{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T23:35:12Z","timestamp":1793316912426,"version":"4.5.0"},"reference-count":76,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,8,8]],"date-time":"2024-08-08T00:00:00Z","timestamp":1723075200000},"content-version":"am","delay-in-days":312,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R21AG072234"],"award-info":[{"award-number":["R21AG072234"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["1R01AI175087"],"award-info":[{"award-number":["1R01AI175087"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain, Behavior, and Immunity"],"published-print":{"date-parts":[[2023,10]]},"DOI":"10.1016\/j.bbi.2023.07.027","type":"journal-article","created":{"date-parts":[[2023,8,2]],"date-time":"2023-08-02T21:12:27Z","timestamp":1691010747000},"page":"341-352","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["Administration of recombinant FOXN1 protein attenuates Alzheimer\u2019s pathology in mice"],"prefix":"10.1016","volume":"113","author":[{"given":"Jin","family":"Zhao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenzhen","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuan Chen","family":"Lai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laijun","family":"Lai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbi.2023.07.027_b0005","doi-asserted-by":"crossref","unstructured":"2022. 2022 Alzheimer's disease facts and figures. Alzheimer's & dementia: the journal of the Alzheimer's Association 18, 700\u2013789.","DOI":"10.1002\/alz.12638"},{"issue":"6","key":"10.1016\/j.bbi.2023.07.027_b0010","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.it.2012.03.005","article-title":"Thymic epithelial cells: working class heroes for T cell development and repertoire selection","volume":"33","author":"Anderson","year":"2012","journal-title":"Trends Immunol."},{"issue":"2","key":"10.1016\/j.bbi.2023.07.027_b0015","doi-asserted-by":"crossref","first-page":"e17397","DOI":"10.1371\/journal.pone.0017397","article-title":"DHA improves cognition and prevents dysfunction of entorhinal cortex neurons in 3xTg-AD mice","volume":"6","author":"Arsenault","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.bbi.2023.07.027_b0020","doi-asserted-by":"crossref","first-page":"7967","DOI":"10.1038\/ncomms8967","article-title":"Breaking immune tolerance by targeting Foxp3(+) regulatory T cells mitigates Alzheimer's disease pathology","volume":"6","author":"Baruch","year":"2015","journal-title":"Nat. Commun."},{"issue":"2","key":"10.1016\/j.bbi.2023.07.027_b0025","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1038\/nm.4022","article-title":"PD-1 immune checkpoint blockade reduces pathology and improves memory in mouse models of Alzheimer's disease","volume":"22","author":"Baruch","year":"2016","journal-title":"Nat. Med."},{"key":"10.1016\/j.bbi.2023.07.027_b0030","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.coph.2015.10.003","article-title":"Linking T cells to Alzheimer's disease: from neurodegeneration to neurorepair","volume":"26","author":"Bryson","year":"2016","journal-title":"Curr. Opin. Pharmacol."},{"key":"10.1016\/j.bbi.2023.07.027_b0035","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.nbd.2008.12.015","article-title":"Abeta-specific Th2 cells provide cognitive and pathological benefits to Alzheimer's mice without infiltrating the CNS","volume":"34","author":"Cao","year":"2009","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.bbi.2023.07.027_b0040","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1182\/blood-2008-05-156265","article-title":"Foxn1 is required to maintain the postnatal thymic microenvironment in a dosage-sensitive manner","volume":"113","author":"Chen","year":"2009","journal-title":"Blood"},{"issue":"8","key":"10.1016\/j.bbi.2023.07.027_b0045","doi-asserted-by":"crossref","first-page":"5836","DOI":"10.1074\/jbc.M109.072124","article-title":"Postnatal tissue-specific disruption of transcription factor FoxN1 triggers acute thymic atrophy","volume":"285","author":"Cheng","year":"2010","journal-title":"J. Biol. Chem."},{"issue":"5","key":"10.1016\/j.bbi.2023.07.027_b0050","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.smim.2007.10.006","article-title":"Impact of niche aging on thymic regeneration and immune reconstitution","volume":"19","author":"Chidgey","year":"2007","journal-title":"Semin. Immunol."},{"issue":"1","key":"10.1016\/j.bbi.2023.07.027_b0055","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1146\/annurev.cellbio.23.090506.123547","article-title":"The thymus as an inductive site for T lymphopoiesis","volume":"23","author":"Ciofani","year":"2007","journal-title":"Annu. Rev. Cell Dev. Biol."},{"issue":"1","key":"10.1016\/j.bbi.2023.07.027_b0060","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.nbd.2007.06.013","article-title":"Age-dependent sexual dimorphism in cognition and stress response in the 3xTg-AD mice","volume":"28","author":"Clinton","year":"2007","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.bbi.2023.07.027_b0065","doi-asserted-by":"crossref","first-page":"7281","DOI":"10.1523\/JNEUROSCI.0490-10.2010","article-title":"Synergistic Interactions between Abeta, tau, and alpha-synuclein: acceleration of neuropathology and cognitive decline","volume":"30","author":"Clinton","year":"2010","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bbi.2023.07.027_b0070","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.bbr.2014.08.002","article-title":"Assessing rodent hippocampal involvement in the novel object recognition task. A review","volume":"285","author":"Cohen","year":"2015","journal-title":"Behav. Brain Res."},{"issue":"38","key":"10.1016\/j.bbi.2023.07.027_b0075","doi-asserted-by":"crossref","first-page":"16613","DOI":"10.1073\/pnas.1004623107","article-title":"Thymopoiesis in mice depends on a Foxn1 -positive thymic epithelial cell lineage","volume":"107","author":"Corbeaux","year":"2010","journal-title":"PNAS"},{"key":"10.1016\/j.bbi.2023.07.027_b0080","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1038\/382716a0","article-title":"Scavenger receptor-mediated adhesion of microglia to beta-amyloid fibrils","volume":"382","author":"El Khoury","year":"1996","journal-title":"Nature"},{"issue":"2","key":"10.1016\/j.bbi.2023.07.027_b0085","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/j.bbr.2012.07.004","article-title":"Cognitive and non-cognitive behaviors in the triple transgenic mouse model of Alzheimer's disease expressing mutated APP, PS1, and Mapt (3xTg-AD)","volume":"234","author":"Filali","year":"2012","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.bbi.2023.07.027_b0090","doi-asserted-by":"crossref","unstructured":"Fisher, Y., Strominger, I., Biton, S., Nemirovsky, A., Baron, R., Monsonego, A., 2014. Th1 polarization of T cells injected into the cerebrospinal fluid induces brain immunosurveillance. J. Immunol. (Baltimore, Md. : 1950) 192, 92\u2013102.","DOI":"10.4049\/jimmunol.1301707"},{"key":"10.1016\/j.bbi.2023.07.027_b0095","doi-asserted-by":"crossref","first-page":"2030","DOI":"10.1038\/ncomms3030","article-title":"Scara1 deficiency impairs clearance of soluble amyloid-\u03b2 by mononuclear phagocytes and accelerates Alzheimer's-like disease progression","volume":"4","author":"Frenkel","year":"2013","journal-title":"Nat. Commun."},{"issue":"8","key":"10.1016\/j.bbi.2023.07.027_b0100","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1007\/s10875-017-0445-z","article-title":"FOXN1 deficiency: from the discovery to novel therapeutic approaches","volume":"37","author":"Gallo","year":"2017","journal-title":"J. Clin. Immunol."},{"issue":"7790","key":"10.1016\/j.bbi.2023.07.027_b0105","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1038\/s41586-019-1895-7","article-title":"Clonally expanded CD8 T cells patrol the cerebrospinal fluid in Alzheimer's disease","volume":"577","author":"Gate","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.bbi.2023.07.027_b0110","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1111\/j.1749-6632.2012.06639.x","article-title":"Peripheral immune system and neuroimmune communication impairment in a mouse model of Alzheimer's disease","volume":"1262","author":"Gim\u00e9nez-Llort","year":"2012","journal-title":"Ann. N. Y. Acad. Sci."},{"issue":"7434","key":"10.1016\/j.bbi.2023.07.027_b0115","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1038\/nature11729","article-title":"NLRP3 is activated in Alzheimer's disease and contributes to pathology in APP\/PS1 mice","volume":"493","author":"Heneka","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.bbi.2023.07.027_b0120","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.brainres.2008.03.079","article-title":"Females exhibit more extensive amyloid, but not tau, pathology in an Alzheimer transgenic model","volume":"1216","author":"Hirata-Fukae","year":"2008","journal-title":"Brain Res."},{"issue":"7632","key":"10.1016\/j.bbi.2023.07.027_b0125","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1038\/nature20587","article-title":"Gamma frequency entrainment attenuates amyloid load and modifies microglia","volume":"540","author":"Iaccarino","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.bbi.2023.07.027_b0130","doi-asserted-by":"crossref","DOI":"10.1016\/j.nbd.2019.104636","article-title":"Active immunization with tau epitope in a mouse model of tauopathy induced strong antibody response together with improvement in short memory and pSer396-tau pathology","volume":"134","author":"Joly-Amado","year":"2020","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.bbi.2023.07.027_b0135","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/s13073-023-01155-w","article-title":"The neuroimmune axis of Alzheimer's disease","volume":"15","author":"Jorfi","year":"2023","journal-title":"Genome Med."},{"issue":"3","key":"10.1016\/j.bbi.2023.07.027_b0140","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.3233\/JAD-170779","article-title":"Sex-dependent differences in spontaneous autoimmunity in adult 3xTg-AD Mice","volume":"63","author":"Kapadia","year":"2018","journal-title":"J. Alzheimer's Disease: JAD"},{"key":"10.1016\/j.bbi.2023.07.027_b0145","doi-asserted-by":"crossref","first-page":"3427","DOI":"10.1093\/brain\/awt259","article-title":"IFN-gamma-dependent activation of the brain's choroid plexus for CNS immune surveillance and repair","volume":"136","author":"Kunis","year":"2013","journal-title":"Brain"},{"key":"10.1016\/j.bbi.2023.07.027_b0150","doi-asserted-by":"crossref","first-page":"3012","DOI":"10.1002\/stem.238","article-title":"Generation of thymic epithelial cell progenitors by mouse embryonic stem cells","volume":"27","author":"Lai","year":"2009","journal-title":"Stem Cells"},{"key":"10.1016\/j.bbi.2023.07.027_b0155","doi-asserted-by":"crossref","first-page":"3552","DOI":"10.1172\/JCI46055","article-title":"Recombinant IL-7\/HGFbeta efficiently induces transplantable murine hematopoietic stem cells","volume":"122","author":"Lai","year":"2012","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bbi.2023.07.027_b0160","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1186\/s12974-021-02320-x","article-title":"Administration of anti-ERMAP antibody ameliorates Alzheimer's disease in mice","volume":"18","author":"Liu","year":"2021","journal-title":"J. Neuroinflammation"},{"issue":"10","key":"10.1016\/j.bbi.2023.07.027_b0165","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1016\/j.it.2015.08.006","article-title":"Revisiting the mechanisms of CNS immune privilege","volume":"36","author":"Louveau","year":"2015","journal-title":"Trends Immunol."},{"issue":"7","key":"10.1016\/j.bbi.2023.07.027_b0170","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/j.it.2009.04.003","article-title":"Thymic involution and immune reconstitution","volume":"30","author":"Lynch","year":"2009","journal-title":"Trends Immunol."},{"issue":"11","key":"10.1016\/j.bbi.2023.07.027_b0175","doi-asserted-by":"crossref","first-page":"2334","DOI":"10.1007\/s00018-003-3020-0","article-title":"Regulation of macrophage activation","volume":"60","author":"Ma","year":"2003","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.bbi.2023.07.027_b0180","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/S1877-1173(10)92005-X","article-title":"Transcriptional regulation of thymus organogenesis and thymic epithelial cell differentiation","volume":"92","author":"Manley","year":"2010","journal-title":"Prog. Mol. Biol. Transl. Sci."},{"issue":"7","key":"10.1016\/j.bbi.2023.07.027_b0185","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1038\/mp.2014.12","article-title":"Preferential loss of dorsal-hippocampus synapses underlies memory impairments provoked by short, multimodal stress","volume":"19","author":"Maras","year":"2014","journal-title":"Mol. Psychiatry"},{"issue":"1","key":"10.1016\/j.bbi.2023.07.027_b0190","doi-asserted-by":"crossref","first-page":"191","DOI":"10.3233\/JAD-131490","article-title":"Autoimmune manifestations in the 3xTg-AD model of Alzheimer's disease","volume":"39","author":"Marchese","year":"2014","journal-title":"J. Alzheimer's Disease: JAD"},{"key":"10.1016\/j.bbi.2023.07.027_b0195","doi-asserted-by":"crossref","first-page":"E1316","DOI":"10.1073\/pnas.1525466113","article-title":"The adaptive immune system restrains Alzheimer\u2019s disease pathogenesis by modulating microglial function","volume":"113","author":"Marsh","year":"2016","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.bbi.2023.07.027_b0200","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.brainresbull.2015.07.001","article-title":"Repeated cognitive stimulation alleviates memory impairments in an Alzheimer's disease mouse model","volume":"117","author":"Martinez-Coria","year":"2015","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.bbi.2023.07.027_b0205","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.regg.2013.04.003","article-title":"Premature immunosenescence in triple-transgenic mice for Alzheimer's disease","volume":"49","author":"Mate","year":"2014","journal-title":"Revista Espanola de Geriatria y Gerontol."},{"key":"10.1016\/j.bbi.2023.07.027_b0210","doi-asserted-by":"crossref","DOI":"10.3389\/fneur.2021.672455","article-title":"Cross-talk of the CNS with immune cells and functions in health and disease","volume":"12","author":"Matejuk","year":"2021","journal-title":"Front. Neurol."},{"issue":"1","key":"10.1016\/j.bbi.2023.07.027_b0215","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.bbi.2009.09.009","article-title":"Depression and immunity: a role for T cells?","volume":"24","author":"Miller","year":"2010","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.bbi.2023.07.027_b0220","doi-asserted-by":"crossref","first-page":"2529","DOI":"10.1182\/blood-2006-08-043794","article-title":"Sustained thymopoiesis and improvement in functional immunity induced by exogenous KGF administration in murine models of aging","volume":"109","author":"Min","year":"2007","journal-title":"Blood"},{"key":"10.1016\/j.bbi.2023.07.027_b0225","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1093\/jmcb\/mjt028","article-title":"A deficiency in CCR2+ monocytes: the hidden side of Alzheimer's disease","volume":"5","author":"Naert","year":"2013","journal-title":"J. Mol. Cell Biol."},{"issue":"6501","key":"10.1016\/j.bbi.2023.07.027_b0230","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1038\/372103a0","article-title":"New member of the winged-helix protein family disrupted in mouse and rat nude mutations","volume":"372","author":"Nehls","year":"1994","journal-title":"Nature"},{"key":"10.1016\/j.bbi.2023.07.027_b0235","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharmthera.2022.108119","article-title":"Blood-brain barrier leakage in Alzheimer's disease: from discovery to clinical relevance","volume":"234","author":"Nehra","year":"2022","journal-title":"Pharmacol. Ther."},{"issue":"11","key":"10.1016\/j.bbi.2023.07.027_b0240","doi-asserted-by":"crossref","first-page":"e1002348","DOI":"10.1371\/journal.pgen.1002348","article-title":"Foxn1 regulates lineage progression in cortical and medullary thymic epithelial cells but is dispensable for medullary sublineage divergence","volume":"7","author":"Nowell","year":"2011","journal-title":"PLoS Genet."},{"issue":"3","key":"10.1016\/j.bbi.2023.07.027_b0245","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/S0896-6273(03)00434-3","article-title":"Triple-transgenic model of Alzheimer's disease with plaques and tangles: intracellular Abeta and synaptic dysfunction","volume":"39","author":"Oddo","year":"2003","journal-title":"Neuron"},{"key":"10.1016\/j.bbi.2023.07.027_b0250","doi-asserted-by":"crossref","DOI":"10.1016\/j.brainres.2021.147437","article-title":"Age and gender differences for the behavioral phenotypes of 3xTg Alzheimer's disease mice","volume":"1762","author":"Pairojana","year":"2021","journal-title":"Brain Res."},{"issue":"1","key":"10.1016\/j.bbi.2023.07.027_b0255","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1146\/annurev.iy.11.040193.001555","article-title":"T cell-dependent B cell activation","volume":"11","author":"Parker","year":"1993","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.bbi.2023.07.027_b0260","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1037\/a0012520","article-title":"Age-dependent phenotypic characteristics of a triple transgenic mouse model of Alzheimer disease","volume":"122","author":"Pietropaolo","year":"2008","journal-title":"Behav. Neurosci."},{"issue":"5","key":"10.1016\/j.bbi.2023.07.027_b0265","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/j.jpsychires.2004.12.005","article-title":"Decline of immune responsiveness: a pathogenetic factor in Alzheimer's disease?","volume":"39","author":"Richartz","year":"2005","journal-title":"J. Psychiatr. Res."},{"key":"10.1016\/j.bbi.2023.07.027_b0270","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1038\/s41467-019-08352-5","article-title":"PD-1\/PD-L1 checkpoint blockade harnesses monocyte-derived macrophages to combat cognitive impairment in a tauopathy mouse model","volume":"10","author":"Rosenzweig","year":"2019","journal-title":"Nat. Commun."},{"issue":"4","key":"10.1016\/j.bbi.2023.07.027_b0275","doi-asserted-by":"crossref","first-page":"830.e1","DOI":"10.1016\/j.neurobiolaging.2011.07.005","article-title":"3xTgAD mice exhibit altered behavior and elevated A\u03b2 after chronic mild social stress","volume":"33","author":"Rothman","year":"2012","journal-title":"Neurobiol. Aging"},{"issue":"6348","key":"10.1016\/j.bbi.2023.07.027_b0280","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1126\/science.aai8231","article-title":"Can immunotherapy treat neurodegeneration?","volume":"357","author":"Schwartz","year":"2017","journal-title":"Science (New York, N.Y.)"},{"key":"10.1016\/j.bbi.2023.07.027_b0285","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.jaut.2014.08.002","article-title":"Breaking peripheral immune tolerance to CNS antigens in neurodegenerative diseases: boosting autoimmunity to fight-off chronic neuroinflammation","volume":"54","author":"Schwartz","year":"2014","journal-title":"J. Autoimmun."},{"key":"10.1016\/j.bbi.2023.07.027_b0290","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1038\/nm1782","article-title":"Amyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory","volume":"14","author":"Shankar","year":"2008","journal-title":"Nat. Med."},{"issue":"7","key":"10.1016\/j.bbi.2023.07.027_b0295","doi-asserted-by":"crossref","first-page":"e1000113","DOI":"10.1371\/journal.pmed.1000113","article-title":"Infiltrating blood-derived macrophages are vital cells playing an anti-inflammatory role in recovery from spinal cord injury in mice","volume":"6","author":"Shechter","year":"2009","journal-title":"PLoS Med."},{"issue":"4","key":"10.1016\/j.bbi.2023.07.027_b0300","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/j.neuron.2006.01.022","article-title":"Bone marrow-derived microglia play a critical role in restricting senile plaque formation in Alzheimer's disease","volume":"49","author":"Simard","year":"2006","journal-title":"Neuron"},{"issue":"6","key":"10.1016\/j.bbi.2023.07.027_b0305","doi-asserted-by":"crossref","first-page":"1518","DOI":"10.1002\/eji.201546196","article-title":"FOXN1 recombinant protein enhances T-cell regeneration after hematopoietic stem cell transplantation in mice","volume":"46","author":"Song","year":"2016","journal-title":"Eur. J. Immunol."},{"issue":"1","key":"10.1016\/j.bbi.2023.07.027_b0310","doi-asserted-by":"crossref","first-page":"335","DOI":"10.3233\/JAD-201015","article-title":"Partial inhibition of mitochondrial complex I reduces tau pathology and improves energy homeostasis and synaptic function in 3xTg-AD mice","volume":"79","author":"Stojakovic","year":"2021","journal-title":"J. Alzheimer's Dis.: JAD"},{"key":"10.1016\/j.bbi.2023.07.027_b0315","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.bbr.2015.04.012","article-title":"Early detection of cognitive deficits in the 3xTg-AD mouse model of Alzheimer's disease","volume":"289","author":"Stover","year":"2015","journal-title":"Behav. Brain Res."},{"issue":"2","key":"10.1016\/j.bbi.2023.07.027_b0320","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1093\/gerona\/gln068","article-title":"Key research opportunities in immune system aging","volume":"64A","author":"Swain","year":"2009","journal-title":"J. Gerontol. Series A, Biol. Sci. Med. Sci."},{"key":"10.1016\/j.bbi.2023.07.027_b0325","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1159\/000237337","article-title":"The murine thymic microenvironment: changes with age","volume":"111","author":"Takeoka","year":"1996","journal-title":"Int. Arch. Allergy Immunol."},{"issue":"8","key":"10.1016\/j.bbi.2023.07.027_b0330","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1038\/nrneurol.2015.119","article-title":"Clearance systems in the brain-implications for Alzheimer disease","volume":"11","author":"Tarasoff-Conway","year":"2015","journal-title":"Nat. Rev. Neurol."},{"issue":"1","key":"10.1016\/j.bbi.2023.07.027_b0335","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1111\/j.0105-2896.2005.00275.x","article-title":"Insights into thymic aging and regeneration","volume":"205","author":"Taub","year":"2005","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.bbi.2023.07.027_b0340","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1186\/s13195-015-0125-2","article-title":"The dynamics of monocytes and microglia in Alzheimer's disease","volume":"7","author":"Theriault","year":"2015","journal-title":"Alzheimers Res. Ther."},{"key":"10.1016\/j.bbi.2023.07.027_b0345","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.nbd.2003.08.009","article-title":"Gender differences in the amount and deposition of amyloidbeta in APPswe and PS1 double transgenic mice","volume":"14","author":"Wang","year":"2003","journal-title":"Neurobiol. Dis."},{"issue":"7","key":"10.1016\/j.bbi.2023.07.027_b0350","doi-asserted-by":"crossref","first-page":"3979","DOI":"10.4049\/jimmunol.0801218","article-title":"CD4-positive T lymphocytes provide a neuroimmunological link in the control of adult hippocampal neurogenesis","volume":"182","author":"Wolf","year":"2009","journal-title":"J. Immunol."},{"issue":"3","key":"10.1016\/j.bbi.2023.07.027_b0355","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.nbd.2011.01.005","article-title":"Mechanism mediating oligomeric A\u03b2 clearance by na\u00efve primary microglia","volume":"42","author":"Yang","year":"2011","journal-title":"Neurobiol. Dis."},{"issue":"5","key":"10.1016\/j.bbi.2023.07.027_b0360","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.smim.2005.05.004","article-title":"Aging and T cell development: interplay between progenitors and their environment","volume":"17","author":"Zediak","year":"2005","journal-title":"Semin. Immunol."},{"issue":"8","key":"10.1016\/j.bbi.2023.07.027_b0365","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.7150\/ijbs.5033","article-title":"Insights on FoxN1 biological significance and usages of the \u201cnude\u201d mouse in studies of T-lymphopoiesis","volume":"8","author":"Zhang","year":"2012","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.bbi.2023.07.027_b0370","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1186\/s13104-020-4916-6","article-title":"An open-source video tracking system for mouse locomotor activity analysis","volume":"13","author":"Zhang","year":"2020","journal-title":"BMC. Res. Notes"},{"key":"10.1016\/j.bbi.2023.07.027_b0375","doi-asserted-by":"crossref","first-page":"1781","DOI":"10.3389\/fimmu.2020.01781","article-title":"Administration of amyloid precursor protein gene deleted mouse ESC-derived thymic epithelial progenitors attenuates Alzheimer's pathology","volume":"11","author":"Zhao","year":"2020","journal-title":"Front. Immunol."},{"issue":"12","key":"10.1016\/j.bbi.2023.07.027_b0380","doi-asserted-by":"crossref","first-page":"2167","DOI":"10.1007\/s00018-017-2463-7","article-title":"Clearance of cerebral A\u03b2 in Alzheimer's disease: reassessing the role of microglia and monocytes","volume":"74","author":"Zuroff","year":"2017","journal-title":"Cell. Mol. Life Sci."}],"container-title":["Brain, Behavior, and Immunity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0889159123002209?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0889159123002209?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T08:24:51Z","timestamp":1760171091000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0889159123002209"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10]]},"references-count":76,"alternative-id":["S0889159123002209"],"URL":"https:\/\/doi.org\/10.1016\/j.bbi.2023.07.027","relation":{},"ISSN":["0889-1591"],"issn-type":[{"value":"0889-1591","type":"print"}],"subject":[],"published":{"date-parts":[[2023,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Administration of recombinant FOXN1 protein attenuates Alzheimer\u2019s pathology in mice","name":"articletitle","label":"Article Title"},{"value":"Brain, Behavior, and Immunity","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbi.2023.07.027","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}