{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T02:41:44Z","timestamp":1782700904120,"version":"3.54.5"},"reference-count":78,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain, Behavior, and Immunity"],"published-print":{"date-parts":[[2024,11]]},"DOI":"10.1016\/j.bbi.2024.08.042","type":"journal-article","created":{"date-parts":[[2024,8,24]],"date-time":"2024-08-24T04:33:34Z","timestamp":1724474014000},"page":"527-546","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Exogenous PD-L1 binds to PD-1 to alleviate and prevent autism-like behaviors in maternal immune activation-induced male offspring mice"],"prefix":"10.1016","volume":"122","author":[{"given":"Xin","family":"Zeng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linlin","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danyang","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengyue","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yutong","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengjun","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lijie","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1542-9702","authenticated-orcid":false,"given":"Shuang","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbi.2024.08.042_b0005","doi-asserted-by":"crossref","first-page":"e1447","DOI":"10.1542\/peds.2012-1107","article-title":"Autism after infection, febrile episodes, and antibiotic use during pregnancy: an exploratory study","volume":"130","author":"Atladottir","year":"2012","journal-title":"Pediatrics"},{"key":"10.1016\/j.bbi.2024.08.042_b0010","doi-asserted-by":"crossref","first-page":"R99","DOI":"10.1152\/ajpregu.00087.2021","article-title":"LPS versus Poly I: C model: comparison of long-term effects of bacterial and viral maternal immune activation on the offspring","volume":"322","author":"Bao","year":"2022","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"10.1016\/j.bbi.2024.08.042_b0015","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1038\/nm.4022","article-title":"PD-1 immune checkpoint blockade reduces pathology and improves memory in mouse models of Alzheimer's disease","volume":"22","author":"Baruch","year":"2016","journal-title":"Nat. Med."},{"key":"10.1016\/j.bbi.2024.08.042_b0020","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1016\/j.tins.2020.08.008","article-title":"Immunometabolism in the brain: how metabolism shapes microglial function","volume":"43","author":"Bernier","year":"2020","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.bbi.2024.08.042_b0025","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1176\/appi.ajp.2018.17121311","article-title":"Maternal immune activation and neuropsychiatric illness: a translational research perspective","volume":"175","author":"Brown","year":"2018","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.bbi.2024.08.042_b0030","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1038\/nbt.4096","article-title":"Integrating single-cell transcriptomic data across different conditions, technologies, and species","volume":"36","author":"Butler","year":"2018","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.bbi.2024.08.042_b0035","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics12010062","article-title":"Antibodies for the treatment of brain metastases, a dream or a reality?","volume":"12","author":"Cavaco","year":"2020","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.bbi.2024.08.042_b0040","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1007\/BF01531304","article-title":"Intrinsic and extrinsic determinants of neuronal development: relation to infantile autism","volume":"12","author":"Ciaranello","year":"1982","journal-title":"J. Autism Dev. Disord."},{"key":"10.1016\/j.bbi.2024.08.042_b0045","doi-asserted-by":"crossref","first-page":"1502","DOI":"10.1016\/S0140-6736(08)61620-7","article-title":"Multiple sclerosis","volume":"372","author":"Compston","year":"2008","journal-title":"Lancet"},{"key":"10.1016\/j.bbi.2024.08.042_b0050","doi-asserted-by":"crossref","DOI":"10.1016\/j.psychres.2020.113568","article-title":"Higher levels of serum IL-1beta and TNF-alpha are associated with an increased probability of major depressive disorder","volume":"295","author":"Das","year":"2021","journal-title":"Psychiatry Res."},{"key":"10.1016\/j.bbi.2024.08.042_b0055","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1093\/nar\/30.1.207","article-title":"Gene expression omnibus: NCBI gene expression and hybridization array data repository","volume":"30","author":"Edgar","year":"2002","journal-title":"Nucl. Acids Res."},{"key":"10.1016\/j.bbi.2024.08.042_b0060","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1126\/science.aag3194","article-title":"Maternal immune activation: implications for neuropsychiatric disorders","volume":"353","author":"Estes","year":"2016","journal-title":"Science"},{"key":"10.1016\/j.bbi.2024.08.042_b0065","doi-asserted-by":"crossref","first-page":"91779","DOI":"10.18632\/oncotarget.21586","article-title":"Recurrent glioma clinical trial, CheckMate-143: the game is not over yet","volume":"8","author":"Filley","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.bbi.2024.08.042_b0070","doi-asserted-by":"crossref","first-page":"D1049","DOI":"10.1093\/nar\/gku1179","article-title":"Gene ontology consortium: going forward","volume":"43","author":"Gene Ontology","year":"2015","journal-title":"Nucl. Acids Res."},{"key":"10.1016\/j.bbi.2024.08.042_b0075","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1007\/s00401-021-02263-w","article-title":"Distinct amyloid-beta and tau-associated microglia profiles in Alzheimer's disease","volume":"141","author":"Gerrits","year":"2021","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.bbi.2024.08.042_b0080","doi-asserted-by":"crossref","first-page":"2847","DOI":"10.1093\/bioinformatics\/btw313","article-title":"Complex heatmaps reveal patterns and correlations in multidimensional genomic data","volume":"32","author":"Gu","year":"2016","journal-title":"Bioinformatics"},{"key":"10.1016\/j.bbi.2024.08.042_b0085","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1016\/j.neubiorev.2020.04.012","article-title":"Maternal immune activation by poly I: C as a preclinical model for neurodevelopmental disorders: a focus on autism and schizophrenia","volume":"113","author":"Haddad","year":"2020","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.bbi.2024.08.042_b0090","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1038\/s41582-021-00530-8","article-title":"Maternal immune activation and neuroinflammation in human neurodevelopmental disorders","volume":"17","author":"Han","year":"2021","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.bbi.2024.08.042_b0095","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1038\/s41586-022-05274-z","article-title":"Prenatal immune stress blunts microglia reactivity, impairing neurocircuitry","volume":"610","author":"Hayes","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.bbi.2024.08.042_b0100","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.biopsych.2019.04.037","article-title":"An exploratory examination of neonatal cytokines and chemokines as predictors of autism risk: the early markers for autism study","volume":"86","author":"Heuer","year":"2019","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.bbi.2024.08.042_b0105","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1001\/jama.2022.23661","article-title":"Autism Spectrum Disorder: A Review","volume":"329","author":"Hirota","year":"2023","journal-title":"J. Am. Med. Assoc."},{"key":"10.1016\/j.bbi.2024.08.042_b0110","doi-asserted-by":"crossref","first-page":"1428","DOI":"10.1126\/science.aaf1292","article-title":"T cell costimulatory receptor CD28 is a primary target for PD-1-mediated inhibition","volume":"355","author":"Hui","year":"2017","journal-title":"Science"},{"key":"10.1016\/j.bbi.2024.08.042_b0115","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/S1726-4901(10)70011-3","article-title":"Congenital rubella syndrome with autistic disorder","volume":"73","author":"Hwang","year":"2010","journal-title":"J. Chin. Med. Assoc."},{"key":"10.1016\/j.bbi.2024.08.042_b0120","doi-asserted-by":"crossref","first-page":"e79","DOI":"10.1038\/psp.2013.56","article-title":"Application of ggplot2 to pharmacometric graphics","volume":"2","author":"Ito","year":"2013","journal-title":"CPT Pharmacometrics Syst. Pharmacol."},{"key":"10.1016\/j.bbi.2024.08.042_b0125","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/s12943-018-0928-4","article-title":"Role of the tumor microenvironment in PD-L1\/PD-1-mediated tumor immune escape","volume":"18","author":"Jiang","year":"2019","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.bbi.2024.08.042_b0130","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.bbi.2016.06.005","article-title":"Maternal infection during pregnancy and risk of autism spectrum disorders: a systematic review and meta-analysis","volume":"58","author":"Jiang","year":"2016","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.bbi.2024.08.042_b0135","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.709466","article-title":"Human placental trophoblasts infected by listeria monocytogenes undergo a pro-inflammatory switch associated with poor pregnancy outcomes","volume":"12","author":"Johnson","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.bbi.2024.08.042_b0140","doi-asserted-by":"crossref","first-page":"487","DOI":"10.3389\/fimmu.2020.00487","article-title":"The role of PD-1 in acute and chronic infection","volume":"11","author":"Jubel","year":"2020","journal-title":"Front. Immunol."},{"key":"10.1016\/j.bbi.2024.08.042_b0145","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1093\/nar\/28.1.27","article-title":"KEGG: kyoto encyclopedia of genes and genomes","volume":"28","author":"Kanehisa","year":"2000","journal-title":"Nucl. Acids Res."},{"key":"10.1016\/j.bbi.2024.08.042_b0150","doi-asserted-by":"crossref","first-page":"e363","DOI":"10.1038\/tp.2013.132","article-title":"Long-term effects of maternal immune activation on depression-like behavior in the mouse","volume":"4","author":"Khan","year":"2014","journal-title":"Transl. Psychiatry"},{"issue":"1466\u20131476","key":"10.1016\/j.bbi.2024.08.042_b0155","first-page":"e1463","article-title":"Programmed cell death ligand 1 alleviates psoriatic inflammation by suppressing IL-17A production from programmed cell death 1-high T cells","volume":"137","author":"Kim","year":"2016","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.bbi.2024.08.042_b0160","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1038\/s41592-019-0619-0","article-title":"Fast, sensitive and accurate integration of single-cell data with harmony","volume":"16","author":"Korsunsky","year":"2019","journal-title":"Nat. Methods"},{"key":"10.1016\/j.bbi.2024.08.042_b0165","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1002\/ana.20514","article-title":"A PD-1 polymorphism is associated with disease progression in multiple sclerosis","volume":"58","author":"Kroner","year":"2005","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.bbi.2024.08.042_b0170","doi-asserted-by":"crossref","DOI":"10.1126\/sciimmunol.abf4034","article-title":"The double-edged sword: harnessing PD-1 blockade in tumor and autoimmunity","volume":"6","author":"Kuchroo","year":"2021","journal-title":"Sci. Immunol."},{"key":"10.1016\/j.bbi.2024.08.042_b0175","doi-asserted-by":"crossref","DOI":"10.15252\/embj.2021108662","article-title":"Microglial PD-1 stimulation by astrocytic PD-L1 suppresses neuroinflammation and Alzheimer's disease pathology","volume":"40","author":"Kummer","year":"2021","journal-title":"EMBO J."},{"key":"10.1016\/j.bbi.2024.08.042_b0180","doi-asserted-by":"crossref","DOI":"10.1016\/j.cyto.2021.155582","article-title":"Role of IL-6 in the regulation of neuronal development, survival and function","volume":"144","author":"Kummer","year":"2021","journal-title":"Cytokine"},{"key":"10.1016\/j.bbi.2024.08.042_b0185","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21207609","article-title":"Pathophysiology and treatment of stroke: present status and future perspectives","volume":"21","author":"Kuriakose","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbi.2024.08.042_b0190","doi-asserted-by":"crossref","DOI":"10.1242\/dev.202252","article-title":"Fetal brain response to maternal inflammation requires microglia","volume":"151","author":"LaMonica Ostrem","year":"2024","journal-title":"Development"},{"key":"10.1016\/j.bbi.2024.08.042_b0195","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/S0140-6736(21)01541-5","article-title":"The lancet commission on the future of care and clinical research in autism","volume":"399","author":"Lord","year":"2022","journal-title":"Lancet"},{"key":"10.1016\/j.bbi.2024.08.042_b0200","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol."},{"issue":"591\u2013610","key":"10.1016\/j.bbi.2024.08.042_b0205","article-title":"Maternal respiratory SARS-CoV-2 infection in pregnancy is associated with a robust inflammatory response at the maternal-fetal interface","volume":"2","author":"Lu-Culligan","year":"2021","journal-title":"Med"},{"key":"10.1016\/j.bbi.2024.08.042_b0210","doi-asserted-by":"crossref","unstructured":"Majerczyk, D., Ayad, E.G., Brewton, K.L., Saing, P., Hart, P.C., 2022. Systemic maternal inflammation promotes ASD via IL-6 and IFN-gamma. Biosci. Rep. 42.","DOI":"10.1042\/BSR20220713"},{"key":"10.1016\/j.bbi.2024.08.042_b0215","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1038\/mp.2014.59","article-title":"Cytokine aberrations in autism spectrum disorder: a systematic review and meta-analysis","volume":"20","author":"Masi","year":"2015","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.bbi.2024.08.042_b0220","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.bbi.2014.01.019","article-title":"Minocycline rescues decrease in neurogenesis, increase in microglia cytokines and deficits in sensorimotor gating in an animal model of schizophrenia","volume":"38","author":"Mattei","year":"2014","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.bbi.2024.08.042_b0225","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/j.biopsych.2013.07.011","article-title":"Prenatal poly(i:C) exposure and other developmental immune activation models in rodent systems","volume":"75","author":"Meyer","year":"2014","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.bbi.2024.08.042_b0230","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1038\/s41380-020-00952-8","article-title":"Behavioral, neuroanatomical, and molecular correlates of resilience and susceptibility to maternal immune activation","volume":"26","author":"Mueller","year":"2021","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.bbi.2024.08.042_b0235","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0278-5846(97)00179-6","article-title":"Psychoneuroimmunology and the cytokine action in the CNS: implications for psychiatric disorders","volume":"22","author":"Muller","year":"1998","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.bbi.2024.08.042_b0240","doi-asserted-by":"crossref","DOI":"10.1111\/aji.13304","article-title":"COVID-19 and Treg\/Th17 imbalance: potential relationship to pregnancy outcomes","volume":"84","author":"Muyayalo","year":"2020","journal-title":"Am. J. Reprod. Immunol."},{"key":"10.1016\/j.bbi.2024.08.042_b0245","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1016\/j.ejcb.2010.11.012","article-title":"Regulation of T cell activation by TLR ligands","volume":"90","author":"Oberg","year":"2011","journal-title":"Eur. J. Cell Biol."},{"key":"10.1016\/j.bbi.2024.08.042_b0250","doi-asserted-by":"crossref","first-page":"1734","DOI":"10.1002\/eji.200738071","article-title":"B7\u2013H1 restricts neuroantigen-specific T cell responses and confines inflammatory CNS damage: implications for the lesion pathogenesis of multiple sclerosis","volume":"38","author":"Ortler","year":"2008","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.bbi.2024.08.042_b0255","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1186\/s12974-024-03106-7","article-title":"Impact of maternal immune activation and sex on placental and fetal brain cytokine and gene expression profiles in a preclinical model of neurodevelopmental disorders","volume":"21","author":"Osman","year":"2024","journal-title":"J. Neuroinflamm."},{"key":"10.1016\/j.bbi.2024.08.042_b0260","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1186\/s12974-015-0270-3","article-title":"Malibatol A regulates microglia M1\/M2 polarization in experimental stroke in a PPARgamma-dependent manner","volume":"12","author":"Pan","year":"2015","journal-title":"J. Neuroinflamm."},{"key":"10.1016\/j.bbi.2024.08.042_b0265","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/941413","article-title":"IL-4 inhibits IL-1beta-induced depressive-like behavior and central neurotransmitter alterations","volume":"2015","author":"Park","year":"2015","journal-title":"Mediators Inflamm."},{"key":"10.1016\/j.bbi.2024.08.042_b0270","doi-asserted-by":"crossref","first-page":"1794","DOI":"10.1038\/mp.2017.201","article-title":"Social impairments in autism spectrum disorder are related to maternal immune history profile","volume":"23","author":"Patel","year":"2018","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.bbi.2024.08.042_b0275","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abd2712","article-title":"Revisiting the PD-1 pathway","volume":"6","author":"Patsoukis","year":"2020","journal-title":"Sci. Adv."},{"key":"10.1016\/j.bbi.2024.08.042_b0280","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1038\/pr.2013.126","article-title":"Maternal inflammation promotes fetal microglial activation and increased cholinergic expression in the fetal basal forebrain: role of interleukin-6","volume":"74","author":"Pratt","year":"2013","journal-title":"Pediatr. Res."},{"key":"10.1016\/j.bbi.2024.08.042_b0285","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1007\/s12264-019-00388-3","article-title":"Dual functions of microglia in ischemic stroke","volume":"35","author":"Qin","year":"2019","journal-title":"Neurosci. Bull."},{"key":"10.1016\/j.bbi.2024.08.042_b0290","doi-asserted-by":"crossref","first-page":"R191","DOI":"10.1530\/REP-13-0262","article-title":"Regulatory T cells and the immune pathogenesis of prenatal infection","volume":"146","author":"Rowe","year":"2013","journal-title":"Reproduction"},{"key":"10.1016\/j.bbi.2024.08.042_b0295","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1038\/ni1443","article-title":"The function of programmed cell death 1 and its ligands in regulating autoimmunity and infection","volume":"8","author":"Sharpe","year":"2007","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.bbi.2024.08.042_b0300","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.molmed.2022.02.004","article-title":"COVID-19 in pregnancy: implications for fetal brain development","volume":"28","author":"Shook","year":"2022","journal-title":"Trends Mol. Med."},{"key":"10.1016\/j.bbi.2024.08.042_b0305","doi-asserted-by":"crossref","first-page":"10695","DOI":"10.1523\/JNEUROSCI.2178-07.2007","article-title":"Maternal immune activation alters fetal brain development through interleukin-6","volume":"27","author":"Smith","year":"2007","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bbi.2024.08.042_b0310","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1136\/gutjnl-2014-307311","article-title":"Protective effects of Fc-fused PD-L1 on two different animal models of colitis","volume":"64","author":"Song","year":"2015","journal-title":"Gut"},{"key":"10.1016\/j.bbi.2024.08.042_b0315","doi-asserted-by":"crossref","first-page":"15545","DOI":"10.1073\/pnas.0506580102","article-title":"Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles","volume":"102","author":"Subramanian","year":"2005","journal-title":"PNAS"},{"key":"10.1016\/j.bbi.2024.08.042_b0320","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.964442","article-title":"The role of PD-1\/PD-L1 and application of immune-checkpoint inhibitors in human cancers","volume":"13","author":"Tang","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.bbi.2024.08.042_b0325","doi-asserted-by":"crossref","unstructured":"Vazquez-Boland, J.A., Krypotou, E., Scortti, M., 2017. Listeria placental infection. mBio 8.","DOI":"10.1128\/mBio.00949-17"},{"key":"10.1016\/j.bbi.2024.08.042_b0330","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/s13229-017-0125-0","article-title":"Vitamin D treatment during pregnancy prevents autism-related phenotypes in a mouse model of maternal immune activation","volume":"8","author":"Vuillermot","year":"2017","journal-title":"Mol. Autism."},{"key":"10.1016\/j.bbi.2024.08.042_b0335","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/j.jpsychires.2020.10.021","article-title":"The interactive effect of genetic polymorphisms of IL-10 and COMT on cognitive function in schizophrenia","volume":"136","author":"Wang","year":"2021","journal-title":"J. Psychiatr. Res."},{"key":"10.1016\/j.bbi.2024.08.042_b0340","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1002\/aur.2079","article-title":"Oral probiotic administration during pregnancy prevents autism-related behaviors in offspring induced by maternal immune activation via anti-inflammation in mice","volume":"12","author":"Wang","year":"2019","journal-title":"Autism Res."},{"key":"10.1016\/j.bbi.2024.08.042_b0345","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1158\/2159-8290.CD-18-0367","article-title":"Fundamental mechanisms of immune checkpoint blockade therapy","volume":"8","author":"Wei","year":"2018","journal-title":"Cancer Discov."},{"key":"10.1016\/j.bbi.2024.08.042_b0350","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.bbi.2016.11.007","article-title":"The placental interleukin-6 signaling controls fetal brain development and behavior","volume":"62","author":"Wu","year":"2017","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.bbi.2024.08.042_b0355","doi-asserted-by":"crossref","first-page":"1896","DOI":"10.1038\/s41386-020-0743-7","article-title":"Modulating microglia activation prevents maternal immune activation induced schizophrenia-relevant behavior phenotypes via arginase 1 in the dentate gyrus","volume":"45","author":"Xia","year":"2020","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.bbi.2024.08.042_b0360","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0104433","article-title":"Gender-dependent effects of maternal immune activation on the behavior of mouse offspring","volume":"9","author":"Xuan","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.bbi.2024.08.042_b0365","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1038\/s41380-021-01092-3","article-title":"Mechanisms of synaptic transmission dysregulation in the prefrontal cortex: pathophysiological implications","volume":"27","author":"Yan","year":"2022","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.bbi.2024.08.042_b0370","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/j.neuroscience.2014.10.011","article-title":"The combined role of serotonin and interleukin-6 as biomarker for autism","volume":"284","author":"Yang","year":"2015","journal-title":"Neuroscience"},{"key":"10.1016\/j.bbi.2024.08.042_b0375","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1186\/s12943-021-01489-2","article-title":"Combination strategies with PD-1\/PD-L1 blockade: current advances and future directions","volume":"21","author":"Yi","year":"2022","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.bbi.2024.08.042_b0380","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1089\/omi.2011.0118","article-title":"clusterProfiler: an R package for comparing biological themes among gene clusters","volume":"16","author":"Yu","year":"2012","journal-title":"OMICS"},{"key":"10.1016\/j.bbi.2024.08.042_b0385","doi-asserted-by":"crossref","DOI":"10.3390\/ijms222111516","article-title":"The role of maternal immune activation in the pathogenesis of autism: a review of the evidence, proposed mechanisms and implications for treatment","volume":"22","author":"Zawadzka","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"2709\u20132726","key":"10.1016\/j.bbi.2024.08.042_b0390","article-title":"PD-L1\/PD-1 checkpoint pathway regulates hippocampal neuronal excitability and learning and memory behavior","volume":"111","author":"Zhao","year":"2023","journal-title":"Neuron"}],"container-title":["Brain, Behavior, and Immunity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0889159124005658?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0889159124005658?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,2,18]],"date-time":"2025-02-18T03:59:09Z","timestamp":1739851149000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0889159124005658"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11]]},"references-count":78,"alternative-id":["S0889159124005658"],"URL":"https:\/\/doi.org\/10.1016\/j.bbi.2024.08.042","relation":{},"ISSN":["0889-1591"],"issn-type":[{"value":"0889-1591","type":"print"}],"subject":[],"published":{"date-parts":[[2024,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Exogenous PD-L1 binds to PD-1 to alleviate and prevent autism-like behaviors in maternal immune activation-induced male offspring mice","name":"articletitle","label":"Article Title"},{"value":"Brain, Behavior, and Immunity","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbi.2024.08.042","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}