{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T18:10:59Z","timestamp":1770833459618,"version":"3.50.1"},"reference-count":40,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain, Behavior, and Immunity"],"published-print":{"date-parts":[[2025,3]]},"DOI":"10.1016\/j.bbi.2024.12.022","type":"journal-article","created":{"date-parts":[[2024,12,17]],"date-time":"2024-12-17T16:30:44Z","timestamp":1734453044000},"page":"21-32","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Egln3 expression in microglia enhances the neuroinflammatory responses in Alzheimer\u2019s disease"],"prefix":"10.1016","volume":"125","author":[{"given":"Jiaxin","family":"Guan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pengfei","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meiling","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chuanlu","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiangqi","family":"Meng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaowei","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meijiao","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Fan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lu","family":"Gan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbi.2024.12.022_b0005","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/s40659-024-00504-2","article-title":"Increased levels and activation of the IL-17 receptor in microglia contribute to enhanced neuroinflammation in cerebellum of hyperammonemic rats","volume":"57","author":"Arenas","year":"2024","journal-title":"Biol Res"},{"key":"10.1016\/j.bbi.2024.12.022_b0010","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.3233\/JAD-200056","article-title":"IL-1\u03b2, IL-6, IL-10, and TNF\u03b1 single nucleotide polymorphisms in human influence the susceptibility to Alzheimer\u2019s disease pathology","volume":"75","author":"Babic Leko","year":"2020","journal-title":"J Alzheimers Dis"},{"key":"10.1016\/j.bbi.2024.12.022_b0015","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1111\/jnc.15327","article-title":"Microglial phagocytosis of neurons in neurodegeneration, and its regulation","volume":"158","author":"Butler","year":"2021","journal-title":"J Neurochem"},{"key":"10.1016\/j.bbi.2024.12.022_b0020","article-title":"Microglia in the neuroinflammatory pathogenesis of Alzheimer's disease and related therapeutic targets","volume":"13","author":"Cai","year":"2022","journal-title":"Front Immunol"},{"key":"10.1016\/j.bbi.2024.12.022_b0025","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1007\/s11064-015-1641-y","article-title":"Changes in hypoxia-inducible factor-1 (HIF-1) and regulatory prolyl hydroxylase (PHD) enzymes following hypoxic-ischemic injury in the neonatal rat","volume":"41","author":"Chu","year":"2016","journal-title":"Neurochem Res"},{"key":"10.1016\/j.bbi.2024.12.022_b0030","doi-asserted-by":"crossref","DOI":"10.1111\/acel.13938","article-title":"Sex\u2010 and APOE\u2010specific genetic risk factors for late\u2010onset Alzheimer's disease: evidence from gene\u2013gene interaction of longevity\u2010related loci","volume":"22","author":"Dato","year":"2023","journal-title":"Aging Cell"},{"key":"10.1016\/j.bbi.2024.12.022_b0035","doi-asserted-by":"crossref","first-page":"1669","DOI":"10.1007\/s10787-021-00889-6","article-title":"Recent advances in molecular pathways and therapeutic implications targeting neuroinflammation for Alzheimer's disease","volume":"29","author":"Dhapola","year":"2021","journal-title":"Inflammopharmacology"},{"key":"10.1016\/j.bbi.2024.12.022_b0040","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1186\/s12987-024-00550-8","article-title":"Endothelial EGLN3-PKM2 signaling induces the formation of acute astrocytic barrier to alleviate immune cell infiltration after subarachnoid hemorrhage","volume":"21","author":"Duan","year":"2024","journal-title":"Fluids Barriers CNS"},{"issue":"4135\u20134152","key":"10.1016\/j.bbi.2024.12.022_b0045","first-page":"e4122","article-title":"SYK coordinates neuroprotective microglial responses in neurodegenerative disease","volume":"185","author":"Ennerfelt","year":"2022","journal-title":"Cell"},{"key":"10.1016\/j.bbi.2024.12.022_b0050","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21165624","article-title":"Involvement of p38 MAPK in Synaptic Function and Dysfunction","volume":"21","author":"Falcicchia","year":"2020","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.bbi.2024.12.022_b0055","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1007\/s00401-021-02263-w","article-title":"Distinct amyloid-beta and tau-associated microglia profiles in Alzheimer's disease","volume":"141","author":"Gerrits","year":"2021","journal-title":"Acta Neuropathol"},{"key":"10.1016\/j.bbi.2024.12.022_b0060","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.ymthe.2020.09.037","article-title":"ESC-sEVs rejuvenate aging hippocampal NSCs by transferring SMADs to regulate the MYT1-egln3-sirt1 axis","volume":"29","author":"Hu","year":"2021","journal-title":"Molecular Therapy : the Journal of the American Society of Gene Therapy"},{"key":"10.1016\/j.bbi.2024.12.022_b0065","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1515\/hsz-2012-0330","article-title":"The regulation, localization, and functions of oxygen-sensing prolyl hydroxylase PHD3","volume":"394","author":"Jaakkola","year":"2013","journal-title":"Biol Chem"},{"key":"10.1016\/j.bbi.2024.12.022_b0070","doi-asserted-by":"crossref","first-page":"4260","DOI":"10.1016\/j.cell.2023.08.021","article-title":"Alzheimer's disease: From immunotherapy to immunoprevention","volume":"186","author":"Jucker","year":"2023","journal-title":"Cell"},{"key":"10.1016\/j.bbi.2024.12.022_b0075","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1186\/s40035-020-00221-2","article-title":"Neuroinflammation in neurodegenerative disorders: the roles of microglia and astrocytes","volume":"9","author":"Kwon","year":"2020","journal-title":"Transl Neurodegener"},{"key":"10.1016\/j.bbi.2024.12.022_b0080","article-title":"Genome-wide knockout screen identifies EGLN3 involving in ammonia neurotoxicity","volume":"10","author":"Li","year":"2022","journal-title":"Front Cell Dev Biol"},{"key":"10.1016\/j.bbi.2024.12.022_b0085","article-title":"Aging, Cellular Senescence, and Alzheimer\u2019s Disease","volume":"23","author":"Liu","year":"2022","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.bbi.2024.12.022_b0090","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1124\/mol.108.053157","volume":"75","author":"Lomb","year":"2009","journal-title":"Mol Pharmacol"},{"key":"10.1016\/j.bbi.2024.12.022_b0095","doi-asserted-by":"crossref","DOI":"10.1111\/acel.13679","article-title":"p38\u03b1-MAPK-deficient myeloid cells ameliorate symptoms and pathology of APP-transgenic AD mice","volume":"21","author":"Luo","year":"2022","journal-title":"Aging Cell"},{"key":"10.1016\/j.bbi.2024.12.022_b0100","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1038\/s43587-021-00054-2","article-title":"Hypoxia compromises the mitochondrial metabolism of Alzheimer's disease microglia via HIF1","volume":"1","author":"March-Diaz","year":"2021","journal-title":"Nat Aging"},{"key":"10.1016\/j.bbi.2024.12.022_b0105","doi-asserted-by":"crossref","DOI":"10.3390\/ijms232112990","article-title":"Microglia and Alzheimer\u2019s Disease","volume":"23","author":"Merighi","year":"2022","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.bbi.2024.12.022_b0110","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.3233\/JAD-231464","article-title":"Leukocytes and endothelial cells participate in the pathogenesis of Alzheimer's disease: identifying new biomarkers mirroring metabolic alterations","volume":"97","author":"Mone","year":"2024","journal-title":"J Alzheimers Dis"},{"key":"10.1016\/j.bbi.2024.12.022_b0115","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2023.110349","article-title":"Methylene blue targets PHD3 expression in murine microglia to mitigate lipopolysaccharide-induced neuroinflammation and neurocognitive impairments","volume":"120","author":"Ou","year":"2023","journal-title":"Int Immunopharmacol"},{"key":"10.1016\/j.bbi.2024.12.022_b0120","article-title":"The China Alzheimer Report 2022","volume":"35","author":"Ren","year":"2022","journal-title":"Gen Psychiatr"},{"key":"10.1016\/j.bbi.2024.12.022_b0125","doi-asserted-by":"crossref","DOI":"10.3390\/cells9071717","article-title":"Microglia: agents of the CNS pro-inflammatory response","volume":"9","author":"Rodriguez-Gomez","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.bbi.2024.12.022_b0130","doi-asserted-by":"crossref","first-page":"2024","DOI":"10.1002\/glia.24380","article-title":"HIF prolyl hydroxylase 2\/3 deletion disrupts astrocytic integrity and exacerbates neuroinflammation","volume":"71","author":"Rosiewicz","year":"2023","journal-title":"Glia"},{"key":"10.1016\/j.bbi.2024.12.022_b0135","doi-asserted-by":"crossref","DOI":"10.3390\/ijms24010107","article-title":"Pathogenesis of Alzheimer\u2019s Disease","volume":"24","author":"Rostagno","year":"2022","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.bbi.2024.12.022_b0140","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1016\/S0140-6736(20)32205-4","article-title":"Alzheimer's disease","volume":"397","author":"Scheltens","year":"2021","journal-title":"Lancet"},{"key":"10.1016\/j.bbi.2024.12.022_b0145","doi-asserted-by":"crossref","first-page":"9628","DOI":"10.1096\/fj.201902731RR","article-title":"Neuronal deficiency of p38alpha-MAPK ameliorates symptoms and pathology of APP or Tau-transgenic Alzheimer's mouse models","volume":"34","author":"Schnoder","year":"2020","journal-title":"FASEB J"},{"key":"10.1016\/j.bbi.2024.12.022_b0150","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1186\/s41232-023-00277-3","article-title":"Neuroinflammation in Alzheimer\u2019s disease: microglial signature and their relevance to disease","volume":"43","author":"Sobue","year":"2023","journal-title":"Inflamm Regen"},{"key":"10.1016\/j.bbi.2024.12.022_b0155","doi-asserted-by":"crossref","first-page":"3665","DOI":"10.1038\/s41388-022-02378-8","article-title":"The multifaceted role of EGLN family prolyl hydroxylases in cancer: going beyond HIF regulation","volume":"41","author":"Strocchi","year":"2022","journal-title":"Oncogene"},{"key":"10.1016\/j.bbi.2024.12.022_b0160","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1007\/s40120-022-00338-8","article-title":"Alzheimer's disease: epidemiology and clinical progression","volume":"11","author":"Tahami Monfared","year":"2022","journal-title":"Neurol Ther"},{"key":"10.1016\/j.bbi.2024.12.022_b0165","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s10753-022-01721-1","article-title":"Neuroinflammation in Alzheimer's disease: current progress in molecular signaling and therapeutics","volume":"46","author":"Thakur","year":"2023","journal-title":"Inflammation"},{"key":"10.1016\/j.bbi.2024.12.022_b0170","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1186\/s12974-018-1304-4","article-title":"Microglia prevent peripheral immune cell invasion and promote an anti-inflammatory environment in the brain of APP-PS1 transgenic mice","volume":"15","author":"Unger","year":"2018","journal-title":"J Neuroinflammation"},{"key":"10.1016\/j.bbi.2024.12.022_b0175","doi-asserted-by":"crossref","DOI":"10.1016\/j.expneurol.2021.113777","article-title":"miR-451 protects against ischemic stroke by targeting Phd3","volume":"343","author":"Wang","year":"2021","journal-title":"Exp Neurol"},{"key":"10.1016\/j.bbi.2024.12.022_b0180","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1038\/s41582-019-0228-7","article-title":"Apolipoprotein E and Alzheimer disease: pathobiology and targeting strategies","volume":"15","author":"Yamazaki","year":"2019","journal-title":"Nat Rev Neurol"},{"key":"10.1016\/j.bbi.2024.12.022_b0185","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1016\/j.tem.2023.05.002","article-title":"Apolipoprotein E in lipid metabolism and neurodegenerative disease","volume":"34","author":"Yang","year":"2023","journal-title":"Trends Endocrinol Metab"},{"key":"10.1016\/j.bbi.2024.12.022_b0190","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.1038\/s41593-023-01355-y","article-title":"Identification of a protective microglial state mediated by miR-155 and interferon-gamma signaling in a mouse model of Alzheimer's disease","volume":"26","author":"Yin","year":"2023","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.bbi.2024.12.022_b0195","doi-asserted-by":"crossref","first-page":"2644","DOI":"10.1002\/glia.24063","article-title":"IL-17 signaling induces iNOS+ microglia activation in retinal vascular diseases","volume":"69","author":"Zhou","year":"2021","journal-title":"Glia"},{"key":"10.1016\/j.bbi.2024.12.022_b0200","doi-asserted-by":"crossref","first-page":"1308","DOI":"10.1038\/s41388-023-02644-3","article-title":"E3 ligase MAEA-mediated ubiquitination and degradation of PHD3 promotes glioblastoma progression","volume":"42","author":"Zhou","year":"2023","journal-title":"Oncogene"}],"container-title":["Brain, Behavior, and Immunity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0889159124007529?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0889159124007529?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,3,10]],"date-time":"2025-03-10T07:24:59Z","timestamp":1741591499000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0889159124007529"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3]]},"references-count":40,"alternative-id":["S0889159124007529"],"URL":"https:\/\/doi.org\/10.1016\/j.bbi.2024.12.022","relation":{},"ISSN":["0889-1591"],"issn-type":[{"value":"0889-1591","type":"print"}],"subject":[],"published":{"date-parts":[[2025,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Egln3 expression in microglia enhances the neuroinflammatory responses in Alzheimer\u2019s disease","name":"articletitle","label":"Article Title"},{"value":"Brain, Behavior, and Immunity","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbi.2024.12.022","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}