{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T19:44:19Z","timestamp":1793303059553,"version":"4.5.0"},"reference-count":61,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain, Behavior, and Immunity"],"published-print":{"date-parts":[[2023,7]]},"DOI":"10.1016\/j.bbi.2023.04.015","type":"journal-article","created":{"date-parts":[[2023,5,4]],"date-time":"2023-05-04T02:31:11Z","timestamp":1683167471000},"page":"312-319","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":34,"special_numbering":"C","title":["Correlations between kynurenines in plasma and CSF, and their relation to markers of Alzheimer\u2019s disease pathology"],"prefix":"10.1016","volume":"111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2160-7018","authenticated-orcid":false,"given":"Lieke","family":"Bakker","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"K\u00f6hler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simone J.P.M.","family":"Eussen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyonghwan","family":"Choe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel L.A.","family":"van den Hove","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gunter","family":"Kenis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bart P.F.","family":"Rutten","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arve","family":"Ulvik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Per M.","family":"Ueland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frans R.J.","family":"Verhey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inez H.G.B.","family":"Ramakers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"11","key":"10.1016\/j.bbi.2023.04.015_b0005","doi-asserted-by":"crossref","first-page":"2445","DOI":"10.1007\/s00125-021-05521-4","article-title":"Associations between plasma kynurenines and cognitive function in individuals with normal glucose metabolism, prediabetes and type 2 diabetes: the Maastricht Study","volume":"64","author":"Bakker","year":"2021","journal-title":"Diabetologia"},{"issue":"14","key":"10.1016\/j.bbi.2023.04.015_b0010","doi-asserted-by":"crossref","first-page":"3650","DOI":"10.1523\/JNEUROSCI.0587-07.2007","article-title":"Accumulation of pathological tau species and memory loss in a conditional model of tauopathy","volume":"27","author":"Berger","year":"2007","journal-title":"J. Neurosci."},{"issue":"3","key":"10.1016\/j.bbi.2023.04.015_b0015","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1038\/nrneurol.2010.4","article-title":"Cerebrospinal fluid and plasma biomarkers in Alzheimer disease","volume":"6","author":"Blennow","year":"2010","journal-title":"Nat. Rev. Neurol."},{"issue":"4","key":"10.1016\/j.bbi.2023.04.015_b0020","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1179\/174329210X12650506623645","article-title":"Indoleamine 2,3-dioxygenase and 3-hydroxykynurenine modifications are found in the neuropathology of Alzheimer's disease","volume":"15","author":"Bonda","year":"2010","journal-title":"Redox Rep."},{"issue":"2","key":"10.1016\/j.bbi.2023.04.015_b0025","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.bbr.2010.02.041","article-title":"Protective effect of systemic L-kynurenine and probenecid administration on behavioural and morphological alterations induced by toxic soluble amyloid beta (25\u201335) in rat hippocampus","volume":"210","author":"Carrillo-Mora","year":"2010","journal-title":"Behav. Brain Res."},{"issue":"6349","key":"10.1016\/j.bbi.2023.04.015_b0030","doi-asserted-by":"crossref","DOI":"10.1126\/science.aaf9794","article-title":"Tryptophan's metabolites in exercise, inflammation, and mental health","volume":"357","author":"Cervenka","year":"2017","journal-title":"Science"},{"key":"10.1016\/j.bbi.2023.04.015_b0035","doi-asserted-by":"crossref","DOI":"10.1016\/j.nbd.2022.105783","article-title":"Systemic perturbations of the kynurenine pathway precede progression to dementia independently of amyloid-beta","volume":"171","author":"Cespedes","year":"2022","journal-title":"Neurobiol. Dis."},{"issue":"1","key":"10.1016\/j.bbi.2023.04.015_b0040","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1186\/s12974-019-1567-4","article-title":"Plasma neurofilament light chain and amyloid-beta are associated with the kynurenine pathway metabolites in preclinical Alzheimer's disease","volume":"16","author":"Chatterjee","year":"2019","journal-title":"J. Neuroinflammation"},{"issue":"4","key":"10.1016\/j.bbi.2023.04.015_b0045","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.18632\/aging.101837","article-title":"Longitudinal plasma metabolomics of aging and sex","volume":"11","author":"Darst","year":"2019","journal-title":"Aging (Albany NY)"},{"issue":"3","key":"10.1016\/j.bbi.2023.04.015_b0050","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/0022-3956(75)90026-6","article-title":"\u201cMini-mental state\u201d. A practical method for grading the cognitive state of patients for the clinician","volume":"12","author":"Folstein","year":"1975","journal-title":"J. Psychiatr. Res."},{"issue":"2","key":"10.1016\/j.bbi.2023.04.015_b0055","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1016\/0014-4886(84)90239-5","article-title":"Studies on the disposition of quinolinic acid after intracerebral or systemic administration in the rat","volume":"84","author":"Foster","year":"1984","journal-title":"Exp. Neurol."},{"issue":"6","key":"10.1016\/j.bbi.2023.04.015_b0060","doi-asserted-by":"crossref","first-page":"2007","DOI":"10.1111\/j.1471-4159.1991.tb03460.x","article-title":"Blood-Brain-Barrier Transport of Kynurenines - Implications for Brain Synthesis and Metabolism","volume":"56","author":"Fukui","year":"1991","journal-title":"J. Neurochem."},{"issue":"3","key":"10.1016\/j.bbi.2023.04.015_b0065","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1007\/BF00964611","article-title":"L-kynurenine: its synthesis and possible regulatory function in brain","volume":"5","author":"Gal","year":"1980","journal-title":"Neurochem. Res."},{"issue":"1","key":"10.1016\/j.bbi.2023.04.015_b0070","doi-asserted-by":"crossref","first-page":"27","DOI":"10.2217\/bmm.09.89","article-title":"Biomarkers of oxidative damage and inflammation in Alzheimer's disease","volume":"4","author":"Galasko","year":"2010","journal-title":"Biomark. Med."},{"issue":"2","key":"10.1016\/j.bbi.2023.04.015_b0075","doi-asserted-by":"crossref","first-page":"495","DOI":"10.3233\/JAD-170485","article-title":"Kynurenine Pathway Metabolites in Alzheimer's Disease","volume":"60","author":"Giil","year":"2017","journal-title":"J. Alzheimers Dis."},{"issue":"4","key":"10.1016\/j.bbi.2023.04.015_b0080","doi-asserted-by":"crossref","first-page":"571","DOI":"10.3390\/biom10040571","article-title":"Kynurenic Acid Levels are Increased in the CSF of Alzheimer's Disease Patients","volume":"10","author":"Gonz\u00e1lez-S\u00e1nchez","year":"2020","journal-title":"Biomolecules"},{"key":"10.1016\/j.bbi.2023.04.015_b0085","first-page":"S200","article-title":"Mass spectroscopic detection of quinolinic acid in microdissected Alzheimer's disease plaques","volume":"54","author":"Guillemin","year":"2005","journal-title":"Inflamm. Res."},{"issue":"8","key":"10.1016\/j.bbi.2023.04.015_b0090","doi-asserted-by":"crossref","first-page":"1356","DOI":"10.1111\/j.1742-4658.2012.08485.x","article-title":"Quinolinic acid, the inescapable neurotoxin","volume":"279","author":"Guillemin","year":"2012","journal-title":"FEBS J."},{"issue":"4","key":"10.1016\/j.bbi.2023.04.015_b0095","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1111\/j.1365-2990.2005.00655.x","article-title":"Indoleamine 2,3 dioxygenase and quinolinic acid immunoreactivity in Alzheimer's disease hippocampus","volume":"31","author":"Guillemin","year":"2005","journal-title":"Neuropathol. Appl. Neurobiol."},{"issue":"2","key":"10.1016\/j.bbi.2023.04.015_b0100","doi-asserted-by":"crossref","first-page":"204","DOI":"10.2478\/v10039-010-0023-6","article-title":"Kynurenine and its metabolites in Alzheimer's disease patients","volume":"55","author":"Gulaj","year":"2010","journal-title":"Adv. Med. Sci."},{"issue":"6","key":"10.1016\/j.bbi.2023.04.015_b0105","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1038\/s41386-020-0607-1","article-title":"Associations among peripheral and central kynurenine pathway metabolites and inflammation in depression","volume":"45","author":"Haroon","year":"2020","journal-title":"Neuropsychopharmacology"},{"issue":"1","key":"10.1016\/j.bbi.2023.04.015_b0110","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1046\/j.1471-4159.1997.68010280.x","article-title":"Quantification of local de novo synthesis versus blood contributions to quinolinic acid concentrations in brain and systemic tissues","volume":"68","author":"Heyes","year":"1997","journal-title":"J. Neurochem."},{"issue":"2","key":"10.1016\/j.bbi.2023.04.015_b0115","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1002\/ana.410290215","article-title":"Quinolinic acid in cerebrospinal fluid and serum in HIV-1 infection: relationship to clinical and neurological status","volume":"29","author":"Heyes","year":"1991","journal-title":"Ann. Neurol."},{"issue":"2","key":"10.1016\/j.bbi.2023.04.015_b0120","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1111\/j.1528-1157.1994.tb02428.x","article-title":"Kynurenine pathway metabolites in cerebrospinal fluid and serum in complex partial seizures","volume":"35","author":"Heyes","year":"1994","journal-title":"Epilepsia"},{"issue":"23","key":"10.1016\/j.bbi.2023.04.015_b0125","doi-asserted-by":"crossref","first-page":"5151","DOI":"10.3390\/nu14235151","article-title":"Longitudinal Associations of Adherence to the Dietary World Cancer Research Fund\/American Institute for Cancer Research (WCRF\/AICR) and Dutch Healthy Diet (DHD) Recommendations with Plasma Kynurenines in Colorectal Cancer Survivors after Treatment","volume":"14","author":"Holthuijsen","year":"2022","journal-title":"Nutrients"},{"issue":"1","key":"10.1016\/j.bbi.2023.04.015_b0130","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/s12929-019-0609-7","article-title":"Clinical trials of new drugs for Alzheimer disease","volume":"27","author":"Huang","year":"2020","journal-title":"J. Biomed. Sci."},{"issue":"1","key":"10.1016\/j.bbi.2023.04.015_b0135","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-021-81306-4","article-title":"Differential effects on blood and cerebrospinal fluid immune protein markers and kynurenine pathway metabolites from aerobic physical exercise in healthy subjects","volume":"11","author":"Isung","year":"2021","journal-title":"Sci. Rep."},{"issue":"3","key":"10.1016\/j.bbi.2023.04.015_b0140","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.cell.2010.06.036","article-title":"Dendritic function of tau mediates amyloid-beta toxicity in Alzheimer's disease mouse models","volume":"142","author":"Ittner","year":"2010","journal-title":"Cell"},{"key":"10.1016\/j.bbi.2023.04.015_b0145","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.neurobiolaging.2019.03.015","article-title":"Correlation between plasma and CSF concentrations of kynurenine pathway metabolites in Alzheimer's disease and relationship to amyloid-beta and tau","volume":"80","author":"Jacobs","year":"2019","journal-title":"Neurobiol. Aging"},{"issue":"19","key":"10.1016\/j.bbi.2023.04.015_b0150","doi-asserted-by":"crossref","first-page":"1924","DOI":"10.1001\/jama.2015.4668","article-title":"Prevalence of cerebral amyloid pathology in persons without dementia A meta-analysis","volume":"313","author":"Jansen","year":"2015","journal-title":"JAMA-J. Am. Med. Assoc."},{"issue":"5","key":"10.1016\/j.bbi.2023.04.015_b0155","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1007\/s11064-020-03002-5","article-title":"Monoaminergic and Kynurenergic Characterization of Frontotemporal Dementia and Amyotrophic Lateral Sclerosis in Cerebrospinal Fluid and Serum","volume":"45","author":"Janssens","year":"2020","journal-title":"Neurochem. Res."},{"issue":"5","key":"10.1016\/j.bbi.2023.04.015_b0160","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1016\/j.bbadis.2016.06.015","article-title":"Linking mitochondrial dysfunction, metabolic syndrome and stress signaling in Neurodegeneration","volume":"1863","author":"Jha","year":"2017","journal-title":"Biochim. Biophys. Acta Mol. basis Dis."},{"key":"10.1016\/j.bbi.2023.04.015_b0165","first-page":"24","article-title":"Exercise and the Kynurenine pathway: Current state of knowledge and results from a randomized cross-over study comparing acute effects of endurance and resistance training","volume":"26","author":"Joisten","year":"2020","journal-title":"Exerc. Immunol. Rev."},{"issue":"8","key":"10.1016\/j.bbi.2023.04.015_b0170","doi-asserted-by":"crossref","first-page":"2045","DOI":"10.1111\/j.1582-4934.2010.01123.x","article-title":"Kynurenines, neurodegeneration and Alzheimer's disease","volume":"14","author":"Kincses","year":"2010","journal-title":"J. Cell Mol. Med."},{"issue":"2","key":"10.1016\/j.bbi.2023.04.015_b0175","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1046\/j.1471-4159.2002.00955.x","article-title":"Effects of systemic and central nervous system localized inflammation on the contributions of metabolic precursors to the L-kynurenine and quinolinic acid pools in brain","volume":"82","author":"Kita","year":"2002","journal-title":"J. Neurochem."},{"issue":"7","key":"10.1016\/j.bbi.2023.04.015_b0180","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1007\/BF00971011","article-title":"Transport of quinolinic acid into rabbit and rat brain","volume":"12","author":"Kitt","year":"1987","journal-title":"Neurochem. Res."},{"issue":"9","key":"10.1016\/j.bbi.2023.04.015_b0185","doi-asserted-by":"crossref","first-page":"604","DOI":"10.7326\/0003-4819-150-9-200905050-00006","article-title":"A new equation to estimate glomerular filtration rate","volume":"150","author":"Levey","year":"2009","journal-title":"Ann. Intern. Med."},{"issue":"10","key":"10.1016\/j.bbi.2023.04.015_b0190","doi-asserted-by":"crossref","first-page":"2908","DOI":"10.1093\/jn\/nxab231","article-title":"Inflammation-related marker profiling of dietary patterns and all-cause mortality in the melbourne collaborative cohort study","volume":"151","author":"Li","year":"2021","journal-title":"J. Nutr."},{"key":"10.1016\/j.bbi.2023.04.015_b0195","doi-asserted-by":"crossref","first-page":"41473","DOI":"10.1038\/srep41473","article-title":"Kynurenine pathway metabolomics predicts and provides mechanistic insight into multiple sclerosis progression","volume":"7","author":"Lim","year":"2017","journal-title":"Sci. Rep."},{"issue":"11","key":"10.1016\/j.bbi.2023.04.015_b0200","doi-asserted-by":"crossref","first-page":"2412","DOI":"10.1212\/WNL.43.11.2412-a","article-title":"The Clinical Dementia Rating (CDR): current version and scoring rules","volume":"43","author":"Morris","year":"1993","journal-title":"Neurology"},{"issue":"1-2","key":"10.1016\/j.bbi.2023.04.015_b0205","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/0304-3940(89)90043-8","article-title":"No changes in central quinolinic acid levels in Alzheimer's disease","volume":"105","author":"Mourdian","year":"1989","journal-title":"Neurosci. Lett."},{"issue":"7","key":"10.1016\/j.bbi.2023.04.015_b0210","doi-asserted-by":"crossref","first-page":"e6344","DOI":"10.1371\/journal.pone.0006344","article-title":"The excitotoxin quinolinic acid induces tau phosphorylation in human neurons","volume":"4","author":"Rahman","year":"2009","journal-title":"PLoS One"},{"issue":"4","key":"10.1016\/j.bbi.2023.04.015_b0215","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1038\/mp.2009.116","article-title":"CSF concentrations of brain tryptophan and kynurenines during immune stimulation with IFN-alpha: relationship to CNS immune responses and depression","volume":"15","author":"Raison","year":"2010","journal-title":"Mol. Psychiatry"},{"issue":"2","key":"10.1016\/j.bbi.2023.04.015_b0220","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/j.expneurol.2009.07.029","article-title":"Structural and functional changes in tau mutant mice neurons are not linked to the presence of NFTs","volume":"223","author":"Rocher","year":"2010","journal-title":"Exp. Neurol."},{"issue":"21","key":"10.1016\/j.bbi.2023.04.015_b0225","doi-asserted-by":"crossref","first-page":"15496","DOI":"10.1016\/S0021-9258(18)82284-0","article-title":"A Mechanism for Increased Quinolinic Acid Formation Following Acute Systemic Immune Stimulation","volume":"268","author":"Saito","year":"1993","journal-title":"J. Biol. Chem."},{"issue":"5733","key":"10.1016\/j.bbi.2023.04.015_b0230","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1126\/science.1113694","article-title":"Tau suppression in a neurodegenerative mouse model improves memory function","volume":"309","author":"SantaCruz","year":"2005","journal-title":"Science"},{"issue":"1","key":"10.1016\/j.bbi.2023.04.015_b0235","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1038\/s41380-019-0414-4","article-title":"The kynurenine pathway: a finger in every pie","volume":"25","author":"Savitz","year":"2020","journal-title":"Mol. Psychiatry"},{"issue":"10","key":"10.1016\/j.bbi.2023.04.015_b0240","doi-asserted-by":"crossref","first-page":"C836","DOI":"10.1152\/ajpcell.00053.2016","article-title":"Endurance exercise increases skeletal muscle kynurenine aminotransferases and plasma kynurenic acid in humans","volume":"310","author":"Schlittler","year":"2016","journal-title":"Am. J. Physiol. Cell Physiol."},{"issue":"7","key":"10.1016\/j.bbi.2023.04.015_b0245","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1038\/nrn3257","article-title":"Kynurenines in the mammalian brain: when physiology meets pathology","volume":"13","author":"Schwarcz","year":"2012","journal-title":"Nat. Rev. Neurosci."},{"issue":"10","key":"10.1016\/j.bbi.2023.04.015_b0250","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1080\/14728222.2018.1524877","article-title":"Rollercoaster ride of kynurenines: steering the wheel towards neuroprotection in Alzheimer's disease","volume":"22","author":"Sharma","year":"2018","journal-title":"Expert Opin. Ther. Targets"},{"key":"10.1016\/j.bbi.2023.04.015_b0255","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.716980","article-title":"Brain Versus Blood: A Systematic Review on the Concordance Between Peripheral and Central Kynurenine Pathway Measures in Psychiatric Disorders","volume":"12","author":"Skorobogatov","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.bbi.2023.04.015_b0260","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.bbi.2018.10.003","article-title":"The kynurenine pathway and cognitive performance in community-dwelling older adults. The Hordaland Health Study","volume":"75","author":"Solvang","year":"2019","journal-title":"Brain Behav. Immun."},{"issue":"5","key":"10.1016\/j.bbi.2023.04.015_b0265","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1111\/jnc.14843","article-title":"Age-and disease-specific changes of the kynurenine pathway in Parkinson's and Alzheimer's disease","volume":"151","author":"Sorgdrager","year":"2019","journal-title":"J. Neurochem."},{"issue":"1","key":"10.1016\/j.bbi.2023.04.015_b0270","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1111\/cei.12092","article-title":"A community-based study on determinants of circulating markers of cellular immune activation and kynurenines: the Hordaland Health Study","volume":"173","author":"Theofylaktopoulou","year":"2013","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.bbi.2023.04.015_b0275","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1093\/brain\/awh130","article-title":"CSF quinolinic acid levels are determined by local HIV infection: cross-sectional analysis and modelling of dynamics following antiretroviral therapy","volume":"127","author":"Valle","year":"2004","journal-title":"Brain"},{"issue":"1","key":"10.1016\/j.bbi.2023.04.015_b0280","doi-asserted-by":"crossref","DOI":"10.1186\/s13195-019-0551-7","article-title":"Systemic and central nervous system metabolic alterations in Alzheimer's disease","volume":"11","author":"van der Velpen","year":"2019","journal-title":"Alzheimers Res. Ther."},{"issue":"1","key":"10.1016\/j.bbi.2023.04.015_b0285","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1038\/nrd3793","article-title":"Kynurenines in the CNS: recent advances and new questions","volume":"12","author":"V\u00e9csei","year":"2013","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.bbi.2023.04.015_b0290","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.bbi.2019.06.033","article-title":"Microglial production of quinolinic acid as a target and a biomarker of the antidepressant effect of ketamine","volume":"81","author":"Verdonk","year":"2019","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.bbi.2023.04.015_b0295","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4137\/IJTR.S13958","article-title":"Kynurenic Acid levels in cerebrospinal fluid from patients with Alzheimer's disease or dementia with lewy bodies","volume":"7","author":"Wennstrom","year":"2014","journal-title":"Int. J. Tryptophan Res."},{"issue":"1","key":"10.1016\/j.bbi.2023.04.015_b0300","doi-asserted-by":"crossref","DOI":"10.1186\/s13195-020-00741-z","article-title":"Metabolic phenotyping reveals a reduction in the bioavailability of serotonin and kynurenine pathway metabolites in both the urine and serum of individuals living with Alzheimer's disease","volume":"13","author":"Whiley","year":"2021","journal-title":"Alzheimers Res. Therapy"},{"issue":"6","key":"10.1016\/j.bbi.2023.04.015_b0305","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1016\/j.cell.2011.05.020","article-title":"Kynurenine 3-monooxygenase inhibition in blood ameliorates neurodegeneration","volume":"145","author":"Zwilling","year":"2011","journal-title":"Cell"}],"container-title":["Brain, Behavior, and Immunity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0889159123001137?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0889159123001137?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T03:37:09Z","timestamp":1762313829000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0889159123001137"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7]]},"references-count":61,"alternative-id":["S0889159123001137"],"URL":"https:\/\/doi.org\/10.1016\/j.bbi.2023.04.015","relation":{},"ISSN":["0889-1591"],"issn-type":[{"value":"0889-1591","type":"print"}],"subject":[],"published":{"date-parts":[[2023,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Correlations between kynurenines in plasma and CSF, and their relation to markers of Alzheimer\u2019s disease pathology","name":"articletitle","label":"Article Title"},{"value":"Brain, Behavior, and Immunity","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbi.2023.04.015","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}