{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T18:52:29Z","timestamp":1780512749964,"version":"3.54.1"},"reference-count":72,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,9,6]],"date-time":"2024-09-06T00:00:00Z","timestamp":1725580800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004047","name":"Karolinska Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004047","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003792","name":"Brain Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003792","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Swedish Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002794","name":"Swedish Cancer Society","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002794","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006313","name":"Childhood Cancer Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006313","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain, Behavior, and Immunity"],"published-print":{"date-parts":[[2025,1]]},"DOI":"10.1016\/j.bbi.2024.09.001","type":"journal-article","created":{"date-parts":[[2024,9,6]],"date-time":"2024-09-06T10:31:47Z","timestamp":1725618707000},"page":"28-42","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"special_numbering":"C","title":["Bi-allelic NRXN1\u03b1 deletion in microglia derived from iPSC of an autistic patient increases interleukin-6 production and impairs supporting function on neuronal networking"],"prefix":"10.1016","volume":"123","author":[{"given":"Raj","family":"Bose","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mercedes","family":"Posada-P\u00e9rez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleni","family":"Karvela","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Skandik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lily","family":"Keane","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Falk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Spulber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bertrand","family":"Joseph","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9367-8480","authenticated-orcid":false,"given":"Sandra","family":"Ceccatelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"12","key":"10.1016\/j.bbi.2024.09.001_b0005","doi-asserted-by":"crossref","first-page":"9299","DOI":"10.1002\/jcp.26322","article-title":"Network analysis of hippocampal neurons by microelectrode array in the presence of HIV-1 tat and cocaine: tat and cocaine disrupt neuronal network function","volume":"233","author":"Ahooyi","year":"2018","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.bbi.2024.09.001_b0010","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.ejmg.2018.07.015","article-title":"NRXN1 deletion syndrome; phenotypic and penetrance data from 34 families","volume":"62","author":"Al Shehhi","year":"2019","journal-title":"Eur. J. Med. Genet."},{"key":"10.1016\/j.bbi.2024.09.001_b0015","doi-asserted-by":"crossref","first-page":"2328","DOI":"10.1038\/s41380-023-02048-5","article-title":"Serotonin sensing by microglia conditions the proper development of neuronal circuits and of social and adaptive skills","volume":"28","author":"Albertini","year":"2023","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.bbi.2024.09.001_b0020","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1038\/s41398-023-02668-z","article-title":"Distinct neurexin isoforms cooperate to initiate and maintain foraging activity","volume":"13","author":"Bastien","year":"2023","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.bbi.2024.09.001_b0025","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1002\/ajmg.b.32148","article-title":"Molecular and clinical characterization of 25 individuals with exonic deletions of NRXN1 and comprehensive review of the literature","volume":"162","author":"B\u00e9na","year":"2013","journal-title":"Am. J. Med. Genet. B Neuropsychiatr. Genet."},{"key":"10.1016\/j.bbi.2024.09.001_b0030","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1111\/cge.13537","article-title":"Phenotypic spectrum of NRXN1 mono- and bi-allelic deficiency: a systematic review","volume":"97","author":"Castronovo","year":"2020","journal-title":"Clin. Genet."},{"issue":"3","key":"10.1016\/j.bbi.2024.09.001_b0035","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1038\/nbt.1529","article-title":"Highly efficient neural conversion of human ES and iPS cells by dual inhibition of SMAD signaling","volume":"27","author":"Chambers","year":"2009","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.bbi.2024.09.001_b0040","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1176\/appi.ajp.2010.09101470","article-title":"Sibling recurrence and the genetic epidemiology of autism","volume":"167","author":"Constantino","year":"2010","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.bbi.2024.09.001_b0045","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.bbi.2023.02.007","article-title":"Acute IL-6 exposure triggers canonical IL6Ra signaling in hiPSC microglia, but not neural progenitor cells","volume":"110","author":"Couch","year":"2023","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.bbi.2024.09.001_b0050","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/j.neuron.2020.11.007","article-title":"Shaping neuronal fate: functional heterogeneity of direct microglia-neuron interactions","volume":"109","author":"Cser\u00e9p","year":"2021","journal-title":"Neuron"},{"key":"10.1016\/j.bbi.2024.09.001_bib352","doi-asserted-by":"crossref","first-page":"4216","DOI":"10.1523\/JNEUROSCI.3441-12.2013","article-title":"Microglia regulate the number of neural precursor cells in the developing cerebral cortex","volume":"33","author":"Cunningham","year":"2013","journal-title":"J. Neurosci. Off. J. Soc. Neurosci."},{"key":"10.1016\/j.bbi.2024.09.001_b0055","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1038\/nature10907","article-title":"Wild-type microglia arrest pathology in a mouse model of Rett syndrome","volume":"484","author":"Derecki","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.bbi.2024.09.001_b0060","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1126\/science.aag3194","article-title":"Maternal immune activation: implications for neuropsychiatric disorders","volume":"353","author":"Estes","year":"2016","journal-title":"Science"},{"key":"10.1016\/j.bbi.2024.09.001_b0065","doi-asserted-by":"crossref","DOI":"10.3390\/cells11010124","article-title":"Microglia-like cells promote neuronal functions in cerebral organoids","volume":"11","author":"Fagerlund","year":"2021","journal-title":"Cells"},{"key":"10.1016\/j.bbi.2024.09.001_b0070","doi-asserted-by":"crossref","first-page":"e29597","DOI":"10.1371\/journal.pone.0029597","article-title":"Capture of neuroepithelial-like stem cells from pluripotent stem cells provides a versatile system for in vitro production of human neurons","volume":"7","author":"Falk","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.bbi.2024.09.001_b0075","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/j.tcb.2016.02.006","article-title":"Microglia: architects of the developing nervous system","volume":"26","author":"Frost","year":"2016","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.bbi.2024.09.001_b0080","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1126\/science.1194637","article-title":"Fate mapping analysis reveals that adult microglia derive from primitive macrophages","volume":"330","author":"Ginhoux","year":"2010","journal-title":"Science"},{"key":"10.1016\/j.bbi.2024.09.001_b0085","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.bbi.2023.03.023","article-title":"Sex-specific microglia state in the Neuroligin-4 knock-out mouse model of autism spectrum disorder","volume":"111","author":"Guneykaya","year":"2023","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.bbi.2024.09.001_b0090","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1038\/s41593-020-00796-z","article-title":"Fully defined human pluripotent stem cell-derived microglia and tri-culture system model C3 production in Alzheimer\u2019s disease","volume":"24","author":"Guttikonda","year":"2021","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.bbi.2024.09.001_b0095","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1038\/nn.3919","article-title":"The idiosyncratic brain: distortion of spontaneous connectivity patterns in autism spectrum disorder","volume":"18","author":"Hahamy","year":"2015","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.bbi.2024.09.001_b0100","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.immuni.2018.11.004","article-title":"Single-cell RNA sequencing of microglia throughout the mouse lifespan and in the injured brain reveals complex cell-state changes","volume":"50","author":"Hammond","year":"2019","journal-title":"Immunity"},{"key":"10.1016\/j.bbi.2024.09.001_b0105","article-title":"Microglia: synaptic modulator in autism spectrum disorder","volume":"13","author":"Hu","year":"2022","journal-title":"Front. Psych."},{"key":"10.1016\/j.bbi.2024.09.001_b0110","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.bbi.2022.12.001","article-title":"Innate immune dysfunction and neuroinflammation in autism spectrum disorder (ASD)","volume":"108","author":"Hughes","year":"2023","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.bbi.2024.09.001_b0115","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.brainres.2009.09.120","article-title":"Increased dendritic spine densities on cortical projection neurons in autism spectrum disorders","volume":"1309","author":"Hutsler","year":"2010","journal-title":"Brain Res."},{"key":"10.1016\/j.bbi.2024.09.001_b0120","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1186\/s11689-020-09325-2","article-title":"Functional characterization of rare NRXN1 variants identified in autism spectrum disorders and schizophrenia","volume":"12","author":"Ishizuka","year":"2020","journal-title":"J. Neurodev. Disord."},{"key":"10.1016\/j.bbi.2024.09.001_b0125","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/0304-3940(94)11792-H","article-title":"Establishment of human microglial cell lines after transfection of primary cultures of embryonic microglial cells with the SV40 large T antigen","volume":"195","author":"Janabi","year":"1995","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.bbi.2024.09.001_b0130","doi-asserted-by":"crossref","first-page":"e1019","DOI":"10.1038\/tp.2016.294","article-title":"Advanced paternal age effects in neurodevelopmental disorders-review of potential underlying mechanisms","volume":"7","author":"Janecka","year":"2017","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.bbi.2024.09.001_b0135","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abh2169","article-title":"A single-cell type transcriptomics map of human tissues","volume":"7","author":"Karlsson","year":"2021","journal-title":"Sci. Adv."},{"key":"10.1016\/j.bbi.2024.09.001_b0140","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.ajhg.2007.09.011","article-title":"Disruption of neurexin 1 associated with autism spectrum disorder","volume":"82","author":"Kim","year":"2008","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.bbi.2024.09.001_b0145","doi-asserted-by":"crossref","first-page":"e0197060","DOI":"10.1371\/journal.pone.0197060","article-title":"Pioglitazone abolishes autistic-like behaviors via the IL-6 pathway","volume":"13","author":"Kirsten","year":"2018","journal-title":"PLoS One"},{"key":"10.1016\/j.bbi.2024.09.001_b0150","doi-asserted-by":"crossref","first-page":"9782","DOI":"10.1523\/JNEUROSCI.4159-15.2016","article-title":"Involvement of Spinal IL-6 trans-signaling in the induction of hyperexcitability of deep dorsal horn neurons by spinal tumor necrosis factor-alpha","volume":"36","author":"K\u00f6nig","year":"2016","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bbi.2024.09.001_b0155","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1111\/jnc.15438","article-title":"Spinal interleukin-1\u03b2 induces mechanical spinal hyperexcitability in rats: Interactions and redundancies with TNF and IL-6","volume":"158","author":"K\u00f6nig","year":"2021","journal-title":"J. Neurochem."},{"key":"10.1016\/j.bbi.2024.09.001_b0160","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1016\/j.stemcr.2020.03.019","article-title":"Developmental IL-6 exposure favors production of PDGF-responsive multipotential progenitors at the expense of neural stem cells and other progenitors","volume":"14","author":"Kumari","year":"2020","journal-title":"Stem Cell Rep."},{"key":"10.1016\/j.bbi.2024.09.001_b0165","doi-asserted-by":"crossref","DOI":"10.1016\/j.cyto.2021.155582","article-title":"Role of IL-6 in the regulation of neuronal development, survival and function","volume":"144","author":"Kummer","year":"2021","journal-title":"Cytokine"},{"key":"10.1016\/j.bbi.2024.09.001_b0170","doi-asserted-by":"crossref","DOI":"10.1016\/j.yexcr.2019.06.014","article-title":"Single cell analysis of autism patient with bi-allelic NRXN1-alpha deletion reveals skewed fate choice in neural progenitors and impaired neuronal functionality","volume":"383","author":"Lam","year":"2019","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.bbi.2024.09.001_b0175","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.jpsychires.2020.07.013","article-title":"Microglia mediated neuroinflammation in autism spectrum disorder","volume":"130","author":"Liao","year":"2020","journal-title":"J. Psychiatr. Res."},{"key":"10.1016\/j.bbi.2024.09.001_b0180","doi-asserted-by":"crossref","first-page":"1434","DOI":"10.1111\/jcmm.12123","article-title":"Interplay between human microglia and neural stem\/progenitor cells in an allogeneic co-culture model","volume":"17","author":"Liu","year":"2013","journal-title":"J. Cell Mol. Med."},{"key":"10.1016\/j.bbi.2024.09.001_b0185","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1016\/j.jaac.2017.03.013","article-title":"What is the male-to-female ratio in autism spectrum disorder? A systematic review and meta-analysis","volume":"56","author":"Loomes","year":"2017","journal-title":"J. Am. Acad. Child Adolesc. Psychiatry"},{"key":"10.1016\/j.bbi.2024.09.001_b0190","doi-asserted-by":"crossref","DOI":"10.1042\/BSR20220713","article-title":"Systemic maternal inflammation promotes ASD via IL-6 and IFN-\u03b3","volume":"42","author":"Majerczyk","year":"2022","journal-title":"Biosci. Rep."},{"key":"10.1016\/j.bbi.2024.09.001_b0195","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1002\/cne.21123","article-title":"Distribution and differentiation of microglia in the human encephalon during the first two trimesters of gestation","volume":"499","author":"Monier","year":"2006","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.bbi.2024.09.001_b0200","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1038\/nmeth.1580","article-title":"A bioinformatic assay for pluripotency in human cells","volume":"8","author":"M\u00fcller","year":"2011","journal-title":"Nat. Methods"},{"key":"10.1016\/j.bbi.2024.09.001_b0205","doi-asserted-by":"crossref","first-page":"1456","DOI":"10.1126\/science.1202529","article-title":"Synaptic pruning by microglia is necessary for normal brain development","volume":"333","author":"Paolicelli","year":"2011","journal-title":"Science"},{"key":"10.1016\/j.bbi.2024.09.001_b0210","doi-asserted-by":"crossref","first-page":"3341","DOI":"10.1073\/pnas.1515105113","article-title":"Network synchronization in hippocampal neurons","volume":"113","author":"Penn","year":"2016","journal-title":"PNAS"},{"key":"10.1016\/j.bbi.2024.09.001_b0215","doi-asserted-by":"crossref","first-page":"2153","DOI":"10.1016\/j.stem.2021.08.015","article-title":"Human microglia states are conserved across experimental models and regulate neural stem cell responses in chimeric organoids","volume":"28","author":"Popova","year":"2021","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.bbi.2024.09.001_b0220","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fgene.2019.00593","article-title":"NRXN1 deletion and exposure to methylmercury increase astrocyte differentiation by different notch-dependent transcriptional mechanisms","volume":"10","author":"Raciti","year":"2019","journal-title":"Front. Genet."},{"key":"10.1016\/j.bbi.2024.09.001_b0225","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1017\/S1740925X12000142","article-title":"Evidence of microglial activation in autism and its possible role in brain underconnectivity","volume":"7","author":"Rodriguez","year":"2011","journal-title":"Neuron Glia Biol."},{"key":"10.1016\/j.bbi.2024.09.001_b0230","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a028415","article-title":"Interleukin-6 family cytokines","volume":"10","author":"Rose-John","year":"2018","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"10.1016\/j.bbi.2024.09.001_b0235","doi-asserted-by":"crossref","DOI":"10.3390\/ijms25137168","article-title":"Impact of interleukin-6 activation and arthritis on epidermal growth factor receptor (EGFR) activation in sensory neurons and the spinal cord","volume":"25","author":"Roy","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbi.2024.09.001_b0240","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1016\/j.neuron.2012.03.026","article-title":"Microglia sculpt postnatal neural circuits in an activity and complement-dependent manner","volume":"74","author":"Schafer","year":"2012","journal-title":"Neuron"},{"key":"10.1016\/j.bbi.2024.09.001_b0245","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.15224","article-title":"Microglia contribute to circuit defects in Mecp2 null mice independent of microglia-specific loss of Mecp2 expression","volume":"5","author":"Schafer","year":"2016","journal-title":"Elife"},{"issue":"1","key":"10.1016\/j.bbi.2024.09.001_b0250","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41467-023-39420-6","article-title":"Schizophrenia-associated NRXN1 deletions induce developmental-timing- and cell-type-specific vulnerabilities in human brain organoids","volume":"14","author":"Sebastian","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bbi.2024.09.001_b0255","doi-asserted-by":"crossref","first-page":"eadd7046","DOI":"10.1126\/science.add7046","article-title":"Transcriptomic diversity of cell types across the adult human brain","volume":"382","author":"Siletti","year":"2023","journal-title":"Science"},{"key":"10.1016\/j.bbi.2024.09.001_b0260","doi-asserted-by":"crossref","DOI":"10.1126\/science.aay5947","article-title":"An atlas of the protein-coding genes in the human, pig, and mouse brain","volume":"367","author":"Sj\u00f6stedt","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.bbi.2024.09.001_b0265","doi-asserted-by":"crossref","first-page":"10695","DOI":"10.1523\/JNEUROSCI.2178-07.2007","article-title":"Maternal immune activation alters fetal brain development through interleukin-6","volume":"27","author":"Smith","year":"2007","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bbi.2024.09.001_b0270","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1016\/j.celrep.2014.07.042","article-title":"Microglia modulate wiring of the embryonic forebrain","volume":"8","author":"Squarzoni","year":"2014","journal-title":"Cell Rep."},{"key":"10.1016\/j.bbi.2024.09.001_b0275","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1016\/j.neuron.2014.07.040","article-title":"Loss of mTOR-dependent macroautophagy causes autistic-like synaptic pruning deficits","volume":"83","author":"Tang","year":"2014","journal-title":"Neuron"},{"key":"10.1016\/j.bbi.2024.09.001_b0280","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1111\/jcpp.12499","article-title":"Heritability of autism spectrum disorders: a meta-analysis of twin studies","volume":"57","author":"Tick","year":"2016","journal-title":"J. Child Psychol. Psychiatry"},{"key":"10.1016\/j.bbi.2024.09.001_b0285","doi-asserted-by":"crossref","first-page":"7526592","DOI":"10.1155\/2017\/7526592","article-title":"Neurodevelopmental disorders and environmental toxicants: epigenetics as an underlying mechanism","volume":"2017","author":"Tran","year":"2017","journal-title":"Int. J. Genomics"},{"key":"10.1016\/j.bbi.2024.09.001_b0290","doi-asserted-by":"crossref","first-page":"e647","DOI":"10.1038\/tp.2015.142","article-title":"Children with autism spectrum disorders, who improved with a luteolin-containing dietary formulation, show reduced serum levels of TNF and IL-6","volume":"5","author":"Tsilioni","year":"2015","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.bbi.2024.09.001_b0295","doi-asserted-by":"crossref","first-page":"1940","DOI":"10.1002\/cne.24664","article-title":"Differential expression of neurexin genes in the mouse brain","volume":"527","author":"Uchigashima","year":"2019","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.bbi.2024.09.001_b0300","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.scr.2016.12.006","article-title":"Derivation of human iPS cell lines from monozygotic twins in defined and xeno free conditions","volume":"18","author":"Uhlin","year":"2017","journal-title":"Stem Cell Res."},{"key":"10.1016\/j.bbi.2024.09.001_b0305","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.neuropharm.2014.10.027","article-title":"Neuromodulatory properties of inflammatory cytokines and their impact on neuronal excitability","volume":"96","author":"Vezzani","year":"2015","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.bbi.2024.09.001_b0310","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.997786","article-title":"Microglia morphophysiological diversity and its implications for the CNS","volume":"13","author":"Vidal-Itriago","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.bbi.2024.09.001_bib351","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1002\/glia.23261","article-title":"Microglia from offspring of dams with allergic asthma exhibit epigenomic alterations in genes dysregulated in autism","volume":"66","author":"Vogel Ciernia","year":"2018","journal-title":"Glia"},{"key":"10.1016\/j.bbi.2024.09.001_b0315","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1002\/aur.1881","article-title":"Neurexin gene family variants as risk factors for autism spectrum disorder","volume":"11","author":"Wang","year":"2018","journal-title":"Autism Res."},{"key":"10.1016\/j.bbi.2024.09.001_b0320","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1186\/1742-2094-8-52","article-title":"IL-6 is increased in the cerebellum of autistic brain and alters neural cell adhesion, migration and synaptic formation","volume":"8","author":"Wei","year":"2011","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.bbi.2024.09.001_b0325","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1016\/j.bbadis.2012.01.011","article-title":"Brain IL-6 elevation causes neuronal circuitry imbalances and mediates autism-like behaviors","volume":"1822","author":"Wei","year":"2012","journal-title":"Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease"},{"key":"10.1016\/j.bbi.2024.09.001_b0330","doi-asserted-by":"crossref","first-page":"1918","DOI":"10.1016\/j.bbadis.2016.07.013","article-title":"Inhibition of IL-6 trans-signaling in the brain increases sociability in the BTBR mouse model of autism","volume":"1862","author":"Wei","year":"2016","journal-title":"Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease"},{"key":"10.1016\/j.bbi.2024.09.001_b0335","doi-asserted-by":"crossref","unstructured":"Wilton, D.K., Dissing-Olesen, L., Stevens, B. 2019. Neuron-Glia Signaling in Synapse Elimination. https:\/\/doi.org\/10.1146\/annurev-neuro-070918-050306 42, 107\u2013127. https:\/\/doi.org\/10.1146\/ANNUREV-NEURO-070918-050306.","DOI":"10.1146\/annurev-neuro-070918-050306"},{"key":"10.1016\/j.bbi.2024.09.001_b0340","doi-asserted-by":"crossref","first-page":"1797","DOI":"10.1038\/s41467-020-15530-3","article-title":"Elevated protein synthesis in microglia causes autism-like synaptic and behavioral aberrations","volume":"11","author":"Xu","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bbi.2024.09.001_b0345","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1002\/aur.2696","article-title":"Global prevalence of autism: a systematic review update","volume":"15","author":"Zeidan","year":"2022","journal-title":"Autism Res."},{"key":"10.1016\/j.bbi.2024.09.001_b0350","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1038\/nn.3641","article-title":"Deficient neuron-microglia signaling results in impaired functional brain connectivity and social behavior","volume":"17","author":"Zhan","year":"2014","journal-title":"Nat. Neurosci."}],"container-title":["Brain, Behavior, and Immunity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0889159124005956?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0889159124005956?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T03:47:27Z","timestamp":1762314447000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0889159124005956"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":72,"alternative-id":["S0889159124005956"],"URL":"https:\/\/doi.org\/10.1016\/j.bbi.2024.09.001","relation":{},"ISSN":["0889-1591"],"issn-type":[{"value":"0889-1591","type":"print"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Bi-allelic NRXN1\u03b1 deletion in microglia derived from iPSC of an autistic patient increases interleukin-6 production and impairs supporting function on neuronal networking","name":"articletitle","label":"Article Title"},{"value":"Brain, Behavior, and Immunity","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbi.2024.09.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}