{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T13:07:18Z","timestamp":1788959238401,"version":"build-2803163510"},"reference-count":87,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T00:00:00Z","timestamp":1770508800000},"content-version":"am","delay-in-days":283,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005440","name":"National Institutes of Health Center for Scientific Review","doi-asserted-by":"publisher","award":["1RO1DA041529"],"award-info":[{"award-number":["1RO1DA041529"]}],"id":[{"id":"10.13039\/100005440","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain, Behavior, and Immunity"],"published-print":{"date-parts":[[2025,5]]},"DOI":"10.1016\/j.bbi.2025.01.019","type":"journal-article","created":{"date-parts":[[2025,2,3]],"date-time":"2025-02-03T11:51:53Z","timestamp":1738583513000},"page":"38-52","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["Increased LPS-induced fever and sickness behavior in adult male and female rats perinatally exposed to morphine"],"prefix":"10.1016","volume":"126","author":[{"given":"Hannah J.","family":"Harder","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morgan G.","family":"Gomez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher T.","family":"Searles","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meghan E.","family":"Vogt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2889-503X","authenticated-orcid":false,"given":"Anne Z.","family":"Murphy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbi.2025.01.019_b0010","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1007\/s11481-021-10019-2","article-title":"Brief hydromorphone exposure during pregnancy sufficient to induce maternal and neonatal microbial dysbiosis","volume":"17","author":"Abu","year":"2022","journal-title":"J. Neuroimmune Pharmacol."},{"key":"10.1016\/j.bbi.2025.01.019_b0005","article-title":"Opioid-induced dysbiosis of maternal gut microbiota during gestation alters offspring gut microbiota and pain sensitivity","volume":"16","author":"Abu","year":"2023","journal-title":"Gut Microbes"},{"key":"10.1016\/j.bbi.2025.01.019_b0015","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1038\/s41575-019-0150-x","article-title":"Gastrointestinal motility, dysbiosis and opioid-induced tolerance: is there a link?","volume":"16","author":"Akbarali","year":"2019","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.bbi.2025.01.019_b0020","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1186\/s12974-020-01892-4","article-title":"Three-dimensional morphometric analysis reveals time-dependent structural changes in microglia and astrocytes in the central amygdala and hypothalamic paraventricular nucleus of heart failure rats","volume":"17","author":"Althammer","year":"2020","journal-title":"J. Neuroinflamm."},{"key":"10.1016\/j.bbi.2025.01.019_b0025","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.pedn.2021.03.011","article-title":"Diagnoses during the first three years of life for children with prenatal opioid exposure and neonatal abstinence syndrome using a large maternal infant data hub","volume":"61","author":"Arter","year":"2021","journal-title":"J. Pediatr. Nurs."},{"key":"10.1016\/j.bbi.2025.01.019_b0030","doi-asserted-by":"crossref","first-page":"1418","DOI":"10.1038\/mi.2016.9","article-title":"Opioid-induced gut microbial disruption and bile dysregulation leads to gut barrier compromise and sustained systemic inflammation","volume":"9","author":"Banerjee","year":"2016","journal-title":"Mucosal Immunol."},{"key":"10.1016\/j.bbi.2025.01.019_b0035","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2018.4169","article-title":"Association of immunoglobulin levels, infectious risk, and mortality with rituximab and hypogammaglobulinemia","volume":"1","author":"Barmettler","year":"2018","journal-title":"JAMA Netw. Open"},{"key":"10.1016\/j.bbi.2025.01.019_b0040","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/0889-1591(89)90013-5","article-title":"Suppression of natural killer cell activity by high-dose narcotic anesthesia in rats","volume":"3","author":"Beilin","year":"1989","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.bbi.2025.01.019_b0045","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/0090-1229(92)90196-U","article-title":"Narcotic-induced suppression of natural killer cell activity in ventilated and nonventilated rats","volume":"64","author":"Beilin","year":"1992","journal-title":"Clin. Immunol. Immunopathol."},{"key":"10.1016\/j.bbi.2025.01.019_b0050","first-page":"492","article-title":"Effects of anesthesia based on large versus small doses of fentanyl on natural killer cell cytotoxicity in the perioperative period","volume":"82","author":"Beilin","year":"1996","journal-title":"Anesth. Analg."},{"key":"10.1016\/j.bbi.2025.01.019_b0055","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1016\/0016-5085(83)90435-3","article-title":"Morphine tissue levels and reduction of gastrointestinal transit in rats. correlation supports primary action site in the gut","volume":"85","author":"Bianchi","year":"1983","journal-title":"Gastroenterology"},{"key":"10.1016\/j.bbi.2025.01.019_b0060","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1080\/13550280902913628","article-title":"Morphine enhances Tat-induced activation in murine microglia","volume":"15","author":"Bokhari","year":"2009","journal-title":"J. Neurovirol."},{"key":"10.1016\/j.bbi.2025.01.019_b0065","doi-asserted-by":"crossref","first-page":"657","DOI":"10.3109\/08923979209005416","article-title":"Differential effects of morphine and naltrexone on the antibody response in various mouse strains","volume":"14","author":"Bussiere","year":"1992","journal-title":"Immunopharmacol. Immunotoxicol."},{"key":"10.1016\/j.bbi.2025.01.019_b0070","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.bbi.2016.08.002","article-title":"Age and sex differences in immune response following LPS treatment in mice","volume":"58","author":"Cai","year":"2016","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.bbi.2025.01.019_b0075","doi-asserted-by":"crossref","first-page":"13035","DOI":"10.3390\/ijms222313035","article-title":"Developmental stressors induce innate immune memory in microglia and contribute to disease risk","volume":"22","author":"Carloni","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbi.2025.01.019_b0080","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1111\/j.1469-7793.1999.0585p.x","article-title":"Brain sites of action of endogenous interleukin-1 in the febrile response to localized inflammation in the rat","volume":"518","author":"Cartmell","year":"1999","journal-title":"J. Physiol."},{"key":"10.1016\/j.bbi.2025.01.019_b0085","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/0143-4179(91)90161-B","article-title":"Inhibition by opioids of phagocytosis in peritoneal macrophages","volume":"18","author":"Casellas","year":"1991","journal-title":"Neuropeptides"},{"key":"10.1016\/j.bbi.2025.01.019_b0090","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1186\/1744-8069-3-28","article-title":"Morphine reduces local cytokine expression and neutrophil infiltration after incision","volume":"3","author":"Clark","year":"2007","journal-title":"Mol. Pain"},{"key":"10.1016\/j.bbi.2025.01.019_b0095","doi-asserted-by":"crossref","first-page":"572","DOI":"10.3758\/s13428-019-01252-y","article-title":"ClusterBootstrap: An R package for the analysis of hierarchical data using generalized linear models with the cluster bootstrap","volume":"52","author":"Deen","year":"2020","journal-title":"Behav. Res. Methods"},{"key":"10.1016\/j.bbi.2025.01.019_b0100","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1002\/jnr.23852","article-title":"Sex differences in innate immunity and its impact on opioid pharmacology","volume":"95","author":"Doyle","year":"2017","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.bbi.2025.01.019_b0105","doi-asserted-by":"crossref","first-page":"3202","DOI":"10.1523\/JNEUROSCI.2906-16.2017","article-title":"Sex differences in microglia activity within the periaqueductal gray of the rat: a potential mechanism driving the dimorphic effects of morphine","volume":"37","author":"Doyle","year":"2017","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bbi.2025.01.019_b0115","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/j.jpain.2012.12.010","article-title":"Persistent peripheral inflammation attenuates morphine-induced periaqueductal gray glial cell activation and analgesic tolerance in the male rat","volume":"14","author":"Eidson","year":"2013","journal-title":"J. Pain"},{"key":"10.1016\/j.bbi.2025.01.019_b0110","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1038\/npp.2016.131","article-title":"Toll-like receptor 4 mediates morphine-induced neuroinflammation and tolerance via soluble tumor necrosis factor signaling","volume":"42","author":"Eidson","year":"2017","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.bbi.2025.01.019_b0120","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1007\/978-1-4615-2980-4_7","article-title":"Immunosuppressive effects of morphine on immune responses in mice","volume":"335","author":"Eisenstein","year":"1993","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.bbi.2025.01.019_b0125","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1006\/cimm.1999.1534","article-title":"Phenotypic analysis of splenocyte subsets following acute morphine treatment in the rat","volume":"195","author":"Fecho","year":"1999","journal-title":"Cell. Immunol."},{"key":"10.1016\/j.bbi.2025.01.019_b0130","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1159\/000447252","article-title":"Increased intestinal permeability and decreased barrier function: does it really influence the risk of inflammation?","volume":"1","author":"Fukui","year":"2016","journal-title":"Inflamm. Intest. Diseases"},{"key":"10.1016\/j.bbi.2025.01.019_b0135","doi-asserted-by":"crossref","first-page":"957","DOI":"10.3389\/fimmu.2017.00957","article-title":"Postnatal innate immune development: from birth to adulthood","volume":"8","author":"Georgountzou","year":"2017","journal-title":"Front. Immunol."},{"key":"10.1016\/j.bbi.2025.01.019_b0145","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/S0162-3109(00)00198-3","article-title":"Differential effects of buprenorphine and morphine on immune and neuroendocrine functions following acute administration in the rat mesencephalon periaqueductal gray","volume":"48","author":"Gomez-Flores","year":"2000","journal-title":"Immunopharmacology"},{"key":"10.1016\/j.bbi.2025.01.019_b0140","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1006\/brbi.1999.0563","article-title":"Suppression of splenic macrophage functions following acute morphine action in the rat mesencephalon periaqueductal gray","volume":"13","author":"Gomez-Flores","year":"1999","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.bbi.2025.01.019_b0150","doi-asserted-by":"crossref","DOI":"10.1016\/j.drugalcdep.2021.108914","article-title":"Prenatal opioid administration induces shared alterations to the maternal and offspring gut microbiome: a preliminary analysis","volume":"227","author":"Grecco","year":"2021","journal-title":"Drug Alcohol Depend."},{"key":"10.1016\/j.bbi.2025.01.019_b0155","doi-asserted-by":"crossref","unstructured":"Hamilton, K.L., Franklin, L. \u2019Tonyia M., Roy, S., Schrott, L.M., 2007. Prenatal opiate exposure attenuates LPS-induced fever in adult rats: Role of interleukin-1\u03b2. Brain Res. 1133, 92\u201399. doi: 10.1016\/j.brainres.2006.11.044.","DOI":"10.1016\/j.brainres.2006.11.044"},{"key":"10.1016\/j.bbi.2025.01.019_b0160","doi-asserted-by":"crossref","DOI":"10.1016\/j.yhbeh.2023.105384","article-title":"Perinatal opioid exposure leads to decreased social play in adolescent male and female rats: potential role of oxytocin signaling in brain regions associated with social reward","volume":"153","author":"Harder","year":"2023","journal-title":"Horm. Behav."},{"key":"10.1016\/j.bbi.2025.01.019_b0165","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/S0149-7634(88)80004-6","article-title":"Biological basis of the behavior of sick animals","volume":"12","author":"Hart","year":"1988","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.bbi.2025.01.019_b0170","article-title":"Prenatal opioid exposure: the next neonatal neuroinflammatory disease","author":"Jantzie","year":"2019","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.bbi.2025.01.019_b0175","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1186\/s12967-021-02839-w","article-title":"The gut microbiota is associated with the small intestinal paracellular permeability and the development of the immune system in healthy children during the first two years of life","volume":"19","author":"Kaczmarczyk","year":"2021","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.bbi.2025.01.019_b0180","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1038\/nri.2016.90","article-title":"Sex differences in immune responses","volume":"16","author":"Klein","year":"2016","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.bbi.2025.01.019_b0185","doi-asserted-by":"crossref","first-page":"e547","DOI":"10.1542\/peds.2013-3524","article-title":"Neonatal abstinence syndrome","volume":"134","author":"Kocherlakota","year":"2014","journal-title":"Pediatrics"},{"key":"10.1016\/j.bbi.2025.01.019_b0190","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0162971","article-title":"Gender difference in bacteria endotoxin-induced inflammatory and anorexic responses","volume":"11","author":"Kuo","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.bbi.2025.01.019_b0195","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.neubiorev.2020.05.001","article-title":"Comparison of bacterial lipopolysaccharide-induced sickness behavior in rodents and humans: relevance for symptoms of anxiety and depression","volume":"115","author":"Lasselin","year":"2020","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.bbi.2025.01.019_b0200","doi-asserted-by":"crossref","first-page":"2606","DOI":"10.1038\/s41386-018-0211-9","article-title":"The gut microbiota mediates reward and sensory responses associated with regimen-selective morphine dependence","volume":"43","author":"Lee","year":"2018","journal-title":"Neuropsychopharmacol. Off. Publ. Am. Coll. Neuropsychopharmacol."},{"key":"10.1016\/j.bbi.2025.01.019_b0205","doi-asserted-by":"crossref","first-page":"14007","DOI":"10.1523\/JNEUROSCI.4123-08.2008","article-title":"Sex differences in \u03bc-opioid receptor expression in the rat midbrain periaqueductal gray are essential for eliciting sex differences in morphine analgesia","volume":"28","author":"Loyd","year":"2008","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bbi.2025.01.019_b0210","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.jneuroim.2006.04.007","article-title":"Altered subcellular signaling in murine peritoneal macrophages upon chronic morphine exposure","volume":"176","author":"Lugo-Chinchilla","year":"2006","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.bbi.2025.01.019_b0215","doi-asserted-by":"crossref","unstructured":"Lyu, Z., Schmidt, R.R., Martin, R.E., Green, M.T., Kinkade, J.A., Mao, J., Bivens, N.J., Joshi, T., Rosenfeld, C.S., 2022. Long-term effects of developmental exposure to oxycodone on gut microbiota and relationship to adult behaviors and metabolism. mSystems 7, e00336-22. doi: 10.1128\/msystems.00336-22.","DOI":"10.1128\/msystems.00336-22"},{"key":"10.1016\/j.bbi.2025.01.019_b0220","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.06426","article-title":"Functional subregions of the human entorhinal cortex","volume":"4","author":"Maass","year":"2015","journal-title":"Elife"},{"key":"10.1016\/j.bbi.2025.01.019_b0225","doi-asserted-by":"crossref","first-page":"2573","DOI":"10.1523\/JNEUROSCI.2887-19.2020","article-title":"EP3R-expressing glutamatergic preoptic neurons mediate inflammatory fever","volume":"40","author":"Machado","year":"2020","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bbi.2025.01.019_b0230","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.jneuroim.2010.10.017","article-title":"Morphine decreases early peritoneal innate immunity responses in Swiss-Webster and C57BL6\/J mice through the inhibition of mast cell TNF-\u03b1 release","volume":"232","author":"Madera-Salcedo","year":"2011","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.bbi.2025.01.019_b0235","doi-asserted-by":"crossref","first-page":"10792","DOI":"10.3389\/adar.2022.10792","article-title":"Methadone alters the peripheral inflammatory and central immune landscape following prenatal exposure in rats","volume":"2","author":"Madurai","year":"2022","journal-title":"Adv. Drug Alcohol Res."},{"key":"10.1016\/j.bbi.2025.01.019_bib431","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.mehy.2016.10.006","article-title":"Neonatal abstinence syndrome and the gastrointestinal tract","volume":"97","author":"Maguire","year":"2016","journal-title":"Med. Hypotheses"},{"key":"10.1016\/j.bbi.2025.01.019_b0240","article-title":"Morphine induces bacterial translocation in mice by compromising intestinal barrier function in a TLR-dependent manner","volume":"8","author":"Meng","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.bbi.2025.01.019_b0245","doi-asserted-by":"crossref","first-page":"10918","DOI":"10.1038\/srep10918","article-title":"Opioid exacerbation of Gram-positive sepsis, induced by gut microbial modulation, is rescued by IL-17A neutralization","volume":"5","author":"Meng","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbi.2025.01.019_b0250","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1111\/j.1440-1681.2004.04086.x","article-title":"Role of endogenous macrophage inflammatory protein-2 in regulating fever induced by bacterial endotoxin in normal and immunosuppressed rats","volume":"31","author":"Mi\u00f1ano","year":"2004","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"10.1016\/j.bbi.2025.01.019_b0255","unstructured":"Motulsky, H., 2023. The mixed model approach to analyzing repeated measures data [WWW Document]. URL https:\/\/www.graphpad.com\/guides\/prism\/latest\/statistics\/stat_anova-approach-vs_-mixed-model.htm (accessed 6.28.23)."},{"key":"10.1016\/j.bbi.2025.01.019_b0260","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1006\/brbi.1999.0575","article-title":"Involvement of central mu- but not delta- or kappa-opioid receptors in immunomodulation","volume":"14","author":"Nelson","year":"2000","journal-title":"Brain Behav. Immun."},{"issue":"Supplement_5","key":"10.1016\/j.bbi.2025.01.019_b0265","doi-asserted-by":"crossref","first-page":"S178","DOI":"10.1086\/317513","article-title":"Circulating cytokines as mediators of fever","volume":"31","author":"Netea","year":"2000","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.bbi.2025.01.019_b0270","doi-asserted-by":"crossref","DOI":"10.3389\/fped.2020.00272","article-title":"Perinatal opioid exposure primes the peripheral immune system toward hyperreactivity","volume":"8","author":"Newville","year":"2020","journal-title":"Front. Pediatr."},{"key":"10.1016\/j.bbi.2025.01.019_b0275","doi-asserted-by":"crossref","unstructured":"Novick, D.M., Ochshorn, M., Ghali, V., Croxson, T.S., Mercer, W.D., Chiorazzi, N., Kreek, M.J., 1989. Natural killer cell activity and lymphocyte subsets in parenteral heroin abusers and long-term methadone maintenance patients. J. Pharmacol. Exp. Ther. 250.","DOI":"10.1016\/S0022-3565(25)22252-2"},{"key":"10.1016\/j.bbi.2025.01.019_b0280","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/S1040-8428(01)00220-7","article-title":"Fever and neutropenia in cancer patients: the diagnostic role of cytokines in risk assessment strategies","volume":"44","author":"Oude Nijhuis","year":"2002","journal-title":"Crit. Rev. Oncol. Hematol."},{"key":"10.1016\/j.bbi.2025.01.019_b0285","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1037\/met0000126","article-title":"Reporting effect sizes in original psychological research: a discussion and tutorial","volume":"23","author":"Pek","year":"2018","journal-title":"Psychol. Methods"},{"key":"10.1016\/j.bbi.2025.01.019_b0290","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1016\/j.neuroscience.2009.01.072","article-title":"Neurochemical and behavioral alterations in an inflammatory model of depression: sex differences exposed","volume":"159","author":"Pitychoutis","year":"2009","journal-title":"Neuroscience"},{"key":"10.1016\/j.bbi.2025.01.019_b0295","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1056\/NEJM199909163411207","article-title":"Fever in immunocompromised patients","volume":"341","author":"Pizzo","year":"1999","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.bbi.2025.01.019_b0300","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/S0165-5728(98)00265-3","article-title":"Morphine synergizes with lipopolysaccharide in a chronic endotoxemia model","volume":"95","author":"Roy","year":"1999","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.bbi.2025.01.019_b0305","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1038\/sj.bjp.0701138","article-title":"Antinociceptive and immunosuppressive effects of opiate drugs: a structure-related activity study","volume":"121","author":"Sacerdote","year":"1997","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.bbi.2025.01.019_b0310","doi-asserted-by":"crossref","first-page":"1880","DOI":"10.1056\/NEJM199406303302609","article-title":"The neurologic basis of fever","volume":"330","author":"Saper","year":"1994","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.bbi.2025.01.019_b0315","article-title":"Application of the hierarchical bootstrap to multi-level data in neuroscience","volume":"3","author":"Saravanan","year":"2020","journal-title":"Neurons Behav. Data Anal. Theory"},{"key":"10.1016\/j.bbi.2025.01.019_b0320","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1093\/ecco-jcc\/jjz188","article-title":"Prescription opioids induce gut dysbiosis and exacerbate colitis in a murine model of inflammatory bowel disease","volume":"14","author":"Sharma","year":"2020","journal-title":"J. Crohns Colitis"},{"key":"10.1016\/j.bbi.2025.01.019_b0325","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1016\/S0091-3057(97)00532-7","article-title":"Effects of prenatal morphine exposure on NK cytotoxicity and responsiveness to LPS in rats","volume":"59","author":"Shavit","year":"1998","journal-title":"Pharmacol. Biochem. Behav"},{"key":"10.1016\/j.bbi.2025.01.019_b0330","doi-asserted-by":"crossref","unstructured":"Smith, B.L., Guzman, T.A., Brendle, A.H., Laaker, C.J., Ford, A., Hiltz, A.R., Zhao, J., Setchell, K.D.R., Reyes, T.M., 2022. Perinatal Morphine Exposure Leads to Sex-Dependent Executive Function Deficits and Microglial Changes in Mice. eNeuro 9, ENEURO.0238-22.2022. doi: 10.1523\/ENEURO.0238-22.2022.","DOI":"10.1523\/ENEURO.0238-22.2022"},{"key":"10.1016\/j.bbi.2025.01.019_b0335","article-title":"The Rat Grimace Scale: a partially automated method for quantifying pain in the laboratory rat via facial expressions","volume":"7","author":"Sotocinal","year":"2011","journal-title":"Mol. Pain"},{"key":"10.1016\/j.bbi.2025.01.019_b0340","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/S0192-0561(97)00017-9","article-title":"Effects of morphine on purified human blood monocytes. modifications of properties involved in antiviral defences","volume":"19","author":"Stoll-Keller","year":"1997","journal-title":"Int. J. Immunopharmacol"},{"key":"10.1016\/j.bbi.2025.01.019_b0345","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1073\/pnas.88.2.360","article-title":"Immunomodulatory activity of mu- and kappa-selective opioid agonists","volume":"88","author":"Taub","year":"1991","journal-title":"PNAS"},{"key":"10.1016\/j.bbi.2025.01.019_b0350","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1128\/CDLI.12.9.1085-1093.2005","article-title":"Circulating inflammatory mediators during start of fever in differential diagnosis of gram-negative and gram-positive infections in leukopenic rats","volume":"12","author":"Tavares","year":"2005","journal-title":"Clin. Vaccine Immunol."},{"key":"10.1016\/j.bbi.2025.01.019_b0355","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1189\/jlb.0106064","article-title":"Endotoxin fever in granulocytopenic rats: evidence that brain cyclooxygenase-2 is more important than circulating prostaglandin E2","volume":"80","author":"Tavares","year":"2006","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.bbi.2025.01.019_b0360","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.jneuroim.2003.10.028","article-title":"Morphine inhibits Fc-mediated phagocytosis through mu and delta opioid receptors","volume":"147","author":"Tomassini","year":"2004","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.bbi.2025.01.019_b0365","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/S0165-5728(96)00213-5","article-title":"Effect of morphine on Fc-mediated phagocytosis by murine macrophages in vitro","volume":"74","author":"Tomei","year":"1997","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.bbi.2025.01.019_b0370","doi-asserted-by":"crossref","first-page":"e811","DOI":"10.1542\/peds.2014-2767","article-title":"Reasons for rehospitalization in children who had neonatal abstinence syndrome","volume":"136","author":"Uebel","year":"2015","journal-title":"Pediatrics"},{"key":"10.1016\/j.bbi.2025.01.019_b0380","doi-asserted-by":"crossref","first-page":"10225","DOI":"10.1074\/jbc.M110.188680","article-title":"Morphine inhibits murine dendritic cell IL-23 production by modulating toll-like receptor 2 and Nod2 signaling","volume":"286","author":"Wang","year":"2011","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbi.2025.01.019_b0375","doi-asserted-by":"crossref","first-page":"6325","DOI":"10.1073\/pnas.1200130109","article-title":"Morphine activates neuroinflammation in a manner parallel to endotoxin","volume":"109","author":"Wang","year":"2012","journal-title":"PNAS"},{"key":"10.1016\/j.bbi.2025.01.019_b0385","doi-asserted-by":"crossref","first-page":"3596","DOI":"10.1038\/s41598-018-21915-8","article-title":"Morphine induces changes in the gut microbiome and metabolome in a morphine dependence model","volume":"8","author":"Wang","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbi.2025.01.019_b0390","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1080\/19490976.2019.1629237","article-title":"Opioid use potentiates the virulence of hospital-acquired infection, increases systemic bacterial dissemination and exacerbates gut dysbiosis in a murine model of Citrobacter rodentium infection","volume":"11","author":"Wang","year":"2020","journal-title":"Gut Microbes"},{"key":"10.1016\/j.bbi.2025.01.019_b0395","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1126\/science.2749256","article-title":"The periaqueductal gray matter mediates opiate-induced immunosuppression","volume":"245","author":"Weber","year":"1989","journal-title":"Science"},{"key":"10.1016\/j.bbi.2025.01.019_b0400","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1037\/0003-066X.54.8.594","article-title":"Statistical methods in psychology journals: guidelines and explanations","volume":"54","author":"Wilkinson","year":"1999","journal-title":"Am. Psychol."},{"key":"10.1016\/j.bbi.2025.01.019_b0405","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1038\/jp.2017.106","article-title":"Neonatal abstinence syndrome and early childhood morbidity and mortality in Washington state: a retrospective cohort study","volume":"37","author":"Witt","year":"2017","journal-title":"J. Perinatol."},{"key":"10.1016\/j.bbi.2025.01.019_b0410","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1016\/j.bbi.2010.03.006","article-title":"Sex-specific social regulation of inflammatory responses and sickness behaviors","volume":"24","author":"Yee","year":"2010","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.bbi.2025.01.019_b0415","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1007\/s00540-004-0247-3","article-title":"Addition of noradrenaline to intrathecal morphine augments the postoperative suppression of natural killer cell activity","volume":"18","author":"Yokota","year":"2004","journal-title":"J. Anesth."},{"key":"10.1016\/j.bbi.2025.01.019_b0420","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1080\/23328940.2015.1102802","article-title":"Central mediators involved in the febrile response: effects of antipyretic drugs","volume":"2","author":"Zampronio","year":"2015","journal-title":"Temperature"},{"key":"10.1016\/j.bbi.2025.01.019_b0425","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.neulet.2010.11.063","article-title":"Essential role of toll-like receptor 2 in morphine-induced microglia activation in mice","volume":"489","author":"Zhang","year":"2011","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.bbi.2025.01.019_b0430","article-title":"Toll-like receptor 4 (TLR4)\/opioid receptor pathway crosstalk and impact on opioid analgesia, immune function, and gastrointestinal motility","volume":"11","author":"Zhang","year":"2020","journal-title":"Front. Immunol."}],"container-title":["Brain, Behavior, and Immunity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0889159125000303?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0889159125000303?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T03:39:50Z","timestamp":1762313990000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0889159125000303"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5]]},"references-count":87,"alternative-id":["S0889159125000303"],"URL":"https:\/\/doi.org\/10.1016\/j.bbi.2025.01.019","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2023.09.20.558690","asserted-by":"object"}]},"ISSN":["0889-1591"],"issn-type":[{"value":"0889-1591","type":"print"}],"subject":[],"published":{"date-parts":[[2025,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Increased LPS-induced fever and sickness behavior in adult male and female rats perinatally exposed to morphine","name":"articletitle","label":"Article Title"},{"value":"Brain, Behavior, and Immunity","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbi.2025.01.019","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}