{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T18:20:02Z","timestamp":1791570002847,"version":"4.3.4"},"reference-count":52,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T00:00:00Z","timestamp":1696896000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain, Behavior, and Immunity"],"published-print":{"date-parts":[[2024,1]]},"DOI":"10.1016\/j.bbi.2023.10.006","type":"journal-article","created":{"date-parts":[[2023,10,12]],"date-time":"2023-10-12T11:58:33Z","timestamp":1697111913000},"page":"169-178","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":27,"special_numbering":"C","title":["The role of the Toll like receptor 4 signaling in sex-specific persistency of depression-like behavior in response to chronic stress"],"prefix":"10.1016","volume":"115","author":[{"given":"Eun-Jeong","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tal","family":"Frolinger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Umar","family":"Iqbal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Molly","family":"Estill","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyle J.","family":"Trageser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1524-5196","authenticated-orcid":false,"given":"Giulio M.","family":"Pasinetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbi.2023.10.006_b0005","unstructured":"Armant, M.A., Fenton, M.J., 2002. Toll-like receptors: a family of pattern-recognition receptors in mammals. Genome Biol 3, REVIEWS3011."},{"key":"10.1016\/j.bbi.2023.10.006_b0010","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1002\/da.23165","article-title":"Sex-related effects in major depressive disorder: Results of the European Group for the Study of Resistant Depression","volume":"38","author":"Bartova","year":"2021","journal-title":"Depress. Anxiety"},{"key":"10.1016\/j.bbi.2023.10.006_b0015","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/j.biopsych.2018.09.031","article-title":"The Impact of Stress and Major Depressive Disorder on Hippocampal and Medial Prefrontal Cortex Morphology","volume":"85","author":"Belleau","year":"2019","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.bbi.2023.10.006_b0020","doi-asserted-by":"crossref","DOI":"10.3389\/fnbeh.2021.699592","article-title":"Functional Contribution of the Medial Prefrontal Circuitry in Major Depressive Disorder and Stress-Induced Depressive-Like Behaviors","volume":"15","author":"Bittar","year":"2021","journal-title":"Front. Behav. Neurosci."},{"key":"10.1016\/j.bbi.2023.10.006_b0025","article-title":"Uncovering microglial pathways driving sex-specific neurobiological effects in stress and depression","volume":"16","author":"Bollinger","year":"2021","journal-title":"Brain Behav Immun Health"},{"key":"10.1016\/j.bbi.2023.10.006_b0030","doi-asserted-by":"crossref","DOI":"10.1016\/j.neulet.2019.134369","article-title":"The formative role of microglia in stress-induced synaptic deficits and associated behavioral consequences","volume":"711","author":"Bollinger","year":"2019","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.bbi.2023.10.006_b0035","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1001\/archpsyc.1986.01800040015003","article-title":"Chronic stress and major depression","volume":"43","author":"Breslau","year":"1986","journal-title":"Arch. Gen. Psychiatry"},{"key":"10.1016\/j.bbi.2023.10.006_b0040","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1016\/j.cpr.2007.02.005","article-title":"Risk for recurrence in depression","volume":"27","author":"Burcusa","year":"2007","journal-title":"Clin. Psychol. Rev."},{"key":"10.1016\/j.bbi.2023.10.006_b0045","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.bbi.2015.12.012","article-title":"Stress-induced neuroinflammation is mediated by GSK3-dependent TLR4 signaling that promotes susceptibility to depression-like behavior","volume":"53","author":"Cheng","year":"2016","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.bbi.2023.10.006_b0050","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1038\/nrd1825","article-title":"The ascent of mouse: advances in modelling human depression and anxiety","volume":"4","author":"Cryan","year":"2005","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.bbi.2023.10.006_b0055","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1016\/j.cell.2008.10.029","article-title":"Application of a translational profiling approach for the comparative analysis of CNS cell types","volume":"135","author":"Doyle","year":"2008","journal-title":"Cell"},{"key":"10.1016\/j.bbi.2023.10.006_b0060","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.jad.2010.05.016","article-title":"Gender differences in the developmental course of depression","volume":"127","author":"Essau","year":"2010","journal-title":"J. Affect. Disord."},{"issue":"457\u2013494","key":"10.1016\/j.bbi.2023.10.006_b0065","first-page":"x","article-title":"Background and rationale for the sequenced treatment alternatives to relieve depression (STAR*D) study","volume":"26","author":"Fava","year":"2003","journal-title":"Psychiatr. Clin. North Am."},{"key":"10.1016\/j.bbi.2023.10.006_b0070","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.neuroscience.2009.04.057","article-title":"Chronic stress effects on dendritic morphology in medial prefrontal cortex: sex differences and estrogen dependence","volume":"162","author":"Garrett","year":"2009","journal-title":"Neuroscience"},{"key":"10.1016\/j.bbi.2023.10.006_b0075","doi-asserted-by":"crossref","DOI":"10.3389\/fnbeh.2022.834821","article-title":"The Duration of Stress Determines Sex Specificities in the Vulnerability to Depression and in the Morphologic Remodeling of Neurons and Microglia","volume":"16","author":"Gaspar","year":"2022","journal-title":"Front. Behav. Neurosci."},{"key":"10.1016\/j.bbi.2023.10.006_b0080","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1016\/j.drudis.2016.01.016","article-title":"Emerging treatment mechanisms for depression: focus on glutamate and synaptic plasticity","volume":"21","author":"Gerhard","year":"2016","journal-title":"Drug Discov. Today"},{"key":"10.1016\/j.bbi.2023.10.006_b0085","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1038\/s41386-018-0195-5","article-title":"Early life stress leads to sex differences in development of depressive-like outcomes in a mouse model","volume":"44","author":"Goodwill","year":"2019","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.bbi.2023.10.006_b0090","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1038\/s41583-019-0221-6","article-title":"The future of rodent models in depression research","volume":"20","author":"Gururajan","year":"2019","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.bbi.2023.10.006_b0095","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1016\/j.cell.2008.10.028","article-title":"A translational profiling approach for the molecular characterization of CNS cell types","volume":"135","author":"Heiman","year":"2008","journal-title":"Cell"},{"key":"10.1016\/j.bbi.2023.10.006_b0100","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1038\/nprot.2014.085","article-title":"Cell type-specific mRNA purification by translating ribosome affinity purification (TRAP)","volume":"9","author":"Heiman","year":"2014","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.bbi.2023.10.006_b0105","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1038\/mp.2017.246","article-title":"Markers of microglia in post-mortem brain samples from patients with Alzheimer's disease: a systematic review","volume":"23","author":"Hopperton","year":"2018","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.bbi.2023.10.006_b0110","doi-asserted-by":"crossref","first-page":"4349","DOI":"10.1523\/JNEUROSCI.1940-20.2021","article-title":"Temporal Contribution of Myeloid-Lineage TLR4 to the Transition to Chronic Pain: A Focus on Sex Differences","volume":"41","author":"Huck","year":"2021","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bbi.2023.10.006_b0115","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/S0165-0327(02)00426-3","article-title":"Epidemiology of women and depression","volume":"74","author":"Kessler","year":"2003","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.bbi.2023.10.006_b0120","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0165-0327(99)00158-5","article-title":"Gender differences in chronic major and double depression","volume":"60","author":"Kornstein","year":"2000","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.bbi.2023.10.006_b0125","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1038\/s41386-018-0156-z","article-title":"Sex differences in antidepressant efficacy","volume":"44","author":"LeGates","year":"2019","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.bbi.2023.10.006_b0130","doi-asserted-by":"crossref","first-page":"309","DOI":"10.3389\/fnins.2014.00309","article-title":"Toll-like receptor 4: innate immune regulator of neuroimmune and neuroendocrine interactions in stress and major depressive disorder","volume":"8","author":"Liu","year":"2014","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.bbi.2023.10.006_b0135","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1017\/S0033291701003877","article-title":"Sex differences in event-related risk for major depression","volume":"31","author":"Maciejewski","year":"2001","journal-title":"Psychol. Med."},{"key":"10.1016\/j.bbi.2023.10.006_b0140","doi-asserted-by":"crossref","first-page":"198","DOI":"10.3389\/fncir.2013.00198","article-title":"The stressed female brain: neuronal activity in the prelimbic but not infralimbic region of the medial prefrontal cortex suppresses learning after acute stress","volume":"7","author":"Maeng","year":"2013","journal-title":"Front. Neural Circuits"},{"key":"10.1016\/j.bbi.2023.10.006_b0145","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.jad.2004.09.008","article-title":"Gender differences in depression: findings from the STAR*D study","volume":"87","author":"Marcus","year":"2005","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.bbi.2023.10.006_b0150","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1038\/nri.2015.5","article-title":"The role of inflammation in depression: from evolutionary imperative to modern treatment target","volume":"16","author":"Miller","year":"2016","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.bbi.2023.10.006_b0155","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1093\/ijnp\/pyac017","article-title":"Sex Differences in Responses to Antidepressant Augmentations in Treatment-Resistant Depression","volume":"25","author":"Moderie","year":"2022","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"10.1016\/j.bbi.2023.10.006_b0160","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1038\/nri3446","article-title":"The history of Toll-like receptors - redefining innate immunity","volume":"13","author":"O'Neill","year":"2013","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.bbi.2023.10.006_b0165","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1016\/j.jad.2013.05.010","article-title":"Sex differences in clinical predictors of depression: a prospective study","volume":"150","author":"Oquendo","year":"2013","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.bbi.2023.10.006_b0170","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1038\/nrneurol.2010.17","article-title":"Microglia in neurodegenerative disease","volume":"6","author":"Perry","year":"2010","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.bbi.2023.10.006_b0175","doi-asserted-by":"crossref","DOI":"10.3389\/fnbeh.2021.655214","article-title":"Editorial: Animal Models of Stress - Current Knowledge and Potential Directions","volume":"15","author":"Pesarico","year":"2021","journal-title":"Front. Behav. Neurosci."},{"key":"10.1016\/j.bbi.2023.10.006_b0180","article-title":"Microglial Inflammatory-Metabolic Pathways and Their Potential Therapeutic Implication in Major Depressive Disorder","volume":"13","author":"Rahimian","year":"2022","journal-title":"Front. Psych."},{"key":"10.1016\/j.bbi.2023.10.006_b0185","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1038\/s41386-018-0148-z","article-title":"Sex differences and the neurobiology of affective disorders","volume":"44","author":"Rubinow","year":"2019","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.bbi.2023.10.006_b0190","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2021.110252","article-title":"Cx3Cr1-Cre induction leads to microglial activation and IFN-1 signaling caused by DNA damage in early postnatal brain","volume":"38","author":"Sahasrabuddhe","year":"2022","journal-title":"Cell Rep."},{"key":"10.1016\/j.bbi.2023.10.006_b0195","doi-asserted-by":"crossref","unstructured":"Schramm, E., Waisman, A., 2022. Microglia as Central Protagonists in the Chronic Stress Response. Neurol Neuroimmunol Neuroinflamm 9.","DOI":"10.1212\/NXI.0000000000200023"},{"key":"10.1016\/j.bbi.2023.10.006_b0200","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1001\/archgenpsychiatry.2009.36","article-title":"Cross-national associations between gender and mental disorders in the World Health Organization World Mental Health Surveys","volume":"66","author":"Seedat","year":"2009","journal-title":"Arch. Gen. Psychiatry"},{"key":"10.1016\/j.bbi.2023.10.006_b0205","doi-asserted-by":"crossref","unstructured":"Seibenhener, M.L., Wooten, M.C., 2015. Use of the Open Field Maze to measure locomotor and anxiety-like behavior in mice. J Vis Exp, e52434.","DOI":"10.3791\/52434-v"},{"key":"10.1016\/j.bbi.2023.10.006_b0210","doi-asserted-by":"crossref","first-page":"17403","DOI":"10.1038\/s41598-019-53624-1","article-title":"Behavioural characterisation of chronic unpredictable stress based on ethologically relevant paradigms in rats","volume":"9","author":"Sequeira-Cordero","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbi.2023.10.006_b0215","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1002\/jnr.23976","article-title":"Do sex differences in rumination explain sex differences in depression?","volume":"95","author":"Shors","year":"2017","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.bbi.2023.10.006_b0220","article-title":"Sex and region-specific effects of variable stress on microglia morphology","volume":"18","author":"Tsyglakova","year":"2021","journal-title":"Brain Behav Immun Health"},{"key":"10.1016\/j.bbi.2023.10.006_b0225","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1038\/nrn3638","article-title":"Inflammasomes in the CNS","volume":"15","author":"Walsh","year":"2014","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.bbi.2023.10.006_b0230","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1186\/s12974-022-02492-0","article-title":"Microglia in depression: an overview of microglia in the pathogenesis and treatment of depression","volume":"19","author":"Wang","year":"2022","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.bbi.2023.10.006_b0235","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1001\/jama.1996.03540040037030","article-title":"Cross-national epidemiology of major depression and bipolar disorder","volume":"276","author":"Weissman","year":"1996","journal-title":"J. Am. Med. Assoc."},{"key":"10.1016\/j.bbi.2023.10.006_b0240","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.670500","article-title":"Chronic Stress-Induced Depression and Anxiety Priming Modulated by Gut-Brain-Axis Immunity","volume":"12","author":"Westfall","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.bbi.2023.10.006_b0245","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1038\/nrn.2016.69","article-title":"Integrating neuroimmune systems in the neurobiology of depression","volume":"17","author":"Wohleb","year":"2016","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.bbi.2023.10.006_b0250","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.biopsych.2017.05.026","article-title":"Stress-Induced Neuronal Colony Stimulating Factor 1 Provokes Microglia-Mediated Neuronal Remodeling and Depressive-like Behavior","volume":"83","author":"Wohleb","year":"2018","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.bbi.2023.10.006_b0255","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1186\/s12974-021-02309-6","article-title":"The semantics of microglia activation: neuroinflammation, homeostasis, and stress","volume":"18","author":"Woodburn","year":"2021","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.bbi.2023.10.006_b0260","doi-asserted-by":"crossref","unstructured":"Yankelevitch-Yahav, R., Franko, M., Huly, A., Doron, R., 2015. The forced swim test as a model of depressive-like behavior. J Vis Exp.","DOI":"10.3791\/52587"}],"container-title":["Brain, Behavior, and Immunity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0889159123003069?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0889159123003069?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T08:22:50Z","timestamp":1760170970000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0889159123003069"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1]]},"references-count":52,"alternative-id":["S0889159123003069"],"URL":"https:\/\/doi.org\/10.1016\/j.bbi.2023.10.006","relation":{},"ISSN":["0889-1591"],"issn-type":[{"value":"0889-1591","type":"print"}],"subject":[],"published":{"date-parts":[[2024,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The role of the Toll like receptor 4 signaling in sex-specific persistency of depression-like behavior in response to chronic stress","name":"articletitle","label":"Article Title"},{"value":"Brain, Behavior, and Immunity","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbi.2023.10.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}