{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T21:02:59Z","timestamp":1790715779961,"version":"4.1.0"},"reference-count":87,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,7,22]],"date-time":"2025-07-22T00:00:00Z","timestamp":1753142400000},"content-version":"am","delay-in-days":355,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["RO1GM128008"],"award-info":[{"award-number":["RO1GM128008"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["R35GM118182"],"award-info":[{"award-number":["R35GM118182"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["RO1GM121102"],"award-info":[{"award-number":["RO1GM121102"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["R21NS130712"],"award-info":[{"award-number":["R21NS130712"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["RO1CA193522"],"award-info":[{"award-number":["RO1CA193522"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain, Behavior, and Immunity"],"published-print":{"date-parts":[[2024,8]]},"DOI":"10.1016\/j.bbi.2024.04.027","type":"journal-article","created":{"date-parts":[[2024,4,24]],"date-time":"2024-04-24T12:33:34Z","timestamp":1713962014000},"page":"630-639","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":24,"special_numbering":"C","title":["Electrical stimulation of the dorsal motor nucleus of the vagus in male mice can regulate inflammation without affecting the heart rate"],"prefix":"10.1016","volume":"120","author":[{"given":"Aidan","family":"Falvey","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Santhoshi P.","family":"Palandira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sangeeta S.","family":"Chavan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Brines","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Dantzer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin J.","family":"Tracey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentin A.","family":"Pavlov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.bbi.2024.04.027_b0005","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1084\/jem.20120571","article-title":"Neural reflexes in inflammation and immunity","volume":"209","author":"Andersson","year":"2012","journal-title":"J. Exp. Med."},{"issue":"1","key":"10.1016\/j.bbi.2024.04.027_b0010","doi-asserted-by":"crossref","first-page":"12","DOI":"10.4161\/viru.26982","article-title":"Gender differences in sepsis: cardiovascular and immunological aspects","volume":"5","author":"Angele","year":"2014","journal-title":"Virulence"},{"issue":"1","key":"10.1016\/j.bbi.2024.04.027_b0015","first-page":"3","article-title":"Endotoxin and the hypothalamo-pituitary-adrenal (HPA) axis","volume":"9","author":"Beishuizen","year":"2003","journal-title":"J. Endotoxin Res."},{"issue":"10","key":"10.1016\/j.bbi.2024.04.027_b0020","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1016\/S0025-6196(12)62272-1","article-title":"The central autonomic network: functional organization, dysfunction, and perspective","volume":"68","author":"Benarroch","year":"1993","journal-title":"Mayo Clin. Proc."},{"issue":"2","key":"10.1016\/j.bbi.2024.04.027_b0025","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/0165-1838(93)90046-W","article-title":"Characterization of vagal innervation to the rat celiac, suprarenal and mesenteric ganglia","volume":"42","author":"Berthoud","year":"1993","journal-title":"J. Auton. Nerv. Syst."},{"issue":"1","key":"10.1016\/j.bbi.2024.04.027_b0030","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1002\/(SICI)1097-0029(19960901)35:1<80::AID-JEMT7>3.0.CO;2-W","article-title":"Interaction between parasympathetic and sympathetic nerves in prevertebral ganglia: morphological evidence for vagal efferent innervation of ganglion cells in the rat","volume":"35","author":"Berthoud","year":"1996","journal-title":"Microsc. Res. Tech."},{"issue":"6","key":"10.1016\/j.bbi.2024.04.027_b0035","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1111\/nmo.12792","article-title":"Chronic vagus nerve stimulation in Crohn's disease: a 6-month follow-up pilot study","volume":"28","author":"Bonaz","year":"2016","journal-title":"Neurogastroenterol. Motil. Off. J. Europ. Gastrointest. Motil. Soc."},{"key":"10.1016\/j.bbi.2024.04.027_b0040","doi-asserted-by":"crossref","first-page":"49","DOI":"10.3389\/fnins.2018.00049","article-title":"The Vagus Nerve at the Interface of the Microbiota-Gut-Brain Axis","volume":"12","author":"Bonaz","year":"2018","journal-title":"Front. Neurosci."},{"issue":"6785","key":"10.1016\/j.bbi.2024.04.027_b0045","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1038\/35013070","article-title":"Vagus nerve stimulation attenuates the systemic inflammatory response to endotoxin","volume":"405","author":"Borovikova","year":"2000","journal-title":"Nature"},{"issue":"10","key":"10.1016\/j.bbi.2024.04.027_b0050","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1038\/nrd1854","article-title":"Animal models of sepsis: setting the stage","volume":"4","author":"Buras","year":"2005","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.bbi.2024.04.027_b0055","doi-asserted-by":"crossref","unstructured":"Caravaca AS, Gallina AL, Tarnawski L, Shavva VS, Colas RA, Dalli J, et al. Vagus nerve stimulation promotes resolution of inflammation by a mechanism that involves Alox15 and requires the \u03b17nAChR subunit. Proceed. Natl. Acad. Sci. U.S.Am. 2022;119(22):e2023285119.","DOI":"10.1073\/pnas.2023285119"},{"issue":"877","key":"10.1016\/j.bbi.2024.04.027_b0060","article-title":"An Effective Method for Acute Vagus Nerve Stimulation in Experimental Inflammation","volume":"13","author":"Caravaca","year":"2019","journal-title":"Front. Neurosci."},{"issue":"6","key":"10.1016\/j.bbi.2024.04.027_b0065","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1016\/j.immuni.2017.06.008","article-title":"Mechanisms and Therapeutic Relevance of Neuro-immune Communication","volume":"46","author":"Chavan","year":"2017","journal-title":"Immunity"},{"issue":"6","key":"10.1016\/j.bbi.2024.04.027_b0070","doi-asserted-by":"crossref","first-page":"7204","DOI":"10.18632\/oncotarget.23208","article-title":"Inflammatory responses and inflammation-associated diseases in organs","volume":"9","author":"Chen","year":"2018","journal-title":"Oncotarget"},{"issue":"5","key":"10.1016\/j.bbi.2024.04.027_b0075","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1097\/SHK.0000000000001361","article-title":"Buprenorphine Markedly Elevates a Panel of Surrogate Markers in a Murine Model of Sepsis","volume":"52","author":"Chen","year":"2019","journal-title":"Shock (Augusta, Ga)"},{"issue":"2","key":"10.1016\/j.bbi.2024.04.027_b0080","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1002\/(SICI)1096-9861(19990726)410:2<320::AID-CNE12>3.0.CO;2-5","article-title":"Projections of the dorsal motor nucleus of the vagus to cardiac ganglia of rat atria: An anterograde tracing study","volume":"410","author":"Cheng","year":"1999","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.bbi.2024.04.027_b0085","doi-asserted-by":"crossref","DOI":"10.1093\/ecco-jcc\/jjad151","article-title":"Neuroimmune modulation through vagus nerve stimulation reduces inflammatory activity in Crohn\u2019s disease patients: a prospective open label study","author":"D\u2019Haens","year":"2023","journal-title":"J. Crohns Colitis"},{"issue":"4","key":"10.1016\/j.bbi.2024.04.027_b0090","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1097\/00000658-199204000-00009","article-title":"Cytokine serum level during severe sepsis in human IL-6 as a marker of severity","volume":"215","author":"Damas","year":"1992","journal-title":"Ann. Surg."},{"key":"10.1016\/j.bbi.2024.04.027_b0095","doi-asserted-by":"crossref","unstructured":"Dunn AJ. The HPA Axis and the Immune System: A Perspective. NeuroImmune Biology. 7: Elsevier; 2007. p. 3-15.","DOI":"10.1016\/S1567-7443(07)00201-3"},{"issue":"6","key":"10.1016\/j.bbi.2024.04.027_b0100","doi-asserted-by":"crossref","first-page":"3550","DOI":"10.1128\/IAI.69.6.3550-3555.2001","article-title":"Tumor necrosis factor-dependent adhesions as a major protective mechanism early in septic peritonitis in mice","volume":"69","author":"Echtenacher","year":"2001","journal-title":"Infect. Immun."},{"issue":"1","key":"10.1016\/j.bbi.2024.04.027_b0105","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/s42234-022-00100-3","article-title":"Vagus nerve stimulation and inflammation: expanding the scope beyond cytokines","volume":"8","author":"Falvey","year":"2022","journal-title":"Bioelectronic Medicine."},{"key":"10.1016\/j.bbi.2024.04.027_b0115","article-title":"Peripheral nerve stimulation and immunity: the expanding opportunities for providing mechanistic insight and therapeutic intervention","author":"Falvey","year":"2021","journal-title":"Int. Immunol."},{"issue":"5","key":"10.1016\/j.bbi.2024.04.027_b0120","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1161\/01.RES.46.5.606","article-title":"Cardiac responses during stimulation of the dorsal motor nucleus and nucleus ambiguus in the cat","volume":"46","author":"Geis","year":"1980","journal-title":"Circ. Res."},{"key":"10.1016\/j.bbi.2024.04.027_b0125","article-title":"Safety and efficacy of neurostimulation with a miniaturised vagus nerve stimulation device in patients with multidrug-refractory rheumatoid arthritis: a two-stage multicentre, randomised pilot study. The Lancet","author":"Genovese","year":"2020","journal-title":"Rheumatology"},{"issue":"10","key":"10.1016\/j.bbi.2024.04.027_b0130","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1038\/nrneurol.2012.183","article-title":"Sepsis-associated encephalopathy","volume":"8","author":"Gofton","year":"2012","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.bbi.2024.04.027_b0135","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.autneu.2016.06.003","article-title":"Cardiac vagal preganglionic neurones: An update","volume":"199","author":"Gourine","year":"2016","journal-title":"Auton. Neurosci."},{"issue":"5","key":"10.1016\/j.bbi.2024.04.027_b0140","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1159\/000026393","article-title":"Role of several mediators of inflammation on the mouse hypothalamo-pituitary-adrenal axis response during acute endotoxemia","volume":"6","author":"Hadid","year":"1999","journal-title":"Neuroimmunomodulation"},{"issue":"2","key":"10.1016\/j.bbi.2024.04.027_b0145","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1016\/j.brs.2019.11.008","article-title":"Clinical trials for deep brain stimulation: Current state of affairs","volume":"13","author":"Harmsen","year":"2020","journal-title":"Brain Stimul."},{"issue":"4","key":"10.1016\/j.bbi.2024.04.027_b0150","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1097\/00024382-199704000-00002","article-title":"CECAL LIGATION AND PUNCTURE (CLP) INDUCES APOPTOSIS IN THYMUS, SPLEEN, LUNG, AND GUT BY AN ENDOTOXIN AND TNF-INDEPENDENT PATHWAY","volume":"7","author":"Hiramatsu","year":"1997","journal-title":"Shock (augusta, Ga)."},{"issue":"7","key":"10.1016\/j.bbi.2024.04.027_b0155","doi-asserted-by":"crossref","first-page":"1623","DOI":"10.1084\/jem.20052362","article-title":"Splenectomy inactivates the cholinergic antiinflammatory pathway during lethal endotoxemia and polymicrobial sepsis","volume":"203","author":"Huston","year":"2006","journal-title":"J. Exp. Med."},{"issue":"3","key":"10.1016\/j.bbi.2024.04.027_b0160","first-page":"610","article-title":"Neuromodulation for brain disorders: challenges and opportunities","volume":"60","author":"Johnson","year":"2013","journal-title":"I.E.E.E. Trans. Biomed. Eng."},{"issue":"3","key":"10.1016\/j.bbi.2024.04.027_b0165","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1111\/j.1469-7793.1998.869bs.x","article-title":"Activity of C fibre cardiac vagal efferents in anaesthetized cats and rats","volume":"507","author":"Jones","year":"1998","journal-title":"J. Physiol."},{"issue":"29","key":"10.1016\/j.bbi.2024.04.027_b0170","doi-asserted-by":"crossref","first-page":"8284","DOI":"10.1073\/pnas.1605635113","article-title":"Vagus nerve stimulation inhibits cytokine production and attenuates disease severity in rheumatoid arthritis","volume":"113","author":"Koopman","year":"2016","journal-title":"PNAS"},{"issue":"2","key":"10.1016\/j.bbi.2024.04.027_b0175","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1038\/s41582-020-00426-z","article-title":"Technology of deep brain stimulation: current status and future directions","volume":"17","author":"Krauss","year":"2021","journal-title":"Nat. Rev. Neurol."},{"issue":"47","key":"10.1016\/j.bbi.2024.04.027_b0180","doi-asserted-by":"crossref","first-page":"29803","DOI":"10.1073\/pnas.2008213117","article-title":"Identification of a brainstem locus that inhibits tumor necrosis factor","volume":"117","author":"Kressel","year":"2020","journal-title":"PNAS"},{"key":"10.1016\/j.bbi.2024.04.027_b0185","doi-asserted-by":"crossref","first-page":"841","DOI":"10.3389\/fphys.2018.00841","article-title":"Changes in Heart Rate and Its Regulation by the Autonomic Nervous System Do Not Differ Between Forced and Voluntary Exercise in Mice","volume":"9","author":"Lakin","year":"2018","journal-title":"Front. Physiol."},{"key":"10.1016\/j.bbi.2024.04.027_b0190","doi-asserted-by":"crossref","first-page":"585","DOI":"10.3389\/fimmu.2019.00585","article-title":"Forebrain Cholinergic Signaling Regulates Innate Immune Responses and Inflammation","volume":"10","author":"Lehner","year":"2019","journal-title":"Front. Immunol."},{"issue":"1","key":"10.1016\/j.bbi.2024.04.027_b0195","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1001\/jama.2014.5804","article-title":"Hospital deaths in patients with sepsis from 2 independent cohorts","volume":"312","author":"Liu","year":"2014","journal-title":"J. Am. Med. Assoc."},{"key":"10.1016\/j.bbi.2024.04.027_b0200","doi-asserted-by":"crossref","first-page":"197","DOI":"10.3389\/fphys.2016.00197","article-title":"Ca(2+)-Clock-Dependent Pacemaking in the Sinus Node Is Impaired in Mice with a Cardiac Specific Reduction in SERCA2 Abundance","volume":"7","author":"Logantha","year":"2016","journal-title":"Front. Physiol."},{"issue":"11","key":"10.1016\/j.bbi.2024.04.027_b0205","doi-asserted-by":"crossref","first-page":"2285","DOI":"10.1016\/j.hrthm.2015.06.005","article-title":"Control of ventricular excitability by neurons of the dorsal motor nucleus of the vagus nerve","volume":"12","author":"Machhada","year":"2015","journal-title":"Heart Rhythm"},{"issue":"14","key":"10.1016\/j.bbi.2024.04.027_b0210","doi-asserted-by":"crossref","first-page":"4017","DOI":"10.1113\/JP270984","article-title":"Origins of the vagal drive controlling left ventricular contractility","volume":"594","author":"Machhada","year":"2016","journal-title":"J. Physiol."},{"issue":"8","key":"10.1016\/j.bbi.2024.04.027_b0215","first-page":"799","article-title":"Optogenetic Stimulation of Vagal Efferent Activity Preserves Left Ventricular Function in Experimental Heart Failure. JACC: Basic to Translational","volume":"5","author":"Machhada","year":"2020","journal-title":"Science"},{"issue":"6","key":"10.1016\/j.bbi.2024.04.027_b0220","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1136\/gutjnl-2013-304676","article-title":"A distinct vagal anti-inflammatory pathway modulates intestinal muscularis resident macrophages independent of the spleen","volume":"63","author":"Matteoli","year":"2014","journal-title":"Gut"},{"issue":"7203","key":"10.1016\/j.bbi.2024.04.027_b0225","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1038\/nature07201","article-title":"Origin and physiological roles of inflammation","volume":"454","author":"Medzhitov","year":"2008","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.bbi.2024.04.027_b0230","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1146\/annurev-immunol-061020-053734","article-title":"Tissue Homeostasis and Inflammation","volume":"39","author":"Meizlish","year":"2021","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.bbi.2024.04.027_b0235","doi-asserted-by":"crossref","DOI":"10.1152\/ajpgi.00195.2018","article-title":"Vagus nerve cholinergic circuitry to the liver and the gastrointestinal tract in the neuroimmune communicatome","author":"Metz","year":"2018","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.bbi.2024.04.027_b0240","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbi.2019.08.188","article-title":"Functional circuitry of neuro-immune communication in the mesenteric lymph node and spleen","author":"Murray","year":"2019","journal-title":"Brain Behav. Immun."},{"issue":"6917","key":"10.1016\/j.bbi.2024.04.027_b0245","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1038\/nature01320","article-title":"Points of control in inflammation","volume":"420","author":"Nathan","year":"2002","journal-title":"Nature"},{"issue":"6","key":"10.1016\/j.bbi.2024.04.027_b0250","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1016\/j.cell.2010.02.029","article-title":"Nonresolving inflammation","volume":"140","author":"Nathan","year":"2010","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.bbi.2024.04.027_b0255","doi-asserted-by":"crossref","first-page":"37","DOI":"10.15424\/bioelectronmed.2015.00006","article-title":"Single-Pulse and Unidirectional Electrical Activation of the Cervical Vagus Nerve Reduces Tumor Necrosis Factor in Endotoxemia","volume":"2","author":"Olofsson","year":"2015","journal-title":"Bioelectronic Medicine."},{"key":"10.1016\/j.bbi.2024.04.027_b0260","series-title":"Inflammation: from Molecular and Cellular Mechanisms to the Clinic","first-page":"1485","article-title":"The Neuroimmune Communicatome in Inflammation","author":"Olofsson","year":"2017"},{"issue":"9\u201310","key":"10.1016\/j.bbi.2024.04.027_b0265","doi-asserted-by":"crossref","first-page":"567","DOI":"10.2119\/2008-00079.Parrish","article-title":"Modulation of TNF release by choline requires alpha7 subunit nicotinic acetylcholine receptor-mediated signaling","volume":"14","author":"Parrish","year":"2008","journal-title":"Mol. Med."},{"key":"10.1016\/j.bbi.2024.04.027_b0275","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharmthera.2020.107794","article-title":"The evolving obesity challenge: targeting the vagus nerve and the inflammatory reflex in the response","volume":"222","author":"Pavlov","year":"2021","journal-title":"Pharmacol. Ther."},{"issue":"13","key":"10.1016\/j.bbi.2024.04.027_b0280","doi-asserted-by":"crossref","first-page":"5219","DOI":"10.1073\/pnas.0600506103","article-title":"Central muscarinic cholinergic regulation of the systemic inflammatory response during endotoxemia","volume":"103","author":"Pavlov","year":"2006","journal-title":"Proceed. Natl. Acad. Sci. U.S.Am."},{"issue":"4","key":"10.1016\/j.bbi.2024.04.027_b0285","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1097\/01.CCM.0000259381.56526.96","article-title":"Selective alpha7-nicotinic acetylcholine receptor agonist GTS-21 improves survival in murine endotoxemia and severe sepsis","volume":"35","author":"Pavlov","year":"2007","journal-title":"Crit. Care Med."},{"issue":"12","key":"10.1016\/j.bbi.2024.04.027_b0290","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1038\/nrendo.2012.189","article-title":"The vagus nerve and the inflammatory reflex\u2013linking immunity and metabolism","volume":"8","author":"Pavlov","year":"2012","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1016\/j.bbi.2024.04.027_b0295","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1146\/annurev-immunol-042617-053158","article-title":"Molecular and Functional Neuroscience in Immunity","volume":"36","author":"Pavlov","year":"2018","journal-title":"Annu. Rev. Immunol."},{"issue":"2","key":"10.1016\/j.bbi.2024.04.027_b0300","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1038\/nn.4477","article-title":"Neural regulation of immunity: molecular mechanisms and clinical translation","volume":"20","author":"Pavlov","year":"2017","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.bbi.2024.04.027_b0305","article-title":"Bioelectronic Medicine: From Preclinical Studies on the Inflammatory Reflex to New Approaches in Disease Diagnosis and Treatment","author":"Pavlov","year":"2019","journal-title":"Cold Spring Harb. Perspect. Med."},{"issue":"1\u20133","key":"10.1016\/j.bbi.2024.04.027_b0310","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1007\/s12026-015-8718-1","article-title":"Neural circuitry and immunity","volume":"63","author":"Pavlov","year":"2015","journal-title":"Immunol. Res."},{"issue":"21","key":"10.1016\/j.bbi.2024.04.027_b0315","doi-asserted-by":"crossref","first-page":"3627","DOI":"10.1016\/j.neuron.2022.09.003","article-title":"Bioelectronic medicine: Preclinical insights and clinical advances","volume":"110","author":"Pavlov","year":"2022","journal-title":"Neuron"},{"issue":"5\u20138","key":"10.1016\/j.bbi.2024.04.027_b0320","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1007\/BF03402177","article-title":"The cholinergic anti-inflammatory pathway: a missing link in neuroimmunomodulation","volume":"9","author":"Pavlov","year":"2003","journal-title":"Mol. Med."},{"issue":"1","key":"10.1016\/j.bbi.2024.04.027_b0325","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.bbi.2008.06.011","article-title":"Brain acetylcholinesterase activity controls systemic cytokine levels through the cholinergic anti-inflammatory pathway","volume":"23","author":"Pavlov","year":"2009","journal-title":"Brain Behav. Immun."},{"issue":"1\u20132","key":"10.1016\/j.bbi.2024.04.027_b0330","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.autneu.2011.05.220","article-title":"Does the dorsal motor nucleus of the vagus control cardiac chronotropism in the rat?","volume":"163","author":"Pickering","year":"2011","journal-title":"Auton. Neurosci."},{"issue":"5","key":"10.1016\/j.bbi.2024.04.027_b0335","doi-asserted-by":"crossref","first-page":"2751","DOI":"10.1128\/IAI.73.5.2751-2757.2005","article-title":"Role of Interleukin-6 in Mortality from and Physiologic Response to Sepsis","volume":"73","author":"Remick","year":"2005","journal-title":"Infect. Immun."},{"issue":"13","key":"10.1016\/j.bbi.2024.04.027_b0340","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1001\/jama.2017.13836","article-title":"Incidence and Trends of Sepsis in US Hospitals Using Clinical vs Claims Data, 2009\u20132014","volume":"318","author":"Rhee","year":"2017","journal-title":"J. Am. Med. Assoc."},{"key":"10.1016\/j.bbi.2024.04.027_b0345","article-title":"Prevalence, Underlying Causes, and Preventability of Sepsis-Associated Mortality in US Acute Care Hospitals","volume":"2(2):e187571-e","author":"Rhee","year":"2019","journal-title":"JAMA Netw. Open"},{"issue":"1","key":"10.1016\/j.bbi.2024.04.027_b0350","doi-asserted-by":"crossref","first-page":"503","DOI":"10.4049\/jimmunol.170.1.503","article-title":"Protective Effects of IL-6 Blockade in Sepsis Are Linked to Reduced C5a Receptor Expression1","volume":"170","author":"Riedemann","year":"2003","journal-title":"J. Immunol."},{"key":"10.1016\/j.bbi.2024.04.027_b0360","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.bbi.2014.07.010","article-title":"Xanomeline suppresses excessive pro-inflammatory cytokine responses through neural signal-mediated pathways and improves survival in lethal inflammation","volume":"44","author":"Rosas-Ballina","year":"2015","journal-title":"Brain Behav. Immun."},{"issue":"1","key":"10.1016\/j.bbi.2024.04.027_b0365","doi-asserted-by":"crossref","DOI":"10.1084\/jem.20190418","article-title":"Biology and therapeutic potential of interleukin-10","volume":"217","author":"Saraiva","year":"2020","journal-title":"J. Exp. Med."},{"issue":"7","key":"10.1016\/j.bbi.2024.04.027_b0370","doi-asserted-by":"crossref","first-page":"2657","DOI":"10.1172\/JCI97943","article-title":"Resolvins in inflammation: emergence of the pro-resolving superfamily of mediators","volume":"128","author":"Serhan","year":"2018","journal-title":"J. Clin. Invest."},{"issue":"1","key":"10.1016\/j.bbi.2024.04.027_b0375","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1089\/vim.2005.18.41","article-title":"Immune modulation of the hypothalamic-pituitary-adrenal (HPA) axis during viral infection","volume":"18","author":"Silverman","year":"2005","journal-title":"Viral Immunol."},{"issue":"8","key":"10.1016\/j.bbi.2024.04.027_b0380","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1001\/jama.2016.0287","article-title":"The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)","volume":"315","author":"Singer","year":"2016","journal-title":"J. Am. Med. Assoc."},{"issue":"10","key":"10.1016\/j.bbi.2024.04.027_b0385","doi-asserted-by":"crossref","first-page":"e13911","DOI":"10.1111\/nmo.13911","article-title":"A 12-month pilot study outcomes of vagus nerve stimulation in Crohn's disease","volume":"32","author":"Sinniger","year":"2020","journal-title":"Neurogastroenterol. Motil. Off. J. Europ. Gastroint. Motil. Soc."},{"issue":"1\u20132","key":"10.1016\/j.bbi.2024.04.027_b0390","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/S0165-5728(99)00206-4","article-title":"IL-10 as a mediator in the HPA axis and brain","volume":"100","author":"Smith","year":"1999","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.bbi.2024.04.027_b0395","doi-asserted-by":"crossref","unstructured":"Tanaka S, Abe C, Abbott SBG, Zheng S, Yamaoka Y, Lipsey JE, et al. Vagus nerve stimulation activates two distinct neuroimmune circuits converging in the spleen to protect mice from kidney injury. Proceedings of the National Academy of Sciences. 2021;118(12):e2021758118.","DOI":"10.1073\/pnas.2021758118"},{"key":"10.1016\/j.bbi.2024.04.027_b0400","doi-asserted-by":"crossref","unstructured":"Thompson DA, Tsaava T, Rishi A, Nadella S, Mishra L, Tuveson DA, et al. Optogenetic stimulation of the brainstem dorsal motor nucleus ameliorates acute pancreatitis: Front Immunol. 2023 Apr 25;14:1166212. doi: 10.3389\/fimmu.2023.1166212. eCollection 2023.","DOI":"10.3389\/fimmu.2023.1166212"},{"issue":"1","key":"10.1016\/j.bbi.2024.04.027_b0405","doi-asserted-by":"crossref","first-page":"41","DOI":"10.4077\/CJP.2017.BAF449","article-title":"Double labeling of vagal preganglionic and sympathetic postganglionic fibers in celiac ganglion, superior mesenteric arteries and myenteric plexus","volume":"60","author":"Ting","year":"2017","journal-title":"Chin. J. Physiol."},{"issue":"6917","key":"10.1016\/j.bbi.2024.04.027_b0410","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1038\/nature01321","article-title":"The inflammatory reflex","volume":"420","author":"Tracey","year":"2002","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.bbi.2024.04.027_b0415","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1146\/annurev.cb.09.110193.001533","article-title":"Tumor necrosis factor, other cytokines and disease","volume":"9","author":"Tracey","year":"1993","journal-title":"Annu. Rev. Cell Biol."},{"issue":"4775","key":"10.1016\/j.bbi.2024.04.027_b0420","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1126\/science.3764421","article-title":"Shock and tissue injury induced by recombinant human cachectin","volume":"234","author":"Tracey","year":"1986","journal-title":"Science (New York, N.Y.)"},{"key":"10.1016\/j.bbi.2024.04.027_b0425","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1146\/annurev.physiol.68.040504.094635","article-title":"Brainstem circuits regulating gastric function","volume":"68","author":"Travagli","year":"2006","journal-title":"Annu. Rev. Physiol."},{"issue":"1","key":"10.1016\/j.bbi.2024.04.027_b0430","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1152\/physrev.1999.79.1.1","article-title":"Regulation of the hypothalamic-pituitary-adrenal axis by cytokines: actions and mechanisms of action","volume":"79","author":"Turnbull","year":"1999","journal-title":"Physiol. Rev."},{"issue":"10","key":"10.1016\/j.bbi.2024.04.027_b0435","doi-asserted-by":"crossref","first-page":"e1075","DOI":"10.1097\/CCM.0000000000002646","article-title":"Selective activation of basal forebrain cholinergic neurons attenuates polymicrobial sepsis\u2013induced inflammation via the cholinergic anti-inflammatory pathway","volume":"45","author":"Zhai","year":"2017","journal-title":"Crit. Care Med."},{"issue":"1","key":"10.1016\/j.bbi.2024.04.027_b0110","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1186\/s12974-020-02016-8","article-title":"Electrostimulation of the carotid sinus nerve in mice attenuates inflammation via glucocorticoid receptor on myeloid immune cells","volume":"17","author":"Falvey","year":"2020","journal-title":"J. Neuroinflammation"},{"issue":"3","key":"10.1016\/j.bbi.2024.04.027_b0270","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1161\/ATVBAHA.114.304455","article-title":"Human Experimental Endotoxemia in Modeling the Pathophysiology, Genomics, and Therapeutics of Innate Immunity in Complex Cardiometabolic Diseases","volume":"35","author":"Patel","year":"2015","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"issue":"6052","key":"10.1016\/j.bbi.2024.04.027_b0355","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1126\/science.1209985","article-title":"Acetylcholine-synthesizing T cells relay neural signals in a vagus nerve circuit","volume":"334","author":"Rosas-Ballina","year":"2011","journal-title":"Science (New York, N.Y.)"}],"container-title":["Brain, Behavior, and Immunity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0889159124003763?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0889159124003763?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T13:08:44Z","timestamp":1778504924000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0889159124003763"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8]]},"references-count":87,"alternative-id":["S0889159124003763"],"URL":"https:\/\/doi.org\/10.1016\/j.bbi.2024.04.027","relation":{},"ISSN":["0889-1591"],"issn-type":[{"value":"0889-1591","type":"print"}],"subject":[],"published":{"date-parts":[[2024,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Electrical stimulation of the dorsal motor nucleus of the vagus in male mice can regulate inflammation without affecting the heart rate","name":"articletitle","label":"Article Title"},{"value":"Brain, Behavior, and Immunity","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbi.2024.04.027","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}