{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T02:54:55Z","timestamp":1783738495954,"version":"3.55.0"},"reference-count":97,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,12,6]],"date-time":"2022-12-06T00:00:00Z","timestamp":1670284800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000770","name":"University of Manchester","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000770","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000268","name":"Biotechnology and Biological Sciences Research Council","doi-asserted-by":"publisher","award":["BB\/M011208\/1"],"award-info":[{"award-number":["BB\/M011208\/1"]}],"id":[{"id":"10.13039\/501100000268","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain, Behavior, and Immunity"],"published-print":{"date-parts":[[2023,2]]},"DOI":"10.1016\/j.bbi.2022.12.003","type":"journal-article","created":{"date-parts":[[2022,12,8]],"date-time":"2022-12-08T03:48:46Z","timestamp":1670471326000},"page":"162-175","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":32,"special_numbering":"C","title":["Maternal behaviours and adult offspring behavioural deficits are predicted by maternal TNF\u03b1 concentration in a rat model of neurodevelopmental disorders"],"prefix":"10.1016","volume":"108","author":[{"given":"Harry G.","family":"Potter","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hager M.","family":"Kowash","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca M.","family":"Woods","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grace","family":"Revill","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy","family":"Grime","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brendan","family":"Deeney","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew A.","family":"Burgess","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toby","family":"Aarons","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jocelyn D.","family":"Glazier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanna C.","family":"Neill","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reinmar","family":"Hager","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbi.2022.12.003_b0005","doi-asserted-by":"crossref","first-page":"1672","DOI":"10.1111\/bph.12131","article-title":"Curcumin: an orally bioavailable blocker of TNF and other pro-inflammatory biomarkers","volume":"169","author":"Aggarwal","year":"2013","journal-title":"Br J Pharmacol."},{"key":"10.1016\/j.bbi.2022.12.003_b0010","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1038\/35099560","article-title":"Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3","volume":"413","author":"Alexopoulou","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.bbi.2022.12.003_b0015","doi-asserted-by":"crossref","first-page":"e11814","DOI":"10.7554\/eLife.11814","article-title":"Genetic variation in offspring indirectly influences the quality of maternal behaviour in mice","volume":"4","author":"Ashbrook","year":"2015","journal-title":"Elife"},{"key":"10.1016\/j.bbi.2022.12.003_b0020","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1007\/7854_2018_81","article-title":"Microglial activation and psychotic disorders: evidence from pre-clinical and clinical studies","volume":"44","author":"Barichello","year":"2020","journal-title":"Curr Top Behav Neurosci."},{"key":"10.1016\/j.bbi.2022.12.003_b0025","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1038\/s41398-019-0449-y","article-title":"Preliminary evidence of increased striatal dopamine in a nonhuman primate model of maternal immune activation","volume":"9","author":"Bauman","year":"2019","journal-title":"Transl. Psychiatry."},{"key":"10.1016\/j.bbi.2022.12.003_b0030","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.bbi.2018.02.008","article-title":"Impact of maternal immune activation on maternal care behavior, offspring emotionality and intergenerational transmission in C3H\/He mice","volume":"70","author":"Berger","year":"2018","journal-title":"Brain Behav Immun."},{"key":"10.1016\/j.bbi.2022.12.003_b0035","doi-asserted-by":"crossref","first-page":"5667","DOI":"10.1007\/s00018-021-03881-z","article-title":"GABAergic signaling by cells of the immune system: more the rule than the exception","volume":"78","author":"Bhandage","year":"2021","journal-title":"Cell Mol Life Sci."},{"key":"10.1016\/j.bbi.2022.12.003_b0040","doi-asserted-by":"crossref","first-page":"4320","DOI":"10.1523\/JNEUROSCI.20-11-04320.2000","article-title":"Medial frontal cortex mediates perceptual attentional set-shifting in the rat","volume":"20","author":"Birrell","year":"2000","journal-title":"J Neurosci."},{"key":"10.1016\/j.bbi.2022.12.003_b0045","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.tins.2014.12.006","article-title":"The role of inflammatory cytokines as key modulators of neurogenesis","volume":"38","author":"Borsini","year":"2015","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.bbi.2022.12.003_b0050","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1016\/0031-9384(95)02043-8","article-title":"Effects of housing on male and female rats: crowding stresses male but calm females","volume":"58","author":"Brown","year":"1995","journal-title":"Physiol Behav."},{"key":"10.1016\/j.bbi.2022.12.003_b0055","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1176\/appi.ajp.162.4.767","article-title":"Maternal exposure to toxoplasmosis and risk of schizophrenia in adult offspring","volume":"162","author":"Brown","year":"2005","journal-title":"Am J Psychiatry."},{"key":"10.1016\/j.bbi.2022.12.003_b0060","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1016\/j.biopsych.2007.09.022","article-title":"Collaborative Study Group on the Perinatal Origins of Severe Psychiatric Disorders. Maternal exposure to herpes simplex virus and risk of psychosis among adult offspring","volume":"63","author":"Buka","year":"2008","journal-title":"Biol Psychiatry."},{"key":"10.1016\/j.bbi.2022.12.003_b0065","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1038\/mp.2015.222","article-title":"Maternal immune activation leads to selective functional deficits in offspring parvalbumin interneurons","volume":"21","author":"Canetta","year":"2016","journal-title":"Mol Psychiatry."},{"key":"10.1016\/j.bbi.2022.12.003_b0070","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/S0304-3835(98)00057-3","article-title":"Tumour necrosis factor-alpha does not cross the rat placenta","volume":"128","author":"Carb\u03cc","year":"1998","journal-title":"Cancer Lett."},{"key":"10.1016\/j.bbi.2022.12.003_b0075","doi-asserted-by":"crossref","unstructured":"Careaga M, Taylor SL, Chang C, Chiang A, Ku KM, Berman RF, Van de Water JA, et al. Variability in PolyIC induced immune response: implications for preclinical maternal immune activation models. J Neuroimmunol. 2018;323: 87-93.","DOI":"10.1016\/j.jneuroim.2018.06.014"},{"key":"10.1016\/j.bbi.2022.12.003_b0080","doi-asserted-by":"crossref","first-page":"2802","DOI":"10.1016\/j.ajpath.2011.02.042","article-title":"Placenal TNF signalling in illness-induced complications of pregnancy","volume":"178","author":"Carpentier","year":"2011","journal-title":"Am J Pathol."},{"key":"10.1016\/j.bbi.2022.12.003_b0085","doi-asserted-by":"crossref","first-page":"6037","DOI":"10.1523\/JNEUROSCI.0526-08.2008","article-title":"Maternal care and hippocampal plasticity: evidence for experience-dependent structural plasticity, altered synaptic functioning, and differential responsiveness to glucocorticoids and stress","volume":"28","author":"Champagne","year":"2008","journal-title":"J Neurosci."},{"key":"10.1016\/j.bbi.2022.12.003_b0090","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/j.pnpbp.2018.09.011","article-title":"Maternal immune activation in rats blunts brain cytokine and kynurenine pathway responses to a second immune challenge in early adulthood","volume":"89","author":"Clark","year":"2019","journal-title":"Prog Neuro-Psychopharmacol Biol Psychiatry."},{"key":"10.1016\/j.bbi.2022.12.003_b0095","doi-asserted-by":"crossref","unstructured":"Clifton VL. Sex and the human placenta: Mediating differential strategies of fetal growth and survival. Placenta. 2010;31:S33-S39.","DOI":"10.1016\/j.placenta.2009.11.010"},{"key":"10.1016\/j.bbi.2022.12.003_b0100","doi-asserted-by":"crossref","first-page":"430","DOI":"10.3389\/fpsyt.2019.00430","article-title":"Maternal immune activation and related factors in the risk of offspring psychiatric disorders","volume":"10","author":"Conway","year":"2019","journal-title":"Front Psychiatry."},{"key":"10.1016\/j.bbi.2022.12.003_b0105","doi-asserted-by":"crossref","unstructured":"Curley JP, Champagne FA. Influence of maternal care on the developing brain: mechanisms, temporal dynamics and sensitive periods. Front Neuroendocrinol. 20156;40: 52-66.","DOI":"10.1016\/j.yfrne.2015.11.001"},{"key":"10.1016\/j.bbi.2022.12.003_b0110","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.bbi.2019.02.002","article-title":"The influence of immune activation at early vs late gestation on fetal NRG1-ErbB4 expression and behavior in juvenile and adult mice offspring","volume":"79","author":"Dabbah-Assadi","year":"2019","journal-title":"Brain Behav Immun."},{"key":"10.1016\/j.bbi.2022.12.003_b0115","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/j.neubiorev.2007.01.005","article-title":"The pharmacology, neuroanatomy and neurogenetics of one-trial object recognition in rodents","volume":"31","author":"Dere","year":"2007","journal-title":"Neurosci Biobehav Rev."},{"key":"10.1016\/j.bbi.2022.12.003_b0120","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/S1074-7427(02)00023-0","article-title":"Does the radial arm maze necessarily test spatial memory?","volume":"79","author":"Dubreuil","year":"2003","journal-title":"Neurobiol Learn Mem."},{"key":"10.1016\/j.bbi.2022.12.003_b0125","doi-asserted-by":"crossref","first-page":"e5518","DOI":"10.1371\/journal.pone.0005518","article-title":"IL-6 mediated degeneration of forebrain GABAergic interneurons and cognitive impairment in aged mice through activation of neuronal NADPH oxidase","volume":"4","author":"Dugan","year":"2009","journal-title":"PLoS One"},{"key":"10.1016\/j.bbi.2022.12.003_b0130","doi-asserted-by":"crossref","first-page":"175","DOI":"10.3758\/BF03193146","article-title":"G*Power 3: A flexible statistical power analysis program for the social, behavioral, and biomedical sciences","volume":"39","author":"Faul","year":"2017","journal-title":"Behav Res Methods."},{"key":"10.1016\/j.bbi.2022.12.003_b0135","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.bbi.2012.07.008","article-title":"Maternal immune activation causes age- and region-specific changes in brain cytokines in offspring throughout development","volume":"31","author":"Garay","year":"2013","journal-title":"Brain Behav Immun."},{"key":"10.1016\/j.bbi.2022.12.003_b0140","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1038\/s41398-018-0112-z","article-title":"Gestational cytokine concentrations and neurocognitive development at 7 years","volume":"8","author":"Ghassabian","year":"2018","journal-title":"Transl Psychiatry."},{"key":"10.1016\/j.bbi.2022.12.003_b0145","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1126\/science.1194637","article-title":"Fate mapping analysis reveals that adult microglia derive from primitive macrophages","volume":"330","author":"Ginhoux","year":"2010","journal-title":"Science"},{"key":"10.1016\/j.bbi.2022.12.003_b0150","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.bbi.2020.05.076","article-title":"Gestational poly(I:C) attenuates, not exacerbates, the behavioral, cytokine and mTOR changes caused by isolation rearing in a rat \u2018dual-hit\u2019 model for neurodevelopmental disorders","volume":"89","author":"Goh","year":"2020","journal-title":"Brain Behav Immun."},{"key":"10.1016\/j.bbi.2022.12.003_b0155","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.bbi.2016.12.003","article-title":"Deep brain stimulation during early adolescence prevents microglial alterations in a model of maternal immune activation","volume":"63","author":"Hadar","year":"2017","journal-title":"Brain Behav Immun."},{"key":"10.1016\/j.bbi.2022.12.003_b0160","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1038\/nature01239","article-title":"The genetic basis of family conflict resolution in mice","volume":"421","author":"Hager","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.bbi.2022.12.003_b0165","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1016\/j.anbehav.2007.01.021","article-title":"Maternal and offspring effects influence provisioning to mixed litters of own and alien young in mice","volume":"74","author":"Hager","year":"2007","journal-title":"Anim. Behav."},{"key":"10.1016\/j.bbi.2022.12.003_b0170","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.smim.2014.05.004","article-title":"Regulation of NF-\u03baB by TNF family cytokines","volume":"26","author":"Hayden","year":"2014","journal-title":"Semin Immun."},{"key":"10.1016\/j.bbi.2022.12.003_b0175","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.bbi.2016.02.021","article-title":"Alteration of transcriptional networks in the entorhinal cortex after maternal immune activation and adolescent cannabinoid exposure","volume":"56","author":"Hollins","year":"2016","journal-title":"Brain Behav Immun."},{"key":"10.1016\/j.bbi.2022.12.003_b0180","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1016\/j.bbi.2010.12.017","article-title":"Activation of the maternal immune system induces endocrine changes in the placenta via IL-6","volume":"25","author":"Hsiao","year":"2011","journal-title":"Brain Behav Immun."},{"key":"10.1016\/j.bbi.2022.12.003_b0185","doi-asserted-by":"crossref","unstructured":"Hughes K, Bellis MA, Hardcastle KA, Sethi D, Butchart A, Mikton C, Jones L, et al. The effect of multiple adverse childhood experiences on health: A systematic review and meta-analysis. Lancet 2017;2: E356-E366.","DOI":"10.1016\/S2468-2667(17)30118-4"},{"key":"10.1016\/j.bbi.2022.12.003_b0190","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1001\/jamapsychiatry.2015.3058","article-title":"Phenotypic manifestation of genetic risk for schizophrenia during adolescence in the general population","volume":"73","author":"Jones","year":"2016","journal-title":"JAMA Psychiat."},{"key":"10.1016\/j.bbi.2022.12.003_b0195","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1038\/s41386-018-0185-7","article-title":"Maternal immune activation: Reporting guidelines to improve the rigor, reproducibility, and transparency of the model","volume":"44","author":"Kentner","year":"2018","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.bbi.2022.12.003_b0200","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.pnpbp.2012.02.001","article-title":"Viral infection, inflammation, and schizophrenia","volume":"42","author":"Kneeland","year":"2015","journal-title":"Prog Neuro-Psychopharmacol Biol Psychiatry."},{"key":"10.1016\/j.bbi.2022.12.003_b0205","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1038\/nrneurol.2014.187","article-title":"Maternal immune activation and abnormal brain development across CNS disorders","volume":"10","author":"Knuesel","year":"2014","journal-title":"Nat Rev Neurol."},{"key":"10.1016\/j.bbi.2022.12.003_b0210","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.bbi.2019.08.006","article-title":"Poly(I:C) source, molecular weight and endotoxin contamination affect dam and prenatal outcomes, implications for models of maternal immune activation","volume":"82","author":"Kowash","year":"2019","journal-title":"Brain Behav Immun."},{"key":"10.1016\/j.bbi.2022.12.003_b0215","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1042\/CS20220245","article-title":"Maternal immune activation in rats induces dysfunction of placental leucine transport and alters fetal brain growth","volume":"136","author":"Kowash","year":"2022","journal-title":"Clin Sci (Lond)."},{"key":"10.1016\/j.bbi.2022.12.003_b0220","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1080\/15592294.2015.1114202","article-title":"Maternal immune activation induces GAD1 and GAD2 promoter remodeling in the offspring prefrontal cortex","volume":"10","author":"Labouesse","year":"2015","journal-title":"Epigenetics"},{"key":"10.1016\/j.bbi.2022.12.003_b0225","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1016\/j.neubiorev.2016.06.029","article-title":"A systematic review comparing sex differences in cognitive function in schizophrenia and in rodent models for schizophrenia, implications for improved therapeutic strategies","volume":"68","author":"Leger","year":"2016","journal-title":"Neurosci Biobehav Rev."},{"key":"10.1016\/j.bbi.2022.12.003_b0230","doi-asserted-by":"crossref","first-page":"8044","DOI":"10.1523\/JNEUROSCI.1176-18.2018","article-title":"Mast cells in the developing brain determine adult sexual behavior","volume":"38","author":"Lenz","year":"2018","journal-title":"J Neurosci."},{"key":"10.1016\/j.bbi.2022.12.003_b0235","article-title":"Clustering of cognitive phenotypes identifies susceptible and resilient offspring in a rat model of maternal immune activation and early-life stress","volume":"25","author":"Lorusso","year":"2022","journal-title":"Brain Behav Immun Health."},{"key":"10.1016\/j.bbi.2022.12.003_b0240","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/bs.ircmb.2022.02.003","article-title":"Developmental programming of macrophages by early life adversity","volume":"368","author":"Magalhaes","year":"2022","journal-title":"Int Rev Cell Mol Biol."},{"key":"10.1016\/j.bbi.2022.12.003_b0245","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.bbi.2014.01.019","article-title":"Minocycline rescues decrease in neurogenesis, increase in microglia cytokines and deficits in sensorimotor gating in an animal model of schizophrenia","volume":"38","author":"Mattei","year":"2014","journal-title":"Brain Behav Immun."},{"key":"10.1016\/j.bbi.2022.12.003_b0250","doi-asserted-by":"crossref","first-page":"e1120","DOI":"10.1038\/tp.2017.80","article-title":"Maternal immune activation results in complex microglial transcriptome signature in the adult offspring that is reversed by minocycline treatment","volume":"7","author":"Mattei","year":"2017","journal-title":"Transl Psychiatry."},{"key":"10.1016\/j.bbi.2022.12.003_b0255","doi-asserted-by":"crossref","first-page":"e13115","DOI":"10.1111\/aji.13115","article-title":"Poly(I:C) alters placental and fetal brain amino acid transport in a rat model of maternal immune activation","volume":"81","author":"McColl","year":"2019","journal-title":"Am J Reprod Immunol."},{"key":"10.1016\/j.bbi.2022.12.003_b0260","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1186\/1742-2094-5-45","article-title":"TNF signaling inhibition in the CNS: implications for normal brain function and neurodegenerative disease","volume":"5","author":"McCoy","year":"2008","journal-title":"J Neuroinflammation."},{"key":"10.1016\/j.bbi.2022.12.003_b0265","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/j.bbi.2021.04.016","article-title":"Double stranded RNA drives anti-viral innate immune responses, sickness behavior and cognitive dysfunction dependent on dsRNA length, IFNAR1 expression and age","volume":"95","author":"McGarry","year":"2021","journal-title":"Brain Behav Immun."},{"key":"10.1016\/j.bbi.2022.12.003_b0270","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.bbr.2007.12.029","article-title":"A preliminary investigation into the effects of antipsychotics on sub-chronic phencyclidine-induced deficits in attentional set-shifting in female rats","volume":"189","author":"McLean","year":"2008","journal-title":"Behav Brain Res."},{"key":"10.1016\/j.bbi.2022.12.003_b0275","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1001\/archpsyc.1988.01800260109013","article-title":"Adult schizophrenia following prenatal exposure to an influenza epidemic","volume":"45","author":"Mednick","year":"1988","journal-title":"Arch Gen Psychiatry."},{"key":"10.1016\/j.bbi.2022.12.003_b0280","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.bbr.2018.03.040","article-title":"Paternal physical exercise demethylates the hippocampal DNA of male pups without modifying the cognitive and physical development","volume":"348","author":"Mega","year":"2018","journal-title":"Behav Brain Res."},{"key":"10.1016\/j.bbi.2022.12.003_b0285","doi-asserted-by":"crossref","first-page":"4752","DOI":"10.1523\/JNEUROSCI.0099-06.2006","article-title":"The time of prenatal immune challenge determines the specificity of inflammation-mediated brain and behavioural pathology","volume":"26","author":"Meyer","year":"2006","journal-title":"J Neurosci."},{"key":"10.1016\/j.bbi.2022.12.003_b0290","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1007\/s00221-006-0419-5","article-title":"Prenatal and postnatal maternal contributions in the infection model of schizophrenia","volume":"173","author":"Meyer","year":"2006","journal-title":"Exp Brain Res."},{"key":"10.1016\/j.bbi.2022.12.003_b0295","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1038\/sj.npp.1301413","article-title":"Relative prenatal and postnatal maternal contributions to schizophrenia-related neurochemical dysfunction after in utero immune challenge","volume":"33","author":"Meyer","year":"2008","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.bbi.2022.12.003_b0300","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.bbi.2014.06.013","article-title":"The risk for behavioural deficits is determined by the maternal immune response to prenatal immune challenge in a neurodevelopmental model","volume":"42","author":"Missault","year":"2014","journal-title":"Brain Behav Immun."},{"key":"10.1016\/j.bbi.2022.12.003_b0305","first-page":"1","article-title":"Prenatal maternal C-reactive protein prospectively predicts child executive functioning at ages 4\u20136 years","volume":"00","author":"Morgan","year":"2020","journal-title":"Dev Psychobiol."},{"key":"10.1016\/j.bbi.2022.12.003_b0310","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1016\/j.bbi.2018.07.014","article-title":"Mouse models of maternal immune activation: Mind your caging system!","volume":"73","author":"Mueller","year":"2018","journal-title":"Brain Behav Immun."},{"key":"10.1016\/j.bbi.2022.12.003_b0315","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1016\/j.bbi.2019.04.019","article-title":"Influence of poly(I:C) variability on thermoregulation, immune responses and pregnancy outcomes in mouse models of maternal immune activation","volume":"80","author":"Mueller","year":"2019","journal-title":"Brain Behav Immun."},{"key":"10.1016\/j.bbi.2022.12.003_b0320","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.bbi.2018.09.005","article-title":"Evolution of a maternal immune activation (mIA) model in rats: early developmental effects","volume":"75","author":"Murray","year":"2019","journal-title":"Brain Behav Immun."},{"key":"10.1016\/j.bbi.2022.12.003_b0325","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.euroneuro.2015.11.016","article-title":"Effects of cariprazine, a novel antipsychotic, on cognitive deficit and negative symptoms in a rodent model of schizophrenia symptomatology","volume":"26","author":"Neill","year":"2016","journal-title":"Eur Neuropsychopharmacol."},{"key":"10.1016\/j.bbi.2022.12.003_b0330","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1523\/JNEUROSCI.22-03-00854.2002","article-title":"Tumor necrosis factor inhibits neurite outgrowth and branching of hippocampal neurons by a rho-dependent mechanism","volume":"22","author":"Neumann","year":"2002","journal-title":"J Neurosci."},{"key":"10.1016\/j.bbi.2022.12.003_b0335","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.bbi.2019.08.192","article-title":"Environmental influences on placental programming and offspring outcomes following maternal immune activation","volume":"83","author":"N\u00fa\u00f1ez Estevez","year":"2020","journal-title":"Brain Behav Immun."},{"key":"10.1016\/j.bbi.2022.12.003_b0340","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/j.neuroscience.2014.06.028","article-title":"Phenotypic effects of maternal immune activation and early postnatal milieu in mice mutant for the schizophrenia risk gene neuregulin-1","volume":"277","author":"O\u2019Leary","year":"2014","journal-title":"Neuroscience"},{"key":"10.1016\/j.bbi.2022.12.003_b0345","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1037\/0097-7403.2.2.97","article-title":"Remembrance of places passed: Spatial memory in rats","volume":"2","author":"Olton","year":"1976","journal-title":"J Exp Psychol Anim Behav Process."},{"key":"10.1016\/j.bbi.2022.12.003_b0350","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1016\/j.bbi.2019.07.018","article-title":"Cannabidiol improves behavioural and neurochemical deficits in adult female offspring of the maternal immune activation (poly I:C) model of neurodevelopmental disorders","volume":"81","author":"Osborne","year":"2019","journal-title":"Brain Behav Immun."},{"key":"10.1016\/j.bbi.2022.12.003_b0355","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.placenta.2020.10.034","article-title":"Differential expression of system L amino acid transporter subtypes in rat placenta and yolk sac","volume":"103","author":"Owaydhah","year":"2020","journal-title":"Placenta"},{"key":"10.1016\/j.bbi.2022.12.003_b0360","doi-asserted-by":"crossref","first-page":"e66","DOI":"10.1038\/emm.2013.97","article-title":"Recognition of lipopolysaccharide pattern by TLR4 complexes","volume":"45","author":"Park","year":"2013","journal-title":"Exp Mol Med."},{"key":"10.1016\/j.bbi.2022.12.003_b0365","series-title":"The rat brain in stereotaxic coordinates","author":"Paxinos","year":"2007"},{"key":"10.1016\/j.bbi.2022.12.003_b0370","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1037\/a0031219","article-title":"Implications of temporal variation in maternal care for the prediction of neurobiological and behavioral outcomes in offspring","volume":"127","author":"Pe\u00f1a","year":"2013","journal-title":"Behav Neurosci."},{"key":"10.1016\/j.bbi.2022.12.003_b0375","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1111\/ejn.12479","article-title":"Effects of maternal care on the development of midbrain dopamine pathways and reward-directed behavior in female offspring","volume":"39","author":"Pe\u00f1a","year":"2014","journal-title":"Eur J Neurosci."},{"key":"10.1016\/j.bbi.2022.12.003_b0380","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.pscychresns.2015.08.003","article-title":"Adverse childhood experiences influence white matter microstructure in patients with schizophrenia","volume":"234","author":"Poletti","year":"2015","journal-title":"Psychiatry Res."},{"key":"10.1016\/j.bbi.2022.12.003_b0385","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.bbi.2013.07.006","article-title":"Prenatal versus postnatal maternal factors in the development of infection-induced working memory impairments in mice","volume":"33","author":"Richetto","year":"2013","journal-title":"Brain Behav Immun."},{"key":"10.1016\/j.bbi.2022.12.003_b0390","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.bbi.2016.10.016","article-title":"Maternal immune activation transgenerationally modulates maternal care and offspring depression-like behaviour","volume":"63","author":"Ronovsky","year":"2017","journal-title":"Brain Behav Immun."},{"key":"10.1016\/j.bbi.2022.12.003_b0395","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.brainresbull.2019.02.005","article-title":"Cumulative multiple early life hits- a potent threat leading to neurological disorders","volume":"147","author":"Sarkar","year":"2019","journal-title":"Brain Res Bull."},{"key":"10.1016\/j.bbi.2022.12.003_b0400","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1038\/nri3386","article-title":"Circadian control of the immune system","volume":"13","author":"Scheiermann","year":"2013","journal-title":"Nat Rev Immunol."},{"key":"10.1016\/j.bbi.2022.12.003_b0405","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1007\/s11689-008-9000-9","article-title":"Deficient maternal care resulting from immunological stress during pregnancy is associated with a sex-dependent enhancement of conditioned fear in the offspring","volume":"1","author":"Schwendener","year":"2009","journal-title":"J Neurodev Disord."},{"key":"10.1016\/j.bbi.2022.12.003_b0410","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1111\/aji.12355","article-title":"Viral infections during pregnancy","volume":"73","author":"Silasi","year":"2015","journal-title":"Am J Reprod Immunol."},{"key":"10.1016\/j.bbi.2022.12.003_b0415","doi-asserted-by":"crossref","unstructured":"Smith SE, Li J, Garbett K, Mirnics K, Patterson PH. Maternal immune activation alters fetal brain development through interleukin-6. J Neurosci. 2007;27: 10695-10672.","DOI":"10.1523\/JNEUROSCI.2178-07.2007"},{"key":"10.1016\/j.bbi.2022.12.003_b0420","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1093\/schbul\/sbn121","article-title":"Association between prenatal exposure to bacterial infection and risk of schizophrenia","volume":"35","author":"Sorensen","year":"2019","journal-title":"Schizophr Bull."},{"key":"10.1016\/j.bbi.2022.12.003_b0425","doi-asserted-by":"crossref","first-page":"248","DOI":"10.3389\/fnins.2015.00248","article-title":"Neuronal and microglial regulators of cortical wiring: Usual and novel guideposts","volume":"9","author":"Squarzoni","year":"2015","journal-title":"Front Neurosci."},{"key":"10.1016\/j.bbi.2022.12.003_b0430","doi-asserted-by":"crossref","first-page":"2586","DOI":"10.1210\/en.2016-1145","article-title":"To cull or not to cull? Considerations for studies of endocrine-disrupting chemicals","volume":"157","author":"Suvorov","year":"2016","journal-title":"Endocrinology"},{"key":"10.1016\/j.bbi.2022.12.003_b0435","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/j.neuron.2017.04.005","article-title":"MUPET-Mouse Ultrasonic Profile ExTraction: a signal processing tool for rapid and unsupervised analysis of ultrasonic vocalizations","volume":"94","author":"Van Segbroeck","year":"2017","journal-title":"Neuron"},{"key":"10.1016\/j.bbi.2022.12.003_b0440","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.expneurol.2014.05.004","article-title":"Prenatal poly I: C age-dependently alters cannabinoid type 1 receptors in offspring: A longitudinal small animal PET study using [(18)F]MK-9470","volume":"257","author":"Verdurand","year":"2014","journal-title":"Exp Neurol."},{"key":"10.1016\/j.bbi.2022.12.003_b0445","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1016\/j.euroneuro.2013.11.008","article-title":"Social interaction and social withdrawal in rodents as readouts for investigating the negative symptoms of schizophrenia","volume":"24","author":"Wilson","year":"2014","journal-title":"Eur Neuropsychopharmacol."},{"key":"10.1016\/j.bbi.2022.12.003_b0450","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/0169-5347(94)90033-7","article-title":"Mother\u2019s little helpers: patterns of male care in mammals","volume":"9","author":"Woodroffe","year":"1994","journal-title":"Trends Ecol Evol."},{"key":"10.1016\/j.bbi.2022.12.003_b0455","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/j.neubiorev.2021.07.015","article-title":"Maternal immune activation in rodent models: A systematic review of neurodevelopmental changes in gene expression and epigenetic modulation in the offspring brain","volume":"129","author":"Woods","year":"2021","journal-title":"Neurosci Biobehav Rev."},{"key":"10.1016\/j.bbi.2022.12.003_b0460","doi-asserted-by":"crossref","first-page":"6525","DOI":"10.1523\/JNEUROSCI.6107-11.2012","article-title":"Reduced excitatory neurotransmission and mild autism-relevant phenotypes in adolescent Shank3 null mutant mice","volume":"32","author":"Yang","year":"2012","journal-title":"J Neursci."},{"key":"10.1016\/j.bbi.2022.12.003_b0465","doi-asserted-by":"crossref","first-page":"e0160409","DOI":"10.1371\/journal.pone.0160409","article-title":"Maternal deprivation influences pup ultrasonic vocalisations of C57BL\/6J mice","volume":"11","author":"Yin","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.bbi.2022.12.003_b0470","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.pharmthera.2009.02.004","article-title":"Using the MATRICS to guide development of a preclinical cognitive test battery for research in schizophrenia","volume":"122","author":"Young","year":"2009","journal-title":"Pharmacol Ther."},{"key":"10.1016\/j.bbi.2022.12.003_b0475","doi-asserted-by":"crossref","unstructured":"Zambon A, Cuenca Rico L, Herman M, Gundacker A, Telalovic A, Hartenberger LM, Kuehn R, Romanov RA, Hussaini SA, Harkany T, Pollak DD. Gestational immune activation disrupts hypothalamic neurocircuits of maternal care behavior. Mol Psychiatry. 2022; Online ahead of print: 1-15.","DOI":"10.1038\/s41380-022-01602-x"},{"key":"10.1016\/j.bbi.2022.12.003_b0480","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.bbi.2021.03.018","article-title":"Poly (I:C)-induced maternal immune activation modifies ventral hippocampal regulation of stress reactivity: prevention by environmental enrichment","volume":"95","author":"Zhao","year":"2021","journal-title":"Brain Behav Immun."},{"key":"10.1016\/j.bbi.2022.12.003_b0485","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1177\/1753425912459975","article-title":"TLR3 activation efficiency by high or low molecular mass poly I:C","volume":"19","author":"Zhou","year":"2013","journal-title":"Innate Immun."}],"container-title":["Brain, Behavior, and Immunity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0889159122004639?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0889159122004639?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T08:21:04Z","timestamp":1760170864000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0889159122004639"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2]]},"references-count":97,"alternative-id":["S0889159122004639"],"URL":"https:\/\/doi.org\/10.1016\/j.bbi.2022.12.003","relation":{},"ISSN":["0889-1591"],"issn-type":[{"value":"0889-1591","type":"print"}],"subject":[],"published":{"date-parts":[[2023,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Maternal behaviours and adult offspring behavioural deficits are predicted by maternal TNF\u03b1 concentration in a rat model of neurodevelopmental disorders","name":"articletitle","label":"Article Title"},{"value":"Brain, Behavior, and Immunity","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbi.2022.12.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}