{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T14:00:12Z","timestamp":1781791212880,"version":"3.54.5"},"reference-count":107,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,4,28]],"date-time":"2025-04-28T00:00:00Z","timestamp":1745798400000},"content-version":"am","delay-in-days":301,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AG056726"],"award-info":[{"award-number":["R01AG056726"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain, Behavior, and Immunity"],"published-print":{"date-parts":[[2024,7]]},"DOI":"10.1016\/j.bbi.2024.04.033","type":"journal-article","created":{"date-parts":[[2024,4,23]],"date-time":"2024-04-23T16:10:38Z","timestamp":1713888638000},"page":"637-647","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"special_numbering":"C","title":["Obesity and the cerebral cortex: Underlying neurobiology in mice and humans"],"prefix":"10.1016","volume":"119","author":[{"given":"Yash","family":"Patel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anita","family":"Woo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sammy","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramy","family":"Ayoub","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean","family":"Shin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy","family":"Botta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Troy","family":"Ketela","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hoon-Ki","family":"Sung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason","family":"Lerch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Nieman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomas","family":"Paus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zdenka","family":"Pausova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbi.2024.04.033_b0005","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuroimage.2022.119008","article-title":"Multiple-mouse magnetic resonance imaging with cryogenic radiofrequency probes for evaluation of brain development","volume":"252","author":"Arbabi","year":"2022","journal-title":"Neuroimage"},{"key":"10.1016\/j.bbi.2024.04.033_b0010","doi-asserted-by":"crossref","first-page":"90","DOI":"10.3389\/fncel.2020.00090","article-title":"Going the extra (synaptic) mile: excitotoxicity as the road toward neurodegenerative diseases","volume":"14","author":"Armada-Moreira","year":"2020","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.bbi.2024.04.033_b0015","doi-asserted-by":"crossref","first-page":"1982","DOI":"10.1016\/j.euroneuro.2014.03.002","article-title":"Obesity and dementia: adipokines interact with the brain","volume":"24","author":"Arnoldussen","year":"2014","journal-title":"Eur. Neuropsychopharmacol."},{"key":"10.1016\/j.bbi.2024.04.033_b0020","first-page":"1","article-title":"Advanced normalization tools (ANTS)","volume":"2","author":"Avants","year":"2009","journal-title":"Insight j"},{"key":"10.1016\/j.bbi.2024.04.033_b0025","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1038\/s41586-020-2777-8","article-title":"Negative feedback control of neuronal activity by microglia","volume":"586","author":"Badimon","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.bbi.2024.04.033_b0030","doi-asserted-by":"crossref","unstructured":"Bates, D., M\u00e4chler, M., Bolker, B. & Walker, S. Fitting linear mixed-effects models using lme4. arXiv preprint arXiv:1406.5823 (2014).","DOI":"10.18637\/jss.v067.i01"},{"key":"10.1016\/j.bbi.2024.04.033_b0035","doi-asserted-by":"crossref","first-page":"e79418","DOI":"10.7554\/eLife.79418","article-title":"Whole-brain comparison of rodent and human brains using spatial transcriptomics","volume":"11","author":"Beauchamp","year":"2022","journal-title":"Elife"},{"key":"10.1016\/j.bbi.2024.04.033_b0040","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1038\/s41588-022-01024-z","article-title":"New insights into the genetic etiology of Alzheimer\u2019s disease and related dementias","volume":"54","author":"Bellenguez","year":"2022","journal-title":"Nat. Genet."},{"key":"10.1016\/j.bbi.2024.04.033_b0045","doi-asserted-by":"crossref","first-page":"15731","DOI":"10.1073\/pnas.1511593112","article-title":"Obesity diminishes synaptic markers, alters microglial morphology, and impairs cognitive function","volume":"112","author":"Bocarsly","year":"2015","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.bbi.2024.04.033_b0050","doi-asserted-by":"crossref","first-page":"1546","DOI":"10.1016\/j.cmet.2021.07.006","article-title":"Astrocyte-neuron metabolic cooperation shapes brain activity","volume":"33","author":"Bonvento","year":"2021","journal-title":"Cell Metab."},{"key":"10.1016\/j.bbi.2024.04.033_b0055","first-page":"120","article-title":"The openCV library","volume":"25","author":"Bradski","year":"2000","journal-title":"Dr. Dobb\u2019s J.: Software Tool. Professional Programmer"},{"key":"10.1016\/j.bbi.2024.04.033_b0060","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1016\/j.jalz.2016.02.010","article-title":"Neuroinflammation in Alzheimer\u2019s disease: current evidence and future directions","volume":"12","author":"Calsolaro","year":"2016","journal-title":"Alzheimer. Dement."},{"key":"10.1016\/j.bbi.2024.04.033_b0065","doi-asserted-by":"crossref","DOI":"10.1016\/j.jdiacomp.2020.107795","article-title":"Phenotypic sexual dimorphism in response to dietary fat manipulation in C57BL\/6J mice","volume":"35","author":"Casimiro","year":"2021","journal-title":"J. Diabetes Complications"},{"key":"10.1016\/j.bbi.2024.04.033_b0070","doi-asserted-by":"crossref","first-page":"1532","DOI":"10.1016\/j.cmet.2022.09.002","article-title":"Hypothalamic astrocytes control systemic glucose metabolism and energy balance","volume":"34","author":"Chao","year":"2022","journal-title":"Cell Metab."},{"key":"10.1016\/j.bbi.2024.04.033_b0075","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1016\/j.cell.2020.06.038","article-title":"Spatial transcriptomics and in situ sequencing to study Alzheimer\u2019s disease","volume":"182","author":"Chen","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.bbi.2024.04.033_b0080","doi-asserted-by":"crossref","first-page":"e20202717","DOI":"10.1084\/jem.20202717","article-title":"Microglia in Alzheimer\u2019s disease at single-cell level. Are there common patterns in humans and mice?","volume":"218","author":"Chen","year":"2021","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.bbi.2024.04.033_b0085","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1097\/00004728-199403000-00005","article-title":"Automatic 3D intersubject registration of MR volumetric data in standardized Talairach space","volume":"18","author":"Collins","year":"1994","journal-title":"J. Comput. Assist. Tomogr."},{"key":"10.1016\/j.bbi.2024.04.033_b0090","doi-asserted-by":"crossref","first-page":"2290","DOI":"10.1093\/eurheartj\/ehz100","article-title":"Associations between vascular risk factors and brain MRI indices in UK Biobank","volume":"40","author":"Cox","year":"2019","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.bbi.2024.04.033_b0095","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1038\/nm.4350","article-title":"Insulin action and resistance in obesity and type 2 diabetes","volume":"23","author":"Czech","year":"2017","journal-title":"Nat. Med."},{"key":"10.1016\/j.bbi.2024.04.033_b0100","doi-asserted-by":"crossref","first-page":"1576","DOI":"10.1038\/s41598-017-01747-8","article-title":"Characterizing microglia activation: a spatial statistics approach to maximize information extraction","volume":"7","author":"Davis","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbi.2024.04.033_b0105","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.cca.2013.02.003","article-title":"Adipokines in obesity","volume":"419","author":"de Oliveira Leal","year":"2013","journal-title":"Clin. Chim. Acta"},{"key":"10.1016\/j.bbi.2024.04.033_b0110","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1212\/WNL.0b013e318227b227","article-title":"Midlife vascular risk factor exposure accelerates structural brain aging and cognitive decline","volume":"77","author":"Debette","year":"2011","journal-title":"Neurology"},{"key":"10.1016\/j.bbi.2024.04.033_b0115","doi-asserted-by":"crossref","first-page":"1936","DOI":"10.1038\/s41366-020-0623-6","article-title":"Fish oil supplementation alleviates metabolic and anxiodepressive effects of diet-induced obesity and associated changes in brain lipid composition in mice","volume":"44","author":"Demers","year":"2020","journal-title":"Int. J. Obes. (lond)"},{"key":"10.1016\/j.bbi.2024.04.033_b0120","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1038\/s41398-022-01779-3","article-title":"Socioeconomic status, BMI, and brain development in children","volume":"12","author":"Dennis","year":"2022","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.bbi.2024.04.033_b0125","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1016\/j.neuroimage.2006.01.021","article-title":"An automated labeling system for subdividing the human cerebral cortex on MRI scans into gyral based regions of interest","volume":"31","author":"Desikan","year":"2006","journal-title":"Neuroimage"},{"key":"10.1016\/j.bbi.2024.04.033_b0130","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.neuroimage.2008.03.037","article-title":"High resolution three-dimensional brain atlas using an average magnetic resonance image of 40 adult C57Bl\/6J mice","volume":"42","author":"Dorr","year":"2008","journal-title":"Neuroimage"},{"key":"10.1016\/j.bbi.2024.04.033_b0135","doi-asserted-by":"crossref","first-page":"4218","DOI":"10.1093\/nar\/gkq130","article-title":"Analytical approaches to RNA profiling data for the identification of genes enriched in specific cells","volume":"38","author":"Dougherty","year":"2010","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.bbi.2024.04.033_b0140","doi-asserted-by":"crossref","first-page":"739","DOI":"10.3233\/JAD-141086","article-title":"2003\u20132013: a decade of body mass index, Alzheimer\u2019s disease, and dementia","volume":"43","author":"Emmerzaal","year":"2015","journal-title":"J. Alzheimer. Diseas."},{"key":"10.1016\/j.bbi.2024.04.033_b0145","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1038\/s41586-022-04518-2","article-title":"A single-cell atlas of human and mouse white adipose tissue","volume":"603","author":"Emont","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.bbi.2024.04.033_b0150","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13059-015-0844-5","article-title":"MAST: a flexible statistical framework for assessing transcriptional changes and characterizing heterogeneity in single-cell RNA sequencing data","volume":"16","author":"Finak","year":"2015","journal-title":"Genome Biol."},{"key":"10.1016\/j.bbi.2024.04.033_b0155","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1038\/s41586-019-1601-9","article-title":"Treatment of type 2 diabetes with the designer cytokine IC7Fc","volume":"574","author":"Findeisen","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.bbi.2024.04.033_b0160","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1001\/jama.2012.39","article-title":"Prevalence of obesity and trends in the distribution of body mass index among US adults, 1999\u20132010","volume":"307","author":"Flegal","year":"2012","journal-title":"J. Am. Med. Assoc."},{"key":"10.1016\/j.bbi.2024.04.033_b0165","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2019.00236","article-title":"The involvement of peripheral and brain insulin resistance in late onset Alzheimer\u2019s dementia","volume":"11","author":"Folch","year":"2019","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.bbi.2024.04.033_b0170","doi-asserted-by":"crossref","first-page":"323","DOI":"10.3389\/fnins.2015.00323","article-title":"A FreeSurfer view of the cortical transcriptome generated from the Allen Human Brain Atlas","volume":"9","author":"French","year":"2015","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.bbi.2024.04.033_b0175","doi-asserted-by":"crossref","first-page":"67","DOI":"10.3389\/fninf.2014.00067","article-title":"Pydpiper: a flexible toolkit for constructing novel registration pipelines","volume":"8","author":"Friedel","year":"2014","journal-title":"Front. Neuroinf."},{"key":"10.1016\/j.bbi.2024.04.033_b0180","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1038\/s41593-018-0298-7","article-title":"A tau homeostasis signature is linked with the cellular and regional vulnerability of excitatory neurons to tau pathology","volume":"22","author":"Fu","year":"2019","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.bbi.2024.04.033_b0185","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1007\/s11154-021-09706-5","article-title":"Mechanisms linking obesity and its metabolic comorbidities with cerebral grey and white matter changes","volume":"23","author":"Garc\u00eda-Garc\u00eda","year":"2022","journal-title":"Rev. Endocr. Metab. Disord."},{"key":"10.1016\/j.bbi.2024.04.033_b0190","doi-asserted-by":"crossref","first-page":"e13573","DOI":"10.1111\/obr.13573","article-title":"Assessing adipokines as potential biomarkers of dementia, Alzheimer\u2019s disease, and mild cognitive impairment: A systematic review and meta-analysis","volume":"24","author":"Garc\u00eda-Garc\u00eda","year":"2023","journal-title":"Obes. Rev."},{"key":"10.1016\/j.bbi.2024.04.033_b0195","doi-asserted-by":"crossref","DOI":"10.12688\/f1000research.73600.1","article-title":"Doublet identification in single-cell sequencing data using scDblFinder","volume":"10","author":"Germain","year":"2021","journal-title":"F1000Research"},{"key":"10.1016\/j.bbi.2024.04.033_b0200","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1038\/s41398-021-01414-7","article-title":"Population-based body\u2013brain mapping links brain morphology with anthropometrics and body composition","volume":"11","author":"Gurholt","year":"2021","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.bbi.2024.04.033_b0205","doi-asserted-by":"crossref","first-page":"e594","DOI":"10.1212\/WNL.0000000000006879","article-title":"Association of body mass index and waist-to-hip ratio with brain structure: UK Biobank study","volume":"92","author":"Hamer","year":"2019","journal-title":"Neurology"},{"key":"10.1016\/j.bbi.2024.04.033_b0210","doi-asserted-by":"crossref","first-page":"3573","DOI":"10.1016\/j.cell.2021.04.048","article-title":"Integrated analysis of multimodal single-cell data","volume":"184","author":"Hao","year":"2021","journal-title":"Cell"},{"key":"10.1016\/j.bbi.2024.04.033_b0215","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.bbi.2015.08.023","article-title":"Dietary obesity reversibly induces synaptic stripping by microglia and impairs hippocampal plasticity","volume":"51","author":"Hao","year":"2016","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.bbi.2024.04.033_b0220","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1038\/nature11405","article-title":"An anatomically comprehensive atlas of the adult human brain transcriptome","volume":"489","author":"Hawrylycz","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.bbi.2024.04.033_b0225","doi-asserted-by":"crossref","first-page":"e2230367","DOI":"10.1001\/jamanetworkopen.2022.30367","article-title":"Effect of minocycline on depressive symptoms in patients with treatment-resistant depression: a randomized clinical trial","volume":"5","author":"Hellmann-Regen","year":"2022","journal-title":"JAMA Netw. Open"},{"key":"10.1016\/j.bbi.2024.04.033_b0230","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/S1474-4422(15)70016-5","article-title":"Neuroinflammation in Alzheimer\u2019s disease","volume":"14","author":"Heneka","year":"2015","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.bbi.2024.04.033_b0235","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1038\/s41586-019-1506-7","article-title":"Conserved cell types with divergent features in human versus mouse cortex","volume":"573","author":"Hodge","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.bbi.2024.04.033_b0240","doi-asserted-by":"crossref","first-page":"108","DOI":"10.3390\/info11020108","article-title":"Fastai: A layered API for deep learning","volume":"11","author":"Howard","year":"2020","journal-title":"Information"},{"key":"10.1016\/j.bbi.2024.04.033_b0245","doi-asserted-by":"crossref","first-page":"e181726","DOI":"10.1001\/jamanetworkopen.2018.1726","article-title":"Adolescent cognitive aptitudes and later-in-life Alzheimer disease and related disorders","volume":"1","author":"Huang","year":"2018","journal-title":"JAMA Netw. Open"},{"key":"10.1016\/j.bbi.2024.04.033_b0250","first-page":"58","article-title":"Prediction of Alzheimer\u2019s disease pathophysiology based on cortical thickness patterns","volume":"2","author":"Hwang","year":"2016","journal-title":"Alzheimer. Dementia: Diagnos., Assessm. Disease Monitor."},{"key":"10.1016\/j.bbi.2024.04.033_b0255","first-page":"685","article-title":"The Alzheimer\u2019s disease neuroimaging initiative (ADNI): MRI methods","volume":"27","author":"Jack","year":"2008","journal-title":"J. Magnet. Reson. Imag. Off. J. Int. Soc. Magnetic Reson. Med."},{"key":"10.1016\/j.bbi.2024.04.033_b0260","doi-asserted-by":"crossref","first-page":"e81863","DOI":"10.7554\/eLife.81863","article-title":"Target cell-specific synaptic dynamics of excitatory to inhibitory neuron connections in supragranular layers of human neocortex","volume":"12","author":"Kim","year":"2023","journal-title":"Elife"},{"key":"10.1016\/j.bbi.2024.04.033_b0265","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1016\/j.cmet.2019.08.010","article-title":"Microglial UCP2 mediates inflammation and obesity induced by high-fat feeding","volume":"30","author":"Kim","year":"2019","journal-title":"Cell Metab."},{"key":"10.1016\/j.bbi.2024.04.033_b0270","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1038\/s41592-019-0619-0","article-title":"Fast, sensitive and accurate integration of single-cell data with Harmony","volume":"16","author":"Korsunsky","year":"2019","journal-title":"Nat. Methods"},{"key":"10.1016\/j.bbi.2024.04.033_b0275","article-title":"Triangulating causality between childhood obesity and neurobehavior: Behavioral genetic and longitudinal evidence","volume":"e13392","author":"Kulisch","year":"2023","journal-title":"Dev. Sci."},{"key":"10.1016\/j.bbi.2024.04.033_b0280","doi-asserted-by":"crossref","DOI":"10.1016\/j.metop.2022.100208","article-title":"Of mice and men: Considerations on adipose tissue physiology in animal models of obesity and human studies","volume":"15","author":"Lempesis","year":"2022","journal-title":"Metabolism Open"},{"key":"10.1016\/j.bbi.2024.04.033_b0285","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2022.937486","article-title":"Global, regional, and national burden of Alzheimer\u2019s disease and other dementias, 1990\u20132019","volume":"14","author":"Li","year":"2022","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.bbi.2024.04.033_b0290","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1038\/s41586-019-1195-2","article-title":"Single-cell transcriptomic analysis of Alzheimer\u2019s disease","volume":"570","author":"Mathys","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.bbi.2024.04.033_b0295","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1038\/s41588-021-00894-z","article-title":"Single-nucleus chromatin accessibility and transcriptomic characterization of Alzheimer\u2019s disease","volume":"53","author":"Morabito","year":"2021","journal-title":"Nat. Genet."},{"key":"10.1016\/j.bbi.2024.04.033_b0300","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1038\/ng.801","article-title":"Common variants at MS4A4\/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer\u2019s disease","volume":"43","author":"Naj","year":"2011","journal-title":"Nat. Genet."},{"key":"10.1016\/j.bbi.2024.04.033_b0305","doi-asserted-by":"crossref","first-page":"216","DOI":"10.3390\/cells10020216","article-title":"Adipokines and autoimmunity in inflammatory arthritis","volume":"10","author":"Neumann","year":"2021","journal-title":"Cells"},{"key":"10.1016\/j.bbi.2024.04.033_b0310","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1001\/jamaneurol.2022.0976","article-title":"Risk factors associated with Alzheimer disease and related dementias by sex and race and ethnicity in the US","volume":"79","author":"Nianogo","year":"2022","journal-title":"JAMA Neurol."},{"key":"10.1016\/j.bbi.2024.04.033_b0315","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1002\/mrm.20590","article-title":"Fast spin-echo for multiple mouse magnetic resonance phenotyping","volume":"54","author":"Nieman","year":"2005","journal-title":"Magnet. Resonan. Med. Offic. J. Int. Soc. Magnet. Reson. Med."},{"key":"10.1016\/j.bbi.2024.04.033_b0320","doi-asserted-by":"crossref","first-page":"e44","DOI":"10.1002\/cpmo.44","article-title":"MRI to assess neurological function","volume":"8","author":"Nieman","year":"2018","journal-title":"Curr. Protoco. Mouse Biol."},{"key":"10.1016\/j.bbi.2024.04.033_b0325","doi-asserted-by":"crossref","first-page":"4839","DOI":"10.1038\/s41380-020-0774-9","article-title":"Brain structural abnormalities in obesity: relation to age, genetic risk, and common psychiatric disorders: Evidence through univariate and multivariate mega-analysis including 6420 participants from the ENIGMA MDD working group","volume":"26","author":"Opel","year":"2021","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.bbi.2024.04.033_b0330","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1016\/j.jalz.2017.04.003","article-title":"Cognitive ability in young adulthood and risk of dementia in a cohort of Danish men, brothers, and twins","volume":"13","author":"Osler","year":"2017","journal-title":"Alzheimer. Dement."},{"key":"10.1016\/j.bbi.2024.04.033_b0335","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1001\/jamapsychiatry.2020.2694","article-title":"Virtual histology of cortical thickness and shared neurobiology in 6 psychiatric disorders","volume":"78","author":"Patel","year":"2021","journal-title":"JAMA Psychiat."},{"key":"10.1016\/j.bbi.2024.04.033_b0340","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.dcn.2014.10.003","article-title":"Saguenay Youth Study: A multi-generational approach to studying virtual trajectories of the brain and cardio-metabolic health","volume":"11","author":"Paus","year":"2015","journal-title":"Dev. Cogn. Neurosci."},{"key":"10.1016\/j.bbi.2024.04.033_b0345","first-page":"e19","article-title":"Cohort profile: the saguenay youth study (SYS)","volume":"46","author":"Pausova","year":"2017","journal-title":"Int. J. Epidemiol."},{"key":"10.1016\/j.bbi.2024.04.033_b0350","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2020.01800","article-title":"Age-dependent changes of adipokine and cytokine secretion from rat adipose tissue by endogenous and exogenous toll-like receptor agonists","volume":"11","author":"Peek","year":"2020","journal-title":"Front. Immunol."},{"key":"10.1016\/j.bbi.2024.04.033_b0355","doi-asserted-by":"crossref","first-page":"e46057","DOI":"10.1371\/journal.pone.0046057","article-title":"Female Mice are Protected against High-Fat Diet Induced Metabolic Syndrome and Increase the Regulatory T Cell Population in Adipose Tissue","volume":"7","author":"Pettersson","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.bbi.2024.04.033_b0360","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.jneuroim.2009.11.010","article-title":"Cognitive impairment following high fat diet consumption is associated with brain inflammation","volume":"219","author":"Pistell","year":"2010","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.bbi.2024.04.033_b0365","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1038\/nmeth.1854","article-title":"Serial two-photon tomography for automated ex vivo mouse brain imaging","volume":"9","author":"Ragan","year":"2012","journal-title":"Nat. Methods"},{"key":"10.1016\/j.bbi.2024.04.033_b0370","first-page":"81","article-title":"Visceral adiposity is associated with metabolic profiles predictive of type 2 diabetes and myocardial infarction","volume":"2","author":"Raheem","year":"2022","journal-title":"Communicat. Med."},{"key":"10.1016\/j.bbi.2024.04.033_b0375","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1146\/annurev.immunol.021908.132528","article-title":"Microglial physiology: unique stimuli, specialized responses","volume":"27","author":"Ransohoff","year":"2009","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.bbi.2024.04.033_b0380","doi-asserted-by":"crossref","first-page":"e2314741","DOI":"10.1001\/jamanetworkopen.2023.14741","article-title":"Association of Healthy Lifestyle Factors and Obesity-Related Diseases in Adults in the UK","volume":"6","author":"Rassy","year":"2023","journal-title":"JAMA Netw. Open"},{"key":"10.1016\/j.bbi.2024.04.033_b0385","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1016\/j.neuroimage.2011.06.025","article-title":"Segmentation of the mouse hippocampal formation in magnetic resonance images","volume":"58","author":"Richards","year":"2011","journal-title":"Neuroimage"},{"key":"10.1016\/j.bbi.2024.04.033_b0390","doi-asserted-by":"crossref","first-page":"9734","DOI":"10.3390\/ijms22189734","article-title":"Should we open fire on microglia? depletion models as tools to elucidate microglial role in health and Alzheimer\u2019s disease","volume":"22","author":"Romero-Molina","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbi.2024.04.033_b0395","doi-asserted-by":"crossref","first-page":"2519","DOI":"10.1093\/cercor\/bhz257","article-title":"Childhood obesity, cortical structure, and executive function in healthy children","volume":"30","author":"Ronan","year":"2020","journal-title":"Cereb. Cortex"},{"key":"10.1016\/j.bbi.2024.04.033_b0400","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1016\/j.neuron.2014.12.063","article-title":"From intrinsic firing properties to selective neuronal vulnerability in neurodegenerative diseases","volume":"85","author":"Roselli","year":"2015","journal-title":"Neuron"},{"key":"10.1016\/j.bbi.2024.04.033_b0405","doi-asserted-by":"crossref","DOI":"10.3389\/fnint.2022.798995","article-title":"The obese brain: mechanisms of systemic and local inflammation, and interventions to reverse the cognitive deficit","volume":"16","author":"Salas-Venegas","year":"2022","journal-title":"Front. Integr. Neurosci."},{"key":"10.1016\/j.bbi.2024.04.033_b0410","doi-asserted-by":"crossref","first-page":"1336","DOI":"10.1038\/ijo.2013.104","article-title":"Visceral fat is associated with lower executive functioning in adolescents","volume":"37","author":"Schwartz","year":"2013","journal-title":"Int. J. Obes. (lond)"},{"key":"10.1016\/j.bbi.2024.04.033_b0415","doi-asserted-by":"crossref","first-page":"3267","DOI":"10.1093\/cercor\/bhx197","article-title":"Cell-specific gene-expression profiles and cortical thickness in the human brain","volume":"28","author":"Shin","year":"2018","journal-title":"Cereb. Cortex"},{"key":"10.1016\/j.bbi.2024.04.033_b0420","doi-asserted-by":"crossref","DOI":"10.2337\/dc23-1105","article-title":"Prediabetic HbA1c and Cortical Atrophy: Underlying Neurobiology","author":"Shin","year":"2023","journal-title":"Diabetes Care dc231105"},{"key":"10.1016\/j.bbi.2024.04.033_b0425","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1001\/archpsyc.63.7.824","article-title":"Association between obesity and psychiatric disorders in the US adult population","volume":"63","author":"Simon","year":"2006","journal-title":"Arch. Gen. Psychiatry"},{"key":"10.1016\/j.bbi.2024.04.033_b0430","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1038\/s41588-018-0129-5","article-title":"Genetic identification of brain cell types underlying schizophrenia","volume":"50","author":"Skene","year":"2018","journal-title":"Nat. Genet."},{"key":"10.1016\/j.bbi.2024.04.033_b0435","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1109\/42.668698","article-title":"A nonparametric method for automatic correction of intensity nonuniformity in MRI data","volume":"17","author":"Sled","year":"1998","journal-title":"IEEE Trans. Med. Imaging"},{"key":"10.1016\/j.bbi.2024.04.033_b0440","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.1038\/s41366-019-0363-7","article-title":"Use of high-fat diets to study rodent obesity as a model of human obesity","volume":"43","author":"Speakman","year":"2019","journal-title":"Int. J. Obes. (lond)"},{"key":"10.1016\/j.bbi.2024.04.033_b0445","doi-asserted-by":"crossref","first-page":"e3802","DOI":"10.1002\/nbm.3802","article-title":"Partitioning k-space for cylindrical three-dimensional rapid acquisition with relaxation enhancement imaging in the mouse brain","volume":"30","author":"Spencer Noakes","year":"2017","journal-title":"NMR Biomed."},{"key":"10.1016\/j.bbi.2024.04.033_b0450","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1002\/aur.1344","article-title":"Genetic effects on cerebellar structure across mouse models of autism using a magnetic resonance imaging atlas","volume":"7","author":"Steadman","year":"2014","journal-title":"Autism Res."},{"key":"10.1016\/j.bbi.2024.04.033_b0455","doi-asserted-by":"crossref","first-page":"1888","DOI":"10.1016\/j.cell.2019.05.031","article-title":"Comprehensive integration of single-cell data","volume":"177","author":"Stuart","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.bbi.2024.04.033_b0460","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1172\/JCI59660","article-title":"Obesity is associated with hypothalamic injury in rodents and humans","volume":"122","author":"Thaler","year":"2012","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bbi.2024.04.033_b0465","doi-asserted-by":"crossref","first-page":"e55851","DOI":"10.7554\/eLife.55851","article-title":"Genetic mapping of etiologic brain cell types for obesity","volume":"9","author":"Timshel","year":"2020","journal-title":"Elife"},{"key":"10.1016\/j.bbi.2024.04.033_b0470","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.neuroimage.2013.04.008","article-title":"A segmentation protocol and MRI atlas of the C57BL\/6J mouse neocortex","volume":"78","author":"Ullmann","year":"2013","journal-title":"Neuroimage"},{"key":"10.1016\/j.bbi.2024.04.033_b0475","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1093\/cercor\/bhx249","article-title":"Adolescent tuning of association cortex in human structural brain networks","volume":"28","author":"V\u00e1\u0161a","year":"2018","journal-title":"Cereb. Cortex"},{"key":"10.1016\/j.bbi.2024.04.033_b0480","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12974-020-01832-2","article-title":"Microglia depletion fails to abrogate inflammation-induced sickness in mice and rats","volume":"17","author":"Vichaya","year":"2020","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.bbi.2024.04.033_b0485","doi-asserted-by":"crossref","first-page":"21803","DOI":"10.1038\/s41598-020-78471-3","article-title":"Cellular correlates of cortical thinning throughout the lifespan","volume":"10","author":"Vidal-Pineiro","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbi.2024.04.033_b0490","unstructured":"Virtanen, P. et al. SciPy 1.0: fundamental algorithms for scientific computing in Python. Nat. Methods 17, 261\u2013272 (2020)."},{"key":"10.1016\/j.bbi.2024.04.033_b0495","doi-asserted-by":"crossref","first-page":"2131","DOI":"10.1001\/jama.282.22.2131","article-title":"Elevated C-reactive protein levels in overweight and obese adults","volume":"282","author":"Visser","year":"1999","journal-title":"J. Am. Med. Assoc."},{"key":"10.1016\/j.bbi.2024.04.033_b0500","doi-asserted-by":"crossref","first-page":"2043","DOI":"10.1007\/s00429-014-0774-0","article-title":"Whole-brain mapping of behaviourally induced neural activation in mice","volume":"220","author":"Vousden","year":"2015","journal-title":"Brain Struct. Funct."},{"key":"10.1016\/j.bbi.2024.04.033_b0505","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1016\/S1474-4422(12)70200-4","article-title":"Neuroimaging correlates of pathologically defined subtypes of Alzheimer\u2019s disease: a case-control study","volume":"11","author":"Whitwell","year":"2012","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.bbi.2024.04.033_b0510","article-title":"An integrated transcriptomic and epigenomic atlas of mouse primary motor cortex cell types","volume":"2020\u201302","author":"Yao","year":"2020","journal-title":"Biorxiv"},{"key":"10.1016\/j.bbi.2024.04.033_b0515","doi-asserted-by":"crossref","first-page":"e856","DOI":"10.7717\/peerj.856","article-title":"Obesity genetics in mouse and human: back and forth, and back again","volume":"3","author":"Yazdi","year":"2015","journal-title":"Peer J."},{"key":"10.1016\/j.bbi.2024.04.033_b0520","doi-asserted-by":"crossref","first-page":"4273","DOI":"10.1038\/s41467-018-05892-0","article-title":"Uncovering the heterogeneity and temporal complexity of neurodegenerative diseases with Subtype and Stage Inference","volume":"9","author":"Young","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bbi.2024.04.033_b0525","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1089\/omi.2011.0118","article-title":"clusterProfiler: an R package for comparing biological themes among gene clusters","volume":"16","author":"Yu","year":"2012","journal-title":"OMICS"},{"key":"10.1016\/j.bbi.2024.04.033_b0530","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1016\/j.cell.2018.06.021","article-title":"Molecular architecture of the mouse nervous system","volume":"174","author":"Zeisel","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.bbi.2024.04.033_b0535","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1038\/s41591-019-0695-9","article-title":"Human and mouse single-nucleus transcriptomics reveal TREM2-dependent and TREM2-independent cellular responses in Alzheimer\u2019s disease","volume":"26","author":"Zhou","year":"2020","journal-title":"Nat. Med."}],"container-title":["Brain, Behavior, and Immunity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0889159124003830?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0889159124003830?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,10,19]],"date-time":"2024-10-19T00:38:52Z","timestamp":1729298332000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0889159124003830"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7]]},"references-count":107,"alternative-id":["S0889159124003830"],"URL":"https:\/\/doi.org\/10.1016\/j.bbi.2024.04.033","relation":{},"ISSN":["0889-1591"],"issn-type":[{"value":"0889-1591","type":"print"}],"subject":[],"published":{"date-parts":[[2024,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Obesity and the cerebral cortex: Underlying neurobiology in mice and humans","name":"articletitle","label":"Article Title"},{"value":"Brain, Behavior, and Immunity","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbi.2024.04.033","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Crown Copyright \u00a9 2024 Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}