{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T20:23:31Z","timestamp":1792268611481,"version":"4.4.0"},"reference-count":79,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31900726"],"award-info":[{"award-number":["31900726"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81871117"],"award-info":[{"award-number":["81871117"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"publisher","award":["BK20190655"],"award-info":[{"award-number":["BK20190655"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain, Behavior, and Immunity"],"published-print":{"date-parts":[[2022,7]]},"DOI":"10.1016\/j.bbi.2022.04.005","type":"journal-article","created":{"date-parts":[[2022,4,12]],"date-time":"2022-04-12T13:35:30Z","timestamp":1649770530000},"page":"85-96","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":44,"special_numbering":"C","title":["Drainage of senescent astrocytes from brain via meningeal lymphatic routes"],"prefix":"10.1016","volume":"103","author":[{"given":"Qian","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weixi","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiachen","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junying","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feifei","family":"Ge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiantian","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ze","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengfei","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles","family":"Marshall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengyu","family":"Sheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongjie","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingkuan","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingping","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbi.2022.04.005_b0005","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.29738","article-title":"Human and nonhuman primate meninges harbor lymphatic vessels that can be visualized noninvasively by MRI","volume":"6","author":"Absinta","year":"2017","journal-title":"Elife"},{"issue":"7767","key":"10.1016\/j.bbi.2022.04.005_b0010","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1038\/s41586-019-1419-5","article-title":"Meningeal lymphatic vessels at the skull base drain cerebrospinal fluid","volume":"572","author":"Ahn","year":"2019","journal-title":"Nature"},{"issue":"7","key":"10.1016\/j.bbi.2022.04.005_b0015","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1084\/jem.20142290","article-title":"A dural lymphatic vascular system that drains brain interstitial fluid and macromolecules","volume":"212","author":"Aspelund","year":"2015","journal-title":"J. Exp. Med."},{"issue":"3","key":"10.1016\/j.bbi.2022.04.005_b0020","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1161\/CIRCRESAHA.115.306544","article-title":"Lymphatic system in cardiovascular medicine","volume":"118","author":"Aspelund","year":"2016","journal-title":"Circ. Res."},{"issue":"4","key":"10.1016\/j.bbi.2022.04.005_b0025","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1172\/JCI95145","article-title":"Cellular senescence in brain aging and neurodegenerative diseases: evidence and perspectives","volume":"128","author":"Baker","year":"2018","journal-title":"J. Clin. Invest."},{"issue":"2","key":"10.1016\/j.bbi.2022.04.005_b0030","doi-asserted-by":"crossref","first-page":"144","DOI":"10.4062\/biomolther.2020.175","article-title":"Late passage cultivation induces aged astrocyte phenotypes in rat primary cultured cells","volume":"29","author":"Bang","year":"2021","journal-title":"Biomol. Ther. (Seoul)"},{"issue":"4","key":"10.1016\/j.bbi.2022.04.005_b0035","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.1182\/blood-2009-11-254490","article-title":"CCR7 is involved in the migration of neutrophils to lymph nodes","volume":"117","author":"Beauvillain","year":"2011","journal-title":"Blood"},{"issue":"2","key":"10.1016\/j.bbi.2022.04.005_b0040","doi-asserted-by":"crossref","DOI":"10.1083\/jcb.202010162","article-title":"Similarities and interplay between senescent cells and macrophages","volume":"220","author":"Behmoaras","year":"2021","journal-title":"J. Cell Biol."},{"issue":"4","key":"10.1016\/j.bbi.2022.04.005_b0045","doi-asserted-by":"crossref","first-page":"2969","DOI":"10.1007\/s12035-016-9880-8","article-title":"Hippocampal astrocyte aultures from adult and aged rats reproduce changes in glial functionality observed in the aging brain","volume":"54","author":"Bellaver","year":"2017","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.bbi.2022.04.005_b0050","doi-asserted-by":"crossref","unstructured":"Bhat, R., Crowe, E. P., Bitto, A., Moh, M., Katsetos, C. D., Garcia, F. U., Johnson, F. B., Trojanowski, J. Q., Sell, C., & Torres, C., 2012. Astrocyte senescence as a component of Alzheimer's disease. PLoS One, 7(9): e45069.","DOI":"10.1371\/journal.pone.0045069"},{"issue":"7728","key":"10.1016\/j.bbi.2022.04.005_b0055","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1038\/s41586-018-0543-y","article-title":"Clearance of senescent glial cells prevents tau-dependent pathology and cognitive decline","volume":"562","author":"Bussian","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.bbi.2022.04.005_b0060","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.bbi.2017.04.009","article-title":"Early enriched physical environment reverses impairments of the hippocampus, but not medial prefrontal cortex, of socially-isolated mice","volume":"64","author":"Cao","year":"2017","journal-title":"Brain Behav. Immun."},{"issue":"3","key":"10.1016\/j.bbi.2022.04.005_b0065","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1159\/000276818","article-title":"The drainage of cerebrospinal fluid into the lymphatic system of the neck in humans","volume":"58","author":"Caversaccio","year":"1996","journal-title":"ORL J. Otorhinolaryngol. Relat. Spec."},{"key":"10.1016\/j.bbi.2022.04.005_b0070","doi-asserted-by":"crossref","first-page":"4034509","DOI":"10.1155\/2021\/4034509","article-title":"Associations among cognitive functions, plasma DNA, and diffusion tensor image along the perivascular space (DTI-ALPS) in patients with Parkinson's disease","volume":"2021","author":"Chen","year":"2021","journal-title":"Oxid. Med. Cell Longev."},{"issue":"1","key":"10.1016\/j.bbi.2022.04.005_b0075","doi-asserted-by":"crossref","first-page":"3159","DOI":"10.1038\/s41467-020-16851-z","article-title":"Meningeal lymphatics clear erythrocytes that arise from subarachnoid hemorrhage","volume":"11","author":"Chen","year":"2020","journal-title":"Nat. Commun."},{"issue":"6311","key":"10.1016\/j.bbi.2022.04.005_b0080","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1126\/science.aaf6659","article-title":"Senescent intimal foam cells are deleterious at all stages of atherosclerosis","volume":"354","author":"Childs","year":"2016","journal-title":"Science"},{"issue":"4","key":"10.1016\/j.bbi.2022.04.005_b0085","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1016\/j.celrep.2017.12.092","article-title":"Cellular senescence is induced by the environmental neurotoxin paraquat and contributes to neuropathology linked to Parkinson's disease","volume":"22","author":"Chinta","year":"2018","journal-title":"Cell Rep."},{"issue":"7","key":"10.1016\/j.bbi.2022.04.005_b0090","doi-asserted-by":"crossref","first-page":"1609","DOI":"10.18632\/aging.101496","article-title":"Signatures of photo-aging and intrinsic aging in skin were revealed by transcriptome network analysis","volume":"10","author":"Cho","year":"2018","journal-title":"Aging (Albany NY)"},{"issue":"40","key":"10.1016\/j.bbi.2022.04.005_b0095","doi-asserted-by":"crossref","first-page":"42270","DOI":"10.1074\/jbc.M402352200","article-title":"Morphological adjustment of senescent cells by modulating caveolin-1 status","volume":"279","author":"Cho","year":"2004","journal-title":"J. Biol. Chem."},{"issue":"4","key":"10.1016\/j.bbi.2022.04.005_b0100","doi-asserted-by":"crossref","first-page":"281","DOI":"10.4196\/kjpp.2019.23.4.281","article-title":"Increased expression of vascular endothelial growth factor-C and vascular endothelial growth factor receptor-3 after pilocarpine-induced status epilepticus in mice","volume":"23","author":"Cho","year":"2019","journal-title":"Korean J. Physiol. Pharmacol."},{"issue":"8","key":"10.1016\/j.bbi.2022.04.005_b0105","doi-asserted-by":"crossref","first-page":"E1896","DOI":"10.1073\/pnas.1800165115","article-title":"Normal aging induces A1-like astrocyte reactivity","volume":"115","author":"Clarke","year":"2018","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"issue":"4","key":"10.1016\/j.bbi.2022.04.005_b0110","doi-asserted-by":"crossref","first-page":"2399","DOI":"10.1016\/S0021-9258(17)41959-4","article-title":"Exposure of phosphatidylserine in the outer leaflet of human red blood cells. Relationship to cell density, cell age, and clearance by mononuclear cells","volume":"269","author":"Connor","year":"1994","journal-title":"J. Biol. Chem."},{"issue":"7717","key":"10.1016\/j.bbi.2022.04.005_b0115","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1038\/s41586-018-0368-8","article-title":"Functional aspects of meningeal lymphatics in ageing and Alzheimer's disease","volume":"560","author":"Da Mesquita","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.bbi.2022.04.005_b0120","doi-asserted-by":"crossref","unstructured":"Debacq-Chainiaux, F., Erusalimsky, JD., Campisi, J., Toussaint, O., 2009. Protocols to detect senescence-associated beta-galactosidase (SA-betagal) activity, a biomarker of senescent cells in culture and in vivo. Nat. Protoc., 4(12):1 798-806.","DOI":"10.1038\/nprot.2009.191"},{"issue":"2","key":"10.1016\/j.bbi.2022.04.005_b0125","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1038\/s41580-020-00314-w","article-title":"Cellular senescence in ageing: from mechanisms to therapeutic opportunities","volume":"22","author":"Di Micco","year":"2021","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"5","key":"10.1016\/j.bbi.2022.04.005_b0130","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1111\/nan.12420","article-title":"Astrogliosis and impaired aquaporin-4 and dystrophin systems in idiopathic normal pressure hydrocephalus","volume":"44","author":"Eide","year":"2018","journal-title":"Neuropathol. Appl. Neurobiol."},{"key":"10.1016\/j.bbi.2022.04.005_b0135","doi-asserted-by":"crossref","unstructured":"Elder, S. S., & Emmerson, E., 2020. Senescent cells and macrophages: key players for regeneration? Open Biol, 10(12): 200309.","DOI":"10.1098\/rsob.200309"},{"key":"10.1016\/j.bbi.2022.04.005_b0140","doi-asserted-by":"crossref","first-page":"518","DOI":"10.3389\/fimmu.2019.00518","article-title":"The interplay between lymphatic vessels and chemokines","volume":"10","author":"Farnsworth","year":"2019","journal-title":"Front. Immunol."},{"issue":"1","key":"10.1016\/j.bbi.2022.04.005_b0145","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1007\/s12307-008-0007-2","article-title":"Role of cancer microenvironment in metastasis: focus on colon cancer","volume":"1","author":"Gout","year":"2008","journal-title":"Cancer Microenviron."},{"issue":"8","key":"10.1016\/j.bbi.2022.04.005_b0150","doi-asserted-by":"crossref","first-page":"2576","DOI":"10.1093\/brain\/awaa179","article-title":"Impaired glymphatic function and clearance of tau in an Alzheimer's disease model","volume":"143","author":"Harrison","year":"2020","journal-title":"Brain"},{"issue":"8","key":"10.1016\/j.bbi.2022.04.005_b0155","doi-asserted-by":"crossref","DOI":"10.21769\/BioProtoc.2819","article-title":"Magnetic resonance imaging and histopathological visualization of human dural lymphatic vessels","volume":"8","author":"Ha","year":"2018","journal-title":"Bio Protoc."},{"issue":"6","key":"10.1016\/j.bbi.2022.04.005_b0160","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1016\/j.cell.2017.05.015","article-title":"Senescence in health and disease","volume":"169","author":"He","year":"2017","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.bbi.2022.04.005_b0165","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1038\/s41467-018-08163-0","article-title":"Neuroinflammation-induced lymphangiogenesis near the cribriform plate contributes to drainage of CNS-derived antigens and immune cells","volume":"10","author":"Hsu","year":"2019","journal-title":"Nat. Commun."},{"issue":"3","key":"10.1016\/j.bbi.2022.04.005_b0170","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1038\/s41422-020-0287-8","article-title":"Meningeal lymphatic vessels regulate brain tumor drainage and immunity","volume":"30","author":"Hu","year":"2020","journal-title":"Cell Res."},{"issue":"147","key":"10.1016\/j.bbi.2022.04.005_b0175","doi-asserted-by":"crossref","first-page":"147ra111","DOI":"10.1126\/scitranslmed.3003748","article-title":"A paravascular pathway facilitates CSF flow through the brain parenchyma and the clearance of interstitial solutes, including amyloid \u03b2","volume":"4","author":"Iliff","year":"2012","journal-title":"Sci. Transl. Med."},{"issue":"46","key":"10.1016\/j.bbi.2022.04.005_b0180","doi-asserted-by":"crossref","first-page":"18190","DOI":"10.1523\/JNEUROSCI.1592-13.2013","article-title":"Cerebral arterial pulsation drives paravascular CSF-interstitial fluid exchange in the murine brain","volume":"33","author":"Iliff","year":"2013","journal-title":"J. Neurosci."},{"issue":"4","key":"10.1016\/j.bbi.2022.04.005_b0185","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1097\/TP.0000000000000561","article-title":"Vascular endothelial growth factor c\/vascular endothelial growth factor receptor 3 signaling regulates chemokine gradients and lymphocyte migration from tissues to lymphatics","volume":"99","author":"Iwami","year":"2015","journal-title":"Transplantation"},{"issue":"6","key":"10.1016\/j.bbi.2022.04.005_b0190","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1038\/nm.4324","article-title":"Local clearance of senescent cells attenuates the development of post-traumatic osteoarthritis and creates a pro-regenerative environment","volume":"23","author":"Jeon","year":"2017","journal-title":"Nat. Med."},{"issue":"2","key":"10.1016\/j.bbi.2022.04.005_b0195","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1002\/glia.23897","article-title":"Vascular endothelial growth factor receptor-3 regulates astroglial glutamate transporter-1 expression via mTOR activation in reactive astrocytes following pilocarpine-induced status epilepticus","volume":"69","author":"Jeong","year":"2021","journal-title":"Glia"},{"issue":"3","key":"10.1016\/j.bbi.2022.04.005_b0200","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1111\/j.1741-4520.2012.00375.x","article-title":"Pluripotent stem cells are protected from cytomegalovirus infection at multiple points: implications of a new pathogenesis for congenital anomaly caused by cytomegalovirus","volume":"52","author":"Kawasaki","year":"2012","journal-title":"Congenit. Anom. (Kyoto)"},{"issue":"6","key":"10.1016\/j.bbi.2022.04.005_b0205","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1002\/ana.24271","article-title":"Impairment of paravascular clearance pathways in the aging brain","volume":"76","author":"Kress","year":"2014","journal-title":"Ann. Neurol."},{"issue":"6","key":"10.1016\/j.bbi.2022.04.005_b0210","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1242\/dev.100495","article-title":"Ccbe1 regulates Vegfc-mediated induction of Vegfr3 signaling during embryonic lymphangiogenesis","volume":"141","author":"Le Guen","year":"2014","journal-title":"Development"},{"issue":"4","key":"10.1016\/j.bbi.2022.04.005_b0215","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1002\/glia.440060402","article-title":"Comparative biochemical, morphological, and immunocytochemical studies between C-6 glial cells of early and late passages and advanced passages of glial cells derived from aged mouse cerebral hemispheres","volume":"6","author":"Lee","year":"1992","journal-title":"Glia"},{"issue":"20","key":"10.1016\/j.bbi.2022.04.005_b0220","doi-asserted-by":"crossref","first-page":"1764","DOI":"10.1182\/blood.2019001736","article-title":"Hemostasis stimulates lymphangiogenesis through release and activation of VEGFC","volume":"134","author":"Lim","year":"2019","journal-title":"Blood"},{"issue":"10","key":"10.1016\/j.bbi.2022.04.005_b0225","doi-asserted-by":"crossref","first-page":"1380","DOI":"10.1038\/s41593-018-0227-9","article-title":"CNS lymphatic drainage and neuroinflammation are regulated by meningeal lymphatic vasculature","volume":"21","author":"Louveau","year":"2018","journal-title":"Nat. Neurosci."},{"issue":"7560","key":"10.1016\/j.bbi.2022.04.005_b0230","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1038\/nature14432","article-title":"Structural and functional features of central nervous system lymphatic vessels","volume":"523","author":"Louveau","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.bbi.2022.04.005_b0235","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.40070","article-title":"Aquaporin-4-dependent glymphatic solute transport in the rodent brain","volume":"7","author":"Mestre","year":"2018","journal-title":"Elife"},{"issue":"6","key":"10.1016\/j.bbi.2022.04.005_b0240","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejcb.2020.151108","article-title":"Aging of the cells: insight into cellular senescence and detection Methods","volume":"99","author":"Mohamad Kamal","year":"2020","journal-title":"Eur. J. Cell Biol."},{"issue":"2\u20133","key":"10.1016\/j.bbi.2022.04.005_b0245","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/S0736-5748(99)00102-1","article-title":"Expression of the glucocorticoid receptor in early and late passage C-6 glioma cells and in normal astrocytes derived from aged mouse cerebral hemispheres","volume":"18","author":"Moutsatsou","year":"2000","journal-title":"Int. J. Dev. Neurosci."},{"issue":"14","key":"10.1016\/j.bbi.2022.04.005_b0250","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.88034","article-title":"Glymphatic fluid transport controls paravascular clearance of AAV vectors from the brain","volume":"1","author":"Murlidharan","year":"2016","journal-title":"JCI Insight"},{"issue":"1","key":"10.1016\/j.bbi.2022.04.005_b0255","article-title":"Peri-arterial pathways for clearance of \u03b1-Synuclein and tau from the brain: implications for the pathogenesis of dementias and for immunotherapy","volume":"12","author":"Nimmo","year":"2020","journal-title":"Alzheimers Dement. (Amst.)"},{"issue":"1","key":"10.1016\/j.bbi.2022.04.005_b0260","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1007\/BF00691806","article-title":"Lymphatic efflux of intracerebrally injected cells","volume":"45","author":"Oehmichen","year":"1979","journal-title":"Acta Neuropathol."},{"issue":"1","key":"10.1016\/j.bbi.2022.04.005_b0265","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/s13024-019-0312-x","article-title":"Dural lymphatics regulate clearance of extracellular tau from the CNS","volume":"14","author":"Patel","year":"2019","journal-title":"Mol. Neurodegener."},{"issue":"1","key":"10.1016\/j.bbi.2022.04.005_b0270","doi-asserted-by":"crossref","first-page":"104","DOI":"10.5607\/en.2019.28.1.104","article-title":"Persistent malfunction of glymphatic and meningeal lymphatic drainage in a mouse model of subarachnoid hemorrhage","volume":"28","author":"Pu","year":"2019","journal-title":"Exp Neurobiol"},{"issue":"8","key":"10.1016\/j.bbi.2022.04.005_b0275","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1038\/s41583-020-0325-z","article-title":"Cellular senescence and Alzheimer disease: the egg and the chicken scenario","volume":"21","author":"Saez-Atienzar","year":"2020","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.bbi.2022.04.005_b0280","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.mce.2016.08.047","article-title":"Cellular senescence: implications for metabolic disease","volume":"455","author":"Schafer","year":"2017","journal-title":"Mol. Cell. Endocrinol."},{"issue":"11","key":"10.1016\/j.bbi.2022.04.005_b0285","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1016\/j.dadm.2019.03.002","article-title":"Nonparenchymal fluid is the source of increased mean diffusivity in preclinical Alzheimer's disease","volume":"22","author":"Sepehrband","year":"2019","journal-title":"Alzheimers Dement. (Amst.)"},{"issue":"5","key":"10.1016\/j.bbi.2022.04.005_b0290","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/j.yexcr.2005.11.012","article-title":"Signal transduction by VEGF receptors in regulation of angiogenesis and lymphangiogenesis","volume":"312","author":"Shibuya","year":"2006","journal-title":"Exp. Cell Res."},{"issue":"5","key":"10.1016\/j.bbi.2022.04.005_b0295","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1007\/s00401-008-0423-x","article-title":"Differential regulation of vascular endothelial growth factor-C and its receptor in the rat hippocampus following transient forebrain ischemia","volume":"116","author":"Shin","year":"2008","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.bbi.2022.04.005_b0300","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2021.111327","article-title":"Evidence and perspectives of cell senescence in neurodegenerative diseases","volume":"137","author":"Si","year":"2021","journal-title":"Biomed. Pharmacother."},{"issue":"1","key":"10.1016\/j.bbi.2022.04.005_b0305","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/s42466-021-00102-7","article-title":"Glymphatic system, AQP4, and their implications in Alzheimer's disease","volume":"3","author":"Silva","year":"2021","journal-title":"Neurol. Res. Pract."},{"issue":"7792","key":"10.1016\/j.bbi.2022.04.005_b0310","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1038\/s41586-019-1912-x","article-title":"VEGF-C-driven lymphatic drainage enables immunosurveillance of brain tumours","volume":"577","author":"Song","year":"2020","journal-title":"Nature"},{"issue":"3","key":"10.1016\/j.bbi.2022.04.005_b0315","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1002\/(SICI)1097-0029(19961015)35:3<294::AID-JEMT8>3.0.CO;2-N","article-title":"Electron microscopic analysis of Drosophila midline glia during embryogenesis and larval development using beta-galactosidase expression as endogenous cell marker","volume":"35","author":"Stollewerk","year":"1996","journal-title":"Microsc. Res. Tech."},{"issue":"4","key":"10.1016\/j.bbi.2022.04.005_b0320","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1159\/000350282","article-title":"Regulation of circulating neutrophil numbers under homeostasis and in disease","volume":"5","author":"Strydom","year":"2013","journal-title":"J. Innate Immun."},{"issue":"2","key":"10.1016\/j.bbi.2022.04.005_b0325","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1002\/(SICI)1097-4547(19980715)53:2<177::AID-JNR6>3.0.CO;2-4","article-title":"Selective deposition of amyloid-beta protein in the entorhinal-dentate projection of a transgenic mouse model of Alzheimer's disease","volume":"53","author":"Su","year":"1998","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.bbi.2022.04.005_b0330","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.bbrc.2020.12.086","article-title":"Normal aging induces PD-1-enriched exhausted microglia and A1-like reactive astrocytes in the hypothalamus","volume":"541","author":"Suda","year":"2021","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"4","key":"10.1016\/j.bbi.2022.04.005_b0335","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1007\/s11604-017-0617-z","article-title":"Evaluation of glymphatic system activity with the diffusion MR technique: diffusion tensor image analysis along the perivascular space (DTI-ALPS) in Alzheimer's disease cases","volume":"35","author":"Taoka","year":"2017","journal-title":"Jpn. J. Radiol."},{"issue":"11","key":"10.1016\/j.bbi.2022.04.005_b0340","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1038\/nrd4608","article-title":"From sewer to saviour - targeting the lymphatic system to promote drug exposure and activity","volume":"14","author":"Trevaskis","year":"2015","journal-title":"Nat. Rev. Drug Discov."},{"issue":"7501","key":"10.1016\/j.bbi.2022.04.005_b0345","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1038\/nature13193","article-title":"The role of senescent cells in ageing","volume":"509","author":"van Deursen","year":"2014","journal-title":"Nature"},{"issue":"2","key":"10.1016\/j.bbi.2022.04.005_b0350","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1111\/bpa.12656","article-title":"Deep cervical lymph node ligation aggravates AD-like pathology of APP\/PS1 mice","volume":"29","author":"Wang","year":"2019","journal-title":"Brain Pathol."},{"issue":"1","key":"10.1016\/j.bbi.2022.04.005_b0355","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00401-008-0457-0","article-title":"Lymphatic drainage of the brain and the pathophysiology of neurological disease","volume":"117","author":"Weller","year":"2009","journal-title":"Acta Neuropathol."},{"issue":"4","key":"10.1016\/j.bbi.2022.04.005_b0360","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1097\/WNR.0b013e3282f64377","article-title":"Pax6 directly modulate Sox2 expression in the neural progenitor cells","volume":"19","author":"Wen","year":"2008","journal-title":"NeuroReport"},{"key":"10.1016\/j.bbi.2022.04.005_b0365","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1186\/s13024-015-0056-1","article-title":"Deletion of aquaporin-4 in APP\/PS1 mice exacerbates brain A\u03b2 accumulation and memory deficits","volume":"10","author":"Xu","year":"2015","journal-title":"Mol. Neurodegener."},{"issue":"1","key":"10.1016\/j.bbi.2022.04.005_b0370","doi-asserted-by":"crossref","first-page":"179","DOI":"10.3233\/JAD-150634","article-title":"Different expression patterns of amyloid-\u03b2 protein precursor secretases in human and mouse hippocampal neurons: a potential contribution to species differences in neuronal susceptibility to amyloid-\u03b2 pathogenesis","volume":"51","author":"Xu","year":"2016","journal-title":"J. Alzheimers Dis."},{"issue":"1","key":"10.1016\/j.bbi.2022.04.005_b0375","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1001\/jamaneurol.2016.4370","article-title":"Association of perivascular localization of aquaporin-4 with cognition and Alzheimer disease in aging brains","volume":"74","author":"Zeppenfeld","year":"2017","journal-title":"JAMA Neurol."},{"issue":"5","key":"10.1016\/j.bbi.2022.04.005_b0380","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1038\/s41593-019-0372-9","article-title":"Senolytic therapy alleviates A\u03b2-associated oligodendrocyte progenitor cell senescence and cognitive deficits in an Alzheimer's disease model","volume":"22","author":"Zhang","year":"2019","journal-title":"Nat. Neurosci."},{"issue":"2","key":"10.1016\/j.bbi.2022.04.005_b0385","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1111\/cns.13194","article-title":"Aquaporin 4 deletion exacerbates brain impairments in a mouse model of chronic sleep disruption","volume":"26","author":"Zhang","year":"2020","journal-title":"CNS Neurosci. Ther."},{"issue":"3","key":"10.1016\/j.bbi.2022.04.005_b0390","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1002\/ana.25670","article-title":"Impairment of the glymphatic pathway and putative meningeal lymphatic vessels in the aging human","volume":"87","author":"Zhou","year":"2020","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.bbi.2022.04.005_b0395","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/s40035-019-0147-y","article-title":"Blocking meningeal lymphatic drainage aggravates Parkinson's disease-like pathology in mice overexpressing mutated \u03b1-synuclein","volume":"8","author":"Zou","year":"2019","journal-title":"Transl. Neurodegener."}],"container-title":["Brain, Behavior, and Immunity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0889159122001039?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0889159122001039?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T08:16:42Z","timestamp":1760170602000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0889159122001039"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7]]},"references-count":79,"alternative-id":["S0889159122001039"],"URL":"https:\/\/doi.org\/10.1016\/j.bbi.2022.04.005","relation":{},"ISSN":["0889-1591"],"issn-type":[{"value":"0889-1591","type":"print"}],"subject":[],"published":{"date-parts":[[2022,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Drainage of senescent astrocytes from brain via meningeal lymphatic routes","name":"articletitle","label":"Article Title"},{"value":"Brain, Behavior, and Immunity","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbi.2022.04.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}