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Protoc."},{"issue":"3","key":"10.1016\/j.bbi.2023.07.024_b0335","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1161\/STROKEAHA.119.028638","article-title":"IL (Interleukin)-15 Bridges Astrocyte-Microglia Crosstalk and Exacerbates Brain Injury Following Intracerebral Hemorrhage","volume":"51","author":"Shi","year":"2020","journal-title":"Stroke"},{"issue":"8","key":"10.1016\/j.bbi.2023.07.024_b0340","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1038\/ng1609","article-title":"Mutations in the endosomal ESCRTIII-complex subunit CHMP2B in frontotemporal dementia","volume":"37","author":"Skibinski","year":"2005","journal-title":"Nat. Genet."},{"issue":"6","key":"10.1016\/j.bbi.2023.07.024_b0345","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1016\/j.ajhg.2012.04.021","article-title":"Strikingly Different Clinicopathological Phenotypes Determined by Progranulin-Mutation Dosage","volume":"90","author":"Smith","year":"2012","journal-title":"Am. J. Hum. Genet."},{"issue":"D1","key":"10.1016\/j.bbi.2023.07.024_b0350","doi-asserted-by":"crossref","first-page":"D607","DOI":"10.1093\/nar\/gky1131","article-title":"STRING v11: protein\u2013protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets","volume":"47","author":"Szklarczyk","year":"2019","journal-title":"Nucleic Acids Res."},{"issue":"2","key":"10.1016\/j.bbi.2023.07.024_b0355","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1007\/s12035-014-9070-5","article-title":"Differential Roles of M1 and M2 Microglia in Neurodegenerative Diseases","volume":"53","author":"Tang","year":"2016","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.bbi.2023.07.024_b0360","doi-asserted-by":"crossref","unstructured":"Tannahill, G. M., Curtis, A. M., Adamik, J., Palsson-Mcdermott, E. M., McGettrick, A. F., Goel, G., Frezza, C., Bernard, N. J., Kelly, B., Foley, N. H., Zheng, L., Gardet, A., Tong, Z., Jany, S. S., Corr, S. C., Haneklaus, M., Caffrey, B. E., Pierce, K., Walmsley, S., \u2026 O\u2019Neill, L. A. J. (2013). Succinate is an inflammatory signal that induces IL-1\u03b2 through HIF-1\u03b1. Nature 2013 496:7444, 496(7444), 238\u2013242. 10.1038\/nature11986.","DOI":"10.1038\/nature11986"},{"issue":"3","key":"10.1016\/j.bbi.2023.07.024_b0365","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1016\/j.nbd.2009.11.004","article-title":"Neuroinflammation in Parkinson\u2019s disease: its role in neuronal death and implications for therapeutic intervention","volume":"37","author":"Tansey","year":"2010","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.bbi.2023.07.024_b0370","doi-asserted-by":"crossref","DOI":"10.1016\/j.nbd.2020.105144","article-title":"Lessons learned from CHMP2B, implications for frontotemporal dementia and amyotrophic lateral sclerosis","volume":"147","author":"Ugbode","year":"2021","journal-title":"Neurobiol. Dis."},{"issue":"11","key":"10.1016\/j.bbi.2023.07.024_b0375","doi-asserted-by":"crossref","first-page":"2228","DOI":"10.1093\/hmg\/ddq100","article-title":"Disruption of endocytic trafficking in frontotemporal dementia with CHMP2B mutations","volume":"19","author":"Urwin","year":"2010","journal-title":"Hum. Mol. 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Neurosci."},{"issue":"15","key":"10.1016\/j.bbi.2023.07.024_b0390","doi-asserted-by":"crossref","first-page":"3341","DOI":"10.1093\/hmg\/ddw182","article-title":"A transgenic mouse expressing CHMP2Bintron5 mutant in neurons develops histological and behavioural features of amyotrophic lateral sclerosis and frontotemporal dementia","volume":"25","author":"Vernay","year":"2016","journal-title":"Hum. Mol. Genet."},{"issue":"1","key":"10.1016\/j.bbi.2023.07.024_b0395","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1038\/s41580-019-0177-4","article-title":"The many functions of ESCRTs","volume":"21","author":"Vietri","year":"2020","journal-title":"In Nature Reviews Molecular Cell Biology (Vol."},{"issue":"JULY","key":"10.1016\/j.bbi.2023.07.024_b0400","doi-asserted-by":"crossref","first-page":"1462","DOI":"10.3389\/fimmu.2019.01462","article-title":"The metabolic signature of macrophage responses","volume":"10","author":"Viola","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.bbi.2023.07.024_b0405","doi-asserted-by":"crossref","unstructured":"Wang, L., Wang, S., & Li, W. (2012). RSeQC: quality control of RNA-seq experiments. 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