{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T20:36:21Z","timestamp":1793046981397,"version":"4.5.0"},"reference-count":153,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,10,22]],"date-time":"2020-10-22T00:00:00Z","timestamp":1603324800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000063","name":"Office of Dietary Supplements","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000063","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000064","name":"National Center for Complementary and Alternative Medicine","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000064","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain, Behavior, and Immunity"],"published-print":{"date-parts":[[2021,1]]},"DOI":"10.1016\/j.bbi.2020.10.013","type":"journal-article","created":{"date-parts":[[2020,10,20]],"date-time":"2020-10-20T22:36:35Z","timestamp":1603233395000},"page":"350-368","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":155,"special_numbering":"C","title":["Microbiota metabolites modulate the T helper 17 to regulatory T cell (Th17\/Treg) imbalance promoting resilience to stress-induced anxiety- and depressive-like behaviors"],"prefix":"10.1016","volume":"91","author":[{"given":"Susan","family":"Westfall","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Caracci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danyue","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing-li","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tal","family":"Frolinger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Simon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulio Maria","family":"Pasinetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbi.2020.10.013_b0005","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1196\/annals.1314.001","article-title":"Protection and damage from acute and chronic stress: allostasis and allostatic overload and relevance to the pathophysiology of psychiatric disorders","volume":"1032","author":"McEwen","year":"2004","journal-title":"Ann N Y Acad Sci."},{"key":"10.1016\/j.bbi.2020.10.013_b0010","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.physbeh.2013.10.014","article-title":"Depressive symptoms are associated with allostatic load among community-dwelling older adults","volume":"123","author":"Kobrosly","year":"2014","journal-title":"Physiol Behav."},{"key":"10.1016\/j.bbi.2020.10.013_b0015","doi-asserted-by":"crossref","first-page":"47","DOI":"10.3389\/fnbeh.2019.00047","article-title":"From Allostatic Load to Allostatic State-An Endogenous Sympathetic Strategy to Deal With Chronic Anxiety and Stress?","volume":"13","author":"Ullmann","year":"2019","journal-title":"Front Behav Neurosci."},{"issue":"7","key":"10.1016\/j.bbi.2020.10.013_b0020","first-page":"3225","article-title":"The microbiota-gut-brain axis as a key regulator of neural function and the stress response: Implications for human and animal health","volume":"95","author":"Wiley","year":"2017","journal-title":"J Anim Sci."},{"key":"10.1016\/j.bbi.2020.10.013_b0025","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.3389\/fnins.2019.01196","article-title":"The Gut Microbiota Links Dietary Polyphenols With Management of Psychiatric Mood Disorders","volume":"13","author":"Westfall","year":"2019","journal-title":"Front Neurosci."},{"issue":"2","key":"10.1016\/j.bbi.2020.10.013_b0030","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1053\/j.gastro.2011.04.052","article-title":"The intestinal microbiota affect central levels of brain-derived neurotropic factor and behavior in mice","volume":"141","author":"Bercik","year":"2011","journal-title":"Gastroenterology."},{"issue":"6","key":"10.1016\/j.bbi.2020.10.013_b0035","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1038\/mp.2016.44","article-title":"Gut microbiome remodeling induces depressive-like behaviors through a pathway mediated by the host's metabolism","volume":"21","author":"Zheng","year":"2016","journal-title":"Mol Psychiatry."},{"issue":"5","key":"10.1016\/j.bbi.2020.10.013_b0040","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1080\/10253890.2019.1617267","article-title":"Fecal microbiota transplantation from chronic unpredictable mild stress mice donors affects anxiety-like and depression-like behavior in recipient mice via the gut microbiota-inflammation-brain axis","volume":"22","author":"Li","year":"2019","journal-title":"Stress."},{"key":"10.1016\/j.bbi.2020.10.013_b0045","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.bbi.2016.12.019","article-title":"Individual differences in stress vulnerability: The role of gut pathobionts in stress-induced colitis","volume":"64","author":"Langgartner","year":"2017","journal-title":"Brain Behav Immun."},{"key":"10.1016\/j.bbi.2020.10.013_b0050","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.bbi.2015.03.016","article-title":"Altered fecal microbiota composition in patients with major depressive disorder","volume":"48","author":"Jiang","year":"2015","journal-title":"Brain Behav Immun."},{"issue":"8","key":"10.1016\/j.bbi.2020.10.013_b0055","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1111\/nmo.12378","article-title":"Correlation between the human fecal microbiota and depression","volume":"26","author":"Naseribafrouei","year":"2014","journal-title":"Neurogastroenterol Motil."},{"issue":"4","key":"10.1016\/j.bbi.2020.10.013_b0060","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1038\/s41564-018-0337-x","article-title":"The neuroactive potential of the human gut microbiota in quality of life and depression","volume":"4","author":"Valles-Colomer","year":"2019","journal-title":"Nat Microbiol."},{"issue":"6","key":"10.1016\/j.bbi.2020.10.013_b0065","doi-asserted-by":"crossref","first-page":"748","DOI":"10.4161\/19490976.2014.972241","article-title":"The structures of the colonic mucosa-associated and luminal microbial communities are distinct and differentially affected by a prolonged murine stressor","volume":"5","author":"Galley","year":"2014","journal-title":"Gut Microbes."},{"key":"10.1016\/j.bbi.2020.10.013_b0070","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.jad.2017.11.063","article-title":"A meta-analysis of the use of probiotics to alleviate depressive symptoms","volume":"228","author":"Ng","year":"2018","journal-title":"J Affect Disord."},{"key":"10.1016\/j.bbi.2020.10.013_b0075","article-title":"Effect of synbiotic and probiotic supplementation on serum brain-derived neurotrophic factor level, depression and anxiety symptoms in hemodialysis patients: a randomized, double-blinded, clinical trial","volume":"1\u201310","author":"Haghighat","year":"2019","journal-title":"Nutr Neurosci."},{"issue":"11","key":"10.1016\/j.bbi.2020.10.013_b0080","doi-asserted-by":"crossref","first-page":"2819","DOI":"10.1007\/s11064-016-2039-1","article-title":"The Gut-Brain Axis, BDNF, NMDA and CNS Disorders","volume":"41","author":"Maqsood","year":"2016","journal-title":"Neurochem Res."},{"key":"10.1016\/j.bbi.2020.10.013_b0085","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.bbi.2015.04.004","article-title":"Gut microbiota depletion from early adolescence in mice: Implications for brain and behaviour","volume":"48","author":"Desbonnet","year":"2015","journal-title":"Brain Behav Immun."},{"issue":"3","key":"10.1016\/j.bbi.2020.10.013_b0090","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1172\/JCI76304","article-title":"Gut\/brain axis and the microbiota","volume":"125","author":"Mayer","year":"2015","journal-title":"J Clin Invest."},{"key":"10.1016\/j.bbi.2020.10.013_b0095","doi-asserted-by":"crossref","unstructured":"N.W. Bellono J.R. Bayrer D.B. Leitch J. Castro C. Zhang T.A. O'Donnell et al. Enterochromaffin Cells Are Gut Chemosensors that Couple to Sensory Neural Pathways Cell. 170 1 2017 185 98.e16.","DOI":"10.1016\/j.cell.2017.05.034"},{"key":"10.1016\/j.bbi.2020.10.013_b0100","doi-asserted-by":"crossref","unstructured":"M. Dehhaghi H. Kazemi Shariat Panahi G.GJ. Microorganisms Tryptophan Metabolism, and Kynurenine Pathway: A Complex Interconnected Loop Influencing Human Health Status Int J Tryptophan Res. 2019;12:1178646919852996.","DOI":"10.1177\/1178646919852996"},{"key":"10.1016\/j.bbi.2020.10.013_b0105","doi-asserted-by":"crossref","first-page":"13","DOI":"10.3389\/fcimb.2018.00013","article-title":"Impact of the Gut Microbiota on Intestinal Immunity Mediated by Tryptophan Metabolism","volume":"8","author":"Gao","year":"2018","journal-title":"Front Cell Infect Microbiol."},{"issue":"5","key":"10.1016\/j.bbi.2020.10.013_b0110","doi-asserted-by":"crossref","first-page":"574","DOI":"10.2174\/1570159X15666170913110426","article-title":"Neuroinflammation and the Immune-Kynurenine Pathway in Anxiety Disorders","volume":"16","author":"Kim","year":"2018","journal-title":"Curr Neuropharmacol."},{"issue":"4","key":"10.1016\/j.bbi.2020.10.013_b0115","doi-asserted-by":"crossref","first-page":"1944","DOI":"10.1096\/fj.201700853R","article-title":"Regulation of proinflammatory monocyte activation by the kynurenine-AhR axis underlies immunometabolic control of depressive behavior in mice","volume":"32","author":"Zang","year":"2018","journal-title":"Faseb j."},{"issue":"7610","key":"10.1016\/j.bbi.2020.10.013_b0120","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1038\/nature18847","article-title":"The microbiome and innate immunity","volume":"535","author":"Thaiss","year":"2016","journal-title":"Nature."},{"issue":"1","key":"10.1016\/j.bbi.2020.10.013_b0125","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1111\/imr.12580","article-title":"Interplay of innate lymphoid cells and the microbiota","volume":"279","author":"Britanova","year":"2017","journal-title":"Immunol Rev."},{"issue":"8","key":"10.1016\/j.bbi.2020.10.013_b0130","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1038\/ni.3780","article-title":"Regulation of inflammation by microbiota interactions with the host","volume":"18","author":"Blander","year":"2017","journal-title":"Nat Immunol."},{"issue":"Suppl 1","key":"10.1016\/j.bbi.2020.10.013_b0135","first-page":"E86","article-title":"Gut-associated lymphoid tissue, T cell trafficking, and chronic intestinal inflammation","volume":"1207 Suppl 1","author":"Koboziev","year":"2010","journal-title":"Ann N Y Acad Sci."},{"issue":"7480","key":"10.1016\/j.bbi.2020.10.013_b0140","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1038\/nature12726","article-title":"Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation","volume":"504","author":"Arpaia","year":"2013","journal-title":"Nature."},{"key":"10.1016\/j.bbi.2020.10.013_b0145","doi-asserted-by":"crossref","first-page":"417","DOI":"10.3389\/fimmu.2017.00417","article-title":"The Microbiota and Epigenetic Regulation of T Helper 17\/Regulatory T Cells. In Search of a Balanced Immune System","volume":"8","author":"Luo","year":"2017","journal-title":"Front Immunol."},{"key":"10.1016\/j.bbi.2020.10.013_b0150","doi-asserted-by":"crossref","first-page":"571","DOI":"10.3389\/fphar.2018.00571","article-title":"Berberine Regulates Treg\/Th17 Balance to Treat Ulcerative Colitis Through Modulating the Gut Microbiota in the Colon","volume":"9","author":"Cui","year":"2018","journal-title":"Front Pharmacol."},{"key":"10.1016\/j.bbi.2020.10.013_b0155","doi-asserted-by":"crossref","unstructured":"G.J. Britton E.J. Contijoch I. Mogno O.H. Vennaro S.R. Llewellyn R. Ng et al. Microbiotas from Humans with Inflammatory Bowel Disease Alter the Balance of Gut Th17 and ROR\u03b3t(+) Regulatory T Cells and Exacerbate Colitis in Mice Immunity. 50 1 2019 212 24.e4.","DOI":"10.1016\/j.immuni.2018.12.015"},{"issue":"1","key":"10.1016\/j.bbi.2020.10.013_b0160","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1159\/000343100","article-title":"Imbalance between Th17 and Treg cells may play an important role in the development of chronic unpredictable mild stress-induced depression in mice","volume":"20","author":"Hong","year":"2013","journal-title":"Neuroimmunomodulation."},{"key":"10.1016\/j.bbi.2020.10.013_b0165","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.imlet.2017.07.013","article-title":"FICZ generates human tDCs that induce CD4(+) CD25(high) Foxp3(+) Treg-like cell differentiation","volume":"190","author":"Jurado-Manzano","year":"2017","journal-title":"Immunol Lett."},{"key":"10.1016\/j.bbi.2020.10.013_b0170","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2019.104513","article-title":"Cinnamtannin D1 attenuates autoimmune arthritis by regulating the balance of Th17 and treg cells through inhibition of aryl hydrocarbon receptor expression","volume":"151","author":"Shi","year":"2020","journal-title":"Pharmacol Res."},{"key":"10.1016\/j.bbi.2020.10.013_b0175","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.biocel.2016.03.014","article-title":"Norisoboldine, an isoquinoline alkaloid, acts as an aryl hydrocarbon receptor ligand to induce intestinal Treg cells and thereby attenuate arthritis","volume":"75","author":"Tong","year":"2016","journal-title":"Int J Biochem Cell Biol."},{"issue":"2","key":"10.1016\/j.bbi.2020.10.013_b0180","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/j.immuni.2013.08.003","article-title":"Tryptophan catabolites from microbiota engage aryl hydrocarbon receptor and balance mucosal reactivity via interleukin-22","volume":"39","author":"Zelante","year":"2013","journal-title":"Immunity."},{"issue":"7191","key":"10.1016\/j.bbi.2020.10.013_b0185","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1038\/nature06881","article-title":"The aryl hydrocarbon receptor links TH17-cell-mediated autoimmunity to environmental toxins","volume":"453","author":"Veldhoen","year":"2008","journal-title":"Nature."},{"issue":"7191","key":"10.1016\/j.bbi.2020.10.013_b0190","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1038\/nature06880","article-title":"Control of T(reg) and T(H)17 cell differentiation by the aryl hydrocarbon receptor","volume":"453","author":"Quintana","year":"2008","journal-title":"Nature."},{"issue":"1","key":"10.1016\/j.bbi.2020.10.013_b0195","doi-asserted-by":"crossref","first-page":"3546","DOI":"10.1038\/s41598-019-39994-6","article-title":"The gut microbiota composition affects dietary polyphenols-mediated cognitive resilience in mice by modulating the bioavailability of phenolic acids","volume":"9","author":"Frolinger","year":"2019","journal-title":"Sci Rep."},{"issue":"10","key":"10.1016\/j.bbi.2020.10.013_b0200","article-title":"Epigenetic modifications by polyphenolic compounds alter gene expression in the hippocampus","volume":"7","author":"Frolinger","year":"2018","journal-title":"Biol Open."},{"issue":"1","key":"10.1016\/j.bbi.2020.10.013_b0205","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1038\/s41467-017-02794-5","article-title":"Epigenetic modulation of inflammation and synaptic plasticity promotes resilience against stress in mice","volume":"9","author":"Wang","year":"2018","journal-title":"Nat Commun."},{"issue":"4","key":"10.1016\/j.bbi.2020.10.013_b0210","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1111\/1751-7915.12368","article-title":"Lactobacillus plantarum WCFS1 and its host interaction: a dozen years after the genome","volume":"9","author":"van den Nieuwboer","year":"2016","journal-title":"Microb Biotechnol."},{"key":"10.1016\/j.bbi.2020.10.013_b0215","doi-asserted-by":"crossref","unstructured":"M.I. Pinto-Sanchez G.B. Hall K. Ghajar A. Nardelli C. Bolino J.T. Lau et al. Probiotic Bifidobacterium longum NCC3001 Reduces Depression Scores and Alters Brain Activity: A Pilot Study in Patients With Irritable Bowel Syndrome Gastroenterology. 153 2 2017 448 59.e8.","DOI":"10.1053\/j.gastro.2017.05.003"},{"issue":"50","key":"10.1016\/j.bbi.2020.10.013_b0220","doi-asserted-by":"crossref","first-page":"16362","DOI":"10.1523\/JNEUROSCI.1392-15.2015","article-title":"Sex Differences in Nucleus Accumbens Transcriptome Profiles Associated with Susceptibility versus Resilience to Subchronic Variable Stress","volume":"35","author":"Hodes","year":"2015","journal-title":"J Neurosci."},{"issue":"10","key":"10.1016\/j.bbi.2020.10.013_b0225","doi-asserted-by":"crossref","first-page":"5390","DOI":"10.1096\/fj.201800030R","article-title":"Dietary polyphenols promote resilience against sleep deprivation-induced cognitive impairment by activating protein translation","volume":"32","author":"Frolinger","year":"2018","journal-title":"Faseb j."},{"key":"10.1016\/j.bbi.2020.10.013_b0230","article-title":"Use of the Open Field Maze to measure locomotor and anxiety-like behavior in mice","volume":"96","author":"Seibenhener","year":"2015","journal-title":"J Vis Exp."},{"key":"10.1016\/j.bbi.2020.10.013_b0235","article-title":"The mouse forced swim test","volume":"59","author":"Can","year":"2012","journal-title":"J Vis Exp."},{"key":"10.1016\/j.bbi.2020.10.013_b0240","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.jnutbio.2018.10.019","article-title":"Heterogeneity in gut microbiota drive polyphenol metabolism that influences \u03b1-synuclein misfolding and toxicity","volume":"64","author":"Ho","year":"2019","journal-title":"The Journal of Nutritional Biochemistry."},{"issue":"4","key":"10.1016\/j.bbi.2020.10.013_b0245","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods."},{"issue":"1","key":"10.1016\/j.bbi.2020.10.013_b0250","doi-asserted-by":"crossref","first-page":"9859","DOI":"10.1038\/s41598-018-28333-w","article-title":"Evaluation at scale of microbiome-derived metabolites as biomarker of flavan-3-ol intake in epidemiological studies","volume":"8","author":"Ottaviani","year":"2018","journal-title":"Scientific Reports."},{"issue":"1","key":"10.1016\/j.bbi.2020.10.013_b0255","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1097\/MED.0b013e32831e9c8e","article-title":"Serotonin in the gastrointestinal tract","volume":"16","author":"Camilleri","year":"2009","journal-title":"Curr Opin Endocrinol Diabetes Obes."},{"issue":"6","key":"10.1016\/j.bbi.2020.10.013_b0260","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1016\/j.immuni.2017.06.008","article-title":"Mechanisms and Therapeutic Relevance of Neuro-immune Communication","volume":"46","author":"Chavan","year":"2017","journal-title":"Immunity."},{"issue":"4","key":"10.1016\/j.bbi.2020.10.013_b0265","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.3233\/JAD-160189","article-title":"Chronic Stress Aggravates Cognitive Impairment and Suppresses Insulin Associated Signaling Pathway in APP\/PS1 Mice","volume":"53","author":"Han","year":"2016","journal-title":"J Alzheimers Dis."},{"key":"10.1016\/j.bbi.2020.10.013_b0270","first-page":"461","volume":"5","author":"Kawasaki","year":"2014","journal-title":"Toll-like receptor signaling pathways. Front Immunol."},{"issue":"4","key":"10.1016\/j.bbi.2020.10.013_b0275","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1038\/s41385-018-0019-2","article-title":"Aryl hydrocarbon receptor and intestinal immunity","volume":"11","author":"Lamas","year":"2018","journal-title":"Mucosal Immunol."},{"issue":"1","key":"10.1016\/j.bbi.2020.10.013_b0280","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.immuni.2017.12.012","article-title":"Regulation of the Immune Response by the Aryl Hydrocarbon Receptor","volume":"48","author":"Guti\u00e9rrez-V\u00e1zquez","year":"2018","journal-title":"Immunity."},{"key":"10.1016\/j.bbi.2020.10.013_b0285","doi-asserted-by":"crossref","first-page":"6309219","DOI":"10.1155\/2016\/6309219","article-title":"Balancing Inflammation: The Link between Th17 and Regulatory T Cells","volume":"2016","author":"Diller","year":"2016","journal-title":"Mediators Inflamm."},{"issue":"1","key":"10.1016\/j.bbi.2020.10.013_b0290","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1021\/tx7001965","article-title":"The search for endogenous activators of the aryl hydrocarbon receptor","volume":"21","author":"Nguyen","year":"2008","journal-title":"Chem Res Toxicol."},{"issue":"7","key":"10.1016\/j.bbi.2020.10.013_b0295","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1016\/j.biopsych.2016.12.031","article-title":"Targeting the Microbiota-Gut-Brain Axis: Prebiotics Have Anxiolytic and Antidepressant-like Effects and Reverse the Impact of Chronic Stress in Mice","volume":"82","author":"Burokas","year":"2017","journal-title":"Biol Psychiatry."},{"key":"10.1016\/j.bbi.2020.10.013_b0300","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1016\/j.neuroscience.2015.09.033","article-title":"Administration of Lactobacillus helveticus NS8 improves behavioral, cognitive, and biochemical aberrations caused by chronic restraint stress","volume":"310","author":"Liang","year":"2015","journal-title":"Neuroscience."},{"issue":"Pt B","key":"10.1016\/j.bbi.2020.10.013_b0305","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.brainres.2018.03.015","article-title":"Neurotransmitter modulation by the gut microbiota","volume":"1693","author":"Strandwitz","year":"2018","journal-title":"Brain Res."},{"key":"10.1016\/j.bbi.2020.10.013_b0310","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1186\/s12970-016-0155-6","article-title":"Exercise-induced stress behavior, gut-microbiota-brain axis and diet: a systematic review for athletes","volume":"13","author":"Clark","year":"2016","journal-title":"J Int Soc Sports Nutr."},{"issue":"5","key":"10.1016\/j.bbi.2020.10.013_b0315","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1016\/j.clinthera.2015.04.002","article-title":"Gut-Microbiota-Brain Axis and Its Effect on Neuropsychiatric Disorders With Suspected Immune Dysregulation","volume":"37","author":"Petra","year":"2015","journal-title":"Clin Ther."},{"key":"10.1016\/j.bbi.2020.10.013_b0320","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.neubiorev.2013.11.009","article-title":"Stress, serotonin, and hippocampal neurogenesis in relation to depression and antidepressant effects","volume":"38","author":"Mahar","year":"2014","journal-title":"Neurosci Biobehav Rev."},{"key":"10.1016\/j.bbi.2020.10.013_b0325","article-title":"Can psychobiotics \u201cmood\u201d ify gut? An update systematic review of randomized controlled trials in healthy and clinical subjects, on anti-depressant effects of probiotics, prebiotics, and synbiotics","author":"Vaghef-Mehrabany","year":"2019","journal-title":"Clin Nutr"},{"issue":"5","key":"10.1016\/j.bbi.2020.10.013_b0330","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1111\/1751-7915.12789","article-title":"Synbiotic approaches to human health and well-being","volume":"10","author":"Gurry","year":"2017","journal-title":"Microb Biotechnol."},{"issue":"1","key":"10.1016\/j.bbi.2020.10.013_b0335","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1002\/hup.178","article-title":"How valuable are animal models in defining antidepressant activity?","volume":"16","author":"Bourin","year":"2001","journal-title":"Hum Psychopharmacol."},{"key":"10.1016\/j.bbi.2020.10.013_b0340","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.bbr.2014.07.027","article-title":"Serotonin, tryptophan metabolism and the brain-gut-microbiome axis","volume":"277","author":"O'Mahony","year":"2015","journal-title":"Behav Brain Res."},{"key":"10.1016\/j.bbi.2020.10.013_b0345","doi-asserted-by":"crossref","first-page":"90","DOI":"10.3389\/fphar.2012.00090","article-title":"A Distinct Profile of Tryptophan Metabolism along the Kynurenine Pathway Downstream of Toll-Like Receptor Activation in Irritable Bowel Syndrome","volume":"3","author":"Clarke","year":"2012","journal-title":"Front Pharmacol."},{"key":"10.1016\/j.bbi.2020.10.013_b0350","doi-asserted-by":"crossref","first-page":"2838","DOI":"10.3389\/fimmu.2018.02838","article-title":"Butyrate Produced by Commensal Bacteria Down-Regulates Indolamine 2,3-Dioxygenase 1 (IDO-1) Expression via a Dual Mechanism in Human Intestinal Epithelial Cells","volume":"9","author":"Martin-Gallausiaux","year":"2018","journal-title":"Front Immunol."},{"issue":"3","key":"10.1016\/j.bbi.2020.10.013_b0355","doi-asserted-by":"crossref","DOI":"10.3390\/ph11030063","article-title":"Role of Microbiota and Tryptophan Metabolites in the Remote Effect of Intestinal Inflammation on Brain and Depression","volume":"11","author":"Waclawikov\u00e1","year":"2018","journal-title":"Pharmaceuticals (Basel)"},{"issue":"3","key":"10.1016\/j.bbi.2020.10.013_b0360","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1111\/cei.12586","article-title":"van Drunen Littel-van den Hurk S. Indolamine 2,3-dioxygenase expression by monocytes and dendritic cell populations in hepatitis C patients","volume":"180","author":"Schulz","year":"2015","journal-title":"Clin Exp Immunol."},{"issue":"2","key":"10.1016\/j.bbi.2020.10.013_b0365","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.tips.2012.09.006","article-title":"An expanding range of targets for kynurenine metabolites of tryptophan","volume":"34","author":"Stone","year":"2013","journal-title":"Trends Pharmacol Sci."},{"key":"10.1016\/j.bbi.2020.10.013_b0370","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1186\/1742-2094-8-94","article-title":"Severe depression is associated with increased microglial quinolinic acid in subregions of the anterior cingulate gyrus: evidence for an immune-modulated glutamatergic neurotransmission?","volume":"8","author":"Steiner","year":"2011","journal-title":"J Neuroinflammation."},{"key":"10.1016\/j.bbi.2020.10.013_b0375","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1007\/7854_2016_12","article-title":"Role of Kynurenine Metabolism Pathway Activation in Major Depressive Disorders","volume":"31","author":"Savitz","year":"2017","journal-title":"Curr Top Behav Neurosci."},{"issue":"8","key":"10.1016\/j.bbi.2020.10.013_b0380","doi-asserted-by":"crossref","DOI":"10.1038\/tp.2016.133","article-title":"An enzyme in the kynurenine pathway that governs vulnerability to suicidal behavior by regulating excitotoxicity and neuroinflammation","volume":"6","author":"Brundin","year":"2016","journal-title":"Transl Psychiatry."},{"issue":"6","key":"10.1016\/j.bbi.2020.10.013_b0385","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0131389","article-title":"Expression of the Kynurenine Pathway in Human Peripheral Blood Mononuclear Cells: Implications for Inflammatory and Neurodegenerative Disease","volume":"10","author":"Jones","year":"2015","journal-title":"PLoS One."},{"key":"10.1016\/j.bbi.2020.10.013_b0390","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1038\/s42003-019-0520-5","article-title":"A brain-permeable inhibitor of the neurodegenerative disease target kynurenine 3-monooxygenase prevents accumulation of neurotoxic metabolites","volume":"2","author":"Zhang","year":"2019","journal-title":"Commun Biol."},{"key":"10.1016\/j.bbi.2020.10.013_b0395","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.bbr.2017.04.020","article-title":"The influence of stress on neuroinflammation and alterations in brain structure and function in major depressive disorder","volume":"329","author":"Kim","year":"2017","journal-title":"Behav Brain Res."},{"issue":"4","key":"10.1016\/j.bbi.2020.10.013_b0400","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1046\/j.1471-4159.2003.01604.x","article-title":"Novel glucocorticoid effects on acute inflammation in the CNS","volume":"84","author":"Dinkel","year":"2003","journal-title":"J Neurochem."},{"issue":"41","key":"10.1016\/j.bbi.2020.10.013_b0405","doi-asserted-by":"crossref","first-page":"13690","DOI":"10.1523\/JNEUROSCI.0303-09.2010","article-title":"Glucocorticoids exacerbate lipopolysaccharide-induced signaling in the frontal cortex and hippocampus in a dose-dependent manner","volume":"30","author":"Munhoz","year":"2010","journal-title":"J Neurosci."},{"issue":"6","key":"10.1016\/j.bbi.2020.10.013_b0410","doi-asserted-by":"crossref","first-page":"2669","DOI":"10.1073\/pnas.0910658107","article-title":"Nuclear factor-kappaB is a critical mediator of stress-impaired neurogenesis and depressive behavior","volume":"107","author":"Koo","year":"2010","journal-title":"Proc Natl Acad Sci U S A."},{"issue":"5","key":"10.1016\/j.bbi.2020.10.013_b0415","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1016\/j.biopsych.2009.09.033","article-title":"A meta-analysis of cytokines in major depression","volume":"67","author":"Dowlati","year":"2010","journal-title":"Biol Psychiatry."},{"issue":"2","key":"10.1016\/j.bbi.2020.10.013_b0420","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1097\/PSY.0b013e3181907c1b","article-title":"Associations of depression with C-reactive protein, IL-1, and IL-6: a meta-analysis","volume":"71","author":"Howren","year":"2009","journal-title":"Psychosom Med."},{"key":"10.1016\/j.bbi.2020.10.013_b0425","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.bbi.2014.05.007","article-title":"Evidence for increased microglial priming and macrophage recruitment in the dorsal anterior cingulate white matter of depressed suicides","volume":"42","author":"Torres-Platas","year":"2014","journal-title":"Brain Behav Immun."},{"issue":"7","key":"10.1016\/j.bbi.2020.10.013_b0430","doi-asserted-by":"crossref","first-page":"2089","DOI":"10.1523\/JNEUROSCI.3567-08.2009","article-title":"Cerebral microglia recruit monocytes into the brain in response to tumor necrosis factoralpha signaling during peripheral organ inflammation","volume":"29","author":"D'Mello","year":"2009","journal-title":"J Neurosci."},{"issue":"1","key":"10.1016\/j.bbi.2020.10.013_b0435","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1124\/pr.113.008144","article-title":"Neuroinflammation and comorbidity of pain and depression","volume":"66","author":"Walker","year":"2014","journal-title":"Pharmacol Rev."},{"issue":"12","key":"10.1016\/j.bbi.2020.10.013_b0440","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1016\/j.biopsych.2013.11.029","article-title":"Re-establishment of anxiety in stress-sensitized mice is caused by monocyte trafficking from the spleen to the brain","volume":"75","author":"Wohleb","year":"2014","journal-title":"Biol Psychiatry."},{"issue":"10","key":"10.1016\/j.bbi.2020.10.013_b0445","doi-asserted-by":"crossref","first-page":"1440","DOI":"10.1038\/mp.2016.118","article-title":"Cellular and molecular basis for stress-induced depression","volume":"22","author":"Seo","year":"2017","journal-title":"Mol Psychiatry."},{"issue":"6","key":"10.1016\/j.bbi.2020.10.013_b0450","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/j.biopsych.2018.09.031","article-title":"The Impact of Stress and Major Depressive Disorder on Hippocampal and Medial Prefrontal Cortex Morphology","volume":"85","author":"Belleau","year":"2019","journal-title":"Biol Psychiatry."},{"issue":"3","key":"10.1016\/j.bbi.2020.10.013_b0455","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/j.mehy.2003.10.009","article-title":"The potential pathogenetic link between peripheral immune activation and the central innate immune response in neuropsychiatric systemic lupus erythematosus","volume":"62","author":"Tomita","year":"2004","journal-title":"Med Hypotheses."},{"key":"10.1016\/j.bbi.2020.10.013_b0460","doi-asserted-by":"crossref","first-page":"232","DOI":"10.3389\/fneur.2019.00232","article-title":"Peripheral-Central Neuroimmune Crosstalk in Parkinson's Disease: What Do Patients and Animal Models Tell Us?","volume":"10","author":"Fuzzati-Armentero","year":"2019","journal-title":"Front Neurol."},{"key":"10.1016\/j.bbi.2020.10.013_b0465","doi-asserted-by":"crossref","first-page":"2231","DOI":"10.3389\/fimmu.2019.02231","article-title":"Mimicry of Central-Peripheral Immunity in Alzheimer's Disease and Discovery of Neurodegenerative Roles in Neutrophil","volume":"10","author":"Park","year":"2019","journal-title":"Front Immunol."},{"issue":"1","key":"10.1016\/j.bbi.2020.10.013_b0470","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1186\/s12974-019-1453-0","article-title":"Exploiting microglial and peripheral immune cell crosstalk to treat Alzheimer's disease","volume":"16","author":"Dionisio-Santos","year":"2019","journal-title":"J Neuroinflammation."},{"key":"10.1016\/j.bbi.2020.10.013_b0475","doi-asserted-by":"crossref","first-page":"216","DOI":"10.3389\/fncel.2017.00216","article-title":"Brain and Peripheral Atypical Inflammatory Mediators Potentiate Neuroinflammation and Neurodegeneration","volume":"11","author":"Kempuraj","year":"2017","journal-title":"Front Cell Neurosci."},{"key":"10.1016\/j.bbi.2020.10.013_b0480","doi-asserted-by":"crossref","first-page":"7254016","DOI":"10.1155\/2018\/7254016","article-title":"TLR4-NF-\u03baB Signal Involved in Depressive-Like Behaviors and Cytokine Expression of Frontal Cortex and Hippocampus in Stressed C57BL\/6 and ob\/ob Mice","volume":"2018","author":"Wang","year":"2018","journal-title":"Neural Plast."},{"key":"10.1016\/j.bbi.2020.10.013_b0485","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.bbi.2018.06.010","article-title":"Principles of inflammasome priming and inhibition: Implications for psychiatric disorders","volume":"73","author":"Herman","year":"2018","journal-title":"Brain Behav Immun."},{"issue":"8","key":"10.1016\/j.bbi.2020.10.013_b0490","doi-asserted-by":"crossref","DOI":"10.1093\/ijnp\/pyv006","article-title":"NLRP3 Inflammasome Mediates Chronic Mild Stress-Induced Depression in Mice via Neuroinflammation","volume":"18","author":"Zhang","year":"2015","journal-title":"Int J Neuropsychopharmacol."},{"key":"10.1016\/j.bbi.2020.10.013_b0495","doi-asserted-by":"crossref","first-page":"2566","DOI":"10.3389\/fimmu.2018.02566","article-title":"The Role of NLRP3 and IL-1\u03b2 in the Pathogenesis of Inflammatory Bowel Disease","volume":"9","author":"Mao","year":"2018","journal-title":"Front Immunol."},{"issue":"5","key":"10.1016\/j.bbi.2020.10.013_b0500","article-title":"Nlrp3-dependent IL-1\u03b2 inhibits CD103+ dendritic cell differentiation in the gut. JCI","volume":"3","author":"Mak'Anyengo","year":"2018","journal-title":"Insight."},{"issue":"4","key":"10.1016\/j.bbi.2020.10.013_b0505","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1038\/mi.2015.109","article-title":"Posttranscriptional control of NLRP3 inflammasome activation in colonic macrophages","volume":"9","author":"Filardy","year":"2016","journal-title":"Mucosal Immunol."},{"key":"10.1016\/j.bbi.2020.10.013_b0510","first-page":"447","article-title":"Monocyte trafficking to the brain with stress and inflammation: a novel axis of immune-to-brain communication that influences mood and behavior","volume":"8","author":"Wohleb","year":"2014","journal-title":"Front Neurosci."},{"issue":"34","key":"10.1016\/j.bbi.2020.10.013_b0515","doi-asserted-by":"crossref","first-page":"13820","DOI":"10.1523\/JNEUROSCI.1671-13.2013","article-title":"Stress-induced recruitment of bone marrow-derived monocytes to the brain promotes anxiety-like behavior","volume":"33","author":"Wohleb","year":"2013","journal-title":"J Neurosci."},{"issue":"9","key":"10.1016\/j.bbi.2020.10.013_b0520","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1016\/j.psyneuen.2012.05.008","article-title":"Stress-induced redistribution of immune cells\u2013from barracks to boulevards to battlefields: a tale of three hormones\u2013Curt Richter Award winner","volume":"37","author":"Dhabhar","year":"2012","journal-title":"Psychoneuroendocrinology."},{"issue":"13","key":"10.1016\/j.bbi.2020.10.013_b0525","doi-asserted-by":"crossref","first-page":"E2960","DOI":"10.1073\/pnas.1720696115","article-title":"Chronic stress promotes colitis by disturbing the gut microbiota and triggering immune system response","volume":"115","author":"Gao","year":"2018","journal-title":"Proc Natl Acad Sci U S A."},{"issue":"6","key":"10.1016\/j.bbi.2020.10.013_b0530","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1182\/blood-2018-02-832519","article-title":"Hematopoiesis and the bacterial microbiome","volume":"132","author":"Yan","year":"2018","journal-title":"Blood."},{"issue":"4","key":"10.1016\/j.bbi.2020.10.013_b0535","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.jnutbio.2003.11.008","article-title":"Butyrate inhibits cytokine-induced VCAM-1 and ICAM-1 expression in cultured endothelial cells: the role of NF-kappaB and PPARalpha","volume":"15","author":"Zapolska-Downar","year":"2004","journal-title":"J Nutr Biochem."},{"issue":"12","key":"10.1016\/j.bbi.2020.10.013_b0540","doi-asserted-by":"crossref","first-page":"1186","DOI":"10.1016\/j.jnutbio.2009.10.004","article-title":"Butyrate reduced lipopolysaccharide-mediated macrophage migration by suppression of Src enhancement and focal adhesion kinase activity","volume":"21","author":"Maa","year":"2010","journal-title":"J Nutr Biochem."},{"issue":"3","key":"10.1016\/j.bbi.2020.10.013_b0545","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1093\/ibd\/izx029","article-title":"A Cross-Talk Between Microbiota-Derived Short-Chain Fatty Acids and the Host Mucosal Immune System Regulates Intestinal Homeostasis and Inflammatory Bowel Disease","volume":"24","author":"Gon\u00e7alves","year":"2018","journal-title":"Inflamm Bowel Dis."},{"issue":"12","key":"10.1016\/j.bbi.2020.10.013_b0550","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.5551\/jat.8136","article-title":"Resveratrol inhibits monocytic cell chemotaxis to MCP-1 and prevents spontaneous endothelial cell migration through Rho kinase-dependent mechanism","volume":"18","author":"Cicha","year":"2011","journal-title":"J Atheroscler Thromb."},{"issue":"1","key":"10.1016\/j.bbi.2020.10.013_b0555","doi-asserted-by":"crossref","first-page":"645","DOI":"10.3892\/mmr.2014.2768","article-title":"Effects of grape seed proanthocyanidin extract on renal injury in type 2 diabetic rats","volume":"11","author":"Bao","year":"2015","journal-title":"Mol Med Rep."},{"issue":"7","key":"10.1016\/j.bbi.2020.10.013_b0560","doi-asserted-by":"crossref","DOI":"10.3390\/ijms18071363","article-title":"5-(3',4'-Dihydroxyphenyl-\u03b3-valerolactone), a Major Microbial Metabolite of Proanthocyanidin, Attenuates THP-1 Monocyte-Endothelial Adhesion","volume":"18","author":"Lee","year":"2017","journal-title":"Int J Mol Sci."},{"issue":"5","key":"10.1016\/j.bbi.2020.10.013_b0565","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1093\/ajcn\/73.5.941","article-title":"Effect of plasma metabolites of (+)-catechin and quercetin on monocyte adhesion to human aortic endothelial cells","volume":"73","author":"Koga","year":"2001","journal-title":"Am J Clin Nutr."},{"issue":"5","key":"10.1016\/j.bbi.2020.10.013_b0570","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1038\/mi.2008.28","article-title":"IL-23 and Th17 cytokines in intestinal homeostasis","volume":"1","author":"Maloy","year":"2008","journal-title":"Mucosal Immunol."},{"issue":"6251","key":"10.1016\/j.bbi.2020.10.013_b0575","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1126\/science.aac4263","article-title":"MUCOSAL IMMUNOLOGY. The microbiota regulates type 2 immunity through ROR\u03b3t+ T cells","volume":"349","author":"Ohnmacht","year":"2015","journal-title":"Science."},{"issue":"7368","key":"10.1016\/j.bbi.2020.10.013_b0580","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1038\/nature10434","article-title":"Peripheral education of the immune system by colonic commensal microbiota","volume":"478","author":"Lathrop","year":"2011","journal-title":"Nature."},{"issue":"6015","key":"10.1016\/j.bbi.2020.10.013_b0585","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1126\/science.1198469","article-title":"Induction of colonic regulatory T cells by indigenous Clostridium species","volume":"331","author":"Atarashi","year":"2011","journal-title":"Science."},{"issue":"7503","key":"10.1016\/j.bbi.2020.10.013_b0590","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1038\/nature13279","article-title":"Focused specificity of intestinal TH17 cells towards commensal bacterial antigens","volume":"510","author":"Yang","year":"2014","journal-title":"Nature."},{"issue":"41","key":"10.1016\/j.bbi.2020.10.013_b0595","doi-asserted-by":"crossref","first-page":"12770","DOI":"10.1073\/pnas.1516617112","article-title":"Requirement of full TCR repertoire for regulatory T cells to maintain intestinal homeostasis","volume":"112","author":"Nishio","year":"2015","journal-title":"Proc Natl Acad Sci U S A."},{"issue":"5","key":"10.1016\/j.bbi.2020.10.013_b0600","doi-asserted-by":"crossref","DOI":"10.1038\/emm.2017.36","article-title":"Microbiota in T-cell homeostasis and inflammatory diseases","volume":"49","author":"Lee","year":"2017","journal-title":"Exp Mol Med."},{"issue":"1","key":"10.1016\/j.bbi.2020.10.013_b0605","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1038\/cr.2009.138","article-title":"Heterogeneity and plasticity of T helper cells","volume":"20","author":"Zhu","year":"2010","journal-title":"Cell Res."},{"key":"10.1016\/j.bbi.2020.10.013_b0610","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/bs.pmbts.2015.07.013","article-title":"The Special Relationship in the Development and Function of T Helper 17 and Regulatory T Cells","volume":"136","author":"Lochner","year":"2015","journal-title":"Prog Mol Biol Transl Sci."},{"issue":"7","key":"10.1016\/j.bbi.2020.10.013_b0615","doi-asserted-by":"crossref","first-page":"4148","DOI":"10.4049\/jimmunol.1001536","article-title":"IL-1\u03b2-mediated signals preferentially drive conversion of regulatory T cells but not conventional T cells into IL-17-producing cells","volume":"185","author":"Li","year":"2010","journal-title":"J Immunol."},{"key":"10.1016\/j.bbi.2020.10.013_b0620","doi-asserted-by":"crossref","first-page":"232","DOI":"10.3389\/fimmu.2013.00232","article-title":"Peripherally induced tregs - role in immune homeostasis and autoimmunity","volume":"4","author":"Yadav","year":"2013","journal-title":"Front Immunol."},{"issue":"3","key":"10.1016\/j.bbi.2020.10.013_b0625","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.jnutbio.2014.10.011","article-title":"A potential role for regulatory T-cells in the amelioration of DSS induced colitis by dietary non-digestible polysaccharides","volume":"26","author":"Hartog","year":"2015","journal-title":"J Nutr Biochem."},{"key":"10.1016\/j.bbi.2020.10.013_b0630","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.clim.2018.09.010","article-title":"Tolerogenic dendritic cells induced the enrichment of CD4(+)Foxp3(+) regulatory T cells via TGF-\u03b2 in mesenteric lymph nodes of murine LPS-induced tolerance model","volume":"197","author":"Jia","year":"2018","journal-title":"Clin Immunol."},{"issue":"11","key":"10.1016\/j.bbi.2020.10.013_b0635","doi-asserted-by":"crossref","DOI":"10.3390\/nu10111618","article-title":"The Immunomodulatory and Anti-Inflammatory Role of Polyphenols","volume":"10","author":"Yahfoufi","year":"2018","journal-title":"Nutrients."},{"key":"10.1016\/j.bbi.2020.10.013_b0640","doi-asserted-by":"crossref","first-page":"669","DOI":"10.3389\/fimmu.2018.00669","article-title":"Intestinal Microbiota at Engraftment Influence Acute Graft-Versus-Host Disease via the Treg\/Th17 Balance in Allo-HSCT Recipients","volume":"9","author":"Han","year":"2018","journal-title":"Front Immunol."},{"issue":"2","key":"10.1016\/j.bbi.2020.10.013_b0645","doi-asserted-by":"crossref","first-page":"G177","DOI":"10.1152\/ajpgi.00038.2014","article-title":"Lactobacillus reuteri DSM 17938 differentially modulates effector memory T cells and Foxp3+ regulatory T cells in a mouse model of necrotizing enterocolitis","volume":"307","author":"Liu","year":"2014","journal-title":"Am J Physiol Gastrointest Liver Physiol."},{"issue":"3","key":"10.1016\/j.bbi.2020.10.013_b0650","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/j.cell.2009.09.033","article-title":"Induction of intestinal Th17 cells by segmented filamentous bacteria","volume":"139","author":"Ivanov","year":"2009","journal-title":"Cell."},{"issue":"4","key":"10.1016\/j.bbi.2020.10.013_b0655","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1016\/j.immuni.2014.03.005","article-title":"Segmented filamentous bacteria antigens presented by intestinal dendritic cells drive mucosal Th17 cell differentiation","volume":"40","author":"Goto","year":"2014","journal-title":"Immunity."},{"issue":"4","key":"10.1016\/j.bbi.2020.10.013_b0660","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1111\/imm.12760","article-title":"The immune response to Prevotella bacteria in chronic inflammatory disease","volume":"151","author":"Larsen","year":"2017","journal-title":"Immunology."},{"key":"10.1016\/j.bbi.2020.10.013_b0665","doi-asserted-by":"crossref","first-page":"58","DOI":"10.3389\/fimmu.2015.00058","article-title":"The Coevolution of IDO1 and AhR in the Emergence of Regulatory T-Cells in Mammals","volume":"6","author":"Grohmann","year":"2015","journal-title":"Front Immunol."},{"issue":"2","key":"10.1016\/j.bbi.2020.10.013_b0670","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/j.bbrc.2011.06.018","article-title":"AhR deficiency impairs expression of LPS-induced inflammatory genes in mice","volume":"410","author":"Wu","year":"2011","journal-title":"Biochem Biophys Res Commun."},{"key":"10.1016\/j.bbi.2020.10.013_b0675","doi-asserted-by":"crossref","first-page":"16014","DOI":"10.1038\/npjbiofilms.2016.14","article-title":"Bidirectional communication between the Aryl hydrocarbon Receptor (AhR) and the microbiome tunes host metabolism","volume":"2","author":"Korecka","year":"2016","journal-title":"NPJ Biofilms Microbiomes."},{"issue":"6","key":"10.1016\/j.bbi.2020.10.013_b0680","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1038\/icb.2010.35","article-title":"Activation of the aryl hydrocarbon receptor pathway may ameliorate dextran sodium sulfate-induced colitis in mice","volume":"88","author":"Takamura","year":"2010","journal-title":"Immunol Cell Biol."},{"key":"10.1016\/j.bbi.2020.10.013_b0685","doi-asserted-by":"crossref","first-page":"640","DOI":"10.3389\/fimmu.2014.00640","article-title":"Tryptophan Feeding of the IDO1-AhR Axis in Host-Microbial Symbiosis","volume":"5","author":"Zelante","year":"2014","journal-title":"Front Immunol."},{"key":"10.1016\/j.bbi.2020.10.013_b0690","doi-asserted-by":"crossref","first-page":"12689","DOI":"10.1038\/srep12689","article-title":"Adaptation of the human aryl hydrocarbon receptor to sense microbiota-derived indoles","volume":"5","author":"Hubbard","year":"2015","journal-title":"Sci Rep."},{"key":"10.1016\/j.bbi.2020.10.013_b0695","first-page":"458","article-title":"The aryl hydrocarbon receptor meets immunology: friend or foe?","volume":"5","author":"Julliard","year":"2014","journal-title":"A little of both. Front Immunol."},{"issue":"10","key":"10.1016\/j.bbi.2020.10.013_b0700","doi-asserted-by":"crossref","first-page":"1760","DOI":"10.1080\/10408398.2019.1598334","article-title":"Tryptophan (Trp) modulates gut homeostasis via aryl hydrocarbon receptor (AhR)","volume":"60","author":"Sun","year":"2020","journal-title":"Crit Rev Food Sci Nutr."},{"issue":"3","key":"10.1016\/j.bbi.2020.10.013_b0705","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.bbrc.2008.07.156","article-title":"Aryl hydrocarbon receptor signaling mediates expression of indoleamine 2,3-dioxygenase","volume":"375","author":"Vogel","year":"2008","journal-title":"Biochem Biophys Res Commun."},{"issue":"48","key":"10.1016\/j.bbi.2020.10.013_b0710","doi-asserted-by":"crossref","first-page":"20768","DOI":"10.1073\/pnas.1009201107","article-title":"An endogenous aryl hydrocarbon receptor ligand acts on dendritic cells and T cells to suppress experimental autoimmune encephalomyelitis","volume":"107","author":"Quintana","year":"2010","journal-title":"Proc Natl Acad Sci U S A."},{"issue":"11","key":"10.1016\/j.bbi.2020.10.013_b0715","doi-asserted-by":"crossref","first-page":"6752","DOI":"10.4049\/jimmunol.176.11.6752","article-title":"The combined effects of tryptophan starvation and tryptophan catabolites down-regulate T cell receptor zeta-chain and induce a regulatory phenotype in naive T cells","volume":"176","author":"Fallarino","year":"2006","journal-title":"J Immunol."},{"issue":"6","key":"10.1016\/j.bbi.2020.10.013_b0720","doi-asserted-by":"crossref","first-page":"3190","DOI":"10.4049\/jimmunol.0903670","article-title":"An interaction between kynurenine and the aryl hydrocarbon receptor can generate regulatory T cells","volume":"185","author":"Mezrich","year":"2010","journal-title":"J Immunol."},{"issue":"46","key":"10.1016\/j.bbi.2020.10.013_b0725","doi-asserted-by":"crossref","first-page":"19961","DOI":"10.1073\/pnas.1014465107","article-title":"Aryl hydrocarbon receptor negatively regulates dendritic cell immunogenicity via a kynurenine-dependent mechanism","volume":"107","author":"Nguyen","year":"2010","journal-title":"Proc Natl Acad Sci U S A."},{"key":"10.1016\/j.bbi.2020.10.013_b0730","doi-asserted-by":"crossref","first-page":"880","DOI":"10.3389\/fimmu.2017.00880","article-title":"The IDO-AhR Axis Controls Th17\/Treg Immunity in a Pulmonary Model of Fungal Infection","volume":"8","author":"de Ara\u00fajo","year":"2017","journal-title":"Front Immunol."},{"issue":"6","key":"10.1016\/j.bbi.2020.10.013_b0735","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1038\/nm.4106","article-title":"Type I interferons and microbial metabolites of tryptophan modulate astrocyte activity and central nervous system inflammation via the aryl hydrocarbon receptor","volume":"22","author":"Rothhammer","year":"2016","journal-title":"Nat Med."},{"issue":"Pt C","key":"10.1016\/j.bbi.2020.10.013_b0740","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.pnpbp.2017.04.035","article-title":"IDO chronic immune activation and tryptophan metabolic pathway: A potential pathophysiological link between depression and obesity","volume":"80","author":"Chaves Filho","year":"2018","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry."},{"issue":"1","key":"10.1016\/j.bbi.2020.10.013_b0745","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1186\/s12974-019-1572-7","article-title":"Aryl hydrocarbon receptor modulates stroke-induced astrogliosis and neurogenesis in the adult mouse brain","volume":"16","author":"Chen","year":"2019","journal-title":"J Neuroinflammation."},{"issue":"18","key":"10.1016\/j.bbi.2020.10.013_b0750","doi-asserted-by":"crossref","first-page":"3117","DOI":"10.1016\/j.phytochem.2007.07.022","article-title":"Influence of food polyphenols on aryl hydrocarbon receptor-signaling pathway estimated by in vitro bioassay","volume":"69","author":"Amakura","year":"2008","journal-title":"Phytochemistry."},{"issue":"9","key":"10.1016\/j.bbi.2020.10.013_b0755","doi-asserted-by":"crossref","first-page":"1878","DOI":"10.1021\/tx300169e","article-title":"Quercetin, resveratrol, and curcumin are indirect activators of the aryl hydrocarbon receptor (AHR)","volume":"25","author":"Mohammadi-Bardbori","year":"2012","journal-title":"Chem Res Toxicol."},{"issue":"4","key":"10.1016\/j.bbi.2020.10.013_b0760","doi-asserted-by":"crossref","DOI":"10.3390\/metabo8040086","article-title":"Urolithin A Is a Dietary Microbiota-Derived Human Aryl Hydrocarbon Receptor Antagonist","volume":"8","author":"Muku","year":"2018","journal-title":"Metabolites."},{"key":"10.1016\/j.bbi.2020.10.013_b0765","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.fct.2017.03.008","article-title":"Hydroxystilbenes and methoxystilbenes activate human aryl hydrocarbon receptor and induce CYP1A genes in human hepatoma cells and human hepatocytes","volume":"103","author":"Pastorkov\u00e1","year":"2017","journal-title":"Food Chem Toxicol."}],"container-title":["Brain, Behavior, and Immunity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0889159120323631?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0889159120323631?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T08:15:10Z","timestamp":1760170510000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0889159120323631"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":153,"alternative-id":["S0889159120323631"],"URL":"https:\/\/doi.org\/10.1016\/j.bbi.2020.10.013","relation":{},"ISSN":["0889-1591"],"issn-type":[{"value":"0889-1591","type":"print"}],"subject":[],"published":{"date-parts":[[2021,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Microbiota metabolites modulate the T helper 17 to regulatory T cell (Th17\/Treg) imbalance promoting resilience to stress-induced anxiety- and depressive-like behaviors","name":"articletitle","label":"Article Title"},{"value":"Brain, Behavior, and Immunity","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbi.2020.10.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}