{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T06:26:35Z","timestamp":1787984795743,"version":"build-2784847793"},"reference-count":40,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,12,17]],"date-time":"2020-12-17T00:00:00Z","timestamp":1608163200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100008384","name":"Stifterverband","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008384","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008384","name":"Stifterverband","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008384","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain, Behavior, and Immunity"],"published-print":{"date-parts":[[2021,2]]},"DOI":"10.1016\/j.bbi.2020.12.012","type":"journal-article","created":{"date-parts":[[2020,12,16]],"date-time":"2020-12-16T04:40:49Z","timestamp":1608093649000},"page":"232-242","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":43,"special_numbering":"C","title":["Neutrophil dynamics, plasticity and function in acute neurodegeneration following neonatal hypoxia\u2013ischemia"],"prefix":"10.1016","volume":"92","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8065-6901","authenticated-orcid":false,"given":"Kerstin","family":"M\u00fclling","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexa Josephine","family":"Fischer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Siakaeva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3110-6137","authenticated-orcid":false,"given":"Mathis","family":"Richter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8766-3135","authenticated-orcid":false,"given":"Sharareh","family":"Bordbari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilona","family":"Spyra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"K\u00f6ster","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dirk M.","family":"Hermann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5534-6055","authenticated-orcid":false,"given":"Matthias","family":"Gunzer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ursula","family":"Felderhoff-M\u00fcser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9751-3640","authenticated-orcid":false,"given":"Ivo","family":"Bendix","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jadwiga","family":"Jablonska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josephine","family":"Herz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"390\u2013402","key":"10.1016\/j.bbi.2020.12.012_b0005","article-title":"A Neutrophil Timer Coordinates Immune Defense and Vascular Protection","volume":"50","author":"Adrover","year":"2019","journal-title":"Immunity"},{"key":"10.1016\/j.bbi.2020.12.012_b0010","doi-asserted-by":"crossref","first-page":"2762","DOI":"10.1038\/s41467-020-16596-9","article-title":"Durable and controlled depletion of neutrophils in mice","volume":"11","author":"Boivin","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bbi.2020.12.012_b0015","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1203\/00006450-199904010-00008","article-title":"Chemokine and inflammatory cell response to hypoxia-ischemia in immature rats","volume":"45","author":"Bona","year":"1999","journal-title":"Pediatr. Res."},{"key":"10.1016\/j.bbi.2020.12.012_b0020","doi-asserted-by":"crossref","first-page":"3498","DOI":"10.1161\/STROKEAHA.113.002470","article-title":"N2 neutrophils, novel players in brain inflammation after stroke: modulation by the PPARgamma agonist rosiglitazone","volume":"44","author":"Cuartero","year":"2013","journal-title":"Stroke"},{"key":"10.1016\/j.bbi.2020.12.012_b0025","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1038\/jcbfm.2010.198","article-title":"Experimental stroke-induced changes in the bone marrow reveal complex regulation of leukocyte responses","volume":"31","author":"Denes","year":"2011","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.bbi.2020.12.012_b0030","doi-asserted-by":"crossref","first-page":"1985","DOI":"10.1056\/NEJMra041996","article-title":"Neonatal brain injury","volume":"351","author":"Ferriero","year":"2004","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.bbi.2020.12.012_b0035","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.cyto.2004.10.007","article-title":"The effects and comparative differences of neutrophil specific chemokines on neutrophil chemotaxis of the neonate","volume":"29","author":"Fox","year":"2005","journal-title":"Cytokine"},{"key":"10.1016\/j.bbi.2020.12.012_b0040","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.ccr.2009.06.017","article-title":"Polarization of tumor-associated neutrophil phenotype by TGF-beta: \u201cN1\u201d versus \u201cN2\u201d TAN","volume":"16","author":"Fridlender","year":"2009","journal-title":"Cancer Cell"},{"key":"10.1016\/j.bbi.2020.12.012_b0045","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1038\/s41583-020-0263-9","article-title":"Immune cell regulation of glia during CNS injury and disease","volume":"21","author":"Greenhalgh","year":"2020","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.bbi.2020.12.012_b0050","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1038\/nmeth.3322","article-title":"Catchup: a mouse model for imaging-based tracking and modulation of neutrophil granulocytes","volume":"12","author":"Hasenberg","year":"2015","journal-title":"Nat. Methods"},{"key":"10.1016\/j.bbi.2020.12.012_b0055","doi-asserted-by":"crossref","first-page":"e40","DOI":"10.1161\/STROKEAHA.118.021564","article-title":"Polymorphonuclear Neutrophils Play a Decisive Role for Brain Injury and Neurological Recovery Poststroke","volume":"50","author":"Hermann","year":"2019","journal-title":"Stroke"},{"key":"10.1016\/j.bbi.2020.12.012_b0060","doi-asserted-by":"crossref","first-page":"1696","DOI":"10.3389\/fimmu.2018.01696","article-title":"Peripheral T Cell Depletion by FTY720 Exacerbates Hypoxic-Ischemic Brain Injury in Neonatal Mice","volume":"9","author":"Herz","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.bbi.2020.12.012_b0065","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbi.2018.02.006","article-title":"Interaction between hypothermia and delayed mesenchymal stem cell therapy in neonatal hypoxic-ischemic brain injury","author":"Herz","year":"2018","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.bbi.2020.12.012_b0070","doi-asserted-by":"crossref","first-page":"2916","DOI":"10.1161\/STROKEAHA.115.010620","article-title":"Role of Neutrophils in Exacerbation of Brain Injury After Focal Cerebral Ischemia in Hyperlipidemic Mice","volume":"46","author":"Herz","year":"2015","journal-title":"Stroke"},{"key":"10.1016\/j.bbi.2020.12.012_b0075","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1016\/j.it.2019.04.013","article-title":"The Neutrophil Life Cycle","volume":"40","author":"Hidalgo","year":"2019","journal-title":"Trends Immunol."},{"key":"10.1016\/j.bbi.2020.12.012_b0080","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1203\/00006450-199705000-00002","article-title":"The role of neutrophils in the production of hypoxic-ischemic brain injury in the neonatal rat","volume":"41","author":"Hudome","year":"1997","journal-title":"Pediatr. Res."},{"key":"10.1016\/j.bbi.2020.12.012_b0085","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1189\/jlb.3MR0117-015R","article-title":"Neutrophil, quo vadis?","volume":"102","author":"Jablonska","year":"2017","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.bbi.2020.12.012_b0090","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1186\/s40478-019-0747-x","article-title":"Neutrophil extracellular trap induced by HMGB1 exacerbates damages in the ischemic brain","volume":"7","author":"Kim","year":"2019","journal-title":"Acta Neuropathol. Commun."},{"key":"10.1016\/j.bbi.2020.12.012_b0095","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0031814","article-title":"An automated method to quantify microglia morphology and application to monitor activation state longitudinally in vivo","volume":"7","author":"Kozlowski","year":"2012","journal-title":"PLoS ONE"},{"key":"10.1016\/j.bbi.2020.12.012_b0100","doi-asserted-by":"crossref","first-page":"23","DOI":"10.3389\/fped.2017.00023","article-title":"Age-Appropriate Functions and Dysfunctions of the Neonatal Neutrophil","volume":"5","author":"Lawrence","year":"2017","journal-title":"Front. Pediatr."},{"key":"10.1016\/j.bbi.2020.12.012_b0105","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1038\/s41419-018-0710-y","article-title":"Neutrophils induce macrophage anti-inflammatory reprogramming by suppressing NF-kappaB activation","volume":"9","author":"Marwick","year":"2018","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.bbi.2020.12.012_b0110","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1097\/SHK.0000000000000800","article-title":"LPS Stimulation of Cord Blood Reveals a Newborn-Specific Neutrophil Transcriptomic Response and Cytokine Production","volume":"47","author":"Mathias","year":"2017","journal-title":"Shock"},{"key":"10.1016\/j.bbi.2020.12.012_b0115","doi-asserted-by":"crossref","first-page":"315","DOI":"10.3109\/08830181003792803","article-title":"Neonatal sepsis and neutrophil insufficiencies","volume":"29","author":"Melvan","year":"2010","journal-title":"Int. Rev. Immunol."},{"key":"10.1016\/j.bbi.2020.12.012_b0120","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1038\/sj.jp.7211750","article-title":"Elevated total peripheral leukocyte count may identify risk for neurological disability in asphyxiated term neonates","volume":"27","author":"Morkos","year":"2007","journal-title":"J. Perinatol."},{"key":"10.1016\/j.bbi.2020.12.012_b0125","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0193970","article-title":"Beware the intruder: Real time observation of infiltrated neutrophils and neutrophil-Microglia interaction during stroke in vivo","volume":"13","author":"Neumann","year":"2018","journal-title":"PLoS ONE"},{"key":"10.1016\/j.bbi.2020.12.012_b0130","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1007\/s00401-014-1355-2","article-title":"Very-late-antigen-4 (VLA-4)-mediated brain invasion by neutrophils leads to interactions with microglia, increased ischemic injury and impaired behavior in experimental stroke","volume":"129","author":"Neumann","year":"2015","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.bbi.2020.12.012_b0135","doi-asserted-by":"crossref","first-page":"5965","DOI":"10.1523\/JNEUROSCI.0060-08.2008","article-title":"Microglia cells protect neurons by direct engulfment of invading neutrophil granulocytes: a new mechanism of CNS immune privilege","volume":"28","author":"Neumann","year":"2008","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bbi.2020.12.012_b0140","doi-asserted-by":"crossref","first-page":"6523","DOI":"10.4049\/jimmunol.176.11.6523","article-title":"Splenic atrophy in experimental stroke is accompanied by increased regulatory T cells and circulating macrophages","volume":"176","author":"Offner","year":"2006","journal-title":"J. Immunol."},{"key":"10.1016\/j.bbi.2020.12.012_b0145","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1002\/emmm.201202382","article-title":"Resolution of inflammation: an integrated view","volume":"5","author":"Ortega-Gomez","year":"2013","journal-title":"EMBO Mol. Med."},{"key":"10.1016\/j.bbi.2020.12.012_b0150","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1007\/s00401-018-1954-4","article-title":"Microglial cell loss after ischemic stroke favors brain neutrophil accumulation","volume":"137","author":"Otxoa-de-Amezaga","year":"2019","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.bbi.2020.12.012_b0155","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1203\/01.PDR.0000113546.03897.FC","article-title":"Timing of neutrophil depletion influences long-term neuroprotection in neonatal rat hypoxic-ischemic brain injury","volume":"55","author":"Palmer","year":"2004","journal-title":"Pediatr. Res."},{"key":"10.1016\/j.bbi.2020.12.012_b0160","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1002\/glia.20207","article-title":"Astrocyte activation and reactive gliosis","volume":"50","author":"Pekny","year":"2005","journal-title":"Glia"},{"key":"10.1016\/j.bbi.2020.12.012_b0165","doi-asserted-by":"crossref","first-page":"13285","DOI":"10.1038\/s41598-018-31675-0","article-title":"Cxcr1 mediates recruitment of neutrophils and supports proliferation of tumor-initiating astrocytes in vivo","volume":"8","author":"Powell","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbi.2020.12.012_b0170","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.expneurol.2016.06.024","article-title":"Endogenous hypothermic response to hypoxia reduces brain injury: Implications for modeling hypoxic-ischemic encephalopathy and therapeutic hypothermia in neonatal mice","volume":"283","author":"Reinboth","year":"2016","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.bbi.2020.12.012_b0175","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1186\/s12974-018-1344-9","article-title":"Peripheral myeloid cells contribute to brain injury in male neonatal mice","volume":"15","author":"Smith","year":"2018","journal-title":"J. Neuroinflammation."},{"key":"10.1016\/j.bbi.2020.12.012_b0180","doi-asserted-by":"crossref","first-page":"2327","DOI":"10.1182\/blood-2016-05-718999","article-title":"Aged neutrophils contribute to the first line of defense in the acute inflammatory response","volume":"128","author":"Uhl","year":"2016","journal-title":"Blood"},{"key":"10.1016\/j.bbi.2020.12.012_b0185","doi-asserted-by":"crossref","DOI":"10.1212\/NXI.0000000000000571","article-title":"Harmful neutrophil subsets in patients with ischemic stroke: Association with disease severity","volume":"6","author":"Weisenburger-Lile","year":"2019","journal-title":"Neurol. Neuroimmunol. Neuroinflamm."},{"key":"10.1016\/j.bbi.2020.12.012_b0190","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1186\/1742-2094-7-53","article-title":"Modulation of polymorphonuclear neutrophil functions by astrocytes","volume":"7","author":"Xie","year":"2010","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.bbi.2020.12.012_b0195","doi-asserted-by":"crossref","first-page":"3323","DOI":"10.1161\/STROKEAHA.110.608257","article-title":"Blood-brain barrier breakdown in acute and chronic cerebrovascular disease","volume":"42","author":"Yang","year":"2011","journal-title":"Stroke"},{"key":"10.1016\/j.bbi.2020.12.012_b0200","doi-asserted-by":"crossref","unstructured":"Yao, H.W., Kuan, C.Y., 2019. Early neutrophil infiltration is critical for inflammation-sensitized hypoxic-ischemic brain injury in newborns. J. Cereb. Blood Flow Metab., 271678X19891839.","DOI":"10.1177\/0271678X19891839"}],"container-title":["Brain, Behavior, and Immunity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0889159120324557?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0889159120324557?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T08:03:37Z","timestamp":1760169817000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0889159120324557"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2]]},"references-count":40,"alternative-id":["S0889159120324557"],"URL":"https:\/\/doi.org\/10.1016\/j.bbi.2020.12.012","relation":{},"ISSN":["0889-1591"],"issn-type":[{"value":"0889-1591","type":"print"}],"subject":[],"published":{"date-parts":[[2021,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Neutrophil dynamics, plasticity and function in acute neurodegeneration following neonatal hypoxia\u2013ischemia","name":"articletitle","label":"Article Title"},{"value":"Brain, Behavior, and Immunity","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbi.2020.12.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}