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A."},{"issue":"15","key":"10.1016\/j.bbi.2022.02.016_b0470","doi-asserted-by":"crossref","first-page":"3839","DOI":"10.1523\/JNEUROSCI.5389-07.2008","article-title":"Insolubility of disrupted-in-schizophrenia 1 disrupts oligomer-dependent interactions with nuclear distribution element 1 and is associated with sporadic mental disease","volume":"28","author":"Leliveld","year":"2008","journal-title":"J. Neurosci."},{"issue":"5","key":"10.1016\/j.bbi.2022.02.016_b0475","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1016\/j.neurobiolaging.2007.08.018","article-title":"Screening of innate immune receptors in neurodegenerative diseases: A similar pattern","volume":"30","author":"Letiembre","year":"2009","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.bbi.2022.02.016_b0480","article-title":"The toll route to structural brain plasticity","volume":"12","author":"Li","year":"2021","journal-title":"Front. 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Physiol. - Gastrointest. Liver Physiol."},{"issue":"10","key":"10.1016\/j.bbi.2022.02.016_b0655","doi-asserted-by":"crossref","first-page":"e47522","DOI":"10.1371\/journal.pone.0047522","article-title":"Evidence for a developmental role for TLR4 in learning and memory","volume":"7","author":"Okun","year":"2012","journal-title":"PLoS One"},{"issue":"35","key":"10.1016\/j.bbi.2022.02.016_b0660","doi-asserted-by":"crossref","first-page":"15625","DOI":"10.1073\/pnas.1005807107","article-title":"Toll-like receptor 3 inhibits memory retention and constrains adult hippocampal neurogenesis","volume":"107","author":"Okun","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbi.2022.02.016_b0665","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1111\/j.1471-4159.2010.06778.x","article-title":"TLR2 activation inhibits embryonic neural progenitor cell proliferation","volume":"114","author":"Okun","year":"2010","journal-title":"J. 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