang, H., Mu, S., Wei, W., Jin, C., Xue, Y., Tong, C., Zha, Y., Song, Z., Gu, G., 2020. Lactate dehydrogenase, a Risk Factor of Severe COVID-19 Patients. medRxiv:2020.2003.2024.20040162."},{"key":"10.1016\/j.bbi.2020.05.078_b0155","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.2002457","article-title":"Extracellular phosphorylation of a receptor tyrosine kinase controls synaptic localization of NMDA receptors and regulates pathological pain","volume":"15","author":"Hanamura","year":"2017","journal-title":"PLoS Biol."},{"key":"10.1016\/j.bbi.2020.05.078_b0160","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.virol.2004.09.006","article-title":"Differential roles of CCL2 and CCR2 in host defense to coronavirus infection","volume":"329","author":"Held","year":"2004","journal-title":"Virology"},{"key":"10.1016\/j.bbi.2020.05.078_b0165","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.mcn.2018.07.002","article-title":"EphBs and ephrin-Bs: Trans-synaptic organizers of synapse development and function","volume":"91","author":"Henderson","year":"2018","journal-title":"Mol. Cell. Neurosci."},{"key":"10.1016\/j.bbi.2020.05.078_b0170","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/j.mcn.2007.07.010","article-title":"The cytokine TNFalpha increases the proportion of DRG neurones expressing the TRPV1 receptor via the TNFR1 receptor and ERK activation","volume":"36","author":"Hensellek","year":"2007","journal-title":"Mol. Cell. Neurosci."},{"key":"10.1016\/j.bbi.2020.05.078_b0175","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1038\/ni.2291","article-title":"Translational control of the activation of transcription factor NF-kappaB and production of type I interferon by phosphorylation of the translation factor eIF4E","volume":"13","author":"Herdy","year":"2012","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.bbi.2020.05.078_b0180","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/S0140-6736(20)30183-5","article-title":"Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China","volume":"395","author":"Huang","year":"2020","journal-title":"The Lancet"},{"key":"10.1016\/j.bbi.2020.05.078_b0185","doi-asserted-by":"crossref","unstructured":"Huang, L., Shi, Y., Gong, B., Jiang, L., Liu, X., Yang, J., Tang, J., You, C., Jiang, Q., Long, B., Zeng, T., Luo, M., Zeng, F., Zeng, F., Wang, S., Yang, X., Yang, Z., 2020b. Blood single cell immune profiling reveals the interferon-MAPK pathway mediated adaptive immune response for COVID-19. medRxiv:2020.2003.2015.20033472.","DOI":"10.1101\/2020.03.15.20033472"},{"key":"10.1016\/j.bbi.2020.05.078_b0190","doi-asserted-by":"crossref","DOI":"10.1152\/ajplung.00403.2019","article-title":"Activation of a nerve injury transcriptional signature in airway-innervating sensory neurons after Lipopolysaccharide induced lung inflammation","author":"Kaelberer","year":"2020","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"10.1016\/j.bbi.2020.05.078_b0195","doi-asserted-by":"crossref","first-page":"W90","DOI":"10.1093\/nar\/gkw377","article-title":"Enrichr: a comprehensive gene set enrichment analysis web server 2016 update","volume":"44","author":"Kuleshov","year":"2016","journal-title":"Nucl. Acids Res."},{"key":"10.1016\/j.bbi.2020.05.078_b0200","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1016\/0306-4522(92)90239-X","article-title":"The sensory and sympathetic innervation of guinea-pig lung and trachea as studied by retrograde neuronal tracing and double-labelling immunohistochemistry","volume":"49","author":"Kummer","year":"1992","journal-title":"Neuroscience"},{"issue":"2508\u20132523","key":"10.1016\/j.bbi.2020.05.078_b0205","article-title":"An atlas of vagal sensory neurons and their molecular specialization","volume":"27","author":"Kupari","year":"2019","journal-title":"Cell Reports"},{"key":"10.1016\/j.bbi.2020.05.078_b0210","doi-asserted-by":"crossref","first-page":"1412","DOI":"10.1126\/science.367.6485.1412","article-title":"Race to find COVID-19 treatments accelerates","volume":"367","author":"Kupferschmidt","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.bbi.2020.05.078_b0215","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41467-018-03751-6","article-title":"Massive mining of publicly available RNA-seq data from human and mouse","volume":"9","author":"Lachmann","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bbi.2020.05.078_b0220","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.neuron.2005.09.017","article-title":"Building excitatory and inhibitory synapses: balancing neuroligin partnerships","volume":"48","author":"Levinson","year":"2005","journal-title":"Neuron"},{"key":"10.1016\/j.bbi.2020.05.078_b0225","doi-asserted-by":"crossref","first-page":"1734","DOI":"10.1111\/cea.12005","article-title":"Nasal cytokine responses to natural colds in asthmatic children","volume":"42","author":"Lewis","year":"2012","journal-title":"Clin. Exp. Allergy"},{"key":"10.1016\/j.bbi.2020.05.078_b0230","doi-asserted-by":"crossref","unstructured":"Liang, Z., Hore, Z., Harley, P., Stanley, F.U., Michrowska, A., Dahiya, M., LaRussa, F., Jager, S.E., Villa, S., Denk, F., 2019. A transcriptional toolbox for exploring peripheral neuro-immune interactions. bioRxiv:813980.","DOI":"10.1101\/813980"},{"key":"10.1016\/j.bbi.2020.05.078_b0235","doi-asserted-by":"crossref","unstructured":"Liao, M., Liu, Y., Yuan, J., Wen, Y., Xu, G., Zhao, J., Chen, L., Li, J., Wang, X., Wang, F., Liu, L., Zhang, S., Zhang, Z., 2020. The landscape of lung bronchoalveolar immune cells in COVID-19 revealed by single-cell RNA sequencing. medRxiv:2020.2002.2023.20026690.","DOI":"10.1101\/2020.02.23.20026690"},{"key":"10.1016\/j.bbi.2020.05.078_b0240","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol."},{"key":"10.1016\/j.bbi.2020.05.078_b0245","doi-asserted-by":"crossref","first-page":"3353","DOI":"10.1172\/JCI87406","article-title":"Epiregulin and EGFR interactions are involved in pain processing","volume":"127","author":"Martin","year":"2017","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bbi.2020.05.078_b0250","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1523\/JNEUROSCI.2661-18.2018","article-title":"Nociceptor translational profiling reveals the ragulator-Rag GTPase complex as a critical generator of neuropathic pain","volume":"39","author":"Megat","year":"2019","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bbi.2020.05.078_b0255","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41467-019-13751-9","article-title":"Obesity and disease severity magnify disturbed microbiome-immune interactions in asthma patients","volume":"10","author":"Michalovich","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bbi.2020.05.078_b0260","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1016\/j.bbrc.2004.05.107","article-title":"Phosphorylation of p38 MAPK and its downstream targets in SARS coronavirus-infected cells","volume":"319","author":"Mizutani","year":"2004","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbi.2020.05.078_b0265","doi-asserted-by":"crossref","first-page":"7481","DOI":"10.1523\/JNEUROSCI.0220-17.2017","article-title":"The MNK-eIF4E signaling axis contributes to injury-induced nociceptive plasticity and the development of chronic pain","volume":"37","author":"Moy","year":"2017","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bbi.2020.05.078_b0270","first-page":"S712","article-title":"Afferent neural pathways mediating cough in animals and humans","volume":"6","author":"Narula","year":"2014","journal-title":"J. Thorac. Dis."},{"key":"10.1016\/j.bbi.2020.05.078_b0275","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1093\/brain\/awz063","article-title":"Electrophysiological and transcriptomic correlates of neuropathic pain in human dorsal root ganglion neurons","volume":"142","author":"North","year":"2019","journal-title":"Brain"},{"key":"10.1016\/j.bbi.2020.05.078_b0280","doi-asserted-by":"crossref","first-page":"7866","DOI":"10.1038\/ncomms8866","article-title":"A draft network of ligand-receptor-mediated multicellular signalling in human","volume":"6","author":"Ramilowski","year":"2015","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bbi.2020.05.078_b0285","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1097\/j.pain.0000000000001217","article-title":"Comparative transcriptome profiling of the human and mouse dorsal root ganglia: an RNA-seq-based resource for pain and sensory neuroscience research","volume":"159","author":"Ray","year":"2018","journal-title":"Pain"},{"key":"10.1016\/j.bbi.2020.05.078_b0290","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1007\/978-1-62703-523-1_7","article-title":"Detection of pyroptosis by measuring released lactate dehydrogenase activity","volume":"1040","author":"Rayamajhi","year":"2013","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.bbi.2020.05.078_b0295","doi-asserted-by":"crossref","first-page":"3516","DOI":"10.1021\/acs.jmedchem.7b01795","article-title":"Structure-based design of pyridone-aminal eFT508 targeting dysregulated translation by selective mitogen-activated protein kinase interacting kinases 1 and 2 (MNK1\/2) inhibition","volume":"61","author":"Reich","year":"2018","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bbi.2020.05.078_b0300","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1093\/bioinformatics\/btp616","article-title":"edgeR: a Bioconductor package for differential expression analysis of digital gene expression data","volume":"26","author":"Robinson","year":"2010","journal-title":"Bioinformatics"},{"key":"10.1016\/j.bbi.2020.05.078_b0305","doi-asserted-by":"crossref","DOI":"10.1016\/j.cell.2020.02.026","article-title":"Mycobacterium tuberculosis sulfolipid-1 activates nociceptive neurons and idunces cough","author":"Ruhl","year":"2020","journal-title":"Cell"},{"issue":"Suppl. 2","key":"10.1016\/j.bbi.2020.05.078_b0310","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1007\/s003930050226","article-title":"Efferent functions of C-fiber nociceptors","volume":"57","author":"Sann","year":"1998","journal-title":"Z. Rheumatol."},{"key":"10.1016\/j.bbi.2020.05.078_b0315","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1038\/s41386-019-0537-y","article-title":"Reversal of peripheral nerve injury-induced neuropathic pain and cognitive dysfunction via genetic and tomivosertib targeting of MNK","volume":"45","author":"Shiers","year":"2020","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.bbi.2020.05.078_b0320","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/0165-1838(87)90113-5","article-title":"Retrograde tracing shows that CGRP-immunoreactive nerves of rat trachea and lung originate from vagal and dorsal root ganglia","volume":"20","author":"Springall","year":"1987","journal-title":"J. Auton. Nerv. Syst."},{"key":"10.1016\/j.bbi.2020.05.078_b0325","doi-asserted-by":"crossref","first-page":"D607","DOI":"10.1093\/nar\/gky1131","article-title":"STRING v11: protein-protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets","volume":"47","author":"Szklarczyk","year":"2019","journal-title":"Nucl. Acids Res."},{"key":"10.1016\/j.bbi.2020.05.078_b0330","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.neuron.2015.06.007","article-title":"Silencing nociceptor neurons reduces allergic airway inflammation","volume":"87","author":"Talbot","year":"2015","journal-title":"Neuron"},{"key":"10.1016\/j.bbi.2020.05.078_b0335","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1080\/22221751.2020.1729069","article-title":"Potent binding of 2019 novel coronavirus spike protein by a SARS coronavirus-specific human monoclonal antibody","volume":"9","author":"Tian","year":"2020","journal-title":"Emerg. Microbes Infect."},{"key":"10.1016\/j.bbi.2020.05.078_b0340","doi-asserted-by":"crossref","first-page":"2376","DOI":"10.1128\/JVI.03089-12","article-title":"Transgenic CCL2 expression in the central nervous system results in a dysregulated immune response and enhanced lethality after coronavirus infection","volume":"87","author":"Trujillo","year":"2013","journal-title":"J. Virol."},{"key":"10.1016\/j.bbi.2020.05.078_b0345","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1038\/nn.3881","article-title":"Unbiased classification of sensory neuron types by large-scale single-cell RNA sequencing","volume":"18","author":"Usoskin","year":"2015","journal-title":"Nat. Neurosci."},{"issue":"709\u2013723","key":"10.1016\/j.bbi.2020.05.078_b0350","article-title":"Calcitonin gene-related peptide negatively regulates alarmin-driven type 2 innate lymphoid cell responses","volume":"51","author":"Wallrapp","year":"2019","journal-title":"Immunity"},{"key":"10.1016\/j.bbi.2020.05.078_b0355","doi-asserted-by":"crossref","DOI":"10.1128\/JVI.00127-20","article-title":"Receptor recognition by the novel coronavirus from Wuhan: an analysis based on decade-long structural studies of SARS coronavirus","volume":"94","author":"Wan","year":"2020","journal-title":"J. Virol."},{"key":"10.1016\/j.bbi.2020.05.078_b0360","doi-asserted-by":"crossref","unstructured":"Wangzhou, A., Paige, C., Neerukonda, S.V., Dussor, G., Ray, P.R., Price, T.J., 2020. A pharmacological interactome platform for discovery of pain mechanisms and targets. bioRxiv:2020.2004.2014.041715.","DOI":"10.1101\/2020.04.14.041715"},{"key":"10.1016\/j.bbi.2020.05.078_b0365","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.neuron.2007.07.016","article-title":"Nociceptors\u2013noxious stimulus detectors","volume":"55","author":"Woolf","year":"2007","journal-title":"Neuron"},{"key":"10.1016\/j.bbi.2020.05.078_b0370","doi-asserted-by":"crossref","unstructured":"Xiong, Y., Liu, Y., Cao, L., Wang, D., Guo, M., Guo, D., Hu, W., Yang, J., Tang, Z., Zhang, Q., Shi, M., Liu, Y., Zhou, Y., Lan, K., Chen, Y., 2020a. Transcriptomic Characteristics of Bronchoalveolar Lavage Fluid and Peripheral Blood Mononuclear Cells in COVID-19 Patients. SSRN Electronic Journal.","DOI":"10.2139\/ssrn.3549993"},{"key":"10.1016\/j.bbi.2020.05.078_b0375","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1080\/22221751.2020.1747363","article-title":"Transcriptomic characteristics of bronchoalveolar lavage fluid and peripheral blood mononuclear cells in COVID-19 patients","volume":"9","author":"Xiong","year":"2020","journal-title":"Emerg. Microbes Infect."},{"key":"10.1016\/j.bbi.2020.05.078_b0380","doi-asserted-by":"crossref","first-page":"1444","DOI":"10.1126\/science.abb2762","article-title":"Structural basis for the recognition of SARS-CoV-2 by full-length human ACE2","volume":"367","author":"Yan","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.bbi.2020.05.078_b0385","doi-asserted-by":"crossref","first-page":"D619","DOI":"10.1093\/nar\/gkw1033","article-title":"Genenames.org: the HGNC and VGNC resources in 2017","volume":"45","author":"Yates","year":"2017","journal-title":"Nucl. Acids Res."},{"key":"10.1016\/j.bbi.2020.05.078_b0390","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1016\/S0140-6736(20)30566-3","article-title":"Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study","volume":"395","author":"Zhou","year":"2020","journal-title":"Lancet"},{"key":"10.1016\/j.bbi.2020.05.078_b0395","doi-asserted-by":"crossref","unstructured":"Zhou, Y., Fu, B., Zheng, X., Wang, D., Zhao, C., qi, Y., Sun, R., Tian, Z., Xu, X., Wei, H., 2020b. Aberrant pathogenic GM-CSF+ T cells and inflammatory CD14+CD16+ monocytes in severe pulmonary syndrome patients of a new coronavirus. bioRxiv:2020.2002.2012.945576.","DOI":"10.1101\/2020.02.12.945576"}],"container-title":["Brain, Behavior, and Immunity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S088915912030670X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S088915912030670X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T08:05:18Z","timestamp":1760169918000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S088915912030670X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10]]},"references-count":79,"alternative-id":["S088915912030670X"],"URL":"https:\/\/doi.org\/10.1016\/j.bbi.2020.05.078","relation":{},"ISSN":["0889-1591"],"issn-type":[{"value":"0889-1591","type":"print"}],"subject":[],"published":{"date-parts":[[2020,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A pharmacological interactome between COVID-19 patient samples and human sensory neurons reveals potential drivers of neurogenic pulmonary dysfunction","name":"articletitle","label":"Article Title"},{"value":"Brain, Behavior, and Immunity","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbi.2020.05.078","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}