{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T21:30:56Z","timestamp":1791495056344,"version":"4.3.4"},"reference-count":34,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100018542","name":"Natural Science Foundation of Sichuan Province","doi-asserted-by":"publisher","award":["2022NSFSC1607"],"award-info":[{"award-number":["2022NSFSC1607"]}],"id":[{"id":"10.13039\/501100018542","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82001432"],"award-info":[{"award-number":["82001432"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002855","name":"Ministry of Science and Technology of the People's Republic of China","doi-asserted-by":"publisher","award":["2022ZD0211700"],"award-info":[{"award-number":["2022ZD0211700"]}],"id":[{"id":"10.13039\/501100002855","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002855","name":"Ministry of Science and Technology of the People's Republic of China","doi-asserted-by":"publisher","award":["2022ZD0205200"],"award-info":[{"award-number":["2022ZD0205200"]}],"id":[{"id":"10.13039\/501100002855","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain, Behavior, and Immunity"],"published-print":{"date-parts":[[2024,3]]},"DOI":"10.1016\/j.bbi.2023.12.031","type":"journal-article","created":{"date-parts":[[2023,12,27]],"date-time":"2023-12-27T21:51:07Z","timestamp":1703713867000},"page":"12-19","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"special_numbering":"C","title":["Differential effects of sleep deprivation on behavior and microglia in a brain-region-specific manner in young and aged male mice"],"prefix":"10.1016","volume":"117","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7421-136X","authenticated-orcid":false,"given":"Rong-Jun","family":"Ni","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Yan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-Jun","family":"Pu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying-Ying","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin-Xue","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lian-Sheng","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Hong","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbi.2023.12.031_b0005","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/j.bbi.2020.11.009","article-title":"Minocycline alleviates depression-like symptoms by rescuing decrease in neurogenesis in dorsal hippocampus via blocking microglia activation\/phagocytosis","volume":"91","author":"Bassett","year":"2021","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.bbi.2023.12.031_b0010","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.bbi.2007.08.014","article-title":"Neuroinflammation and disruption in working memory in aged mice after acute stimulation of the peripheral innate immune system","volume":"22","author":"Chen","year":"2008","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.bbi.2023.12.031_b0015","doi-asserted-by":"crossref","first-page":"e0148469","DOI":"10.1371\/journal.pone.0148469","article-title":"High-Throughput Method for Automated Colony and Cell Counting by Digital Image Analysis Based on Edge Detection","volume":"11","author":"Choudhry","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.bbi.2023.12.031_b0020","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.sleep.2007.03.006","article-title":"Neuroimaging in sleep medicine","volume":"8","author":"Dang-Vu","year":"2007","journal-title":"Sleep Med."},{"key":"10.1016\/j.bbi.2023.12.031_b0025","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.jphs.2021.03.006","article-title":"Microglial heterogeneity in aging and Alzheimer's disease: Is sex relevant?","volume":"146","author":"Delage","year":"2021","journal-title":"J. Pharmacol. Sci."},{"key":"10.1016\/j.bbi.2023.12.031_b0030","doi-asserted-by":"crossref","first-page":"2030","DOI":"10.1038\/s41467-021-22301-1","article-title":"Loss of microglial SIRP\u03b1 promotes synaptic pruning in preclinical models of neurodegeneration","volume":"12","author":"Ding","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bbi.2023.12.031_b0035","article-title":"Microglia in aging and alzheimer's disease","volume":"10","author":"Edler","year":"2021","journal-title":"A Comparative Species Review. Cells"},{"key":"10.1016\/j.bbi.2023.12.031_b0040","doi-asserted-by":"crossref","first-page":"10528","DOI":"10.1523\/JNEUROSCI.0416-14.2014","article-title":"Neuronal hyperactivity recruits microglial processes via neuronal NMDA receptors and microglial P2Y12 receptors after status epilepticus","volume":"34","author":"Eyo","year":"2014","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bbi.2023.12.031_b0045","doi-asserted-by":"crossref","first-page":"2196","DOI":"10.1038\/npp.2017.13","article-title":"The Neurosteroidogenic Enzyme 5\u03b1-Reductase Mediates Psychotic-Like Complications of Sleep Deprivation","volume":"42","author":"Frau","year":"2017","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.bbi.2023.12.031_b0050","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.bbi.2015.09.015","article-title":"Prenatal immune activation causes hippocampal synaptic deficits in the absence of overt microglia anomalies","volume":"55","author":"Giovanoli","year":"2016","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.bbi.2023.12.031_b0055","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1038\/nn.4222","article-title":"Microglial brain region-dependent diversity and selective regional sensitivities to aging","volume":"19","author":"Grabert","year":"2016","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.bbi.2023.12.031_b0060","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1111\/j.1365-2818.1977.tb00062.x","article-title":"Notes on the estimation of the numerical density of arbitrary profiles: the edge effect","volume":"111","author":"Gundersen","year":"1977","journal-title":"J. Microsc."},{"key":"10.1016\/j.bbi.2023.12.031_b0065","doi-asserted-by":"crossref","DOI":"10.1093\/sleep\/zsaa108","article-title":"Homeostatic state of microglia in a rat model of chronic sleep restriction","volume":"43","author":"Hall","year":"2020","journal-title":"Sleep"},{"key":"10.1016\/j.bbi.2023.12.031_b0070","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1007\/s11064-007-9584-6","article-title":"Comparison of ionized calcium-binding adapter molecule 1 immunoreactivity of the hippocampal dentate gyrus and CA1 region in adult and aged dogs","volume":"33","author":"Hwang","year":"2008","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.bbi.2023.12.031_b0075","doi-asserted-by":"crossref","first-page":"e0182746","DOI":"10.1371\/journal.pone.0182746","article-title":"REM sleep deprivation induces endothelial dysfunction and hypertension in middle-aged rats: Roles of the eNOS\/NO\/cGMP pathway and supplementation with L-arginine","volume":"12","author":"Jiang","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.bbi.2023.12.031_b0080","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.sleep.2017.04.002","article-title":"Changes in subcortical shape and cognitive function in patients with chronic insomnia","volume":"35","author":"Koo","year":"2017","journal-title":"Sleep Med."},{"key":"10.1016\/j.bbi.2023.12.031_b0085","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/0306-4522(90)90229-W","article-title":"Heterogeneity in the distribution and morphology of microglia in the normal adult mouse brain","volume":"39","author":"Lawson","year":"1990","journal-title":"Neuroscience"},{"key":"10.1016\/j.bbi.2023.12.031_b0090","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.neuron.2018.12.006","article-title":"Developmental Heterogeneity of Microglia and Brain Myeloid Cells Revealed by Deep Single-Cell RNA Sequencing","volume":"101","author":"Li","year":"2019","journal-title":"Neuron"},{"key":"10.1016\/j.bbi.2023.12.031_b0095","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2022.175149","article-title":"Sleep deprivation leads to further impairment of hippocampal synaptic plasticity by suppressing melatonin secretion in the pineal gland of chronically unpredictable stress rats","volume":"930","author":"Li","year":"2022","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.bbi.2023.12.031_b0100","doi-asserted-by":"crossref","first-page":"1432","DOI":"10.1523\/JNEUROSCI.23-04-01432.2003","article-title":"Sleep-related consolidation of a visuomotor skill: brain mechanisms as assessed by functional magnetic resonance imaging","volume":"23","author":"Maquet","year":"2003","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bbi.2023.12.031_b0105","doi-asserted-by":"crossref","first-page":"989","DOI":"10.24272\/j.issn.2095-8137.2022.278","article-title":"Chronic lithium treatment ameliorates ketamine-induced mania-like behavior via the PI3K-AKT signaling pathway","volume":"43","author":"Ni","year":"2022","journal-title":"Zool. Res."},{"key":"10.1016\/j.bbi.2023.12.031_b0110","doi-asserted-by":"crossref","first-page":"543","DOI":"10.24272\/j.issn.2095-8137.2022.389","article-title":"Depletion of microglia with PLX3397 attenuates MK-801-induced hyperactivity associated with regulating inflammation-related genes in the brain","volume":"44","author":"Ni","year":"2023","journal-title":"Zool. Res."},{"key":"10.1016\/j.bbi.2023.12.031_b0115","doi-asserted-by":"crossref","first-page":"1677","DOI":"10.5665\/sleep.3126","article-title":"Lithium prevents REM sleep deprivation-induced impairments on memory consolidation","volume":"36","author":"Ota","year":"2013","journal-title":"Sleep"},{"key":"10.1016\/j.bbi.2023.12.031_b0120","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.neuroscience.2019.11.033","article-title":"Effects of Chronic Dim-light-at-night Exposure on Sleep in Young and Aged Mice","volume":"426","author":"Panagiotou","year":"2020","journal-title":"Neuroscience"},{"key":"10.1016\/j.bbi.2023.12.031_b0125","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.neuron.2005.12.004","article-title":"Cannabinoids in microglia: a new trick for immune surveillance and neuroprotection","volume":"49","author":"Rivest","year":"2006","journal-title":"Neuron"},{"key":"10.1016\/j.bbi.2023.12.031_b0130","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.bbi.2016.01.006","article-title":"Glial cell morphological and density changes through the lifespan of rhesus macaques","volume":"55","author":"Robillard","year":"2016","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.bbi.2023.12.031_b0135","doi-asserted-by":"crossref","first-page":"3190","DOI":"10.1007\/s12035-023-03258-2","article-title":"Sleep deprivation induces dopamine system maladaptation and escalated corticotrophin-releasing factor signaling in adolescent mice","volume":"60","author":"Tuan","year":"2023","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.bbi.2023.12.031_b0140","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1186\/s12974-017-0998-z","article-title":"Inhibiting the microglia activation improves the spatial memory and adult neurogenesis in rat hippocampus during 48 h of sleep deprivation","volume":"14","author":"Wadhwa","year":"2017","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.bbi.2023.12.031_b0145","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.bbi.2019.08.004","article-title":"Complement activation sustains neuroinflammation and deteriorates adult neurogenesis and spatial memory impairment in rat hippocampus following sleep deprivation","volume":"82","author":"Wadhwa","year":"2019","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.bbi.2023.12.031_b0150","doi-asserted-by":"crossref","DOI":"10.1111\/joa.13874","article-title":"Dynamic changes in microglia in the mouse hippocampus during administration and withdrawal of the CSF1R inhibitor PLX3397","author":"Wang","year":"2023","journal-title":"J. Anat."},{"key":"10.1016\/j.bbi.2023.12.031_b0155","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1097\/CM9.0000000000001769","article-title":"CX3C-chemokine receptor 1 modulates cognitive dysfunction induced by sleep deprivation","volume":"135","author":"Xin","year":"2021","journal-title":"Chin Med J (Engl)"},{"key":"10.1016\/j.bbi.2023.12.031_b0160","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2021.109234","article-title":"Differential effect of sleep deprivation on place cell representations, sleep architecture, and memory in young and old mice","volume":"35","author":"Yuan","year":"2021","journal-title":"Cell Rep."},{"key":"10.1016\/j.bbi.2023.12.031_b0165","article-title":"Targeting Microglia Using Cx3cr1-Cre Lines","volume":"eNeuro 6","author":"Zhao","year":"2019","journal-title":"Revisiting the Specificity."},{"key":"10.1016\/j.bbi.2023.12.031_b0170","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1002\/hbm.25221","article-title":"Altered thalamic connectivity in insomnia disorder during wakefulness and sleep","volume":"42","author":"Zou","year":"2021","journal-title":"Hum. Brain Mapp."}],"container-title":["Brain, Behavior, and Immunity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0889159123004130?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0889159123004130?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T23:57:10Z","timestamp":1778543830000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0889159123004130"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3]]},"references-count":34,"alternative-id":["S0889159123004130"],"URL":"https:\/\/doi.org\/10.1016\/j.bbi.2023.12.031","relation":{},"ISSN":["0889-1591"],"issn-type":[{"value":"0889-1591","type":"print"}],"subject":[],"published":{"date-parts":[[2024,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Differential effects of sleep deprivation on behavior and microglia in a brain-region-specific manner in young and aged male mice","name":"articletitle","label":"Article Title"},{"value":"Brain, Behavior, and Immunity","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbi.2023.12.031","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}