{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T08:10:38Z","timestamp":1772784638367,"version":"3.50.1"},"reference-count":119,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100003329","name":"Ministerio de Econom\u00eda y Competitividad","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003329","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain, Behavior, and Immunity"],"published-print":{"date-parts":[[2020,10]]},"DOI":"10.1016\/j.bbi.2020.08.010","type":"journal-article","created":{"date-parts":[[2020,8,13]],"date-time":"2020-08-13T11:46:23Z","timestamp":1597319183000},"page":"675-688","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["Increased vulnerability to impulsive behavior after streptococcal antigen exposure and antibiotic treatment in rats"],"prefix":"10.1016","volume":"89","author":[{"given":"Santiago","family":"Mora","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena","family":"Mart\u00edn-Gonz\u00e1lez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00c1ngeles","family":"Prados-Pardo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joaqu\u00edn","family":"Moreno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda Jos\u00e9","family":"L\u00f3pez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fuencisla","family":"Pilar-Cuellar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena","family":"Castro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00c1lvaro","family":"D\u00edaz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pilar","family":"Flores","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margarita","family":"Moreno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbi.2020.08.010_b0005","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1007\/s11481-017-9742-9","article-title":"Systemic inflammation during the first postnatal month and the risk of attention deficit hyperactivity disorder characteristics among 10 year-old children born extremely preterm","volume":"12","author":"Allred","year":"2017","journal-title":"J Neuroimmune Pharmacol"},{"key":"10.1016\/j.bbi.2020.08.010_b0010","series-title":"Diagnostic and Statistical Manual of Mental Disorders","author":"American Psychiatric Association","year":"2013"},{"key":"10.1016\/j.bbi.2020.08.010_b0020","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1186\/s13063-019-4040-x","article-title":"Treating impulsivity with probiotics in adults (PROBIA): study protocol of a multicenter, double-blind, randomized, placebo-controlled trial","volume":"21","author":"Arteaga-Henr\u00edquez","year":"2020","journal-title":"Trials"},{"key":"10.1016\/j.bbi.2020.08.010_b0030","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1038\/nprot.2008.41","article-title":"The application of the 5-choice serial reaction time task for the assessment of visual attentional processes and impulse control in rats","volume":"3","author":"Bari","year":"2008","journal-title":"Nat Protoc"},{"key":"10.1016\/j.bbi.2020.08.010_b0035","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.pneurobio.2013.06.005","article-title":"Inhibition and Impulsivity: Behavioral and Neural Basis of Response Control","volume":"108","author":"Bari","year":"2013","journal-title":"Prog Neurobiol"},{"key":"10.1016\/j.bbi.2020.08.010_b0040","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1037\/0894-4105.15.3.351","article-title":"Time perception and reproduction in young adults with attention deficit hyperactivity disorder","volume":"15","author":"Barkley","year":"2001","journal-title":"Neuropsychology"},{"key":"10.1016\/j.bbi.2020.08.010_b0045","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1207\/s15374424jccp3401_14","article-title":"Time Estimation and Performance on Reproduction Tasks in Subtypes of Children With Attention Deficit Hyperactivity Disorder","volume":"34","author":"Bauermeister","year":"2006","journal-title":"J Clin Child Adolesc Psychol"},{"key":"10.1016\/j.bbi.2020.08.010_b0055","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/j.biopsych.2013.09.023","article-title":"The epidemiologic evidence linking autoimmune diseases and psychosis","volume":"75","author":"Benros","year":"2014","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.bbi.2020.08.010_b0060","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1089\/cap.2010.0034","article-title":"Comparison of clinical characteristics of pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections and childhood obsessive-compulsive disorder","volume":"20","author":"Bernstein","year":"2010","journal-title":"J Child Adolesc Psychopharmacol"},{"key":"10.1016\/j.bbi.2020.08.010_b0065","doi-asserted-by":"crossref","first-page":"2076","DOI":"10.1038\/npp.2012.56","article-title":"Behavioral, pharmacological, and immunological abnormalities after streptococcal exposure: a novel rat model of Sydenham chorea and related neuropsychiatric disorders","volume":"37","author":"Brimberg","year":"2012","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.bbi.2020.08.010_b0070","doi-asserted-by":"crossref","first-page":"2820","DOI":"10.4049\/jimmunol.151.5.2820","article-title":"Epitopes of streptococcal M proteins that evoke antibodies that cross-react with human brain","volume":"151","author":"Bronze","year":"1993","journal-title":"J Immunol"},{"key":"10.1016\/j.bbi.2020.08.010_b0075","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1007\/s12640-009-9149-3","article-title":"Impulsivity as long-term sequelae after chlorpyrifos intoxication: time course and individual differences","volume":"19","author":"Cardona","year":"2011","journal-title":"Neurotox Res"},{"key":"10.1016\/j.bbi.2020.08.010_b0080","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1007\/s00213-006-0547-4","article-title":"Vulnerability of long-term neurotoxicity of chlorpyrifos: effect on schedule-induced polydipsia and a delay discounting task","volume":"189","author":"Cardona","year":"2006","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.bbi.2020.08.010_b0085","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/0166-4328(83)90138-9","article-title":"Effects of lesions to ascending noradrenergic neurones on performance of a 5-choice serial reaction task in rats; implications for theories of dorsal noradrenergic bundle function based on selective attention and arousal","volume":"9","author":"Carli","year":"1983","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.bbi.2020.08.010_b0090","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1016\/j.jpsychires.2012.04.023","article-title":"Impulsivity in the general population: A national study","volume":"46","author":"Chamorro","year":"2012","journal-title":"J Psychiatr Res"},{"key":"10.1016\/j.bbi.2020.08.010_b0095","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.jad.2018.09.005","article-title":"The role of substance use, smoking, and inflammation in risk for suicidal behavior","volume":"243","author":"Chang","year":"2019","journal-title":"J Affect Disord"},{"key":"10.1016\/j.bbi.2020.08.010_b0100","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1590\/S0100-879X2009001100002","article-title":"Glutamate-N-methyl-D-aspartate receptor modulation and minocycline for the treatment of patients with schizophrenia: an update","volume":"42","author":"Chaves","year":"2009","journal-title":"Braz J Med Biol Res"},{"key":"10.1016\/j.bbi.2020.08.010_b0105","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1161\/01.STR.0000252091.36912.65","article-title":"Pharmacological Induction of Ischemic Tolerance by Glutamate Transporter-1 (EAAT2) Upregulation","volume":"38","author":"Chu","year":"2007","journal-title":"Stroke"},{"key":"10.1016\/j.bbi.2020.08.010_b0110","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1212\/WNL.59.2.227","article-title":"Anti-basal ganglia antibodies in acute and persistent Sydenham\u2019s chorea","volume":"59","author":"Church","year":"2002","journal-title":"Neurology"},{"key":"10.1016\/j.bbi.2020.08.010_b0115","series-title":"Statistical power analysis for the behavioral sciences","author":"Cohen","year":"1988"},{"key":"10.1016\/j.bbi.2020.08.010_b0120","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.psyneuen.2017.02.017","article-title":"IL-6 and TNF-alpha in unmedicated adults with ADHD: Relationship to cortisol awakening response","volume":"79","author":"Corominas-Roso","year":"2017","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.bbi.2020.08.010_b0125","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.psychres.2019.05.030","article-title":"Association between inflammatory cytokines and ADHD symptoms in children and adolescents with obesity: A pilot study","volume":"278","author":"Cortese","year":"2019","journal-title":"Psychiatry Res"},{"key":"10.1016\/j.bbi.2020.08.010_b0135","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1097\/BOR.0b013e32835461d3","article-title":"Streptococcus and rheumatic fever","volume":"24","author":"Cunningham","year":"2012","journal-title":"Curr Opin Rheumatol"},{"key":"10.1016\/j.bbi.2020.08.010_b0140","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.yfrne.2018.04.002","article-title":"The Neuroendocrinology of the Microbiota-Gut-Brain Axis: A Behavioural Perspective","volume":"51","author":"Cussotto","year":"2018","journal-title":"Front Neuroendocrinol"},{"key":"10.1016\/j.bbi.2020.08.010_b0145","first-page":"785","article-title":"Post-streptococcal autoimmune disorders of the central nervous system","volume":"47","author":"Dale","year":"2005","journal-title":"Dev Med Child Neurol"},{"key":"10.1016\/j.bbi.2020.08.010_b0150","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1136\/adc.2003.031856","article-title":"Dyskinesias and associated psychiatric disorders following streptococcal infections","volume":"89","author":"Dale","year":"2004","journal-title":"Arch Dis Child"},{"issue":"3","key":"10.1016\/j.bbi.2020.08.010_b0155","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1007\/s00213-002-1215-y","article-title":"Specific abnormalities in serotonin release in the prefrontal cortex of isolation-reared rats measured during behavioural performance of a task assessing visuospatial attention and impulsivity","volume":"164","author":"Dalley","year":"2002","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.bbi.2020.08.010_b0160","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1016\/j.neuron.2011.01.020","article-title":"Impulsivity, Compulsivity, and Top-Down Cognitive Control","volume":"69","author":"Dalley","year":"2011","journal-title":"Neuron"},{"key":"10.1016\/j.bbi.2020.08.010_b0165","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1038\/nrn.2017.8","article-title":"Fractionating impulsivity: neuropsychiatric implications","volume":"18","author":"Dalley","year":"2017","journal-title":"Nat Rev Neurosci"},{"key":"10.1016\/j.bbi.2020.08.010_b0170","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1038\/sj.npp.1300590","article-title":"Cognitive sequelae of intravenous amphetamine self-administration in rats: evidence for selective effects on attentional performance","volume":"30","author":"Dalley","year":"2005","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.bbi.2020.08.010_b0175","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.jpsychires.2018.06.002","article-title":"A meta-analysis of cytokine concentrations in eating disorders","volume":"103","author":"Dalton","year":"2018","journal-title":"J Psychiatr Res"},{"key":"10.1016\/j.bbi.2020.08.010_b0180","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.biopsych.2007.07.011","article-title":"Impulsive choice and impulsive action predict vulnerability to distinct stages of nicotine seeking in rats","volume":"63","author":"Diergaarde","year":"2008","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.bbi.2020.08.010_b0185","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1177\/026988110201600417","article-title":"Maintained improvement with minocycline of a patient with advanced Huntington\u2019s disease","volume":"16","author":"Denovan-Wright","year":"2002","journal-title":"J Psychopharmacol"},{"key":"10.1016\/j.bbi.2020.08.010_b0190","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/j.tips.2004.10.001","article-title":"Neuroprotection by tetracyclines","volume":"25","author":"Domercq","year":"2004","journal-title":"Trends Pharmacol Sci"},{"key":"10.1016\/j.bbi.2020.08.010_b0195","article-title":"Anti-Yo Antibodies in Children With ADHD: First Results About Serum Cytokines","author":"Donfrancesco","year":"2016","journal-title":"J Atten Disord"},{"key":"10.1016\/j.bbi.2020.08.010_b0200","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1007\/PL00005481","article-title":"Varieties of impulsivity","volume":"146","author":"Evenden","year":"1999","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.bbi.2020.08.010_b0205","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1007\/s002130050121","article-title":"The pharmacology of impulsive behaviour in rats: the effects of drugs on response choice with varying delays of reinforcement","volume":"128","author":"Evenden","year":"1996","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.bbi.2020.08.010_b0210","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1016\/j.pnpbp.2007.08.031","article-title":"Phencyclidine-induced cognitive deficits in mice are improved by subsequent subchronic administration of the antibiotic drug minocycline","volume":"32","author":"Fujita","year":"2008","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"10.1016\/j.bbi.2020.08.010_b0215","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.jneuroim.2009.06.015","article-title":"Antineuronal antibodies in OCD: comparisons in children with OCD-only, OCD+chronic tics and OCD+PANDAS","volume":"214","author":"Gause","year":"2009","journal-title":"J Neuroimmunol"},{"key":"10.1016\/j.bbi.2020.08.010_b0220","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1001\/archpsyc.1989.01810110054008","article-title":"The Yale-Brown Obsessive Compulsive Scale","volume":"46","author":"Goodman","year":"1989","journal-title":"II. Validity. Arch Gen Psychiatry"},{"key":"10.1016\/j.bbi.2020.08.010_b0225","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1001\/archpsyc.1989.01810110048007","article-title":"The Yale-Brown Obsessive Compulsive Scale. I. Development, use, and reliability","volume":"46","author":"Goodman","year":"1989","journal-title":"Arch Gen Psychiatry"},{"key":"10.1016\/j.bbi.2020.08.010_b0230","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1016\/j.braindev.2012.10.003","article-title":"Autoimmune neurological disorders associated with group-A beta-hemolytic streptococcal infection","volume":"35","author":"Hachiya","year":"2013","journal-title":"Brain Dev"},{"key":"10.1016\/j.bbi.2020.08.010_bib651","series-title":"Multivariate Data Analysis","author":"Hair","year":"2010"},{"key":"10.1016\/j.bbi.2020.08.010_b0235","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1080\/09297040802186899","article-title":"Executive and attention functioning among children in the PANDAS subgroup","volume":"15","author":"Hirschtritt","year":"2009","journal-title":"Child Neuropsychol"},{"key":"10.1016\/j.bbi.2020.08.010_b0240","doi-asserted-by":"crossref","first-page":"1780","DOI":"10.1523\/JNEUROSCI.0887-03.2004","article-title":"A murine model for neuropsychiatric disorders associated with group A beta-hemolytic streptococcal infection","volume":"24","author":"Hoffman","year":"2004","journal-title":"J Neurosci"},{"key":"10.1016\/j.bbi.2020.08.010_b0245","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1084\/jem.144.4.1094","article-title":"Antibodies reacting with cytoplasm of subthalamic and caudate nuclei neurons in chorea and acute rheumatic fever","volume":"144","author":"Husby","year":"1976","journal-title":"J Exp Med"},{"key":"10.1016\/j.bbi.2020.08.010_b0250","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.neuropharm.2018.08.026","article-title":"Gut microbiome correlates with altered striatal dopamine receptor expression in a model of compulsive alcohol seeking","volume":"141","author":"Jadhav","year":"2018","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.bbi.2020.08.010_b0255","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.1111\/ejn.12146","article-title":"Dopaminergic and GABA-ergic markers of impulsivity in rats: evidence for anatomical localisation in ventral striatum and prefrontal cortex","volume":"37","author":"Jupp","year":"2013","journal-title":"Eur J Neurosci."},{"key":"10.1016\/j.bbi.2020.08.010_b0260","doi-asserted-by":"crossref","first-page":"6684","DOI":"10.1038\/s41598-020-63646-9","article-title":"Impulsivity is a heritable trait in rodents and associated with a novel quantitative trait locus on chromosome 1","volume":"10","author":"Jupp","year":"2020","journal-title":"Sci Rep"},{"key":"10.1016\/j.bbi.2020.08.010_b0265","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/0165-6147(92)90012-U","article-title":"Sickness behavior as a new target for drug development","volume":"13","author":"Kent","year":"1992","journal-title":"Trends Pharmacol Sci"},{"key":"10.1016\/j.bbi.2020.08.010_b0270","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1089\/jmf.2006.9.321","article-title":"Dietary supplementation of probiotic Bacillus polyfermenticus, Bispan strain, modulates natural killer cell and T cell subset populations and immunoglobulin G levels in human subjects","volume":"9","author":"Kim","year":"2006","journal-title":"J Med Food"},{"key":"10.1016\/j.bbi.2020.08.010_b0275","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1038\/nm892","article-title":"Mimicry and autoantibody-mediated neuronal cell signaling in Sydenham chorea","volume":"9","author":"Kirvan","year":"2003","journal-title":"Nat Med"},{"key":"10.1016\/j.bbi.2020.08.010_b0280","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1128\/CDLI.5.6.836-839.1998","article-title":"Antineuronal antibodies in rheumatic chorea","volume":"5","author":"Kotby","year":"1998","journal-title":"Clin Diagn Lab Immunol"},{"key":"10.1016\/j.bbi.2020.08.010_b0285","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1016\/j.biopsych.2004.12.004","article-title":"Increased serum levels of interleukin-12 and tumor necrosis factor-alpha in Tourette\u2019s syndrome","volume":"57","author":"Leckman","year":"2005","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.bbi.2020.08.010_b0290","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1177\/0033294118755674","article-title":"Exploring the Effects of Working Memory on Time Perception in Attention Deficit Hyperactivity Disorder","volume":"122","author":"Lee","year":"2018","journal-title":"Psychol Rep"},{"key":"10.1016\/j.bbi.2020.08.010_b0295","doi-asserted-by":"crossref","first-page":"3084","DOI":"10.1007\/s11064-017-2341-6","article-title":"Increased Oxidative Parameters and Decreased Cytokine Levels in an Animal Model of Attention-Deficit\/Hyperactivity Disorder","volume":"42","author":"Leffa","year":"2017","journal-title":"Neurochem Res"},{"key":"10.1016\/j.bbi.2020.08.010_b0300","first-page":"1","article-title":"A Review on the Role of Inflammation in Attention-Deficit\/Hyperactivity Disorder","volume":"003","author":"Leffa","year":"2018","journal-title":"Neuroimmunomodulation"},{"key":"10.1016\/j.bbi.2020.08.010_b0305","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.1097\/CHI.0b013e3181825a3d","article-title":"Neuropsychiatric disorders associated with streptococcal infection: a case-control study among privately insured children","volume":"47","author":"Leslie","year":"2008","journal-title":"J Am Acad Child Adolesc Psychiatry"},{"key":"10.1016\/j.bbi.2020.08.010_b0310","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.schres.2007.12.025","article-title":"Minocycline ameliorates negative symptoms and cognitive deficits in early-phase schizophrenia: A double-blind, randomized placebo-controlled study","volume":"98","author":"Levkovitz","year":"2008","journal-title":"Abstract. Schizophr Res"},{"key":"10.1016\/j.bbi.2020.08.010_b0315","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.brainres.2007.03.080","article-title":"Minocycline, a second-generation tetracycline, as a neuroprotective agent in an animal model of schizophrenia","volume":"1154","author":"Levkovitz","year":"2007","journal-title":"Brain Res"},{"key":"10.1016\/j.bbi.2020.08.010_b0320","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1007\/s00381-015-2692-8","article-title":"Streptococcal infection and immune response in children with Tourette\u2019s syndrome","volume":"31","author":"Li","year":"2015","journal-title":"Childs Nerv Syst"},{"key":"10.1016\/j.bbi.2020.08.010_b0325","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/0008-8749(82)90457-9","article-title":"Acute experimental autoimmune encephalomyelitis in mice. I. Adjuvant action of Bordetella pertussis is due to vasoactive amine sensitization and increased vascular permeability of the central nervous system","volume":"73","author":"Linthicum","year":"1982","journal-title":"Cell Immunol"},{"key":"10.1016\/j.bbi.2020.08.010_b0330","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1016\/j.neuroscience.2007.02.003","article-title":"Neuroprotective potential of ceftriaxone in in vitro models of stroke","volume":"146","author":"Lipski","year":"2007","journal-title":"Neuroscience"},{"key":"10.1016\/j.bbi.2020.08.010_b0335","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.bbi.2014.02.009","article-title":"Behavioral and neural effects of intra-striatal infusion of anti-streptococcal antibodies in rats","volume":"38","author":"Lotan","year":"2014","journal-title":"Brain Behav Immun"},{"key":"10.1016\/j.bbi.2020.08.010_b0340","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0101257","article-title":"Antibiotic treatment attenuates behavioral and neurochemical changes induced by exposure of rats to group a streptococcal antigen","volume":"9","author":"Lotan","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.bbi.2020.08.010_b0345","doi-asserted-by":"crossref","first-page":"13257","DOI":"10.1038\/srep13257","article-title":"Mice repeatedly exposed to Group-A beta-Haemolytic Streptococcus show perseverative behaviors, impaired sensorimotor gating, and immune activation in rostral diencephalon","volume":"5","author":"Macri","year":"2015","journal-title":"Sci Rep"},{"key":"10.1016\/j.bbi.2020.08.010_b0350","doi-asserted-by":"crossref","first-page":"149","DOI":"10.2174\/156720206776875894","article-title":"Autoantibodies associated with psychiatric disorders","volume":"3","author":"Margutti","year":"2006","journal-title":"Curr Neurovasc Res"},{"key":"10.1016\/j.bbi.2020.08.010_b0355","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.beproc.2006.08.009","article-title":"Impulsive responding on the peak-interval procedure","volume":"74","author":"Matell","year":"2007","journal-title":"Behav Processes"},{"key":"10.1016\/j.bbi.2020.08.010_b0360","first-page":"64","article-title":"Time Perception Differences in Children With and Without ADHD","volume":"17","author":"Meaux","year":"2003","journal-title":"J Pediatr Health Care"},{"key":"10.1016\/j.bbi.2020.08.010_b0365","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1542\/peds.2004-2058","article-title":"Association between streptococcal infection and obsessive-compulsive disorder, Tourette\u2019s syndrome, and tic disorder","volume":"116","author":"Mell","year":"2005","journal-title":"Pediatrics"},{"key":"10.1016\/j.bbi.2020.08.010_b0370","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.neuroscience.2008.02.004","article-title":"Up-regulation of GLT1 expression increases glutamate uptake and attenuates the Huntington\u2019s disease phenotype in the R6\/2 mouse","volume":"153","author":"Miller","year":"2008","journal-title":"Neuroscience"},{"key":"10.1016\/j.bbi.2020.08.010_b0375","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1080\/09297049.2016.1172561","article-title":"Time-based Prospective Memory Difficulties in Children With ADHD and the Role of Time Perception and Working Memory","volume":"23","author":"Mioni","year":"2017","journal-title":"Child Neuropsychol"},{"key":"10.1016\/j.bbi.2020.08.010_b0380","doi-asserted-by":"crossref","first-page":"2994","DOI":"10.4049\/jimmunol.159.6.2994","article-title":"Cerebrospinal fluid cytokines in pediatric neuropsychiatric disease","volume":"159","author":"Mittleman","year":"1997","journal-title":"J Immunol"},{"key":"10.1016\/j.bbi.2020.08.010_b0385","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1016\/j.pnpbp.2006.08.013","article-title":"Possible antipsychotic effects of minocycline in patients with schizophrenia","volume":"31","author":"Miyaoka","year":"2007","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"10.1016\/j.bbi.2020.08.010_b0390","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.bbi.2019.02.027","article-title":"Neuropsychiatric consequences of childhood group A streptococcal infection: A systematic review of preclinical models","volume":"86","author":"Mora","year":"2020","journal-title":"Brain Behav Immun"},{"key":"10.1016\/j.bbi.2020.08.010_b0395","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.toxlet.2007.11.003","article-title":"Long-term monoamine changes in the striatum and nucleus accumbens after acute chlorpyrifos exposure","volume":"176","author":"Moreno","year":"2008","journal-title":"Toxicol Lett"},{"key":"10.1016\/j.bbi.2020.08.010_b0400","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1038\/npp.2009.224","article-title":"Impulsivity characterization in the roman high-and low-avoidance rat strains: Behavioral and neurochemical differences","volume":"35","author":"Moreno","year":"2010","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.bbi.2020.08.010_b0405","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1007\/s00213-011-2575-y","article-title":"Poor inhibitory control and neurochemical differences in high compulsive drinker rats selected by schedule-induced polydipsia","volume":"219","author":"Moreno","year":"2012","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.bbi.2020.08.010_b0410","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1016\/0892-0362(95)02002-0","article-title":"Comparisons of the acute effects of cholinesterase inhibitors using a neurobehavioral screening battery in rats","volume":"17","author":"Moser","year":"1995","journal-title":"Neurotoxicol Teratol"},{"key":"10.1016\/j.bbi.2020.08.010_b0415","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1001\/archpedi.156.4.356","article-title":"Prospective identification and treatment of children with pediatric autoimmune neuropsychiatric disorder associated with group A streptococcal infection (PANDAS)","volume":"156","author":"Murphy","year":"2002","journal-title":"Arch Pediatr Adolesc Med"},{"key":"10.1016\/j.bbi.2020.08.010_b0420","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1089\/cap.2010.0043","article-title":"The immunobiology of Tourette\u2019s disorder, pediatric autoimmune neuropsychiatric disorders associated with Streptococcus, and related disorders: a way forward","volume":"20","author":"Murphy","year":"2010","journal-title":"J Child Adolesc Psychopharmacol"},{"key":"10.1016\/j.bbi.2020.08.010_b0425","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/j.psc.2006.02.003","article-title":"Immunology of Obsessive-Compulsive Disorder","volume":"29","author":"Murphy","year":"2006","journal-title":"Psychiatr Clin North Am"},{"key":"10.1016\/j.bbi.2020.08.010_b0435","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.jad.2005.11.015","article-title":"Cytokine profiles in bipolar affective disorder: focus on acutely ill patients","volume":"90","author":"O\u2019Brien","year":"2006","journal-title":"J Affect Disord"},{"key":"10.1016\/j.bbi.2020.08.010_b0440","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1038\/pr.2014.41","article-title":"Elevated blood levels of inflammation-related proteins are associated with an attention problem at age 24 mo in extremely preterm infants","volume":"75","author":"O\u2019Shea","year":"2014","journal-title":"Pediatr Res"},{"key":"10.1016\/j.bbi.2020.08.010_b0445","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1007\/s12402-011-0062-2","article-title":"An exploration of the associations of pregnancy and perinatal features with cytokines and tryptophan\/kynurenine metabolism in children with attention-deficit hyperactivity disorder (ADHD)","volume":"3","author":"Oades","year":"2011","journal-title":"Atten Defic Hyperact Disord"},{"key":"10.1016\/j.bbi.2020.08.010_b0460","article-title":"Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal Infections (PANDAS) - PubMed - NCBI","volume":"1\u201343","author":"Orefici","year":"2016","journal-title":"Streptococcus pyogenes Basic Biol to Clin Manifestations"},{"key":"10.1016\/j.bbi.2020.08.010_b0465","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.jpsychires.2011.08.006","article-title":"Proinflammatory cytokines in the prefrontal cortex of teenage suicide victims","volume":"46","author":"Pandey","year":"2012","journal-title":"J Psychiatr Res"},{"key":"10.1016\/j.bbi.2020.08.010_b0470","series-title":"The rat brain in stereotaxic coordinates","author":"Paxinos","year":"1998"},{"key":"10.1016\/j.bbi.2020.08.010_b0475","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1001\/archpsyc.57.4.364","article-title":"Preliminary findings of antistreptococcal antibody titers and basal ganglia volumes in tic, obsessive-compulsive, and attention deficit\/hyperactivity disorders","volume":"57","author":"Peterson","year":"2000","journal-title":"Arch Gen Psychiatry"},{"key":"10.1016\/j.bbi.2020.08.010_b0480","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2020.102769","article-title":"Sex-dependent associations between addiction-related behaviors and the microbiome in outbred rats","volume":"55","author":"Peterson","year":"2020","journal-title":"EBioMedicine"},{"key":"10.1016\/j.bbi.2020.08.010_b0485","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0200728","article-title":"Reduced Microbiome Alpha Diversity in Young Patients With ADHD","volume":"13","author":"Prehn-Kristensen","year":"2018","journal-title":"PLoS One"},{"key":"10.1016\/j.bbi.2020.08.010_b0490","doi-asserted-by":"crossref","first-page":"3918","DOI":"10.12659\/MSM.914225","article-title":"Clinical Implications of the Perception of Time in Attention Deficit Hyperactivity Disorder (ADHD): A Review","volume":"25","author":"Ptacek","year":"2019","journal-title":"Med Sci Monit"},{"key":"10.1016\/j.bbi.2020.08.010_b0495","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1007\/s00213-002-1154-7","article-title":"The 5-choice serial reaction time task: behavioural pharmacology and functional neurochemistry","volume":"163","author":"Robbins","year":"2002","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.bbi.2020.08.010_b0500","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.tics.2011.11.009","article-title":"Neurocognitive endophenotypes of impulsivity and compulsivity: Towards dimensional psychiatry","volume":"16","author":"Robbins","year":"2012","journal-title":"Trends Cogn Sci"},{"key":"10.1016\/j.bbi.2020.08.010_b0505","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1038\/nature03180","article-title":"Beta-lactam antibiotics offer neuroprotection by increasing glutamate transporter expression","volume":"433","author":"Rothstein","year":"2005","journal-title":"Nature"},{"key":"10.1016\/j.bbi.2020.08.010_b0515","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.ntt.2003.10.008","article-title":"Long-term functional neurotoxicity of paraoxon and chlorpyrifos: Behavioural and pharmacological evidence","volume":"26","author":"S\u00e1nchez-Santed","year":"2004","journal-title":"Neurotoxicol Teratol"},{"key":"10.1016\/j.bbi.2020.08.010_b0520","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.beproc.2013.07.018","article-title":"Adaptation of Timing Behavior to a Regular Change in Criterion","volume":"101","author":"Sanabra","year":"2014","journal-title":"Behav Processes"},{"key":"10.1016\/j.bbi.2020.08.010_b0525","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1097\/00004583-199706000-00023","article-title":"Children\u2019s Yale-Brown Obsessive Compulsive Scale: reliability and validity","volume":"36","author":"Scahill","year":"1997","journal-title":"J Am Acad Child Adolesc Psychiatry"},{"key":"10.1016\/j.bbi.2020.08.010_b0530","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.neubiorev.2018.01.001","article-title":"Treatment of PANDAS and PANS: a systematic review","volume":"86","author":"Sigra","year":"2018","journal-title":"Neurosci Biobehav Rev"},{"key":"10.1016\/j.bbi.2020.08.010_b0535","doi-asserted-by":"crossref","first-page":"1618","DOI":"10.1212\/WNL.50.6.1618","article-title":"Antibodies against human putamen in children with Tourette syndrome","volume":"50","author":"Singer","year":"1998","journal-title":"Neurology"},{"key":"10.1016\/j.bbi.2020.08.010_b0540","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1111\/1469-7610.00043","article-title":"Evidence for a pure time perception deficit in children with ADHD","volume":"43","author":"Smith","year":"2002","journal-title":"J Child Psychol Psychiatry"},{"key":"10.1016\/j.bbi.2020.08.010_b0545","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1038\/sj.mp.4001542","article-title":"PANDAS: current status and directions for research","volume":"9","author":"Snider","year":"2004","journal-title":"Mol Psychiatry"},{"key":"10.1016\/j.bbi.2020.08.010_b0550","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1016\/j.biopsych.2004.12.035","article-title":"Antibiotic prophylaxis with azithromycin or penicillin for childhood-onset neuropsychiatric disorders","volume":"57","author":"Snider","year":"2005","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.bbi.2020.08.010_b0555","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1089\/cap.2000.10.133","article-title":"Infection-triggered anorexia nervosa in children: clinical description of four cases","volume":"10","author":"Sokol","year":"2000","journal-title":"J Child Adolesc Psychopharmacol"},{"key":"10.1016\/j.bbi.2020.08.010_b0560","doi-asserted-by":"crossref","first-page":"1430","DOI":"10.1176\/appi.ajp.159.8.1430","article-title":"D8\/17 expression on B lymphocytes in anorexia nervosa","volume":"159","author":"Sokol","year":"2002","journal-title":"Am J Psychiatry"},{"key":"10.1016\/j.bbi.2020.08.010_b0570","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1176\/ajp.155.2.264","article-title":"Pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections: clinical description of the first 50 cases","volume":"155","author":"Swedo","year":"1998","journal-title":"Am J Psychiatry"},{"key":"10.1016\/j.bbi.2020.08.010_b0575","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1176\/ajp.154.1.110","article-title":"Identification of children with pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections by a marker associated with rheumatic fever","volume":"154","author":"Swedo","year":"1997","journal-title":"Am J Psychiatry"},{"key":"10.1016\/j.bbi.2020.08.010_b0585","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.ejphar.2010.04.021","article-title":"Pharmacological evaluation of glutamate transporter 1 (GLT-1) mediated neuroprotection following cerebral ischemia\/reperfusion injury","volume":"638","author":"Verma","year":"2010","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.bbi.2020.08.010_b0590","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1177\/1087054712454570","article-title":"Adjustment of Time Perception in the Range of Seconds and Milliseconds: The Nature of Time-Processing Alterations in Children With ADHD","volume":"19","author":"Walg","year":"2015","journal-title":"J Atten Disord"},{"key":"10.1016\/j.bbi.2020.08.010_b0595","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1177\/0194599815577784","article-title":"Pediatric autoimmune neuropsychiatric disorder associated with streptococcus immunology: A pilot study","volume":"153","author":"Walls","year":"2015","journal-title":"Otolaryngol - Head Neck Surg (United States)"},{"key":"10.1016\/j.bbi.2020.08.010_b0600","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1097\/TA.0b013e31825133c0","article-title":"The beta-lactam antibiotic, ceftriaxone, provides neuroprotective potential via anti-excitotoxicity and anti-inflammation response in a rat model of traumatic brain injury","volume":"73","author":"Wei","year":"2012","journal-title":"J Trauma Acute Care Surg"},{"key":"10.1016\/j.bbi.2020.08.010_b0605","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1111\/j.1476-5381.2011.01323.x","article-title":"The utility of rat models of impulsivity in developing pharmacotherapies for impulse control disorders","volume":"164","author":"Winstanley","year":"2011","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.bbi.2020.08.010_b0610","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/j.cpr.2006.01.001","article-title":"Behavioral models of impulsivity in relation to ADHD: Translation between clinical and preclinical studies","volume":"26","author":"Winstanley","year":"2006","journal-title":"Clin Psychol Rev"},{"key":"10.1016\/j.bbi.2020.08.010_b0615","doi-asserted-by":"crossref","first-page":"4718","DOI":"10.1523\/JNEUROSCI.5606-03.2004","article-title":"Contrasting roles of basolateral amygdala and orbitofrontal cortex in impulsive choice","volume":"24","author":"Winstanley","year":"2004","journal-title":"J Neurosci"},{"key":"10.1016\/j.bbi.2020.08.010_b0630","doi-asserted-by":"crossref","unstructured":"Yaddanapudi K, Hornig M, Serge R, De Miranda J, Baghban a, Villar G, Lipkin WI (2010) Passive transfer of streptococcus-induced antibodies reproduces behavioral disturbances in a mouse model of pediatric autoimmune neuropsychiatric disorders associated with streptococcal infection. Mol Psychiatry 15:712\u201326. doi: 10.1038\/mp.2009.77.","DOI":"10.1038\/mp.2009.77"},{"key":"10.1016\/j.bbi.2020.08.010_b0635","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.brainres.2007.07.021","article-title":"Time Perception Deficit in Children With ADHD","volume":"1170","author":"Yang","year":"2007","journal-title":"Brain Res"},{"key":"10.1016\/j.bbi.2020.08.010_b0640","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/j.bbi.2012.01.005","article-title":"Anti-streptococcus IgM antibodies induce repetitive stereotyped movements: cell activation and co-localization with Fcalpha\/mu receptors in the striatum and motor cortex","volume":"26","author":"Zhang","year":"2012","journal-title":"Brain Behav Immun"},{"key":"10.1016\/j.bbi.2020.08.010_b0645","doi-asserted-by":"crossref","first-page":"23","DOI":"10.3389\/fcimb.2016.00023","article-title":"Streptococcus pneumoniae Endopeptidase O (PepO) Elicits a Strong Innate Immune Response in Mice via TLR2 and TLR4 Signaling Pathways","volume":"6","author":"Zhang","year":"2016","journal-title":"Front Cell Infect Microbiol"},{"key":"10.1016\/j.bbi.2020.08.010_b0650","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ejphar.2006.05.047","article-title":"Protective effects of minocycline on 3,4-methylenedioxymethamphetamine-induced neurotoxicity in serotonergic and dopaminergic neurons of mouse brain","volume":"544","author":"Zhang","year":"2006","journal-title":"Eur J Pharmacol"}],"container-title":["Brain, Behavior, and Immunity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0889159120300830?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0889159120300830?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T08:06:25Z","timestamp":1760169985000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0889159120300830"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10]]},"references-count":119,"alternative-id":["S0889159120300830"],"URL":"https:\/\/doi.org\/10.1016\/j.bbi.2020.08.010","relation":{},"ISSN":["0889-1591"],"issn-type":[{"value":"0889-1591","type":"print"}],"subject":[],"published":{"date-parts":[[2020,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Increased vulnerability to impulsive behavior after streptococcal antigen exposure and antibiotic treatment in rats","name":"articletitle","label":"Article Title"},{"value":"Brain, Behavior, and Immunity","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbi.2020.08.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}