{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T14:18:32Z","timestamp":1791555512551,"version":"4.3.4"},"reference-count":78,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T00:00:00Z","timestamp":1760054400000},"content-version":"am","delay-in-days":282,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000871","name":"Mayo Clinic","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["R35NS132326"],"award-info":[{"award-number":["R35NS132326"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["R01NS088627"],"award-info":[{"award-number":["R01NS088627"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["R01NS112144"],"award-info":[{"award-number":["R01NS112144"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain, Behavior, and Immunity"],"published-print":{"date-parts":[[2025,1]]},"DOI":"10.1016\/j.bbi.2024.09.034","type":"journal-article","created":{"date-parts":[[2024,9,30]],"date-time":"2024-09-30T01:52:43Z","timestamp":1727661163000},"page":"540-555","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":28,"special_numbering":"C","title":["Microglial TREM2 promotes phagocytic clearance of damaged neurons after status epilepticus"],"prefix":"10.1016","volume":"123","author":[{"given":"Dale B.","family":"Bosco","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vaclav","family":"Kremen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koichiro","family":"Haruwaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shunyi","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingxiao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Blake A.","family":"Ebner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaying","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manling","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aastha","family":"Dheer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jadyn F.","family":"Perry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abhijeet","family":"Barath","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aivi T.","family":"Nguyen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory A.","family":"Worrell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8019-3380","authenticated-orcid":false,"given":"Long-Jun","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbi.2024.09.034_b0005","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.nbd.2014.11.009","article-title":"Role of fractalkine\u2013CX3CR1 pathway in seizure-induced microglial activation, neurodegeneration, and neuroblast production in the adult rat brain","volume":"74","author":"Ali","year":"2015","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.bbi.2024.09.034_b0010","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1002\/glia.23757","article-title":"Activated microglia desialylate their surface, stimulating complement receptor 3-mediated phagocytosis of neurons","volume":"68","author":"Allendorf","year":"2020","journal-title":"Glia"},{"key":"10.1016\/j.bbi.2024.09.034_b0015","doi-asserted-by":"crossref","first-page":"193","DOI":"10.3389\/fphar.2018.00193","article-title":"The metabotropic purinergic P2Y receptor family as novel drug target in epilepsy","volume":"9","author":"Alves","year":"2018","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.bbi.2024.09.034_b0020","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1038\/s41586-020-2777-8","article-title":"Negative feedback control of neuronal activity by microglia","volume":"586","author":"Badimon","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.bbi.2024.09.034_b0025","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1111\/j.1750-3639.2012.00583.x","article-title":"Defining clinico-neuropathological subtypes of mesial temporal lobe epilepsy with hippocampal sclerosis","volume":"22","author":"Bl\u00fcmcke","year":"2012","journal-title":"Brain Pathol. (Zurich, Switzerland)"},{"key":"10.1016\/j.bbi.2024.09.034_b0030","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1186\/s13041-018-0376-5","article-title":"RNAseq analysis of hippocampal microglia after kainic acid-induced seizures","volume":"11","author":"Bosco","year":"2018","journal-title":"Mol. Brain"},{"key":"10.1016\/j.bbi.2024.09.034_b0035","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1001\/jamaneurol.2013.6237","article-title":"TREM2 variant p. R47H as a risk factor for sporadic amyotrophic lateral sclerosis","volume":"71","author":"Cady","year":"2014","journal-title":"JAMA Neurol."},{"key":"10.1016\/j.bbi.2024.09.034_b0040","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1097\/00019052-200404000-00013","article-title":"Febrile seizures and mesial temporal sclerosis","volume":"17","author":"Cendes","year":"2004","journal-title":"Curr. Opin. Neurol."},{"key":"10.1016\/j.bbi.2024.09.034_b0045","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1007\/s00401-020-02193-z","article-title":"TREM2 activation on microglia promotes myelin debris clearance and remyelination in a model of multiple sclerosis","volume":"140","author":"Cignarella","year":"2020","journal-title":"Acta Neuropathol."},{"issue":"194","key":"10.1016\/j.bbi.2024.09.034_b0050","first-page":"e113","article-title":"A novel mutation in TREM2 gene causing Nasu-Hakola disease and review of the literature","volume":"53","author":"Dardiotis","year":"2017","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.bbi.2024.09.034_b0055","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2021.103245","article-title":"Interdependence of neural network dysfunction and microglial alterations in Alzheimer\u2019s disease-related models","volume":"24","author":"Das","year":"2021","journal-title":"iScience"},{"key":"10.1016\/j.bbi.2024.09.034_b0060","doi-asserted-by":"crossref","DOI":"10.1016\/j.nbd.2023.106263","article-title":"Alzheimer risk-increasing TREM2 variant causes aberrant cortical synapse density and promotes network hyperexcitability in mouse models","volume":"186","author":"Das","year":"2023","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.bbi.2024.09.034_b0065","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1007\/978-94-017-8914-1_9","article-title":"When and how do seizures kill neurons, and is cell death relevant to epileptogenesis?","volume":"813","author":"Dingledine","year":"2014","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.bbi.2024.09.034_b0070","doi-asserted-by":"crossref","first-page":"10528","DOI":"10.1523\/JNEUROSCI.0416-14.2014","article-title":"Neuronal hyperactivity recruits microglial processes via neuronal NMDA receptors and microglial P2Y12 receptors after status epilepticus","volume":"34","author":"Eyo","year":"2014","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bbi.2024.09.034_b0075","doi-asserted-by":"crossref","DOI":"10.1523\/ENEURO.0209-16.2016","article-title":"Regulation of physical microglia-neuron interactions by fractalkine signaling after status epilepticus","volume":"3","author":"Eyo","year":"2016","journal-title":"eNeuro"},{"key":"10.1016\/j.bbi.2024.09.034_b0080","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1002\/glia.23006","article-title":"Microglia-neuron communication in epilepsy","volume":"65","author":"Eyo","year":"2017","journal-title":"Glia"},{"key":"10.1016\/j.bbi.2024.09.034_b0085","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1001\/archneur.1964.00460150003001","article-title":"Etiology and pathogenesis of temporal lobe epilepsy","volume":"10","author":"Falconer","year":"1964","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.bbi.2024.09.034_b0090","doi-asserted-by":"crossref","first-page":"1434","DOI":"10.1002\/glia.23616","article-title":"Microglial proliferation and monocyte infiltration contribute to microgliosis following status epilepticus","volume":"67","author":"Feng","year":"2019","journal-title":"Glia"},{"key":"10.1016\/j.bbi.2024.09.034_b0095","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1016\/j.immuni.2018.04.016","article-title":"The microglial innate immune receptor TREM2 is required for synapse elimination and normal brain connectivity","volume":"48","author":"Filipello","year":"2018","journal-title":"Immunity"},{"key":"10.1016\/j.bbi.2024.09.034_b0100","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1111\/j.1528-1167.2011.03091.x","article-title":"Seizure outcome and its predictors after temporal lobe epilepsy surgery in patients with normal MRI","volume":"52","author":"Fong","year":"2011","journal-title":"Epilepsia"},{"key":"10.1016\/j.bbi.2024.09.034_b0105","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1016\/j.celrep.2016.06.018","article-title":"Spinal microgliosis due to resident microglial proliferation is required for pain hypersensitivity after peripheral nerve injury","volume":"16","author":"Gu","year":"2016","journal-title":"Cell Rep."},{"key":"10.1016\/j.bbi.2024.09.034_b0110","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1056\/NEJMoa1211851","article-title":"TREM2 variants in Alzheimer's disease","volume":"368","author":"Guerreiro","year":"2013","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.bbi.2024.09.034_b0115","doi-asserted-by":"crossref","DOI":"10.3390\/cells7040026","article-title":"Microglia after seizures and in epilepsy","volume":"7","author":"Hiragi","year":"2018","journal-title":"Cells"},{"key":"10.1016\/j.bbi.2024.09.034_b0120","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1111\/j.1471-4159.2009.06042.x","article-title":"A role for TREM2 ligands in the phagocytosis of apoptotic neuronal cells by microglia","volume":"109","author":"Hsieh","year":"2009","journal-title":"J. Neurochem."},{"key":"10.1016\/j.bbi.2024.09.034_b0125","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1038\/s41590-021-00913-5","article-title":"Microglia use TAM receptors to detect and engulf amyloid \u03b2 plaques","volume":"22","author":"Huang","year":"2021","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.bbi.2024.09.034_b0130","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1056\/NEJMoa1211103","article-title":"Variant of TREM2 associated with the risk of alzheimer's disease","volume":"368","author":"Jonsson","year":"2012","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.bbi.2024.09.034_b0135","doi-asserted-by":"crossref","first-page":"3384","DOI":"10.1523\/JNEUROSCI.2620-14.2015","article-title":"Triggering receptor expressed on myeloid cells 2 (TREM2) deficiency attenuates phagocytic activities of microglia and exacerbates ischemic damage in experimental stroke","volume":"35","author":"Kawabori","year":"2015","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bbi.2024.09.034_b0140","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1016\/j.cell.2017.05.018","article-title":"A unique microglia type associated with restricting development of Alzheimer\u2019s disease","volume":"169","author":"Keren-Shaul","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.bbi.2024.09.034_b0145","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1038\/nature05704","article-title":"UDP acting at P2Y6 receptors is a mediator of microglial phagocytosis","volume":"446","author":"Koizumi","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.bbi.2024.09.034_b0150","doi-asserted-by":"crossref","first-page":"206","DOI":"10.3389\/fncel.2018.00206","article-title":"Microglial TREM2\/DAP12 signaling: a double-edged sword in neural diseases","volume":"12","author":"Konishi","year":"2018","journal-title":"Front. Cell Neurosci."},{"key":"10.1016\/j.bbi.2024.09.034_b0155","doi-asserted-by":"crossref","DOI":"10.1088\/1741-2552\/aa5688","article-title":"Behavioral state classification in epileptic brain using intracranial electrophysiology","volume":"14","author":"Kremen","year":"2017","journal-title":"J. Neural Eng."},{"key":"10.1016\/j.bbi.2024.09.034_b0160","doi-asserted-by":"crossref","DOI":"10.1016\/j.expneurol.2020.113492","article-title":"Seizure burden fluctuates with the female reproductive cycle in a mouse model of chronic temporal lobe epilepsy","volume":"334","author":"Li","year":"2020","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.bbi.2024.09.034_b0165","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1002\/cbin.10975","article-title":"TREM2 inhibits inflammatory responses in mouse microglia by suppressing the PI3K\/NF-\u03baB signaling","volume":"43","author":"Li","year":"2019","journal-title":"Cell Biol. Int."},{"key":"10.1016\/j.bbi.2024.09.034_b0170","doi-asserted-by":"crossref","first-page":"e1989","DOI":"10.21769\/BioProtoc.1989","article-title":"Protocol for primary microglial culture preparation","volume":"6","author":"Lian","year":"2016","journal-title":"Bio Protoc."},{"key":"10.1016\/j.bbi.2024.09.034_b0175","doi-asserted-by":"crossref","first-page":"3224","DOI":"10.1093\/hmg\/ddaa209","article-title":"Trem2 promotes anti-inflammatory responses in microglia and is suppressed under pro-inflammatory conditions","volume":"29","author":"Liu","year":"2020","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.bbi.2024.09.034_b0180","doi-asserted-by":"crossref","first-page":"C605","DOI":"10.1152\/ajpcell.00205.2020","article-title":"Microglia depletion exacerbates acute seizures and hippocampal neuronal degeneration in mouse models of epilepsy","volume":"319","author":"Liu","year":"2020","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.bbi.2024.09.034_b0185","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol."},{"key":"10.1016\/j.bbi.2024.09.034_b0190","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1016\/j.nurt.2010.05.014","article-title":"Microglial activation and chronic neurodegeneration","volume":"7","author":"Lull","year":"2010","journal-title":"Neurotherapeutics"},{"key":"10.1016\/j.bbi.2024.09.034_b0195","doi-asserted-by":"crossref","first-page":"5370","DOI":"10.1038\/s41467-020-19227-5","article-title":"Gene expression and functional deficits underlie TREM2-knockout microglia responses in human models of Alzheimer's disease","volume":"11","author":"McQuade","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bbi.2024.09.034_b0200","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.nbd.2010.04.001","article-title":"Microglial ablation and lipopolysaccharide preconditioning affects pilocarpine-induced seizures in mice","volume":"39","author":"Mirrione","year":"2010","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.bbi.2024.09.034_b0205","doi-asserted-by":"crossref","first-page":"9453","DOI":"10.1523\/JNEUROSCI.0487-19.2019","article-title":"Microglial P2Y12 receptor regulates seizure-induced neurogenesis and immature neuronal projections","volume":"39","author":"Mo","year":"2019","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bbi.2024.09.034_b0210","doi-asserted-by":"crossref","first-page":"1242","DOI":"10.1007\/s12264-020-00573-9","article-title":"Characterization of the expression of the ATP-gated P2X7 receptor following status epilepticus and during epilepsy using a P2X7-EGFP reporter mouse","volume":"36","author":"Morgan","year":"2020","journal-title":"Neurosci. Bull."},{"key":"10.1016\/j.bbi.2024.09.034_b0215","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.brainres.2008.03.061","article-title":"Unilateral hippocampal CA3-predominant damage and short latency epileptogenesis after intra-amygdala microinjection of kainic acid in mice","volume":"1213","author":"Mouri","year":"2008","journal-title":"Brain Res."},{"key":"10.1016\/j.bbi.2024.09.034_b0220","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2021.742065","article-title":"Microglia in neuroinflammation and neurodegeneration: from understanding to therapy","volume":"15","author":"Muzio","year":"2021","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.bbi.2024.09.034_b0225","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1186\/s12974-020-01915-0","article-title":"Therapeutic Trem2 activation ameliorates amyloid-beta deposition and improves cognition in the 5XFAD model of amyloid deposition","volume":"17","author":"Price","year":"2020","journal-title":"J. Neuroinflamm."},{"key":"10.1016\/j.bbi.2024.09.034_b0230","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1186\/s12974-018-1192-7","article-title":"The role of inflammation in the development of epilepsy","volume":"15","author":"Rana","year":"2018","journal-title":"J. Neuroinflamm."},{"key":"10.1016\/j.bbi.2024.09.034_b0235","article-title":"Microglia in health and disease","volume":"8","author":"Ransohoff","year":"2015","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"10.1016\/j.bbi.2024.09.034_b0240","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.neulet.2011.02.040","article-title":"Inflammation and prevention of epileptogenesis","volume":"497","author":"Ravizza","year":"2011","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.bbi.2024.09.034_b0245","doi-asserted-by":"crossref","first-page":"11421","DOI":"10.1523\/JNEUROSCI.2251-04.2004","article-title":"Impaired synaptic function in the microglial KARAP\/DAP12-deficient mouse","volume":"24","author":"Roumier","year":"2004","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bbi.2024.09.034_b0250","doi-asserted-by":"crossref","first-page":"e105380","DOI":"10.15252\/embj.2020105380","article-title":"Local externalization of phosphatidylserine mediates developmental synaptic pruning by microglia","volume":"39","author":"Scott-Hewitt","year":"2020","journal-title":"EMBO J."},{"key":"10.1016\/j.bbi.2024.09.034_b0255","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1016\/j.tcb.2015.08.003","article-title":"An Apoptotic \u2018Eat Me\u2019 signal: phosphatidylserine exposure","volume":"25","author":"Segawa","year":"2015","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.bbi.2024.09.034_b0260","doi-asserted-by":"crossref","first-page":"7508","DOI":"10.1038\/s41598-019-43535-6","article-title":"Aminophospholipids are signal-transducing TREM2 ligands on apoptotic cells","volume":"9","author":"Shirotani","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbi.2024.09.034_b0265","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1111\/j.1528-1167.2008.01906.x","article-title":"Report of the american epilepsy society and the epilepsy foundation joint task force on sudden unexplained death in epilepsy","volume":"50","author":"So","year":"2009","journal-title":"Epilepsia"},{"key":"10.1016\/j.bbi.2024.09.034_b0270","doi-asserted-by":"crossref","first-page":"837","DOI":"10.3233\/JAD-210041","article-title":"TREM2 deficiency disrupts network oscillations leading to epileptic activity and aggravates amyloid-\u03b2-related hippocampal pathophysiology in mice","volume":"88","author":"Stoiljkovic","year":"2021","journal-title":"J. Alzheimers. Dis."},{"key":"10.1016\/j.bbi.2024.09.034_b0275","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1096\/fj.03-0374fje","article-title":"Neuronal apoptotic bodies: phagocytosis and degradation by primary microglial cells","volume":"18","author":"Stolzing","year":"2004","journal-title":"FASEB J."},{"key":"10.1016\/j.bbi.2024.09.034_b0280","doi-asserted-by":"crossref","first-page":"3520","DOI":"10.4049\/jimmunol.177.6.3520","article-title":"Cutting Edge: TREM-2 attenuates macrophage activation1","volume":"177","author":"Turnbull","year":"2006","journal-title":"J. Immunol."},{"key":"10.1016\/j.bbi.2024.09.034_b0285","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1038\/s41582-018-0072-1","article-title":"TREM2 \u2014 a key player in microglial biology and Alzheimer disease","volume":"14","author":"Ulland","year":"2018","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.bbi.2024.09.034_b0290","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.expneurol.2016.02.014","article-title":"Repeated low-dose kainate administration in C57BL\/6J mice produces temporal lobe epilepsy pathology but infrequent spontaneous seizures","volume":"279","author":"Umpierre","year":"2016","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.bbi.2024.09.034_b0295","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuron.2024.03.017","article-title":"Microglial P2Y6 calcium signaling promotes phagocytosis and shapes neuroimmune responses in epileptogenesis","author":"Umpierre","year":"2024","journal-title":"Neuron"},{"key":"10.1016\/j.bbi.2024.09.034_b0300","doi-asserted-by":"crossref","first-page":"1959","DOI":"10.1016\/j.neuron.2024.03.017","article-title":"Microglial P2Y(6) calcium signaling promotes phagocytosis and shapes neuroimmune responses in epileptogenesis","volume":"112","author":"Umpierre","year":"2024","journal-title":"Neuron"},{"key":"10.1016\/j.bbi.2024.09.034_b0305","doi-asserted-by":"crossref","first-page":"1637","DOI":"10.1002\/glia.23961","article-title":"How microglia sense and regulate neuronal activity","volume":"69","author":"Umpierre","year":"2021","journal-title":"Glia"},{"key":"10.1016\/j.bbi.2024.09.034_b0310","first-page":"416","article-title":"A TREM2-activating antibody with a blood\u2013brain barrier transport vehicle enhances microglial metabolism in Alzheimer\u2019s disease models","volume":"26","author":"van Lengerich","year":"2023","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.bbi.2024.09.034_b0315","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1038\/nrneurol.2010.178","article-title":"The role of inflammation in epilepsy","volume":"7","author":"Vezzani","year":"2011","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.bbi.2024.09.034_b0320","first-page":"234","article-title":"Microglial contributions to aberrant neurogenesis and pathophysiology of epilepsy","volume":"7","author":"Victor","year":"2020","journal-title":"Neuroimmunol. Neuroinflamm."},{"key":"10.1016\/j.bbi.2024.09.034_b0325","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.bbi.2018.09.006","article-title":"Microglia have a protective role in viral encephalitis-induced seizure development and hippocampal damage","volume":"74","author":"Waltl","year":"2018","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.bbi.2024.09.034_b0330","doi-asserted-by":"crossref","DOI":"10.3390\/cells11132091","article-title":"Microglia phenotypes in aging and neurodegenerative diseases","volume":"11","author":"Wendimu","year":"2022","journal-title":"Cells"},{"key":"10.1016\/j.bbi.2024.09.034_b0335","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1146\/annurev-physiol-022516-034406","article-title":"Microglia in physiology and disease","volume":"79","author":"Wolf","year":"2017","journal-title":"Annu. Rev. Physiol."},{"key":"10.1016\/j.bbi.2024.09.034_b0340","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.bbi.2020.06.028","article-title":"Microglial depletion aggravates the severity of acute and chronic seizures in mice","volume":"89","author":"Wu","year":"2020","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.bbi.2024.09.034_b0345","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1177\/1535759719890336","article-title":"Emerging roles for microglial phagocytic signaling in epilepsy","volume":"20","author":"Wyatt-Johnson","year":"2020","journal-title":"Epilepsy Currents"},{"key":"10.1016\/j.bbi.2024.09.034_b0350","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1038\/s41593-021-00975-6","article-title":"TREM2 interacts with TDP-43 and mediates microglial neuroprotection against TDP-43-related neurodegeneration","volume":"25","author":"Xie","year":"2022","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.bbi.2024.09.034_b0355","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1002\/dneu.22864","article-title":"Microglial TREM2 in amyotrophic lateral sclerosis","volume":"82","author":"Xie","year":"2022","journal-title":"Dev. Neurobiol."},{"key":"10.1016\/j.bbi.2024.09.034_b0360","doi-asserted-by":"crossref","DOI":"10.3390\/cells10020321","article-title":"TREM2 mediates microglial anti-inflammatory activations in Alzheimer's disease: lessons learned from transcriptomics","volume":"10","author":"Xue","year":"2021","journal-title":"Cells"},{"key":"10.1016\/j.bbi.2024.09.034_b0365","doi-asserted-by":"crossref","first-page":"457","DOI":"10.3389\/fncel.2019.00457","article-title":"Distinct signaling pathways regulate TREM2 phagocytic and NF\u03baB antagonistic activities","volume":"13","author":"Yao","year":"2019","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.bbi.2024.09.034_b0370","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1016\/j.molmed.2017.03.008","article-title":"TREM2, microglia, and neurodegenerative diseases","volume":"23","author":"Yeh","year":"2017","journal-title":"Trends Mol. Med."},{"key":"10.1016\/j.bbi.2024.09.034_b0375","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1007\/s12035-022-03100-1","article-title":"TREM2 and microglia contribute to the synaptic plasticity: from physiology to pathology","volume":"60","author":"Yu","year":"2023","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.bbi.2024.09.034_b0380","doi-asserted-by":"crossref","first-page":"2080","DOI":"10.1016\/j.celrep.2018.02.004","article-title":"Noninflammatory changes of microglia are sufficient to cause epilepsy","volume":"22","author":"Zhao","year":"2018","journal-title":"Cell Rep"},{"key":"10.1016\/j.bbi.2024.09.034_b0385","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1016\/j.neuron.2018.01.031","article-title":"TREM2 is a receptor for beta-amyloid that mediates microglial function","volume":"97","author":"Zhao","year":"2018","journal-title":"Neuron"},{"key":"10.1016\/j.bbi.2024.09.034_b0390","doi-asserted-by":"crossref","first-page":"1772","DOI":"10.1523\/JNEUROSCI.2459-16.2017","article-title":"TREM2 promotes microglial survival by activating Wnt\/\u03b2-catenin pathway","volume":"37","author":"Zheng","year":"2017","journal-title":"J. Neurosci."}],"container-title":["Brain, Behavior, and Immunity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0889159124006378?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0889159124006378?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,5,21]],"date-time":"2025-05-21T18:26:39Z","timestamp":1747851999000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0889159124006378"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":78,"alternative-id":["S0889159124006378"],"URL":"https:\/\/doi.org\/10.1016\/j.bbi.2024.09.034","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2023.12.31.573794","asserted-by":"object"}]},"ISSN":["0889-1591"],"issn-type":[{"value":"0889-1591","type":"print"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Microglial TREM2 promotes phagocytic clearance of damaged neurons after status epilepticus","name":"articletitle","label":"Article Title"},{"value":"Brain, Behavior, and Immunity","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbi.2024.09.034","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}