{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T20:39:08Z","timestamp":1790023148492,"version":"4.0.1"},"reference-count":50,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain, Behavior, and Immunity"],"published-print":{"date-parts":[[2025,3]]},"DOI":"10.1016\/j.bbi.2024.12.150","type":"journal-article","created":{"date-parts":[[2024,12,28]],"date-time":"2024-12-28T16:15:37Z","timestamp":1735402537000},"page":"168-177","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":23,"special_numbering":"C","title":["Association between gut microbiota and perinatal depression and anxiety among a pregnancy cohort in Hunan, China"],"prefix":"10.1016","volume":"125","author":[{"given":"Shuyin","family":"Xu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jintao","family":"Xiong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuemei","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohan","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yilin","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junzhe","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueqing","family":"Nie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xing","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yali","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yumeng","family":"Ju","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bangshan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingjiang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbi.2024.12.150_b0005","doi-asserted-by":"crossref","first-page":"9066","DOI":"10.1080\/14767058.2021.2014450","article-title":"Association between diagnosed perinatal mood and anxiety disorders and adverse perinatal outcomes","volume":"35","author":"Accortt","year":"2022","journal-title":"J. Matern. Fetal Neonatal Med."},{"key":"10.1016\/j.bbi.2024.12.150_b0010","doi-asserted-by":"crossref","first-page":"1581","DOI":"10.1007\/s00127-022-02386-9","article-title":"Prevalence and correlates of perinatal depression","volume":"58","author":"Al-Abri","year":"2023","journal-title":"Soc. Psychiatry Psychiatr. Epidemiol."},{"key":"10.1016\/j.bbi.2024.12.150_b0015","doi-asserted-by":"crossref","DOI":"10.1128\/mSystems.00857-19","article-title":"Depletion of Blautia species in the microbiota of obese children relates to intestinal inflammation and metabolic phenotype worsening","volume":"5","author":"Ben\u00edtez-P\u00e1ez","year":"2020","journal-title":"mSystems"},{"key":"10.1016\/j.bbi.2024.12.150_b0020","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1038\/nmeth.f.303","article-title":"QIIME allows analysis of high-throughput community sequencing data","volume":"7","author":"Caporaso","year":"2010","journal-title":"Nat. Methods"},{"key":"10.1016\/j.bbi.2024.12.150_b0025","doi-asserted-by":"crossref","first-page":"1460","DOI":"10.3390\/nu16101460","article-title":"Exploring the association between anxiety, depression, and gut microbiota during pregnancy: findings from a pregnancy cohort study in Shijiazhuang, Hebei Province, China","volume":"16","author":"Chi","year":"2024","journal-title":"Nutrients"},{"key":"10.1016\/j.bbi.2024.12.150_b0030","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1007\/s11920-022-01334-3","article-title":"Suicide and maternal mortality","volume":"24","author":"Chin","year":"2022","journal-title":"Curr. Psychiatry Rep."},{"key":"10.1016\/j.bbi.2024.12.150_b0035","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1007\/7854_2022_384","article-title":"The microbiome and mental health across the lifespan","volume":"61","author":"Dickerson","year":"2023","journal-title":"Curr. Top. Behav. Neurosci."},{"key":"10.1016\/j.bbi.2024.12.150_b0040","doi-asserted-by":"crossref","first-page":"8411","DOI":"10.1007\/s00253-021-11622-2","article-title":"A next-generation probiotic: Akkermansia muciniphila ameliorates chronic stress-induced depressive-like behavior in mice by regulating gut microbiota and metabolites","volume":"105","author":"Ding","year":"2021","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"10.1016\/j.bbi.2024.12.150_b0045","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1016\/j.jpsychires.2023.06.034","article-title":"Inflammatory cytokines and prenatal depression: is there a mediating role of maternal gut microbiota?","volume":"164","author":"Fang","year":"2023","journal-title":"J. Psychiatr. Res."},{"key":"10.1016\/j.bbi.2024.12.150_b0050","doi-asserted-by":"crossref","DOI":"10.4088\/JCP.18r12527","article-title":"The prevalence of anxiety disorders during pregnancy and the postpartum period: a multivariate Bayesian meta-analysis","volume":"80","author":"Fawcett","year":"2019","journal-title":"J. Clin. Psychiatry"},{"key":"10.1016\/j.bbi.2024.12.150_b0055","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.psychres.2010.10.022","article-title":"Comparative performance of the Edinburgh Postnatal Depression Scale and the Patient Health Questionnaire-9 in pregnant and postpartum women seeking psychiatric services","volume":"187","author":"Flynn","year":"2011","journal-title":"Psychiatry Res."},{"key":"10.1016\/j.bbi.2024.12.150_b0060","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1186\/s40001-024-01702-0","article-title":"Dynamic changes in the gut microbiota during three consecutive trimesters of pregnancy and their correlation with abnormal glucose and lipid metabolism","volume":"29","author":"Gao","year":"2024","journal-title":"Eur. J. Med. Res."},{"key":"10.1016\/j.bbi.2024.12.150_b0065","doi-asserted-by":"crossref","first-page":"9961","DOI":"10.3390\/ijerph19169961","article-title":"Changes in the gut microbiome and pathologies in pregnancy","volume":"19","author":"Gorczyca","year":"2022","journal-title":"Int. J. Environ. Res. Public Health"},{"key":"10.1016\/j.bbi.2024.12.150_b0070","doi-asserted-by":"crossref","first-page":"1532","DOI":"10.1038\/s41591-018-0164-x","article-title":"Regional variation limits applications of healthy gut microbiome reference ranges and disease models","volume":"24","author":"He","year":"2018","journal-title":"Nat. Med."},{"key":"10.1016\/j.bbi.2024.12.150_b0075","doi-asserted-by":"crossref","first-page":"4463","DOI":"10.1038\/s41598-019-40434-8","article-title":"Association between psychosocial stress and Fecal microbiota in pregnant women","volume":"9","author":"Hechler","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbi.2024.12.150_b0080","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.bbi.2015.03.016","article-title":"Altered fecal microbiota composition in patients with major depressive disorder","volume":"48","author":"Jiang","year":"2015","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.bbi.2024.12.150_b0085","doi-asserted-by":"crossref","first-page":"84","DOI":"10.3389\/fcimb.2015.00084","article-title":"Insights into the role of erysipelotrichaceae in the human host","volume":"5","author":"Kaakoush","year":"2015","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.bbi.2024.12.150_b0090","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1111\/jmwh.12603","article-title":"Consensus bundle on maternal mental health: perinatal depression and anxiety","volume":"62","author":"Kendig","year":"2017","journal-title":"J. Midwifery Womens Health"},{"key":"10.1016\/j.bbi.2024.12.150_b0095","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbr.2021.113635","article-title":"Metabolite trajectories across the perinatal period and mental health: a preliminary study of tryptophan-related metabolites, bile acids and microbial composition","volume":"418","author":"Kimmel","year":"2022","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.bbi.2024.12.150_b0100","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1016\/j.cell.2012.07.008","article-title":"Host remodeling of the gut microbiome and metabolic changes during pregnancy","volume":"150","author":"Koren","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.bbi.2024.12.150_b0105","doi-asserted-by":"crossref","first-page":"395","DOI":"10.32598\/bcn.12.3.2838.1","article-title":"Glycine\/NMDA receptor pathway mediates the rapid-onset antidepressant effect of alkaloids from Trichilia monadelpha","volume":"12","author":"Kukuia","year":"2021","journal-title":"Basic Clin. Neurosci."},{"key":"10.1016\/j.bbi.2024.12.150_b0110","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1038\/nbt.2676","article-title":"Predictive functional profiling of microbial communities using 16S rRNA marker gene sequences","volume":"31","author":"Langille","year":"2013","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.bbi.2024.12.150_b0115","doi-asserted-by":"crossref","DOI":"10.1016\/j.nbd.2022.105757","article-title":"Antibiotic cocktail-induced gut microbiota depletion in different stages could cause host cognitive impairment and emotional disorders in adulthood in different manners","volume":"170","author":"Li","year":"2022","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.bbi.2024.12.150_b0120","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/19490976.2021.1875796","article-title":"Blautia-a new functional genus with potential probiotic properties?","volume":"13","author":"Liu","year":"2021","journal-title":"Gut Microbes"},{"key":"10.1016\/j.bbi.2024.12.150_b0125","article-title":"Composition of the intestinal microbiota and its variations between the second and third trimesters in women with gestational diabetes mellitus and without gestational diabetes mellitus","volume":"14","author":"Liu","year":"2023","journal-title":"Front. Endocrinol. (Lausanne)"},{"key":"10.1016\/j.bbi.2024.12.150_b0130","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1186\/s12905-020-00996-6","article-title":"Perinatal mood and anxiety disorders, serious mental illness, and delivery-related health outcomes, United States, 2006-2015","volume":"20","author":"McKee","year":"2020","journal-title":"BMC Womens Health"},{"key":"10.1016\/j.bbi.2024.12.150_b0135","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1016\/j.jad.2019.11.061","article-title":"Metabolomic markers of antepartum depression and suicidal ideation","volume":"262","author":"Mitro","year":"2020","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.bbi.2024.12.150_b0140","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1080\/19490976.2015.1134082","article-title":"Formation of short chain fatty acids by the gut microbiota and their impact on human metabolism","volume":"7","author":"Morrison","year":"2016","journal-title":"Gut Microbes"},{"key":"10.1016\/j.bbi.2024.12.150_b0145","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1016\/j.jad.2020.07.046","article-title":"Prevalence of perinatal depression and its determinants in Mainland China: a systematic review and meta-analysis","volume":"277","author":"Nisar","year":"2020","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.bbi.2024.12.150_b0150","doi-asserted-by":"crossref","first-page":"483","DOI":"10.3390\/nu16040483","article-title":"Dynamics of the gut microbiota and faecal and serum metabolomes during pregnancy \u2013 a longitudinal study","volume":"16","author":"Pan","year":"2024","journal-title":"Nutrients"},{"key":"10.1016\/j.bbi.2024.12.150_b0155","doi-asserted-by":"crossref","first-page":"D590","DOI":"10.1093\/nar\/gks1219","article-title":"The SILVA ribosomal RNA gene database project: improved data processing and web-based tools","volume":"41","author":"Quast","year":"2013","journal-title":"Nucl. Acids Res."},{"key":"10.1016\/j.bbi.2024.12.150_b0160","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.psyneuen.2018.05.020","article-title":"Emerging literature in the microbiota-brain axis and perinatal mood and anxiety disorders","volume":"95","author":"Rackers","year":"2018","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.bbi.2024.12.150_b0165","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1111\/j.1574-6941.2007.00375.x","article-title":"Multivariate analyses in microbial ecology","volume":"62","author":"Ramette","year":"2007","journal-title":"FEMS Microbiol. Ecol."},{"key":"10.1016\/j.bbi.2024.12.150_b0170","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1007\/s11920-019-0998-z","article-title":"The relationship between perinatal mental health and stress: a review of the microbiome","volume":"21","author":"Redpath","year":"2019","journal-title":"Curr. Psychiatry Rep."},{"key":"10.1016\/j.bbi.2024.12.150_b0175","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1001\/jamapsychiatry.2023.0069","article-title":"Prevalence of perinatal depression in low- and middle-income countries: a systematic review and meta-analysis","volume":"80","author":"Roddy Mitchell","year":"2023","journal-title":"JAMA Psychiat."},{"key":"10.1016\/j.bbi.2024.12.150_b0180","doi-asserted-by":"crossref","DOI":"10.7717\/peerj.2584","article-title":"VSEARCH: a versatile open source tool for metagenomics","volume":"4","author":"Rognes","year":"2016","journal-title":"PeerJ"},{"key":"10.1016\/j.bbi.2024.12.150_b0185","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.whi.2022.12.001","article-title":"Association between perinatal mental health and pregnancy and neonatal complications: a retrospective birth cohort study","volume":"33","author":"Runkle","year":"2023","journal-title":"Womens Health Issues"},{"key":"10.1016\/j.bbi.2024.12.150_b0190","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23158272","article-title":"Regulation of CD4(+) and CD8(+) T cell biology by short-chain fatty acids and its relevance for autoimmune pathology","volume":"23","author":"Schiweck","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbi.2024.12.150_b0195","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1038\/s41398-022-01801-8","article-title":"Cytokines and tryptophan metabolites can predict depressive symptoms in pregnancy","volume":"12","author":"Sha","year":"2022","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.bbi.2024.12.150_b0200","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.ebiom.2017.09.013","article-title":"Effect of Lactobacillus rhamnosus HN001 in pregnancy on postpartum symptoms of depression and anxiety: a randomised double-blind placebo-controlled trial","volume":"24","author":"Slykerman","year":"2017","journal-title":"EBioMedicine"},{"key":"10.1016\/j.bbi.2024.12.150_b0205","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1055\/s-0037-1604412","article-title":"Maternal gut microbiome biodiversity in pregnancy","volume":"35","author":"Smid","year":"2018","journal-title":"Am. J. Perinatol."},{"key":"10.1016\/j.bbi.2024.12.150_b0210","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1111\/aogs.14056","article-title":"Links between perinatal risk factors and maternal psychological distress: a network analysis","volume":"100","author":"Speyer","year":"2021","journal-title":"Acta Obstet. Gynecol. Scand."},{"key":"10.1016\/j.bbi.2024.12.150_b0215","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1038\/s41586-018-0617-x","article-title":"Temporal development of the gut microbiome in early childhood from the TEDDY study","volume":"562","author":"Stewart","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.bbi.2024.12.150_b0220","series-title":"Prenatal Stress, the Placenta and Maternal Microbial Transmission; Implications for Health and Disease","author":"Togher","year":"2018"},{"key":"10.1016\/j.bbi.2024.12.150_b0225","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1097\/CM9.0000000000000734","article-title":"Gut microbiota dysbiosis in preeclampsia patients in the second and third trimesters","volume":"133","author":"Wang","year":"2020","journal-title":"Chin. Med. J. (Engl.)"},{"key":"10.1016\/j.bbi.2024.12.150_b0230","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1007\/s00726-013-1493-1","article-title":"Glycine metabolism in animals and humans: implications for nutrition and health","volume":"45","author":"Wang","year":"2013","journal-title":"Amino Acids"},{"key":"10.1016\/j.bbi.2024.12.150_b0235","doi-asserted-by":"crossref","DOI":"10.1016\/j.ynstr.2023.100592","article-title":"Association between gut microbiota and its functional metabolites with prenatal depression in women","volume":"28","author":"Xie","year":"2024","journal-title":"Neurobiol. Stress"},{"key":"10.1016\/j.bbi.2024.12.150_b0240","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.jad.2022.11.075","article-title":"Prevalence of perinatal anxiety and its determinants in mainland China: a systematic review and meta-analysis","volume":"323","author":"Yang","year":"2023","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.bbi.2024.12.150_b0245","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.neuroscience.2022.06.024","article-title":"Taxonomic and metabolic signatures of gut microbiota for assessing the severity of depression and anxiety in major depressive disorder patients","volume":"496","author":"Zhang","year":"2022","journal-title":"Neuroscience"},{"key":"10.1016\/j.bbi.2024.12.150_b0250","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2020.567268","article-title":"Fecal microbiota changes in patients with postpartum depressive disorder","volume":"10","author":"Zhou","year":"2020","journal-title":"Front. Cell. Infect. Microbiol."}],"container-title":["Brain, Behavior, and Immunity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0889159124008791?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0889159124008791?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,3,10]],"date-time":"2025-03-10T07:25:30Z","timestamp":1741591530000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0889159124008791"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3]]},"references-count":50,"alternative-id":["S0889159124008791"],"URL":"https:\/\/doi.org\/10.1016\/j.bbi.2024.12.150","relation":{},"ISSN":["0889-1591"],"issn-type":[{"value":"0889-1591","type":"print"}],"subject":[],"published":{"date-parts":[[2025,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Association between gut microbiota and perinatal depression and anxiety among a pregnancy cohort in Hunan, China","name":"articletitle","label":"Article Title"},{"value":"Brain, Behavior, and Immunity","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbi.2024.12.150","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}