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Med."},{"key":"10.1016\/j.bbi.2023.11.029_b0280","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1007\/s13539-012-0082-6","article-title":"Anorexia\/cachexia of chronic diseases: a role for the TGF-\u03b2 family cytokine MIC-1\/GDF15","volume":"3","author":"Tsai","year":"2012","journal-title":"J. Cachexia Sarcopenia Muscle"},{"key":"10.1016\/j.bbi.2023.11.029_b0285","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1038\/ijo.2015.242","article-title":"Anorexia\u2013cachexia and obesity treatment may be two sides of the same coin: role of the TGF-b superfamily cytokine MIC-1\/GDF15","volume":"40","author":"Tsai","year":"2016","journal-title":"Int. J. Obes. (Lond)"},{"key":"10.1016\/j.bbi.2023.11.029_b0290","first-page":"e55174","article-title":"TGF-b superfamily cytokine MIC-1\/GDF15 is a physiological appetite and body weight regulator","volume":"8","author":"Tsai","year":"2013","journal-title":"Public Library Sci. 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Med."},{"key":"10.1016\/j.bbi.2023.11.029_b0325","doi-asserted-by":"crossref","first-page":"2529","DOI":"10.1038\/s41598-021-81349-7","article-title":"Inhibition of mitochondrial function by metformin increases glucose uptake, glycolysis and GDF-15 release from intestinal cells","volume":"11","author":"Yang","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbi.2023.11.029_b0330","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1016\/j.cmet.2023.03.014","article-title":"Metformin triggers a kidney GDF15-dependent area postrema axis to regulate food intake and body weight","volume":"35","author":"Zhang","year":"2023","journal-title":"Cell Metab."},{"key":"10.1016\/j.bbi.2023.11.029_b0335","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.redox.2018.01.013","article-title":"Fasting exacerbates hepatic growth differentiation factor 15 to promote fatty acid \u03b2-oxidation and ketogenesis via activating XBP1 signaling in liver","volume":"16","author":"Zhang","year":"2018","journal-title":"Redox Biol."},{"key":"10.1016\/j.bbi.2023.11.029_b0340","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.4049\/jimmunol.2100605","article-title":"Cutting edge: CD36 mediates phagocyte tropism and avirulence of Toxoplasma gondii","volume":"207","author":"Zhao","year":"2021","journal-title":"J. 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