{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T00:55:36Z","timestamp":1778028936311,"version":"3.51.4"},"reference-count":42,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,2,8]],"date-time":"2024-02-08T00:00:00Z","timestamp":1707350400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["DA052209"],"award-info":[{"award-number":["DA052209"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["MH087332"],"award-info":[{"award-number":["MH087332"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["MH104131"],"award-info":[{"award-number":["MH104131"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["MH105330"],"award-info":[{"award-number":["MH105330"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain, Behavior, and Immunity"],"published-print":{"date-parts":[[2024,5]]},"DOI":"10.1016\/j.bbi.2024.02.014","type":"journal-article","created":{"date-parts":[[2024,2,13]],"date-time":"2024-02-13T16:48:15Z","timestamp":1707842895000},"page":"1-21","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Interferon-\u03b2 deficiency alters brain response to chronic HIV-1 envelope protein exposure in a transgenic model of NeuroHIV"],"prefix":"10.1016","volume":"118","author":[{"given":"Hina","family":"Singh","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey","family":"Koury","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ricky","family":"Maung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amanda J.","family":"Roberts","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3202-670X","authenticated-orcid":false,"given":"Marcus","family":"Kaul","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbi.2024.02.014_b0005","doi-asserted-by":"crossref","first-page":"4008","DOI":"10.4049\/jimmunol.1003757","article-title":"Simian immunodeficiency virus infection in the brain and lung leads to differential type I IFN signaling during acute infection","volume":"186","author":"Alammar","year":"2011","journal-title":"J. Immunol."},{"issue":"Suppl 1","key":"10.1016\/j.bbi.2024.02.014_b0010","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1080\/753312747","article-title":"Innate immune responses and control of acute simian immunodeficiency virus replication in the central nervous system","volume":"10","author":"Barber","year":"2004","journal-title":"J. Neurovirol."},{"key":"10.1016\/j.bbi.2024.02.014_b0015","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1111\/j.1365-2559.2004.02004.x","article-title":"An update on the neuropathology of HIV in the HAART era","volume":"45","author":"Bell","year":"2004","journal-title":"Histopathology"},{"key":"10.1016\/j.bbi.2024.02.014_b0020","doi-asserted-by":"crossref","first-page":"e29291","DOI":"10.1371\/journal.pone.0029291","article-title":"Genomic HIV RNA induces innate immune responses through RIG-I-dependent sensing of secondary-structured RNA","volume":"7","author":"Berg","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.bbi.2024.02.014_b0025","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1038\/nrd2422","article-title":"Interferons at age 50: past, current and future impact on biomedicine","volume":"6","author":"Borden","year":"2007","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.bbi.2024.02.014_b0030","doi-asserted-by":"crossref","first-page":"1811","DOI":"10.1126\/science.270.5243.1811","article-title":"Identification of RANTES, MIP-1 alpha, and MIP-1 beta as the major HIV-suppressive factors produced by CD8+ T cells","volume":"270","author":"Cocchi","year":"1995","journal-title":"Science"},{"key":"10.1016\/j.bbi.2024.02.014_b0035","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1038\/nrmicro3449","article-title":"HIV-1 and interferons: who's interfering with whom?","volume":"13","author":"Doyle","year":"2015","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.bbi.2024.02.014_b0040","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1515\/REVNEURO.2008.19.4-5.341","article-title":"Role of signal transducer and activator of transcription 3 in neuronal survival and regeneration","volume":"19","author":"Dziennis","year":"2008","journal-title":"Rev. Neurosci."},{"key":"10.1016\/j.bbi.2024.02.014_b0045","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/S0960-9822(98)70086-7","article-title":"Interferon-beta is required for interferon-alpha production in mouse fibroblasts","volume":"8","author":"Erlandsson","year":"1998","journal-title":"Curr. Biol."},{"key":"10.1016\/j.bbi.2024.02.014_b0050","doi-asserted-by":"crossref","first-page":"e46178","DOI":"10.1371\/journal.pone.0046178","article-title":"The national NeuroAIDS tissue consortium brain gene array: two types of HIV-associated neurocognitive impairment","volume":"7","author":"Gelman","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.bbi.2024.02.014_b0055","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.expneurol.2014.09.010","article-title":"Combination of methamphetamine and HIV-1 gp120 causes distinct long-term alterations of behavior, gene expression, and injury in the central nervous system","volume":"263","author":"Hoefer","year":"2015","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.bbi.2024.02.014_b0060","doi-asserted-by":"crossref","first-page":"8212","DOI":"10.1073\/pnas.96.14.8212","article-title":"Chemokines and activated macrophages in HIV gp120-induced neuronal apoptosis","volume":"96","author":"Kaul","year":"1999","journal-title":"PNAS"},{"issue":"Suppl 1","key":"10.1016\/j.bbi.2024.02.014_b0065","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1038\/sj.cdd.4401623","article-title":"HIV-1 infection and AIDS: consequences for the central nervous system","volume":"12","author":"Kaul","year":"2005","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.bbi.2024.02.014_b0070","first-page":"396","article-title":"Pathological roles of MAPK signaling pathways in human diseases","volume":"1802","author":"Kim","year":"2010","journal-title":"BBA"},{"key":"10.1016\/j.bbi.2024.02.014_b0075","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/S0165-5728(00)00315-5","article-title":"Role of MIP-1beta and RANTES in HIV-1 infection of microglia: inhibition of infection and induction by IFNbeta","volume":"110","author":"Kitai","year":"2000","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.bbi.2024.02.014_b0080","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20061346","article-title":"Roles of cyclic AMP Response element binding activation in the ERK1\/2 and p38 MAPK signalling pathway in central nervous system, cardiovascular system, osteoclast differentiation and mucin and cytokine production","volume":"20","author":"Koga","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbi.2024.02.014_b0085","doi-asserted-by":"crossref","first-page":"500","DOI":"10.3109\/13550289909045379","article-title":"Measuring HIV-1 RNA and interferon-alpha in the cerebrospinal fluid of AIDS patients: insights into the pathogenesis of AIDS dementia complex","volume":"5","author":"Krivine","year":"1999","journal-title":"J. Neurovirol."},{"key":"10.1016\/j.bbi.2024.02.014_b0090","first-page":"87","article-title":"Diagnosis of mediastinal neuro-endocrine tumor using endosonography guided transesophageal puncture biopsy","volume":"22","author":"Le Dreau","year":"1998","journal-title":"Gastroenterol. Clin. Biol."},{"key":"10.1016\/j.bbi.2024.02.014_b0095","doi-asserted-by":"crossref","first-page":"353","DOI":"10.4097\/kja.d.18.00242","article-title":"What is the proper way to apply the multiple comparison test?","volume":"71","author":"Lee","year":"2018","journal-title":"Korean J. Anesthesiol."},{"key":"10.1016\/j.bbi.2024.02.014_b0100","doi-asserted-by":"crossref","first-page":"711","DOI":"10.3892\/etm.2021.10143","article-title":"Targeted inhibition of STAT3 in neural stem cells promotes neuronal differentiation and functional recovery in rats with spinal cord injury","volume":"22","author":"Li","year":"2021","journal-title":"Exp. Ther. Med."},{"key":"10.1016\/j.bbi.2024.02.014_b0105","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2\u2212\u0394\u0394CT method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"10.1016\/j.bbi.2024.02.014_b0110","doi-asserted-by":"crossref","first-page":"1895","DOI":"10.4049\/jimmunol.1302915","article-title":"CCR5 knockout prevents neuronal injury and behavioral impairment induced in a transgenic mouse model by a CXCR4-using HIV-1 glycoprotein 120","volume":"193","author":"Maung","year":"2014","journal-title":"J. Immunol."},{"key":"10.1016\/j.bbi.2024.02.014_b0115","doi-asserted-by":"crossref","first-page":"4883","DOI":"10.4049\/jimmunol.0902535","article-title":"Activation of p38 MAPK is required in monocytic and neuronal cells for HIV glycoprotein 120-induced neurotoxicity","volume":"185","author":"Medders","year":"2010","journal-title":"J. Immunol."},{"key":"10.1016\/j.bbi.2024.02.014_b0120","doi-asserted-by":"crossref","first-page":"iii","DOI":"10.1016\/0024-3205(89)90147-1","article-title":"Detection of high levels of immunoreactive human beta-1 interferon in sera from HIV-infected patients","volume":"45","author":"Minagawa","year":"1989","journal-title":"Life Sci."},{"key":"10.1016\/j.bbi.2024.02.014_b0125","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1615\/CritRevNeurobiol.v16.i12.50","article-title":"Brain-derived neurotrophic factor activation of TrkB protects neurons from HIV-1\/gp120-induced cell death","volume":"16","author":"Mocchetti","year":"2004","journal-title":"Crit. Rev. Neurobiol."},{"key":"10.1016\/j.bbi.2024.02.014_b0130","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1002\/hipo.20122","article-title":"Hippocampal damage and anterograde object-recognition in rats after long retention intervals","volume":"15","author":"Mumby","year":"2005","journal-title":"Hippocampus"},{"key":"10.1016\/j.bbi.2024.02.014_b0135","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.bbi.2020.06.016","article-title":"Lipocalin-2 mediates HIV-1 induced neuronal injury and behavioral deficits by overriding CCR5-dependent protection","volume":"89","author":"Ojeda-Juarez","year":"2020","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.bbi.2024.02.014_b0140","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1016\/S0031-9384(01)00515-7","article-title":"Learning impairments and motor dysfunctions in adult Lhx5-deficient mice displaying hippocampal disorganization","volume":"73","author":"Paylor","year":"2001","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.bbi.2024.02.014_b0145","first-page":"51","article-title":"Transforming growth factor beta-1 and interferon-alpha in the AIDS dementia complex (ADC): possible relationship with cerebral viral load?","volume":"12","author":"Perrella","year":"2001","journal-title":"Eur. Cytokine Netw."},{"key":"10.1016\/j.bbi.2024.02.014_b0150","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1006\/brbi.1995.1034","article-title":"A potential role for interferon-alpha in the pathogenesis of HIV-associated dementia","volume":"9","author":"Rho","year":"1995","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.bbi.2024.02.014_b0155","first-page":"40","volume":"10","author":"Ru","year":"2017","journal-title":"HIV-Associated Synaptic Degeneration. Molecular Brain"},{"key":"10.1016\/j.bbi.2024.02.014_b0160","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1097\/00002030-199809000-00009","article-title":"Chemokines and receptors in HIV encephalitis","volume":"12","author":"Sanders","year":"1998","journal-title":"AIDS"},{"key":"10.1016\/j.bbi.2024.02.014_b0165","doi-asserted-by":"crossref","first-page":"e0175316","DOI":"10.1371\/journal.pone.0175316","article-title":"Gene expression patterns associated with neurological disease in human HIV infection","volume":"12","author":"Sanna","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.bbi.2024.02.014_b0170","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1038\/nrneurol.2016.27","article-title":"HIV-associated neurocognitive disorder\u2013pathogenesis and prospects for treatment","volume":"12","author":"Saylor","year":"2016","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.bbi.2024.02.014_b0175","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1038\/nature09907","article-title":"A diverse range of gene products are effectors of the type I interferon antiviral response","volume":"472","author":"Schoggins","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.bbi.2024.02.014_b0180","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1186\/s12974-020-01894-2","article-title":"A pivotal role for Interferon-\u03b1 receptor-1 in neuronal injury induced by HIV-1","volume":"17","author":"Singh","year":"2020","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.bbi.2024.02.014_b0185","doi-asserted-by":"crossref","DOI":"10.3390\/v13020170","article-title":"Innate immune sensing of viruses and its consequences for the central nervous system","volume":"13","author":"Singh","year":"2021","journal-title":"Viruses"},{"key":"10.1016\/j.bbi.2024.02.014_b0190","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1089\/vim.2018.0085","article-title":"Type I interferons in NeuroHIV","volume":"32","author":"Thaney","year":"2019","journal-title":"Viral Immunol."},{"key":"10.1016\/j.bbi.2024.02.014_b0195","doi-asserted-by":"crossref","first-page":"46514","DOI":"10.1038\/srep46514","article-title":"IFNbeta protects neurons from damage in a murine model of HIV-1 associated brain injury","volume":"7","author":"Thaney","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbi.2024.02.014_b0200","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1038\/367188a0","article-title":"Central nervous system damage produced by expression of the HIV-1 coat protein gp120 in transgenic mice","volume":"367","author":"Toggas","year":"1994","journal-title":"Nature"},{"key":"10.1016\/j.bbi.2024.02.014_b0205","doi-asserted-by":"crossref","first-page":"5901","DOI":"10.1523\/JNEUROSCI.1346-04.2004","article-title":"Double dissociation between the effects of peri-postrhinal cortex and hippocampal lesions on tests of object recognition and spatial memory: heterogeneity of function within the temporal lobe","volume":"24","author":"Winters","year":"2004","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bbi.2024.02.014_b0210","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.mvr.2008.11.003","article-title":"HIV-1 gp120 induces cytokine expression, leukocyte adhesion, and transmigration across the blood-brain barrier: modulatory effects of STAT1 signaling","volume":"77","author":"Yang","year":"2009","journal-title":"Microvasc. Res."}],"container-title":["Brain, Behavior, and Immunity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0889159124002502?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0889159124002502?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,3,17]],"date-time":"2025-03-17T03:07:16Z","timestamp":1742180836000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0889159124002502"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5]]},"references-count":42,"alternative-id":["S0889159124002502"],"URL":"https:\/\/doi.org\/10.1016\/j.bbi.2024.02.014","relation":{},"ISSN":["0889-1591"],"issn-type":[{"value":"0889-1591","type":"print"}],"subject":[],"published":{"date-parts":[[2024,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Interferon-\u03b2 deficiency alters brain response to chronic HIV-1 envelope protein exposure in a transgenic model of NeuroHIV","name":"articletitle","label":"Article Title"},{"value":"Brain, Behavior, and Immunity","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbi.2024.02.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}