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Psychiat."},{"issue":"2","key":"10.1016\/j.bbi.2024.03.002_b0325","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1002\/anxi.3070010203","article-title":"Serum interleukin-2 and soluble interleukin-2 receptor levels in generalized social phobia","volume":"1","author":"Rapaport","year":"1994","journal-title":"Anxiety"},{"issue":"Suppl 3","key":"10.1016\/j.bbi.2024.03.002_b0330","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1192\/bja.2020.82","article-title":"The immunology of stress and the impact of inflammation on the brain and behavior","volume":"27","author":"Ravi","year":"2021","journal-title":"Bjpsychol. 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Neuroimag."},{"issue":"10","key":"10.1016\/j.bbi.2024.03.002_b0360","doi-asserted-by":"crossref","DOI":"10.1038\/npp.2016.57","article-title":"Altered stress-induced regulation of genes in monocytes in adults with a history of childhood adversity","volume":"41","author":"Schwaiger","year":"2016","journal-title":"Neuropsychopharmacology"},{"issue":"10","key":"10.1016\/j.bbi.2024.03.002_b0365","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1001\/jamapsychiatry.2020.0431","article-title":"Psychosocial interventions and immune system function: a systematic review and meta-analysis of randomized clinical trials","volume":"77","author":"Shields","year":"2020","journal-title":"JAMA Psychiat."},{"issue":"3","key":"10.1016\/j.bbi.2024.03.002_b0370","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1037\/a0035302","article-title":"From stress to inflammation and major depressive disorder: A social signal transduction theory of depression","volume":"140","author":"Slavich","year":"2014","journal-title":"Psychol. 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