{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T23:27:40Z","timestamp":1790810860269,"version":"4.1.0"},"reference-count":44,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100019014","name":"Chengdu Municipal Science and Technology Program","doi-asserted-by":"publisher","award":["2019 -YF09-00120-SN"],"award-info":[{"award-number":["2019 -YF09-00120-SN"]}],"id":[{"id":"10.13039\/501100019014","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U23A20335"],"award-info":[{"award-number":["U23A20335"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004829","name":"Science and Technology Department of Sichuan Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004829","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012542","name":"Sichuan Provincial Science and Technology Support Program","doi-asserted-by":"publisher","award":["2024YFHZ0080"],"award-info":[{"award-number":["2024YFHZ0080"]}],"id":[{"id":"10.13039\/100012542","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012542","name":"Sichuan Provincial Science and Technology Support Program","doi-asserted-by":"publisher","award":["2022NSFSC1481"],"award-info":[{"award-number":["2022NSFSC1481"]}],"id":[{"id":"10.13039\/100012542","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain, Behavior, and Immunity"],"published-print":{"date-parts":[[2024,10]]},"DOI":"10.1016\/j.bbi.2024.07.012","type":"journal-article","created":{"date-parts":[[2024,7,16]],"date-time":"2024-07-16T10:00:15Z","timestamp":1721124015000},"page":"13-25","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["Placenta-specific CYP11A1 overexpression lead to autism-like symptom in offspring with altered steroid hormone biosynthesis in the placenta-brain axis and rescued by vitamin D intervention"],"prefix":"10.1016","volume":"121","author":[{"given":"Heng","family":"Yin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yajun","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juncen","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andras","family":"Dinnyes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qun","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinghui","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guolin","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenming","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiang","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.bbi.2024.07.012_b0005","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1179\/1476830514Y.0000000114","article-title":"Alexithymia is associated with low level of vitamin D in young healthy adults","volume":"17","author":"Altb\u00e4cker","year":"2014","journal-title":"Nutr. Neurosci."},{"issue":"41","key":"10.1016\/j.bbi.2024.07.012_b0010","doi-asserted-by":"crossref","first-page":"4357","DOI":"10.2174\/1381612825666191122092215","article-title":"Role of vitamin D in autism spectrum disorder","volume":"25","author":"Alzghoul","year":"2019","journal-title":"Curr. Pharm. Des."},{"issue":"6","key":"10.1016\/j.bbi.2024.07.012_b0015","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1016\/j.mehy.2013.03.014","article-title":"Role of perfumes in pathogenesis of autism","volume":"80","author":"Bagasra","year":"2013","journal-title":"Med. Hypotheses"},{"issue":"6","key":"10.1016\/j.bbi.2024.07.012_b0020","doi-asserted-by":"crossref","first-page":"e1001081","DOI":"10.1371\/journal.pbio.1001081","article-title":"Why are autism spectrum conditions more prevalent in males?","volume":"9","author":"Baron-Cohen","year":"2011","journal-title":"PLoS Biol."},{"issue":"3","key":"10.1016\/j.bbi.2024.07.012_b0025","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1038\/mp.2014.48","article-title":"Elevated fetal steroidogenic activity in autism","volume":"20","author":"Baron-Cohen","year":"2015","journal-title":"Mol. Psychiatry"},{"issue":"1","key":"10.1016\/j.bbi.2024.07.012_b0030","doi-asserted-by":"crossref","first-page":"e10405","DOI":"10.1002\/jbm4.10405","article-title":"Vitamin D and immune regulation: antibacterial, antiviral, anti-inflammatory","volume":"5","author":"Bishop","year":"2021","journal-title":"JBMR Plus"},{"issue":"3","key":"10.1016\/j.bbi.2024.07.012_b0035","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.yfrne.2010.05.001","article-title":"Of mice and rats: key species variations in the sexual differentiation of brain and behavior","volume":"31","author":"Bonthuis","year":"2010","journal-title":"Front. Neuroendocrinol."},{"issue":"1","key":"10.1016\/j.bbi.2024.07.012_b0040","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1007\/s11882-010-0161-8","article-title":"The impact of vitamin D on regulatory T cells","volume":"11","author":"Chambers","year":"2011","journal-title":"Curr. Allergy Asthma Rep."},{"issue":"2","key":"10.1016\/j.bbi.2024.07.012_b0045","doi-asserted-by":"crossref","first-page":"279","DOI":"10.24425\/pjvs.2019.129218","article-title":"Effect of genistein on the gene expressions of androgen generating key enzymes StAR, P450scc and CYP19 in rat ovary","volume":"22","author":"Chi","year":"2019","journal-title":"Pol. J. Vet. Sci."},{"issue":"1","key":"10.1016\/j.bbi.2024.07.012_b0050","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1093\/bmb\/ldy010","article-title":"Maternal vitamin D supplementation during pregnancy","volume":"126","author":"Curtis","year":"2018","journal-title":"Br. Med. Bull."},{"issue":"6","key":"10.1016\/j.bbi.2024.07.012_b0055","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1177\/0883073815620672","article-title":"A family-based association study of CYP11A1 and CYP11B1 gene polymorphisms with autism in Chinese trios","volume":"31","author":"Deng","year":"2016","journal-title":"J. Child Neurol."},{"issue":"12","key":"10.1016\/j.bbi.2024.07.012_b0060","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2021474118","article-title":"Attention recruits frontal cortex in human infants","volume":"118","author":"Ellis","year":"2021","journal-title":"PNAS"},{"issue":"6","key":"10.1016\/j.bbi.2024.07.012_b0065","first-page":"612","article-title":"Multisociety consensus quality improvement revised consensus statement for endovascular therapy of acute ischemic stroke","volume":"13","author":"From the American Association of Neurological Surgeons (AANS)","year":"2018","journal-title":"Int. J. Stroke"},{"issue":"1","key":"10.1016\/j.bbi.2024.07.012_b0070","doi-asserted-by":"crossref","DOI":"10.3390\/diseases9010013","article-title":"Testosterone\/epitestosterone ratios-further hints to explain hyperandrogenemia in children with autism","volume":"9","author":"Gasser","year":"2021","journal-title":"Diseases"},{"key":"10.1016\/j.bbi.2024.07.012_b0075","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.bbi.2023.12.024","article-title":"Maternal selenium dietary supplementation alters sociability and reinforcement learning deficits induced by in utero exposure to maternal immune activation in mice","volume":"116","author":"Gillespie","year":"2024","journal-title":"Brain Behav. Immun."},{"issue":"1","key":"10.1016\/j.bbi.2024.07.012_b0080","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1186\/s12888-023-04586-2","article-title":"Analysis of salivary steroid hormones in boys with autism spectrum disorder","volume":"23","author":"He","year":"2023","journal-title":"BMC Psychiatry"},{"issue":"3","key":"10.1016\/j.bbi.2024.07.012_b0085","doi-asserted-by":"crossref","first-page":"e59609","DOI":"10.1371\/journal.pone.0059609","article-title":"Abnormal apoptosis of trophoblastic cells is related to the up-regulation of CYP11A gene in placenta of preeclampsia patients","volume":"8","author":"He","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.bbi.2024.07.012_b0090","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.bcp.2017.05.019","article-title":"Sex steroids and neurogenesis","volume":"141","author":"Heberden","year":"2017","journal-title":"Biochem. Pharmacol."},{"issue":"2","key":"10.1016\/j.bbi.2024.07.012_b0095","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1177\/1362361316632710","article-title":"Sensory and repetitive behaviors among children with autism spectrum disorder at home","volume":"21","author":"Kirby","year":"2017","journal-title":"Autism"},{"issue":"2","key":"10.1016\/j.bbi.2024.07.012_b0100","doi-asserted-by":"crossref","first-page":"73","DOI":"10.30773\/pi.2021.0094","article-title":"The relationship of steroid hormones, genes related to testosterone metabolism and behavior in boys with autism in Slovakia","volume":"19","author":"Lakato\u0161ov\u00e1","year":"2022","journal-title":"Psych. Investig."},{"issue":"5","key":"10.1016\/j.bbi.2024.07.012_b0105","doi-asserted-by":"crossref","first-page":"1578","DOI":"10.1038\/s41380-019-0578-y","article-title":"Developmental vitamin D and autism spectrum disorders: findings from the Stockholm Youth Cohort","volume":"26","author":"Lee","year":"2021","journal-title":"Mol. Psychiatry"},{"issue":"10146","key":"10.1016\/j.bbi.2024.07.012_b0110","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1016\/S0140-6736(18)31129-2","article-title":"Autism spectrum disorder","volume":"392","author":"Lord","year":"2018","journal-title":"Lancet"},{"key":"10.1016\/j.bbi.2024.07.012_b0115","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.bbi.2019.04.037","article-title":"The influence of neuroinflammation in autism spectrum disorder","volume":"79","author":"Matta","year":"2019","journal-title":"Brain Behav. Immun."},{"issue":"11","key":"10.1016\/j.bbi.2024.07.012_b0120","first-page":"687","article-title":"The effects of vitamin D supplementation on maternal and neonatal outcome: A randomized clinical trial","volume":"13","author":"Mojibian","year":"2015","journal-title":"Iran J. Reprod. Med."},{"issue":"6","key":"10.1016\/j.bbi.2024.07.012_b0125","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.1093\/ajcn\/67.6.1108","article-title":"Sunlight, season, skin pigmentation, vitamin D, and 25-hydroxyvitamin D: integral components of the vitamin D endocrine system","volume":"67","author":"Norman","year":"1998","journal-title":"Am. J. Clin. Nutr."},{"issue":"8","key":"10.1016\/j.bbi.2024.07.012_b0130","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1016\/j.psyneuen.2011.02.007","article-title":"Increased serum androstenedione in adults with autism spectrum conditions","volume":"36","author":"Ruta","year":"2011","journal-title":"Psychoneuroendocrinology"},{"issue":"1","key":"10.1016\/j.bbi.2024.07.012_b0135","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1007\/s00404-013-2939-0","article-title":"Common polymorphisms in the CYP1A1 and CYP11A1 genes and polycystic ovary syndrome risk: a meta-analysis and meta-regression","volume":"289","author":"Shen","year":"2014","journal-title":"Arch. Gynecol. Obstet."},{"key":"10.1016\/j.bbi.2024.07.012_b0140","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.jsbmb.2014.11.010","article-title":"Novel activities of CYP11A1 and their potential physiological significance","volume":"151","author":"Slominski","year":"2015","journal-title":"J. Steroid Biochem. Mol. Biol."},{"issue":"10","key":"10.1016\/j.bbi.2024.07.012_b0145","doi-asserted-by":"crossref","DOI":"10.3390\/ijms19103072","article-title":"Differential and overlapping effects of 20,23(OH)\u2082D3 and 1,25(OH)\u2082D3 on gene expression in human epidermal keratinocytes: identification of AhR as an alternative receptor for 20,23(OH)\u2082D3","volume":"19","author":"Slominski","year":"2018","journal-title":"Int. J. Mol. Sci."},{"issue":"2","key":"10.1016\/j.bbi.2024.07.012_b0150","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1007\/s12013-020-00913-6","article-title":"Photoprotective properties of vitamin D and lumisterol hydroxyderivatives","volume":"78","author":"Slominski","year":"2020","journal-title":"Cell Biochem. Biophys."},{"issue":"1","key":"10.1016\/j.bbi.2024.07.012_b0155","doi-asserted-by":"crossref","first-page":"8002","DOI":"10.1038\/s41598-021-87061-w","article-title":"Vitamin D and lumisterol derivatives can act on liver X receptors (LXRs)","volume":"11","author":"Slominski","year":"2021","journal-title":"Sci. Rep."},{"issue":"8","key":"10.1016\/j.bbi.2024.07.012_b0160","doi-asserted-by":"crossref","first-page":"e22451","DOI":"10.1096\/fj.202200578R","article-title":"Metabolic activation of tachysterol(3) to biologically active hydroxyderivatives that act on VDR, AhR, LXRs, and PPAR\u03b3 receptors","volume":"36","author":"Slominski","year":"2022","journal-title":"FASEB J."},{"issue":"21","key":"10.1016\/j.bbi.2024.07.012_b0165","doi-asserted-by":"crossref","first-page":"4178","DOI":"10.1111\/j.1432-1033.2004.04356.x","article-title":"A novel pathway for sequential transformation of 7-dehydrocholesterol and expression of the P450scc system in mammalian skin","volume":"271","author":"Slominski","year":"2004","journal-title":"Eur. J. Biochem."},{"issue":"13","key":"10.1016\/j.bbi.2024.07.012_b0170","doi-asserted-by":"crossref","first-page":"2891","DOI":"10.1111\/j.1742-4658.2006.05302.x","article-title":"An alternative pathway of vitamin D metabolism. Cytochrome P450scc (CYP11A1)-mediated conversion to 20-hydroxyvitamin D2 and 17,20-dihydroxyvitamin D2","volume":"273","author":"Slominski","year":"2006","journal-title":"FEBS J."},{"issue":"2","key":"10.1016\/j.bbi.2024.07.012_b0175","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/S0960-0760(02)00058-4","article-title":"Placental cytochrome P450scc (CYP11A1): comparison of catalytic properties between conditions of limiting and saturating adrenodoxin reductase","volume":"81","author":"Tuckey","year":"2002","journal-title":"J. Steroid Biochem. Mol. Biol."},{"issue":"2","key":"10.1016\/j.bbi.2024.07.012_b0180","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1192\/bjpo.bp.116.004077","article-title":"Gestational vitamin D deficiency and autism spectrum disorder","volume":"3","author":"Vinkhuyzen","year":"2017","journal-title":"Bjpsych Open"},{"key":"10.1016\/j.bbi.2024.07.012_b0185","article-title":"CYP11A1 upregulation leads to trophoblast oxidative stress and fetal neurodevelopmental toxicity that can be rescued by vitamin D","volume":"7","author":"Wang","year":"2020","journal-title":"Front. Mol. Biosci."},{"issue":"1","key":"10.1016\/j.bbi.2024.07.012_b0190","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1007\/s11154-011-9195-z","article-title":"Vitamin D metabolism and signaling in the immune system","volume":"13","author":"White","year":"2012","journal-title":"Rev. Endocr. Metab. Disord."},{"issue":"47","key":"10.1016\/j.bbi.2024.07.012_b0195","doi-asserted-by":"crossref","first-page":"82390","DOI":"10.18632\/oncotarget.19326","article-title":"Immunological cytokine profiling identifies TNF-\u03b1 as a key molecule dysregulated in autistic children","volume":"8","author":"Xie","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.bbi.2024.07.012_b0200","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/531518","article-title":"Inflammatory cytokines: potential biomarkers of immunologic dysfunction in autism spectrum disorders","volume":"2015","author":"Xu","year":"2015","journal-title":"Mediators Inflamm."},{"key":"10.1016\/j.bbi.2024.07.012_b0205","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.physbeh.2014.09.014","article-title":"Prenatal hyperandrogenic environment induced autistic-like behavior in rat offspring","volume":"138","author":"Xu","year":"2015","journal-title":"Physiol. Behav."},{"issue":"3","key":"10.1016\/j.bbi.2024.07.012_b0210","doi-asserted-by":"crossref","first-page":"e201","DOI":"10.1055\/s-0039-1693016","article-title":"The Effect of BML-111 in preeclampsia rat model induced by the low dose of cadmium chloride","volume":"9","author":"Zhang","year":"2019","journal-title":"AJP Rep"},{"key":"10.1016\/j.bbi.2024.07.012_b0215","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1016\/j.envpol.2016.07.073","article-title":"Cadmium-induced immune abnormality is a key pathogenic event in human and rat models of preeclampsia","volume":"218","author":"Zhang","year":"2016","journal-title":"Environ. Pollut."},{"issue":"12","key":"10.1016\/j.bbi.2024.07.012_b0220","doi-asserted-by":"crossref","first-page":"2666","DOI":"10.1021\/acssynbio.9b00018","article-title":"Pregnenolone overproduction in Yarrowia lipolytica by integrative components pairing of the cytochrome P450scc system","volume":"8","author":"Zhang","year":"2019","journal-title":"ACS Synth. Biol."}],"container-title":["Brain, Behavior, and Immunity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0889159124004811?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0889159124004811?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,10,9]],"date-time":"2024-10-09T04:18:16Z","timestamp":1728447496000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0889159124004811"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10]]},"references-count":44,"alternative-id":["S0889159124004811"],"URL":"https:\/\/doi.org\/10.1016\/j.bbi.2024.07.012","relation":{},"ISSN":["0889-1591"],"issn-type":[{"value":"0889-1591","type":"print"}],"subject":[],"published":{"date-parts":[[2024,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Placenta-specific CYP11A1 overexpression lead to autism-like symptom in offspring with altered steroid hormone biosynthesis in the placenta-brain axis and rescued by vitamin D intervention","name":"articletitle","label":"Article Title"},{"value":"Brain, Behavior, and Immunity","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbi.2024.07.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}