{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T01:56:59Z","timestamp":1789696619321,"version":"4.0.1"},"reference-count":69,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"am","delay-in-days":305,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["2T32HL007427"],"award-info":[{"award-number":["2T32HL007427"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000016","name":"U.S. Department of Health and Human Services","doi-asserted-by":"publisher","award":["75N92021D00002"],"award-info":[{"award-number":["75N92021D00002"]}],"id":[{"id":"10.13039\/100000016","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000016","name":"U.S. Department of Health and Human Services","doi-asserted-by":"publisher","award":["75N92021D00001"],"award-info":[{"award-number":["75N92021D00001"]}],"id":[{"id":"10.13039\/100000016","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000016","name":"U.S. Department of Health and Human Services","doi-asserted-by":"publisher","award":["75N92021D00004"],"award-info":[{"award-number":["75N92021D00004"]}],"id":[{"id":"10.13039\/100000016","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000016","name":"U.S. Department of Health and Human Services","doi-asserted-by":"publisher","award":["75N92021D00003"],"award-info":[{"award-number":["75N92021D00003"]}],"id":[{"id":"10.13039\/100000016","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000016","name":"U.S. Department of Health and Human Services","doi-asserted-by":"publisher","award":["75N92021D00005"],"award-info":[{"award-number":["75N92021D00005"]}],"id":[{"id":"10.13039\/100000016","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000016","name":"U.S. Department of Health and Human Services","doi-asserted-by":"publisher","award":["HHSN268201300008C"],"award-info":[{"award-number":["HHSN268201300008C"]}],"id":[{"id":"10.13039\/100000016","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["HHSN268201300008C"],"award-info":[{"award-number":["HHSN268201300008C"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AG05160001A1"],"award-info":[{"award-number":["R01AG05160001A1"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["UM1CA186107"],"award-info":[{"award-number":["UM1CA186107"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01CA49449"],"award-info":[{"award-number":["R01CA49449"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain, Behavior, and Immunity"],"published-print":{"date-parts":[[2023,11]]},"DOI":"10.1016\/j.bbi.2023.08.010","type":"journal-article","created":{"date-parts":[[2023,8,7]],"date-time":"2023-08-07T20:43:17Z","timestamp":1691440997000},"page":"262-274","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"special_numbering":"C","title":["Metabolomic profiles of chronic distress are associated with cardiovascular disease risk and inflammation-related risk factors"],"prefix":"10.1016","volume":"114","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1488-1692","authenticated-orcid":false,"given":"Raji","family":"Balasubramanian","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine H.","family":"Shutta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Guasch-Ferre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianyi","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaili C.","family":"Jha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiwen","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aladdin H.","family":"Shadyab","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JoAnn E.","family":"Manson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dolores","family":"Corella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Montserrat","family":"Fit\u00f3","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank B.","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathryn M.","family":"Rexrode","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clary B.","family":"Clish","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan E.","family":"Hankinson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura D.","family":"Kubzansky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbi.2023.08.010_b0005","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.2337\/db14-0228","article-title":"Bilirubin as a potential causal factor in type 2 diabetes risk: a Mendelian randomization study","volume":"64","author":"Abbasi","year":"2015","journal-title":"Diabetes"},{"issue":"8","key":"10.1016\/j.bbi.2023.08.010_b0010","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1016\/j.psyneuen.2012.11.014","article-title":"Metabolomic profiles in individuals with negative affectivity and social inhibition: a population-based study of Type D personality","volume":"38","author":"Altmaier","year":"2013","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.bbi.2023.08.010_b0015","first-page":"1039","article-title":"The nurses' health study","volume":"78","author":"Belanger","year":"1978","journal-title":"Am. J. Nurs."},{"issue":"5","key":"10.1016\/j.bbi.2023.08.010_b0020","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1017\/S0033291716002828","article-title":"Oxidative stress in major depressive and anxiety disorders, and the association with antidepressant use; results from a large adult cohort","volume":"47","author":"Black","year":"2017","journal-title":"Psychol. Med."},{"issue":"Pt 1","key":"10.1016\/j.bbi.2023.08.010_b0025","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1111\/j.2044-8341.1987.tb00001.x","article-title":"Discriminant validity of the Crown-Crisp Experiential Index","volume":"60","author":"Burgess","year":"1987","journal-title":"Br. J. Med. Psychol."},{"key":"10.1016\/j.bbi.2023.08.010_b0030","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2020.576347","article-title":"Adipocyte Ceramides-The Nexus of Inflammation and Metabolic Disease","volume":"11","author":"Chaurasia","year":"2020","journal-title":"Front. Immunol."},{"key":"10.1016\/j.bbi.2023.08.010_b0035","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1038\/s41398-018-0245-0","article-title":"Urinary biomarker panel for diagnosing patients with depression and anxiety disorders","volume":"8","author":"Chen","year":"2018","journal-title":"Transl. Psychiatry"},{"issue":"10","key":"10.1016\/j.bbi.2023.08.010_b0040","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1038\/s41569-021-00536-1","article-title":"Ceramides and other sphingolipids as drivers of cardiovascular disease","volume":"18","author":"Choi","year":"2021","journal-title":"Nat. Rev. Cardiol."},{"key":"10.1016\/j.bbi.2023.08.010_b0045","doi-asserted-by":"crossref","first-page":"S122","DOI":"10.1016\/S1047-2797(03)00048-6","article-title":"Outcomes ascertainment and adjudication methods in the Women's Health Initiative","volume":"13","author":"Curb","year":"2003","journal-title":"Ann. Epidemiol."},{"issue":"6","key":"10.1016\/j.bbi.2023.08.010_b0050","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1161\/CIRCULATIONAHA.107.699579","article-title":"General cardiovascular risk profile for use in primary care: the Framingham Heart Study","volume":"117","author":"D\u2019Agostino","year":"2008","journal-title":"Circulation"},{"issue":"7","key":"10.1016\/j.bbi.2023.08.010_b0055","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1586\/14737175.2015.1049999","article-title":"What is the tryptophan kynurenine pathway and why is it important to neurotherapeutics?","volume":"15","author":"Davis","year":"2015","journal-title":"Expert Rev. Neurother."},{"issue":"1","key":"10.1016\/j.bbi.2023.08.010_b0060","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.jpsychores.2006.07.009","article-title":"The role of depression and anxiety in onset of diabetes in a large population-based study","volume":"62","author":"Engum","year":"2007","journal-title":"J. Psychosom. Res."},{"key":"10.1016\/j.bbi.2023.08.010_b0065","doi-asserted-by":"crossref","first-page":"e34","DOI":"10.1056\/NEJMoa1800389","article-title":"Primary Prevention of Cardiovascular Disease with a Mediterranean Diet Supplemented with Extra-Virgin Olive Oil or Nuts","volume":"378","author":"Estruch","year":"2018","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.bbi.2023.08.010_b0070","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1186\/s12888-014-0371-z","article-title":"Depression and the risk of coronary heart disease: a meta-analysis of prospective cohort studies","volume":"14","author":"Gan","year":"2014","journal-title":"BMC Psychiatry"},{"key":"10.1016\/j.bbi.2023.08.010_b0075","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.abb.2013.11.009","article-title":"Heme-dependent dioxygenases in tryptophan oxidation","volume":"544","author":"Geng","year":"2014","journal-title":"Arch. Biochem. Biophys."},{"issue":"1","key":"10.1016\/j.bbi.2023.08.010_b0080","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1161\/STROKEAHA.116.013554","article-title":"Changes in Depressive Symptoms and Subsequent Risk of Stroke in the Cardiovascular Health Study","volume":"48","author":"Gilsanz","year":"2017","journal-title":"Stroke"},{"key":"10.1016\/j.bbi.2023.08.010_b0085","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1097\/PSY.0b013e318197a4d5","article-title":"Lifetime history of major depression predicts the development of the metabolic syndrome in middle-aged women","volume":"71","author":"Goldbacher","year":"2009","journal-title":"Psychosom. Med."},{"issue":"2","key":"10.1016\/j.bbi.2023.08.010_b0090","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1176\/jnp.23.2.jnp215","article-title":"Elevated plasma ceramides in depression","volume":"23","author":"Gracia-Garcia","year":"2011","journal-title":"J. Neuropsychiatry Clin. Neurosci."},{"issue":"11","key":"10.1016\/j.bbi.2023.08.010_b0095","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.117.006524","article-title":"Plasma Metabolites From Choline Pathway and Risk of Cardiovascular Disease in the PREDIMED (Prevention With Mediterranean Diet) Study","volume":"6","author":"Guasch\u2010Ferr\u00e9","year":"2017","journal-title":"J. Am. Heart Assoc."},{"issue":"11","key":"10.1016\/j.bbi.2023.08.010_b0100","doi-asserted-by":"crossref","first-page":"1896","DOI":"10.1016\/j.jada.2008.08.016","article-title":"Development of the Healthy Eating Index-2005","volume":"108","author":"Guenther","year":"2008","journal-title":"J. Am. Diet. Assoc."},{"issue":"12","key":"10.1016\/j.bbi.2023.08.010_b0105","doi-asserted-by":"crossref","first-page":"2424","DOI":"10.1161\/ATVBAHA.116.307497","article-title":"Circulating Ceramides Predict Cardiovascular Outcomes in the Population-Based FINRISK 2002 Cohort","volume":"36","author":"Havulinna","year":"2016","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.bbi.2023.08.010_b0110","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2020.570628","article-title":"Ceramides and Ceramide Scores: Clinical Applications for Cardiometabolic Risk Stratification","volume":"11","author":"Hilvo","year":"2020","journal-title":"Front Endocrinol (Lausanne)."},{"issue":"7","key":"10.1016\/j.bbi.2023.08.010_b0115","doi-asserted-by":"crossref","first-page":"3315","DOI":"10.1038\/s41380-020-00870-9","article-title":"Associations of depression status with plasma levels of candidate lipid and amino acid metabolites: a meta-analysis of individual data from three independent samples of US postmenopausal women","volume":"26","author":"Huang","year":"2021","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.bbi.2023.08.010_b0120","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1037\/a0020761","article-title":"A general approach to causal mediation analysis","volume":"15","author":"Imai","year":"2010","journal-title":"Psychol. Methods"},{"key":"10.1016\/j.bbi.2023.08.010_b0130","doi-asserted-by":"crossref","first-page":"2273","DOI":"10.1016\/j.jacc.2020.02.062","article-title":"Circulating Ceramide 16:0 in Heart Failure With Preserved Ejection Fraction","volume":"75","author":"Javaheri","year":"2020","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.bbi.2023.08.010_b0135","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/1756-6606-2-8","article-title":"Tryptophan 2,3-dioxygenase is a key modulator of physiological neurogenesis and anxiety-related behavior in mice","volume":"2","author":"Kanai","year":"2009","journal-title":"Mol. Brain"},{"issue":"15","key":"10.1016\/j.bbi.2023.08.010_b0140","doi-asserted-by":"crossref","first-page":"1845","DOI":"10.1089\/104303402760372945","article-title":"Heme oxygenase 1 mediates the immunomodulatory and antiapoptotic effects of interleukin 13 gene therapy in vivo and in vitro","volume":"13","author":"Ke","year":"2002","journal-title":"Hum. Gene Ther."},{"issue":"3","key":"10.1016\/j.bbi.2023.08.010_b0145","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1161\/ATVBAHA.114.304929","article-title":"Circulating total bilirubin and risk of incident cardiovascular disease in the general population","volume":"35","author":"Kunutsor","year":"2015","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.bbi.2023.08.010_b0150","doi-asserted-by":"crossref","unstructured":"Levine GN, Cohen BE, Commodore-Mensah Y, Fleury J, Huffman JC, Khalid U, Labarthe DR, Lavretsky H, Michos ED, Spatz ES and Kubzansky LD. Psychological Health, Well-Being, and the Mind-Heart-Body Connection: A Scientific Statement From the American Heart Association. Circulation. 2021;143:e763-e783.","DOI":"10.1161\/CIR.0000000000000947"},{"issue":"1","key":"10.1016\/j.bbi.2023.08.010_b0155","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000354910","article-title":"Posttraumatic stress disorder and cardiometabolic disease","volume":"127","author":"Levine","year":"2013","journal-title":"Cardiology"},{"key":"10.1016\/j.bbi.2023.08.010_b0160","doi-asserted-by":"crossref","unstructured":"Li J, Guasch-Ferre M, Chung W, Ruiz-Canela M, Toledo E, Corella D, Bhupathiraju SN, Tobias DK, Tabung FK, Hu J, Zhao T, Turman C, Feng YA, Clish CB, Mucci L, Eliassen AH, Costenbader KH, Karlson EW, Wolpin BM, Ascherio A, Rimm EB, Manson JE, Qi L, Martinez-Gonzalez MA, Salas-Salvado J, Hu FB and Liang L. The Mediterranean diet, plasma metabolome, and cardiovascular disease risk. Eur Heart J. 2020;41:2645-2656.","DOI":"10.1093\/eurheartj\/ehaa209"},{"issue":"5","key":"10.1016\/j.bbi.2023.08.010_b0165","doi-asserted-by":"crossref","first-page":"2322","DOI":"10.1021\/acs.jproteome.5b00144","article-title":"Discovery and validation of plasma biomarkers for major depressive disorder classification based on liquid chromatography-mass spectrometry","volume":"14","author":"Liu","year":"2015","journal-title":"J. Proteome Res."},{"issue":"2","key":"10.1016\/j.bbi.2023.08.010_b0170","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.jacl.2020.01.005","article-title":"Ceramides and risk of major adverse cardiovascular events: A meta-analysis of longitudinal studies","volume":"14","author":"Mantovani","year":"2020","journal-title":"J. Clin. Lipidol."},{"key":"10.1016\/j.bbi.2023.08.010_b0175","doi-asserted-by":"crossref","unstructured":"Miki T, Eguchi M, Kochi T, Fukunaga A, Chen S, Nanri A, Kabe I and Mizoue T. Prospective study on the association between serum amino acid profiles and depressive symptoms among the Japanese working population. PLoS One. 2021;16:e0256337.","DOI":"10.1371\/journal.pone.0256337"},{"issue":"Suppl","key":"10.1016\/j.bbi.2023.08.010_b0180","first-page":"28","article-title":"Acute tryptophan depletion: a method of studying antidepressant action","volume":"53","author":"Miller","year":"1992","journal-title":"J. Clin. Psychiatry"},{"key":"10.1016\/j.bbi.2023.08.010_b0185","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.atherosclerosis.2017.06.925","article-title":"Baseline serum phosphatidylcholine plasmalogen concentrations are inversely associated with incident myocardial infarction in patients with mixed peripheral artery disease presentations","volume":"263","author":"Moxon","year":"2017","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.bbi.2023.08.010_b0190","first-page":"3","article-title":"Large-scale plasma lipidomic profiling identifies lipids that predict cardiovascular events in secondary prevention","author":"Mundra","year":"2018","journal-title":"JCI Insight"},{"key":"10.1016\/j.bbi.2023.08.010_b0195","doi-asserted-by":"crossref","first-page":"2143","DOI":"10.1038\/s41598-020-59051-x","article-title":"Plasma lipid profile associates with the improvement of psychological well-being in individuals with perceived stress symptoms","volume":"10","author":"Noerman","year":"2020","journal-title":"Sci. Rep."},{"issue":"3","key":"10.1016\/j.bbi.2023.08.010_b0200","doi-asserted-by":"crossref","first-page":"197","DOI":"10.3164\/jcbn.2008029","article-title":"Integrative survival response evoked by heme oxygenase-1 and heme metabolites","volume":"42","author":"Pae","year":"2008","journal-title":"J. Clin. Biochem. Nutr."},{"key":"10.1016\/j.bbi.2023.08.010_b0205","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1038\/s41398-018-0183-x","article-title":"Diagnosis of major depressive disorder based on changes in multiple plasma neurotransmitters: a targeted metabolomics study","volume":"8","author":"Pan","year":"2018","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.bbi.2023.08.010_b0210","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.plipres.2019.04.003","article-title":"Plasmalogens: A potential therapeutic target for neurodegenerative and cardiometabolic disease","volume":"74","author":"Paul","year":"2019","journal-title":"Prog. Lipid Res."},{"issue":"8","key":"10.1016\/j.bbi.2023.08.010_b0215","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1161\/CIRCULATIONAHA.117.029468","article-title":"Metabolic Predictors of Incident Coronary Heart Disease in Women","volume":"137","author":"Paynter","year":"2018","journal-title":"Circulation"},{"key":"10.1016\/j.bbi.2023.08.010_b0220","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1007\/978-1-4684-5952-4_32","article-title":"Tryptophan nutrition and metabolism: an overview","volume":"294","author":"Peters","year":"1991","journal-title":"Adv. Exp. Med. Biol."},{"issue":"5","key":"10.1016\/j.bbi.2023.08.010_b0225","first-page":"661","article-title":"A prospective study of phobic anxiety, risk of ovarian cancer, and survival among patients","volume":"27","author":"Poole","year":"2016","journal-title":"Cancer Causes Control"},{"key":"10.1016\/j.bbi.2023.08.010_b0230","doi-asserted-by":"crossref","unstructured":"Poss AM, Holland WL and Summers SA. Risky lipids: refining the ceramide score that measures cardiovascular health. Eur. Heart J. 2020;41:381-382.","DOI":"10.1093\/eurheartj\/ehz525"},{"issue":"1","key":"10.1016\/j.bbi.2023.08.010_b0235","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/biomet\/73.1.1","article-title":"A case-cohort design for epidemiologic cohort studies and disease prevention trials","volume":"73","author":"Prentice","year":"1986","journal-title":"Biometrika"},{"issue":"1","key":"10.1016\/j.bbi.2023.08.010_b0240","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1146\/annurev.publhealth.29.020907.090947","article-title":"The women's health initiative: lessons learned","volume":"29","author":"Prentice","year":"2008","journal-title":"Annu. Rev. Public Health"},{"issue":"5","key":"10.1016\/j.bbi.2023.08.010_b0245","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1080\/13510002.2015.1101889","article-title":"Decreased expression of heme oxygenase is associated with depressive symptoms and may contribute to depressive and hypertensive comorbidity","volume":"21","author":"Robaczewska","year":"2016","journal-title":"Redox Rep."},{"key":"10.1016\/j.bbi.2023.08.010_b0250","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1373\/clinchem.2015.251710","article-title":"Plasma Branched-Chain Amino Acids and Incident Cardiovascular Disease in the PREDIMED Trial","volume":"62","author":"Ruiz-Canela","year":"2016","journal-title":"Clin. Chem."},{"issue":"3","key":"10.1016\/j.bbi.2023.08.010_b0255","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1038\/nrcardio.2016.185","article-title":"Inflammatory processes in cardiovascular disease: a route to targeted therapies","volume":"14","author":"Ruparelia","year":"2017","journal-title":"Nat. Rev. Cardiol."},{"key":"10.1016\/j.bbi.2023.08.010_b0260","doi-asserted-by":"crossref","first-page":"105420","DOI":"10.1016\/j.psyneuen.2021.105420","article-title":"Plasma metabolomic profiles associated with chronic distress in women","volume":"133","author":"Shutta","year":"2021","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.bbi.2023.08.010_b0265","doi-asserted-by":"crossref","unstructured":"Spielberger C GR, Lushene R, Vaag P, Jacobs G. Manual for the State-Trait Anxiety Inventory. 1983.","DOI":"10.1037\/t06496-000"},{"issue":"18","key":"10.1016\/j.bbi.2023.08.010_b0270","doi-asserted-by":"crossref","first-page":"1821","DOI":"10.1161\/CIRCULATIONAHA.113.002500","article-title":"Lipidomics profiling and risk of cardiovascular disease in the prospective population-based Bruneck study","volume":"129","author":"Stegemann","year":"2014","journal-title":"Circulation"},{"issue":"2","key":"10.1016\/j.bbi.2023.08.010_b0275","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1007\/s12160-014-9615-x","article-title":"Optimizing Approaches to Addressing Depression in Cardiac Patients: a Comment on O\u2019Neil et al.","volume":"48","author":"Stewart","year":"2014","journal-title":"Ann. Behav. Med."},{"key":"10.1016\/j.bbi.2023.08.010_b0280","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.atherosclerosis.2016.01.003","article-title":"Decreased phosphatidylcholine plasmalogens\u2013A putative novel lipid signature in patients with stable coronary artery disease and acute myocardial infarction","volume":"246","author":"Sutter","year":"2016","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.bbi.2023.08.010_b0285","doi-asserted-by":"crossref","unstructured":"Tabassum R, Ramo JT, Ripatti P, Koskela JT, Kurki M, Karjalainen J, Palta P, Hassan S, Nunez-Fontarnau J, Kiiskinen TTJ, Soderlund S, Matikainen N, Gerl MJ, Surma MA, Klose C, Stitziel NO, Laivuori H, Havulinna AS, Service SK, Salomaa V, Pirinen M, FinnGen P, Jauhiainen M, Daly MJ, Freimer NB, Palotie A, Taskinen MR, Simons K and Ripatti S. Genetic architecture of human plasma lipidome and its link to cardiovascular disease. Nat Commun. 2019;10:4329.","DOI":"10.1016\/j.atherosclerosis.2019.06.040"},{"issue":"10071","key":"10.1016\/j.bbi.2023.08.010_b0290","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1016\/S0140-6736(16)31714-7","article-title":"Relation between resting amygdalar activity and cardiovascular events: a longitudinal and cohort study","volume":"389","author":"Tawakol","year":"2017","journal-title":"Lancet"},{"key":"10.1016\/j.bbi.2023.08.010_b0295","doi-asserted-by":"crossref","unstructured":"Tsuchihashi S, Livhits M, Zhai Y, Busuttil RW, Araujo JA and Kupiec-Weglinski JW. Basal rather than induced heme oxygenase-1 levels are crucial in the antioxidant cytoprotection. J Immunol. 2006;177:4749-57.","DOI":"10.4049\/jimmunol.177.7.4749"},{"key":"10.1016\/j.bbi.2023.08.010_b0300","doi-asserted-by":"crossref","unstructured":"Tworoger SS, Eliassen AH, Zhang X, Qian J, Sluss PM, Rosner BA and Hankinson SE. A 20-year prospective study of plasma prolactin as a risk marker of breast cancer development. Cancer Res. 2013;73:4810-9.","DOI":"10.1158\/0008-5472.CAN-13-0665"},{"key":"10.1016\/j.bbi.2023.08.010_b0305","doi-asserted-by":"crossref","unstructured":"Vaarhorst AA, Verhoeven A, Weller CM, Bohringer S, Goraler S, Meissner A, Deelder AM, Henneman P, Gorgels AP, van den Brandt PA, Schouten LJ, van Greevenbroek MM, Merry AH, Verschuren WM, van den Maagdenberg AM, van Dijk KW, Isaacs A, Boomsma D, Oostra BA, van Duijn CM, Jukema JW, Boer JM, Feskens E, Heijmans BT and Slagboom PE. A metabolomic profile is associated with the risk of incident coronary heart disease. Am Heart J. 2014;168:45-52 e7.","DOI":"10.1016\/j.ahj.2014.01.019"},{"issue":"7","key":"10.1016\/j.bbi.2023.08.010_b0310","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1038\/mp.2011.9","article-title":"Mechanism of acute tryptophan depletion: is it only serotonin?","volume":"16","author":"van Donkelaar","year":"2011","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.bbi.2023.08.010_b0315","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1093\/ije\/dyu242","article-title":"Serum bilirubin and the risk of hypertension","volume":"44","author":"Wang","year":"2015","journal-title":"Int. J. Epidemiol."},{"key":"10.1016\/j.bbi.2023.08.010_b0320","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.atherosclerosis.2019.04.225","article-title":"Association between plasma essential amino acids and atherogenic lipid profile in a Chinese population: A cross-sectional study","volume":"286","author":"Wang","year":"2019","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.bbi.2023.08.010_b0325","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1001\/archinte.164.3.289","article-title":"Depression and cardiovascular sequelae in postmenopausal women. The Women's Health Initiative (WHI)","volume":"164","author":"Wassertheil-Smoller","year":"2004","journal-title":"Arch. Intern. Med."},{"key":"10.1016\/j.bbi.2023.08.010_b0330","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1038\/s41398-021-01208-x","article-title":"The placental lipidome of maternal antenatal depression predicts socio-emotional problems in the offspring","volume":"11","author":"Wong","year":"2021","journal-title":"Transl. Psychiatry"},{"issue":"9","key":"10.1016\/j.bbi.2023.08.010_b0335","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1161\/CIRCULATIONAHA.114.013116","article-title":"Metabolite profiling and cardiovascular event risk: a prospective study of 3 population-based cohorts","volume":"131","author":"W\u00fcrtz","year":"2015","journal-title":"Circulation"},{"key":"10.1016\/j.bbi.2023.08.010_b0340","doi-asserted-by":"crossref","unstructured":"Yin X, Willinger CM, Keefe J, Liu J, Fernandez-Ortiz A, Ibanez B, Penalvo J, Adourian A, Chen G, Corella D, Pamplona R, Portero-Otin M, Jove M, Courchesne P, van Duijn CM, Fuster V, Ordovas JM, Demirkan A, Larson MG and Levy D. Lipidomic profiling identifies signatures of metabolic risk. EBioMedicine. 2020;51:102520.","DOI":"10.1016\/j.ebiom.2019.10.046"},{"key":"10.1016\/j.bbi.2023.08.010_b0345","doi-asserted-by":"crossref","first-page":"314","DOI":"10.3945\/jn.116.241711","article-title":"Increases in Plasma Tryptophan Are Inversely Associated with Incident Cardiovascular Disease in the Prevencion con Dieta Mediterranea (PREDIMED) Study","volume":"147","author":"Yu","year":"2017","journal-title":"J. Nutr."},{"key":"10.1016\/j.bbi.2023.08.010_b0350","doi-asserted-by":"crossref","unstructured":"Zhu Y, Jha SC, Shutta KH, Huang T, Balasubramanian R, Clish CB, Hankinson SE and Kubzansky LD. Psychological distress and metabolomic markers: A systematic review of posttraumatic stress disorder, anxiety, and subclinical distress. Neurosci. Biobehav. Rev. 2022;143:104954.","DOI":"10.1016\/j.neubiorev.2022.104954"}],"container-title":["Brain, Behavior, and Immunity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0889159123002337?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0889159123002337?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T19:24:48Z","timestamp":1777577088000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0889159123002337"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11]]},"references-count":69,"alternative-id":["S0889159123002337"],"URL":"https:\/\/doi.org\/10.1016\/j.bbi.2023.08.010","relation":{},"ISSN":["0889-1591"],"issn-type":[{"value":"0889-1591","type":"print"}],"subject":[],"published":{"date-parts":[[2023,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Metabolomic profiles of chronic distress are associated with cardiovascular disease risk and inflammation-related risk factors","name":"articletitle","label":"Article Title"},{"value":"Brain, Behavior, and Immunity","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbi.2023.08.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}